Category: Nevin Manimala

J Environ Health Sci Eng. 2021 Aug 22;19(2):1701-1712. doi: 10.1007/s40201-021-00724-8. eCollection 2021 Dec.

ABSTRACT

Laboratory and epidemiological researches have indicated that ambient air particulate matter have a plays critical role in causing diseases. The current research evaluated the chemical attributes of PM2.5 in the ambient air of the cities of Karaj and Fardis and determined its toxicological effects on human lung epithelial cells (A549). In the study city, 16 points were selected from the two high-traffic and low-traffic points for sampling. A sampling of ambient air was carried out in spring, summer, autumn, and winter 2018-19. Air sampling was performed for 24 h according to the EPA-TO/13A guidelines. To analyze of toxic metals and polycyclic aromatic hydrocarbons (PAHs), ICP-OES and GC-MS were used, respectively, and for cell toxicity analysis, an ELISA reader was used. Then from SPSS, Excel and R software were used for statistical analysis. The results of the current study indicated that the concentration of PAHs carcinogenic in the autumn season in high-traffic stations was the highest and equal to 9.3 ng/m³, and in the spring season in the low-traffic stations, it was the lowest and equal to 5.82 ng/m³. In general, during the period of study, Heavy metals including Zn, Fe, Pb, Cu, and Al had the highest concentration compared to other metals. However, Hg, Cr, As, Pb, Cu, Cd, and Zn were higher concentration in the winter and autumn seasons than in the spring and summer seasons. Cell viability measurements by using MTT showed that low-traffic and high-traffic stations had the highest toxicity in autumn season compared to other seasons. (p < 0.05). In general, high-traffic stations had the highest toxicity than low-traffic stations. The general conclusion of the present study was that PM2.5-bound PAHs and toxic metals, due to their high concentration, were toxic pollutants in air for residents of Karaj and Fardis. Also, the high concentration of PM2.5 caused the mitochondrial activity of A549 cells to stop and this stop was more significant in cold seasons and high-traffic areas.

PMID:34900299 | PMC:PMC8617124 | DOI:10.1007/s40201-021-00724-8

J Environ Health Sci Eng. 2021 Jul 14;19(2):1447-1455. doi: 10.1007/s40201-021-00699-6. eCollection 2021 Dec.

ABSTRACT

BACKGROUND: Nosocomial infections usually occur 48 hours after admission to the hospital or up to 72 hours after discharge from the hospital. They lead to an increase in mortality and health costs. The purpose of this study is to measure the knowledge, attitude, and performance of paramedical staff about nosocomial infection control.

MATERIALS AND METHODS: This cross-sectional study was conducted in Tehran hospitals in 2019. A valid and reliable questionnaire was used to collect data. The questionnaires were distributed among 405 randomly selected paramedical staff at 25 hospitals in Tehran. The data were analyzed using SPSS18.

RESULTS: The mean scores of paramedical staff’s knowledge, attitude, and performance in terms of nosocomial infection control were 11.2 ± 2.2 (good), 21.7 ± 3.7 (good), and 49.2 ± 9.4 (good) respectively. A statistically significant relationship was obtained between paramedical staff’s work experience and type of hospital and their knowledge, attitude, and performance in terms of nosocomial infection control (P <0.05). In addition, a statistically significant relationship was found between gender, age, education, and, employment type and nosocomial infection control performance (P <0.05).

CONCLUSIONS: The knowledge, attitude, and performance of paramedical staff about nosocomial infections in Tehran hospitals were good. Education, continuous supervision, and provision of the necessary equipment are needed for improving the paramedical staff’s knowledge, attitude, and performance in terms of nosocomial infections.

PMID:34900279 | PMC:PMC8617098 | DOI:10.1007/s40201-021-00699-6

J Environ Health Sci Eng. 2021 Jul 12;19(2):1473-1481. doi: 10.1007/s40201-021-00702-0. eCollection 2021 Dec.

ABSTRACT

PURPOSE: Second-hand smoke is recognized as a major indoor pollutant. Evidences indicated that Second-hand smoke exposure can influence on not only physical health, but also mental well-being. As the correlation of secondhand smoke exposure with sleep quality and quality of life has not yet been clarified sufficiently, the purpose of this study was to evaluate the association between Second-hand smoke exposure, with sleep quality and quality of life after adjusting for active smoking and other relevant confounders.

