Category: Nevin Manimala

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15622. Online ahead of print.

ABSTRACT

BACKGROUND: Oral licen planus (OLP) is a chronic inflammatory disease and may have immunological background. Both intralesional injection of PRP and steroids succeeded in treating and decreasing recurrence of the disease.

PATIENTS AND METHODS: Twenty-four participants with clinically diagnosed as OLP were enrolled in this study. We separated the patients in 2 groups, 12 patients in group A were treated by intralesional PRP every two weeks for 2 months or stopped if healing occurred earlier. Group B (12 patients) treated by intralesional Triamcinolone Acetonide (TA) (20 mg) every two weeks for 2 months or may be less if healing occurred earlier. The response of OLP lesions to treatment was evaluated by reduction of lesional areas, REU scores, and NRS scores. The patients with complete response (CR; 80%-100% reduction in the lesion area) were followed for 3 months biweekly.

RESULTS: There was a statistically significant decrease in REU and pain score in both groups after treatment compared to before. There was a statistically increase in frequency of side effects among patients received PRP especially pain compared to those treated by steroid. Also, recurrence of the disease after treatment during follow-up for 3 months was more significant among patients treated by PRP.

CONCLUSION: Intralesional PRP is a good and safe modality for treatment of OLP and intralesional TA. However, there were some side effects and recurrence of disease after follow-up for three months in patients treated by PRP more than those treated by TA.

PMID:36718838 | DOI:10.1111/jocd.15622

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15634. Online ahead of print.

ABSTRACT

BACKGROUND: Consequently, the management of post burn hypertrophic scars and keloid in children are a great challenge for the physicians, parents, and children themselves.

PURPOSE OF THE STUDY: To assess the efficacy and safety of treating hypertrophic and keloid scars with botulinum toxins injections.

PATIENTS AND METHODS: This is a randomized intra-patient comparative study was conducted on 15 children with post burn hypertrophic and keloid scars. Children were randomized to receive Intralesional injection of botulinum toxins on one part of the hypertrophic scar/keloid where the other part was left as a control. The assessment of clinical improvement was measured by the Vancouver scar scale (VSS) and by skin analysis camera system. Sessions were performed every month for 6 months.

RESULTS: Clinical and statistical dramatic improvement in the vascularity, pliability, and height of the lesions which have been injected with neuronox. Evaluation of the lesions by the Antera camera has proven marked changes in the vascularity and height. There was no correlations between Vancouver score improvement and variables such as the age, sex, skin type, and duration and lesion type.

CONCLUSIONS: The botulinum toxins proved its efficacy and safety in treatment of hypertrophic scars and keloid in children. It improved the associated itching and pain. Moreover it improves the pliability, erythema, and thickness of the scars.

PMID:36718819 | DOI:10.1111/jocd.15634

Interact J Med Res. 2023 Jan 31. doi: 10.2196/40883. Online ahead of print.

ABSTRACT

BACKGROUND: Despite significant improvement in the last decade, road trauma remains a significant contributor to deaths in Vietnam. The COVID-19 pandemic necessitated public health measures which had an unforeseen benefit on road trauma in high income countries. We investigate if this reduction was also seen in a low to middle income country, Vietnam.

OBJECTIVE: Our aim was to investigate how the COVID-19 pandemic, and the government policies to address it, impacted on road trauma fatalities in Vietnam. We also compared this impact with other government policies intended to road trauma in the preceding 14 years (2007 to 2020).

METHODS: COVID-19 data was extracted from the Vietnamese Ministry of Health (MoH) database. Road traffic deaths from 2007 to 2021 were derived from the Vietnamese General Statistical Office (GSO). We used Stata software 17 for statistical analysis. Poisson regression modelling, with the logarithm of the national population of Vietnam of each year included as an offset, was used to estimate trends in rates of road fatalities from the annual national mortality data for the period 2007-2021. The actual change in road traffic mortality in 2021 was compared with calculated figures to demonstrate the effect of COVID-19 on road trauma fatalities. We also compared this impact with other government road toll reduction policies for 14 years (2007 to 2020).

RESULTS: Between 2007 and 2020 the number of annual road traffic deaths had more than halved from 15.3 to 7.0 per 100,000, an average reduction of 5.4% per annum. We estimated that the road traffic mortality rate declined by 12.1% (95% CI 8.9 to 15.3%) in 2021 relative to trend. The actual number of road trauma deaths fell by 16.4%. This reduction was largely seen from August to October 2021 when lockdown and social distancing were in force.

CONCLUSIONS: In 2021, the road traffic death reduction in Vietnam was 3 times greater than the trend over the preceding 14 years. The public heath response to the COVID-19 pandemic in Vietnam was associated with a third of this reduction. It can thus be reasonably concluded that government policies to address the COVID-19 pandemic resulted in a 4.3% decrease of road traffic deaths in 2021. This has been observed in High-Income Countries but was demonstrated by us for the first time in a Low- and Middle-Income Country.

PMID:36718815 | DOI:10.2196/40883

Q J Exp Psychol (Hove). 2023 Jan 31:17470218231155897. doi: 10.1177/17470218231155897. Online ahead of print.

