Category: Nevin Manimala

Ann Am Thorac Soc. 2023 Mar 8. doi: 10.1513/AnnalsATS.202209-829OC. Online ahead of print.

ABSTRACT

RATIONALE: Studies estimating rate of lung function decline in cystic fibrosis (CF) have been inconsistent regarding methods used. How the methodology used impacts validity of the results and comparability between studies is unknown.

OBJECTIVES: The Cystic Fibrosis Foundation established a workgroup whose tasks were to examine the impact of differing approaches to estimating rate of decline in lung function and to provide analysis guidelines.

METHODS: We utilized a natural history cohort of 35,252 individuals with CF aged > 6 years of the Cystic Fibrosis Foundation Patient Registry (CFFPR), 2003-2016. Modeling strategies using linear and nonlinear forms of marginal and mixed-effects models, which have previously quantified rate of forced expiratory volume in 1 second (FEV1) decline (% predicted/year), were evaluated under clinically relevant scenarios of available lung function data. Scenarios varied by sample size (overall CFFPR, medium-sized cohort of 3,000 subjects, and small-sized cohort of 150), data collection/reporting frequency (encounter, quarterly, and annual), inclusion of FEV1 during pulmonary exacerbation, and follow-up length (<2 years, 2-5 years, entire duration).

RESULTS: Rate-of-FEV1-decline estimates (% predicted/year) differed between linear marginal and mixed-effects models; overall cohort estimates (95% confidence interval) were 1.26 (1.24-1.29) and 1.40 (1.38-1.42), respectively. Marginal models consistently estimated less rapid lung function decline than mixed-effects models across scenarios except for short-term follow-up (both were ~1.4). Rate-of-decline estimates from nonlinear models diverged by age 30. Among mixed-effects models, nonlinear and stochastic terms fit best except for short-term follow-up (< 2 years). Overall CFFPR analysis from a joint longitudinal-survival model implied that an increase in rate of decline of 1% predicted/year in FEV1 associated with a 1.52-fold (52%) increase in the hazard of death/lung transplantation, but results exhibited immortal cohort bias.

CONCLUSIONS: Differences were as high as 0.5% predicted/year between rate-of-decline estimates, but we found estimates were robust to lung function data availability scenarios except short-term follow-up and older age ranges. Inconsistencies among previous study results may be attributable to inherent differences in study design, inclusion criteria, or covariate adjustment. Results-based decision points reported herein will support researchers in selecting a strategy to model lung function decline most reflective of nuanced, study-specific goals.

PMID:36884219 | DOI:10.1513/AnnalsATS.202209-829OC

J Robot Surg. 2023 Mar 8. doi: 10.1007/s11701-023-01551-9. Online ahead of print.

ABSTRACT

The present study aimed to compare the efficacy and safety between robot-assisted nephroureterectomy (RANU) and open nephroureterectomy (ONU) for the treatment of upper tract urothelial carcinoma (UTUC). We systematically searched four electronic databases (PubMed, Embase, Web of Science, and Cochrane Library) to locate pertinent studies published in English up to January 2023. The primary outcomes evaluated included perioperative results, complications, and oncologic outcomes. Statistical analyses and calculations were performed using Review Manager 5.4. The study was registered with PROSPERO (ID: CRD42022383035). In total, eight comparative trials, including 37,984 patients were enrolled. Compared to ONU, RANU was associated with a significantly shorter length of stay (weighted mean difference [WMD] – 1.63 days, 95% confidence interval [CI] – 2.90, – 0.35; p = 0.01), less blood loss (WMD – 107.04 mL, 95% CI – 204.97, – 9.11; p = 0.03), less major complication(OR 0.78, 95% CI 0.70, 0.88; p < 0.0001), and lower positive surgical margin (PSM) (OR 0.33, 95% CI 0.12, 0.92; p = 0.03). However, no statistically significant differences were observed between the two groups in operative time, transfusion rates, rate of lymph node dissection, lymph node yield, overall complications, overall survival, cancer-specific survival, recurrence-free survival, and progression-free survival. RANU has superior advantages compared to ONU in terms of length of hospital stay, blood loss, postoperative complications, and PSM, while providing comparable oncologic outcomes in patients with UTUC.

PMID:36884204 | DOI:10.1007/s11701-023-01551-9

Environ Sci Pollut Res Int. 2023 Mar 8. doi: 10.1007/s11356-023-26221-z. Online ahead of print.