METHODS: The participants of this study were 1790 staff in Tehran University of Medical Sciences with different jobs employed in various academic departments (clinical, research, services, educational and technical ones). They participated voluntarily in this research project and completed the informed consent form between 2018 and 2019. A translated questionnaire of Global Adult Tobacco Survey was used to gather information about smoke exposure. When to evaluate the quality of life, the WHOQOL-BREF tool was applied. All statistical analyses were executed using STATA V14 software.

RESULTS: High rate of smoking and also exposure to second-hand smoke significantly increased sleep disorder and reduced the quality of life. In other words, smokers or those who are exposed to second-hand smoke suffer from sleep disturbances and had a poorer physical, psychological, and environmental quality of life. Additionally, the results of multivariate regression analysis demonstrated that the secondhand-smoke group had 1.38 times higher rate of sleep disorder in comparison with non-smokers, that was statistically significant. The women had 2.68 times higher odds of having sleep disorder compared to men. (95 % CI: 2.20 to 3.27). On the other hand, mean score of psychological domain of quality of life in secondhand-smoke group was lower with the size of difference as 0.66 than that in non-smokers, and the difference was statistically significant (p = 0.001).

CONCLUSIONS: Both active smoking and exposure to second hand smoke have a negative impact on sleep quality and quality of life.

PMID:34900281 | PMC:PMC8617127 | DOI:10.1007/s40201-021-00702-0

Stat (Int Stat Inst). 2021 Dec;10(1):e408. doi: 10.1002/sta4.408. Epub 2021 Aug 18.

ABSTRACT

The coronavirus disease 2019 (COVID-19) pandemic has led to tremendous loss of human life and has severe social and economic impacts worldwide. The spread of the disease has also caused dramatic uncertainty in financial markets, especially in the early stages of the pandemic. In this paper, we adopt the stochastic actor-oriented model (SAOM) to model dynamic/longitudinal financial networks with the covariates constructed from the network statistics of COVID-19 dynamic pandemic networks. Our findings provide evidence that the transmission risk of the COVID-19, measured in the transformed pandemic risk scores, is a main explanatory factor of financial network connectedness from March to May 2020. The pandemic statistics and transformed pandemic risk scores can give early signs of the intense connectedness of the financial markets in mid-March 2020. We can make use of the SAOM approach to predict possible financial contagion using pandemic network statistics and transformed pandemic risk scores of the COVID-19 and other pandemics.

PMID:34900251 | PMC:PMC8646286 | DOI:10.1002/sta4.408

J Environ Health Sci Eng. 2021 Jul 30;19(2):1277-1286. doi: 10.1007/s40201-021-00683-0. eCollection 2021 Dec.

ABSTRACT

PURPOSE: Environmental contamination with various pesticides accompanied by uncontrolled use contributes to severe ecological and health problems. Although extensive research was conducted on pesticides degradation, very few reports have demonstrated the degradation of mixed pesticides. Consequently, this study aimed to evaluate the removal efficacy of highly potent bacterial isolate for pesticide mixture under optimal culture conditions, followed by their application in milk.

METHODS: Isolation and selection of bacterial isolates were performed from 40 milk samples by enrichment culture technique and were screened to obtain highly potent bacterial strain identified by 16 S rDNA analysis. The statistics-based experimental designs were applied to optimize the culture conditions towards the best degradation of pesticides mixture, followed by subsequent utilization in milk. The degradation ratio of pesticides was analyzed using gas chromatography-mass spectrometry.

RESULTS: In this study, a bacterial strain S6A identified as Bacillus subtilis-mw1 efficiently eliminated environmental contaminants from different groups of pesticide residues. The statistical optimization showcased optimum settings that accomplished the highest pesticide mixture degradation (61.59 %). The application experiment manifested that degradation of pesticide mixtures of sterile milk (STM) was relatively faster than non-sterile milk (NSTM).

CONCLUSIONS: The obtained results assist in eliminating environmental contamination with various groups of pesticide residues. Furthermore, it can be employed in reducing pesticide residues that cause milk contamination to increase safety and quality.Graphical abstract.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40201-021-00683-0.