ABSTRACT

The Dual strategy model suggests that people can either use a Statistical or a Counterexample reasoning strategy, which reflects two qualitatively different way of processing information. This model has been shown to capture individual differences in a wide array of tasks, such as contingency learning. Here, we examined whether this extends to individual differences in the interpretation of contingency information where effects are ambiguous. Previous studies, using perceptually complex stimuli, have shown that the way which participants interpret ambiguous effects predicts causal judgments, In two studies, we attempted to replicate this effect using a small number of clearly identifiable cues. Results show that interpretation of ambiguous effects as effect present is related to final contingency judgments. In addition, results showed that Statistical reasoners had a stronger tendency to interpret ambiguous effects as effect present than Counterexample reasoners, which mediates the difference in contingency judgements.

PMID:36718805 | DOI:10.1177/17470218231155897

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15606. Online ahead of print.

ABSTRACT

BACKGROUND: Currently, even individuals who do physical activity regularly have some degree of dissatisfaction with their own bodies. The electromagnetic field for supramaximal muscle contraction has been the subject of research. High-intensity supramaximal muscle stimulation (HI-SMS) is a non-invasive technology used to strengthen, firm, and tone the abdominal muscles, arms, buttocks, and thighs and has been indicated for aesthetic purposes.

AIMS: The present study aimed to examine the safety and efficacy of HI-SMS used in the abdominal muscles of patients through the analysis of clinical evaluation, biochemical serum profile, and patient satisfaction with the procedure.

PATIENTS/METHODS: This is retrospective non-randomized and non-controlled study collected in a private clinic; all data from healthy participants (n = 25), aged between 18 and 55 years, were compiled and analyzed. All received eight 30 min sessions of electromagnetic field ONIX HI-SMS (intensity of the 90%-100%) located in abdominal, twice a week with intervals of 2-3 days.

RESULTS: The results show that BMI, fat thickness, and waist circumference improved the body contour after the treatment. There was no statistical difference in the data referring to the values of AST, ALT, ALP, creatinine, cholesterol, LDL-C, VLDL-C, HDL-C, glycemia, LDH, CK, and IL-6. However, there was a reduction of “non-esterified” free fatty acids when compared to baseline. This treatment provided high levels of tolerance, comfort, and high level of satisfaction.

CONCLUSIONS: Thus, it can be suggested that the treatment with HI-SMS in abdominal muscles proves to be a safe technology with potential for non-invasive therapy for aesthetic purposes.

PMID:36718803 | DOI:10.1111/jocd.15606

Q J Exp Psychol (Hove). 2023 Jan 31:17470218231155738. doi: 10.1177/17470218231155738. Online ahead of print.

ABSTRACT

Voice identification parades can be unreliable due to the error-prone nature of earwitness responses. UK government guidelines recommend that voice parades should have nine voices, each played for 60 seconds. This makes parades resource-consuming to construct. In the present paper we conducted two experiments to see if voice parade procedures could be simplified. In Experiment 1 (N=271, 135F), we investigated if reducing the duration of the voice samples on a nine-voice parade would negatively affect identification performance using both conventional logistic and signal detection approaches. In Experiment 2 (N=270, 136F), we first explored if the same sample duration conditions used in Experiment 1 would lead to different outcomes if we reduced the parade size to include only six voices. Following this, we pooled the data from both experiments to investigate the influence of target-position effects. The results show that 15s sample durations result in statistically equivalent voice identification performance to the longer 60s sample durations, but that the 30s sample duration suffers in terms of overall signal sensitivity. This pattern of results was replicated using both a nine- and a six-voice parade. Performance on target-absent parades were at chance-levels in both parade sizes and response criteria were mostly liberal. Additionally, unwanted position effects were present. The results provide initial evidence that the sample duration used in a voice parade may be reduced, but we argue that the guidelines recommending a parade with nine-voices should be maintained to provide additional protection for a potentially innocent suspect given the low target-absent accuracy.

PMID:36718784 | DOI:10.1177/17470218231155738

Environ Toxicol Chem. 2023 Jan 31. doi: 10.1002/etc.5549. Online ahead of print.

ABSTRACT

The high-production-volume chemical 4,4′-methylenedianiline (4,4′-MDA) is an aromatic amine used to manufacture 4,4′-methylenedianiline diisocyanate for polyurethane production. Based on 4,4′-MDA’s octanol/water partition coefficient (K_OW ) and correlations with the transpiration stream concentration factor (TSCF), significant plant uptake and root-to-shoot transfer are predicted. However, most correlations between K_OW and TSCF were developed for neutral organics and may not be applicable for ionizable bases such as 4,4′-MDA. To investigate, TSCF values for 4,4′-MDA were measured using pressure chamber and intact plant approaches for tomato, soybean, and wheat (intact plants only). ¹⁴ C-labeled 4,4′-MDA was used to increase analytical sensitivity and facilitate measurement of distribution within plant tissues. The TSCF of ¹⁴ C-MDA determined using the pressure chamber method was 0.04 ± 0.00 for tomato and 0.17 ± 0.10 for soybean. These values were lower than predicted from log K_OW and within the range of values for ¹⁴ C-pyrene also measured in our study (0.14 ± 0.00 for tomato and 0.16 ± 0.09 for soybean). The TSCF values calculated from measurements made from intact plants grown to maturity were statistically equivalent to those obtained from the pressure chamber method for soybean and tomato. The distributions of ¹⁴ C within the three plants species were similar, with the roots > leaves ≈ stems > fruit. The log root concentration factors for 4,4′-MDA ranged from 3.68 to 4.33 for the three plant species. This finding indicates that the aromatic amine sorption to root materials is much greater than would be predicted based on its log K_OW and may be the reason for the limited root-to-shoot transfer observed in the pressure chamber and intact plant studies. Environ Toxicol Chem 2023;00:1-8. © 2023 SETAC.