ABSTRACT

Environmental degradation has attained much attention from researchers and policymakers at national and global levels. The ever-increasing energy use in production methods is considered one of the fundamental reasons for environmental degradation. The concept of environmental efficiency in the wake of sustainable growth evolved in the last three decades. The present study has been designed to estimate environmental efficiency using the Malmquist-Luenberger productivity index (MLI) using annual data from 43 Asian countries from 1990 to 2019. The MLI is an established econometric approach to estimate cases where input variables are used to get output variables in desirable and undesirable forms. Labor, capital, and energy consumption are input variables, while carbon dioxide (CO₂) emissions (undesirable variable) and gross domestic product (undesirable variable) are taken as output variables. The results suggested that, on average, environmental efficiency has decreased by 0.3% over the period in selected Asian countries. Cambodia, Turkey, and Nepal have the highest total factor productivity (TFP) output growth rate on average among 43 Asian countries. These countries are excellent examples of sustainable development that balances environmental protection and efficiency. On the other hand, Kuwait, Mongolia, and Yemen showed the least TFP growth. The study also employed unconditional and convergence tests where the countries’ conditional convergence is based on foreign direct investment, population density, inflation, industrialization, and globalization. Some policy implications for Asian countries are also discussed at the end of the study.

PMID:36884174 | DOI:10.1007/s11356-023-26221-z

Environ Sci Pollut Res Int. 2023 Mar 8. doi: 10.1007/s11356-023-26156-5. Online ahead of print.

ABSTRACT

Electrolytic manganese residue (EMR) is a solid waste produced in the process of electrolytic manganese metal (EMM) production. In recent years, the accumulation of EMR has caused increasingly serious environmental problems. To better understand the state of EMR recycling in recent years, this paper used a comprehensive literature database to conduct a statistical analysis of EMR-related publications from 2010 to 2022 from two perspectives: harmless green treatment and resource utilization. The results showed that the research on the comprehensive utilization of EMR mainly focused on the fields of chemical hazard-free treatment and manufacturing building materials. The related studies of EMR in the fields of biological harmlessness, applied electric field harmlessness, manganese series materials, adsorbents, geopolymers, glass-ceramics, catalysts, and agriculture were also reported. Finally, we put forward some suggestions to solve the EMR problem, hoping that this work could provide a reference for the clean disposal and efficient utilization of EMR.

PMID:36884169 | DOI:10.1007/s11356-023-26156-5

J Gambl Stud. 2023 Mar 8. doi: 10.1007/s10899-023-10195-1. Online ahead of print.

ABSTRACT

Gambling disorder is a common and problematic behavioral disorder associated with depression, substance abuse, domestic violence, bankruptcy, and high suicide rates. In the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), pathological gambling was renamed “gambling disorder” and moved to the Substance-Related and Addiction Disorders chapter to acknowledge that research suggests that pathological gambling and alcohol and drug addiction are related. Therefore, this paper provides a systematic review of risk factors for gambling disorder. Systematic searches of EBSCO, PubMed, and Web of Science identified 33 records that met study inclusion criteria. A revised study acknowledges as risk factors for developing/maintaining a gambling disorder being a single young male, or married for less than 5 years, living alone, having a poor education, and struggling financially.

PMID:36884150 | DOI:10.1007/s10899-023-10195-1

Neotrop Entomol. 2023 Mar 8. doi: 10.1007/s13744-023-01038-0. Online ahead of print.

ABSTRACT

Scirtothrips dorsalis Hood (Thysanoptera: Thripidae) is an invasive pest that is popularly known as chilli thrips. This insect pest has a wide range of hosts distributed across 72 plant families, causing damage to numerous crops of great economic importance. In the Americas, it is present in the USA, Mexico, Suriname, Venezuela, Colombia, and some Caribbean Islands. Knowing the regions which have environmentally suitable conditions for the survival of this pest is important for phytosanitary monitoring and inspection. Thus, our objective was to forecast the distribution potential of S. dorsalis with a focus on the Americas. Models were produced to design this distribution, in which the environmental variables used were made available in Wordclim version 2.1. The algorithms used for the modeling were the generalized additive model (GAM), generalized linear model (GLM), maximum entropy (MAXENT), random forest (RF), and Bioclim, in addition to the ensemble, which consisted of the grouping of the algorithms used. The metrics used to evaluate the models were area over the curve (AUC), true ability statistics (TSS), and Sorensen score. All models had satisfactory results (> 0.8) for all metrics used. In North America, the model showed favorable regions on the west coast of the USA and east coast near New York. In South America, the potential distribution of the pest is significant, encompassing regions in all countries. It is concluded that S. dorsalis has suitable areas for the occurrence in the three American subcontinents and, in particular, a large part of South America.