PMID:34900265 | PMC:PMC8617149 | DOI:10.1007/s40201-021-00683-0

Int J Inflam. 2021 Dec 2;2021:4919410. doi: 10.1155/2021/4919410. eCollection 2021.

ABSTRACT

BACKGROUND: Colorectal cancer (CRC) is a malignancy derived from the glandular epithelial cells in the colon. Patients with inflammatory bowel disease (IBD) are more likely to develop CRC. Cancer proliferation is characterized by the loss of inhibition of apoptosis, which involves caspase-3 activation. This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%.

METHODS: The experimental study was done in six groups. All treatments were done in 42 days. The groups were all induced by DSS through water drinking, except for the normal group, which was only given water. The treatments given included the pomegranate extract in two doses (240 mg and 480 mg/kg bw/day), aspirin, and ellagic acid. The specimens were then fixated and stained for the immunohistochemistry scoring for the expression of caspase-3, which was then analyzed statistically.

RESULTS: The H-scores of each treatment group were 213.23 ± 8.32 (DSS group), 243.81 ± 18.69 (normal group), 226.10 ± 12.38 (pomegranate peel extract of 240 mg/kg/d), 238.84 ± 15.81 (pomegranate peel extract of 480 mg/kg/d), 227.47 ± 12.15 (aspirin), and 224.01 ± 18.39 (ellagic acid). Statistical differences were found in one-way analysis of variance (ANOVA) and post hoc analysis among the DSS group, normal group, and dose 2 group (pomegranate peel extract of 480 mg/kg/day).

CONCLUSIONS: The ethanol extract of pomegranate was able to induce apoptosis, which was demonstrated by the increase of caspase-3 expression.

PMID:34900217 | PMC:PMC8660243 | DOI:10.1155/2021/4919410

J Healthc Eng. 2021 Dec 1;2021:3081549. doi: 10.1155/2021/3081549. eCollection 2021.

ABSTRACT

According to the statistical analysis, the incidence of stroke disease has gradually increased, particularly in recent years, which poses a huge threat to the safety of human life. Due to the advancement in science and technology specifically big data and sensors, a new research dome known as data mining technology has been introduced, which has the potential value from the perspective of large amount of data analysis. Information has become a new trend of science and technology, and data mining has been used in various application areas to analyze and predict strokes at home and abroad. In this study, big data technology is utilized to collect potential information and explores clinical pathways of level-3 rehabilitation in certain regions of China. Moreover, application effects of data mining in the rehabilitation of patients with the first ischemic stroke have been evaluated and reported. For this purpose, fifty (50) first-time ischemic stroke patients have been screened through big data and were nonartificially assigned to level-3 clinical pathway and conventional rehabilitation groups, respectively, specifically through software. The first group of patients enters the clinical path of the corresponding level according to the way of three-level referral. These patients were analyzed based on the collected results of completing the unified rehabilitation treatment plan of the three-level rehabilitation medical institution in the patient record form. The second group was selected according to the routine rehabilitation model and method of the medical institution where the patients visited were divided into four stages: before treatment, three weeks after treatment, nine weeks after treatment, and seventeen weeks after treatment. For this purpose, a simplified Fugl-Meyer analysis (FMA), recording of various functions of limb movement, and modified Barthel index (MBI) scale were used to analyze and evaluate the ability of daily activities and compare their effects. The final results showed that FMA and MBI scores of the two groups were improved in the three stages after treatment. The FMA and MBI scores of the clinical pathway group on 3rd and 9th weekends were significantly different from those of the conventional rehabilitation group (which is p < 0.05). Moreover, difference in FMA and MBI scores between the two at the 17th weekend was not significant. The total cost of the clinical pathway group, particularly at the ninth weekend, was higher than that of the conventional rehabilitation group, but the cost-benefit ratio was better and the incidence of complications was lower than that of the other group.

PMID:34900181 | PMC:PMC8654541 | DOI:10.1155/2021/3081549

Iperception. 2021 Dec 6;12(6):20416695211048513. doi: 10.1177/20416695211048513. eCollection 2021 Nov.