PMID:36718782 | DOI:10.1002/etc.5549

Can Assoc Radiol J. 2023 Jan 31:8465371231153828. doi: 10.1177/08465371231153828. Online ahead of print.

ABSTRACT

Purpose: Determine whether standardized template reporting for the preoperative assessment of potential living renal transplant donors improves the comprehensiveness of radiology reports to meet the needs of urologists performing renal transplants. Methods: Urologist and radiologist stakeholders from renal transplant centers in our province ratified a standardized reporting template for evaluation of potential renal donors. Three centers (A, B, and C) were designated “intervention” groups. Center D was the control group, given employment of a site-specific standardized template prior to study commencement. Up to 100 consecutive CT scan reports per center, pre- and post-implementation of standardized reporting, were evaluated for reporting specific outcome measures. Results: At baseline, all intervention groups demonstrated poor reporting of urologist-desired outcome measures. Center A discussed 5/13 variables (38%), Center B discussed 6/13 variables (46%), and Center C only discussed 1/13 variables (8%) with ≥90% reliability. The control group exhibited consistent reporting, with 11/13 variables (85%) reported at ≥90% reliability. All institutions in the intervention group exhibited excellent compliance to structured reporting post-template implementation (Centers A = 95%, B = 100%, and C = 77%, respectively). Additionally, all intervention centers demonstrated a significant improvement in the comprehensiveness of reports post-template implementation, with statistically significant increases in the reporting of all variables under-reported at baseline (P > .01). Conclusion: Standardized templates across our province for CT scans of potential renal donors promote completeness of reports. Radiologists can reliably provide our surgical colleagues with needed preoperative anatomy and incidental findings, helping to determine suitable transplant donors and reduce potential complications associated with organ retrieval.

PMID:36718778 | DOI:10.1177/08465371231153828

Pain Manag. 2023 Jan 31. doi: 10.2217/pmt-2022-0059. Online ahead of print.

ABSTRACT

Aim: We sought to investigate the impact of social determinants of health on pain clinic attendance. Materials & methods: Retrospective data were collected from the Pain Center at Montefiore Medical Center from 2016 to 2020 and analyzed with multivariable logistic regression. Results: African-Americans were less likely to attend appointments compared with White patients (odds ratio [OR]: 0.73; 95% CI: 0.70-0.77; p < 0.001). Males had decreased attendance compared with females (OR: 0.89; 95% CI: 0.87-0.92; p < 0.001). Compared with Commercial, those with Medicaid (OR: 0.69; 95% CI: 0.66-0.72; p < 0.001) and Medicare (OR: 0.76; 95% CI: 0.73-0.80; p < 0.001) insurance had decreased attendance. Conclusion: Significant disparities exist in pain clinic attendance based upon social determinants of health including race, gender and insurance type.

PMID:36718774 | DOI:10.2217/pmt-2022-0059

J Cosmet Dermatol. 2023 Jan 31. doi: 10.1111/jocd.15599. Online ahead of print.

ABSTRACT

BACKGROUND: Carboxytherapy is one of the most popular procedures used in dermatology. The treatments are known to be minimally invasive and highly effective for various skin disorders. Therefore, the research carried out in the paper is purposeful and addresses an important area of aesthetic therapies.

AIMS: Objective, apparatus-based assessment of the effect of carboxytherapy on skin elasticity around the eyes.

PATIENTS/METHODS: The study included a group of 39 Caucasian individuals aged 35-55 years. Participants were subjected to a series of five carboxytherapy treatments of eye area at weekly intervals. The Cutometer measuring probe was used to assess skin elasticity. Additionally, photographic documentation was out using the Fotomedicus system.

RESULTS: In this study, statistically significant increase in R2 parameter was found as the result of applied treatment. This parameter is considered to be the most important indicator of changes in skin elasticity. In 29 out of 39 subjects, the carboxytherapy treatment significantly improved skin tension and elasticity. Such therapy may also exert a beneficial effect on flexibility since in 28 participants the favorable change in the R7 parameter was visible.

CONCLUSIONS: The objective analysis of the impact of carboxytherapy treatment on parameters determining skin elasticity revealed that this therapy can be used as an anti-aging method in the eye area. Obtained results are in agreement with other biochemical, histological, and photographical documentation analyses of the effect of carboxytherapy on skin, performed by independent researchers.

PMID:36718772 | DOI:10.1111/jocd.15599