PMID:36884146 | DOI:10.1007/s13744-023-01038-0

Med Biol Eng Comput. 2023 Mar 8. doi: 10.1007/s11517-023-02814-1. Online ahead of print.

ABSTRACT

PURPOSE: Fetal echocardiography is widely used for the assessment of fetal heart development and detection of congenital heart disease (CHD). Preliminary examination of the fetal heart involves the four-chamber view which indicates the presence of all the four chambers and its structural symmetry. Examination of various cardiac parameters is generally done using the clinically selected diastole frame. This largely depends on the expertise of the sonographer and is prone to intra- and interobservational errors. To overcome this, automated frame selection technique is proposed for the recognition of fetal cardiac chamber from fetal echocardiography.

METHODS: Three techniques have been proposed in this research study to automate the process of determining the frame referred as “Master Frame” that can be used for the measurement of the cardiac parameters. The first method uses frame similarity measures (FSM) for the determination of the master frame from the given cine loop ultrasonic sequences. FSM makes use of similarity measures such as correlation, structural similarity index (SSIM), peak signal to noise ratio (PSNR), and mean square error (MSE) to identify the cardiac cycle, and all the frames in one cardiac cycle are superimposed to form the master frame. The final master frame is obtained by considering the average of the master frame obtained using each similarity measure. The second method uses averaging of ± 20% from the midframes (AMF). The third method uses averaging of all the frames (AAF) of the cine loop sequence. Both diastole and master frames have been annotated by the clinical experts, and their ground truths are compared for validation. No segmentation techniques have been used to avoid the variability of the performance of various segmentation techniques. All the proposed schemes were evaluated using six fidelity metrics such as Dice coefficient, Jaccard ratio, Hausdorff distance, structural similarity index, mean absolute error, and Pratt figure of merit.

RESULTS: The three proposed techniques were tested on the frames extracted from 95 ultrasound cine loop sequences between 19 and 32 weeks of gestation. The feasibility of the techniques was determined by the computation of fidelity metrics between the master frame derived and the diastole frame chosen by the clinical experts. The FSM-based identified master frame found to closely match with manually chosen diastole frame and also ensures statistically significant. The method also detects automatically the cardiac cycle. The resultant master frame obtained through AMF though found to be identical to that of the diastole frame, the size of the chambers found to be reduced that can lead to inaccurate chamber measurement. The master frame obtained through AAF was not found to be identical to that of clinical diastole frame.

CONCLUSION: It can be concluded that the frame similarity measure (FSM)-based master frame can be introduced in the clinical routine for segmentation followed by cardiac chamber measurements. Such automated master frame selection also overcomes the manual intervention of earlier reported techniques in the literature. The fidelity metrics assessment further confirms the suitability of proposed master frame for automated fetal chamber recognition.

PMID:36884143 | DOI:10.1007/s11517-023-02814-1

Prev Sci. 2023 Mar 8. doi: 10.1007/s11121-023-01515-3. Online ahead of print.

ABSTRACT

There is increasing interest about the fidelity with which interventions are implemented because it is theorized that better implementation fidelity by facilitators is associated with better participant outcomes. However, in the parenting program literature, there is mixed evidence on the relationship between implementation fidelity and outcomes. This paper provides a synthesis of the evidence on the relationship between facilitator delivery and outcomes in the parenting program literature. Following PRISMA guidelines, this paper synthesizes the results of a systematic review of studies on parenting programs aiming to reduce violence against children and child behavior problems. Specifically, it examines associations between observational measures of facilitator competent adherence and parent and child outcomes. A meta-analysis was not feasible due to study heterogeneity. As a result, Synthesis Without Meta-Analysis guidelines were followed. Searches in electronic databases, reference searching, forward citation tracking, and expert input identified 9653 articles. After screening using pre-specified criteria, 18 articles were included. The review found that most studies (n = 13) reported a statistically significant positive relationship with at least one parent or child outcome. However, eight studies reported inconsistent findings across outcomes, and four studies found no association with outcomes. The results suggest that better facilitator competent adherence is generally associated with positive parent and child outcomes. However, this finding is weakened by the methodological heterogeneity of included studies and due to the wide variety of ways in which studies conceptualized competent adherence-outcome relationships.