ABSTRACT

People associate information with different senses but the mechanism by which this happens is unclear. Such associations are thought to arise from innate structural associations in the brain, statistical associations in the environment, via shared affective content, or through language. A developmental perspective on crossmodal associations can help determine which explanations are more likely for specific associations. Certain associations with pitch (e.g., pitch-height) have been observed early in infancy, but others may only occur late into childhood (e.g., pitch-size). In contrast, tactile-chroma associations have been observed in children, but not adults. One modality that has received little attention developmentally is olfaction. In the present investigation, we explored crossmodal associations from sound, tactile stimuli, and odor to a range of stimuli by testing a broad range of participants. Across the three modalities, we found little evidence for crossmodal associations in young children. This suggests an account based on innate structures is unlikely. Instead, the number and strength of associations increased over the lifespan. This suggests that experience plays a crucial role in crossmodal associations from sound, touch, and smell to other senses.

PMID:34900211 | PMC:PMC8652194 | DOI:10.1177/20416695211048513

Comput Struct Biotechnol J. 2021 Nov 18;19:6169-6178. doi: 10.1016/j.csbj.2021.11.022. eCollection 2021.

ABSTRACT

Aging is a major risk factor for metabolic impairment that may lead to age-related diseases such as cardiovascular disease. Different mechanisms that may explain the interplay between aging and lipoproteins, and between aging and low-molecular-weight metabolites (LMWMs), in the metabolic dysregulation associated with age-related diseases have been described separately. Here, we statistically evaluated the possible mediation effects of LMWMs on the relationships between chronological age and lipoprotein concentrations in healthy men ranging from 19 to 75 years of age. Relative and absolute concentrations of LMWMs and lipoproteins, respectively, were assessed by nuclear magnetic resonance (NMR) spectroscopy. Multivariate linear regression and mediation analysis were conducted to explore the associations between age, lipoproteins and LMWMs. The statistical significance of the identified mediation effects was evaluated using the bootstrapping technique, and the identified mediation effects were validated on a publicly available dataset. Chronological age was statistically associated with five lipoprotein classes and subclasses. The mediation analysis showed that serine mediated 24.1% (95% CI: 22.9 – 24.7) of the effect of age on LDL-P, and glutamate mediated 17.9% (95% CI: 17.6 – 18.5) of the effect of age on large LDL-P. In the publicly available data, glutamate mediated the relationship between age and an NMR-derived surrogate of cholesterol. Our results suggest that the age-related increase in LDL particles may be mediated by a decrease in the nonessential amino acid glutamate. Future studies may contribute to a better understanding of the potential biological role of glutamate and LDL particles in aging mechanisms and age-related diseases.

PMID:34900130 | PMC:PMC8632714 | DOI:10.1016/j.csbj.2021.11.022

Avicenna J Med Biotechnol. 2021 Oct-Dec;13(4):201-206.

ABSTRACT

BACKGROUND: The inhibitory effect of selenium nanoparticles (SeNPs) on cancer cells has been reported in many studies. In this study, the purpose was to compare the in vitro effects of SeNPs and calcium sulfate coated selenium nanoparticles (CaSO₄@SeNPs) on breast cancer cells.

METHODS: CaSO₄@SeNPs and SeNPs were chemically synthesized and characterized with Field Emission Scanning Electron Microscope (FESEM) and energy-dispersive X-ray spectroscopy (EDX). By applying MTT assay, the cytotoxicity effect of both nanomaterials on the 4T1 cancer cells was investigated.

RESULTS: While LD₅₀ of SeNPs on 4T1 cancer cells was 80 μg, the LD₅₀ of CaSO₄@SeNPs was reported to be only 15 μg. The difference between the inhibition rates obtained for SeNPs and CaSO₄@SeNPs was statistically significant (p=0.05). In addition, at higher concentrations (50 μg) of CaSO₄@SeNPs, the cytotoxicity was 100% more than SeNPs alone.

CONCLUSION: According to the result of the present work, it can be concluded that decoration of SeNPs with calcium sulfate leads to an increase in potency by decreasing the effective dose. This effect can be attributed to activation of intrinsic apoptosis signaling and/or pH regulatory properties of CaSO₄@SeNPs. However, further studies are still needed to determine the exact corresponding mechanisms of this synergistic effect.

PMID:34900146 | PMC:PMC8606114