PMID:36884129 | DOI:10.1007/s11121-023-01515-3

J Sports Med Phys Fitness. 2023 Mar 8. doi: 10.23736/S0022-4707.23.14253-8. Online ahead of print.

ABSTRACT

BACKGROUND: Gastrointestinal tract illness (GITill) in rugby players is underreported. The incidence, severity (% time loss illness, days lost per illness) and burden of GITill with/without systemic symptoms and signs in professional South African male rugby players during the Super Rugby tournament (2013-2017) are reported.

METHODS: Team physicians completed daily illness logs of players (N.=537; 1141 player-seasons, 102738 player-days). The incidence (illnesses/1000 player-days, 95% CI), severity (% ≥1-day time-loss; days until return-to-play [DRTP]/single illness [mean: 95% CI]) and illness burden (IB: days lost to illness/1000 player-days) for the subcategories of GITill with/without systemic symptoms and signs (GITill+ss; GITill-ss), and gastroenteritis with/without systemic symptoms and signs (GE+ss; GE-ss) are reported.

RESULTS: The incidence of all GITill was 1.0 (0.8-1.2). Incidence was similar for GITill+ss 0.6 (0.4-0.8) and GITill-ss 0.4 (0.3-0.5; P=0.0603). Incidence of GE+ss 0.6 (0.4-0.7) was higher than GE-ss 0.3 (0.2-0.4; P=0.0045). GITill caused ≥1-day time-loss in 62% of cases (GE+ss 66.7%; GE-ss 53.6%). GITill caused an average of 1.1 DRTP/single GITill, which was similar for subcategories. IB of GITill+ss was higher than GITill-ss (IB Ratio: 2.1 [1.1-3.9; P=0.0253]). IB for GITill+ss is 2 times higher than GITill-ss (IB Ratio: 2.1 [1.1-3.9]; P=0.0253); and GE+ss >3 times higher than GE-ss (IB Ratio: 3.0 [1.6-5.8]; P=0.0007).

CONCLUSIONS: GITill accounted for 21.9% of all illnesses during the Super Rugby tournament, with >60% of GITill resulting in time-loss. The average DRTP/single illness was 1.1. GITill+ss and GE+ss resulted in higher IB. Targeted interventions to reduce the incidence and severity of GITill+ss and GE+ss should be developed.

PMID:36884121 | DOI:10.23736/S0022-4707.23.14253-8

J Cancer Res Clin Oncol. 2023 Mar 8. doi: 10.1007/s00432-023-04649-7. Online ahead of print.

ABSTRACT

PURPOSE: It was reported that individual heterogeneity among malignancies (IHAM) might correlate well to the prognosis of lung cancer; however, seldom radiomic study is on this field. Standard deviation (SD) in statistics could scale average amount of variability of a variable; therefore, we used SD of CT feature (Feature_SD) among primary tumor and malignant lymph nodes (LNs) in an individual to represent IHAM, and its prognostic ability was explored.

METHODS: The enrolled patients who had accepted PET/CT scans were selected from our previous study (ClinicalTrials.gov, NCT03648151). The patients had primary tumor and at least one LN, and standardized uptake value of LN higher than 2.0 and 2.5 were enrolled as the cohort 1 (n = 94) and 2 (n = 88), respectively. Feature_SD from the combined or thin-section CT were calculated among primary tumor and malignant LNs in each patient, and were separately selected by the survival XGBoost method. Finally, their prognostic ability was compared to the significant patient characteristics identified by the Cox regression.

RESULTS: In the univariate and multi-variate Cox analysis, surgery, target therapy, and TNM stage were significantly against OS in the both cohorts. In the survival XGBoost analysis of the thin-section CT dataset, none Feature_SD could be repeatably ranked on the top list of the both cohorts. For the combined CT dataset, only one Feature_SD ranked in the top three of both cohorts, but the three significant factors in the Cox regression were not even on the list. Both in the cohort 1 and 2, C-index of the model composed of the three factors could be improved by integrating the continuous Feature_SD; furthermore, that of each factor was obviously lower than Feature_SD.

CONCLUSION: Standard deviation of CT features among malignant foci within an individual was a powerful prognostic factor in vivo for lung cancer patients.

PMID:36884114 | DOI:10.1007/s00432-023-04649-7