Category: Nevin Manimala

J Speech Lang Hear Res. 2021 Mar 30:1-12. doi: 10.1044/2020_JSLHR-20-00561. Online ahead of print.

ABSTRACT

Purpose Analysis of connected speech in the field of adult neurogenic communication disorders is essential for research and clinical purposes, yet time and expertise are often cited as limiting factors. The purpose of this project was to create and evaluate an automated program to score and compute the measures from the Quantitative Production Analysis (QPA), an objective and systematic approach for measuring morphological and structural features of connected speech. Method The QPA was used to analyze transcripts of Cinderella stories from 109 individuals with acute-subacute left hemisphere stroke. Regression slopes and residuals were used to compare the results of manual scoring and automated scoring using the newly developed C-QPA command in CLAN, a set of programs for automatic analysis of language samples. Results The C-QPA command produced two spreadsheet outputs: an analysis spreadsheet with scores for each utterance in the language sample, and a summary spreadsheet with 18 score totals from the analysis spreadsheet and an additional 15 measures derived from those totals. Linear regression analysis revealed that 32 of the 33 measures had good agreement; auxiliary complexity index was the one score that did not have good agreement. Conclusions The C-QPA command can be used to perform automated analyses of language transcripts, saving time and training and providing reliable and valid quantification of connected speech. Transcribing in CHAT, the CLAN editor, also streamlined the process of transcript preparation for QPA and allowed for precise linking of media files to language transcripts for temporal analyses.

PMID:33784197 | DOI:10.1044/2020_JSLHR-20-00561

Phys Rev Lett. 2021 Mar 12;126(10):102001. doi: 10.1103/PhysRevLett.126.102001.

ABSTRACT

We report a study of the processes of e^{+}e^{-}→K^{+}D_{s}^{-}D^{*0} and K^{+}D_{s}^{*-}D^{0} based on e^{+}e^{-} annihilation samples collected with the BESIII detector operating at BEPCII at five center-of-mass energies ranging from 4.628 to 4.698 GeV with a total integrated luminosity of 3.7 fb^{-1}. An excess of events over the known contributions of the conventional charmed mesons is observed near the D_{s}^{-}D^{*0} and D_{s}^{*-}D^{0} mass thresholds in the K^{+} recoil-mass spectrum for events collected at sqrt[s]=4.681 GeV. The structure matches a mass-dependent-width Breit-Wigner line shape, whose pole mass and width are determined as (3982.5_{-2.6}^{+1.8}±2.1) MeV/c^{2} and (12.8_{-4.4}^{+5.3}±3.0) MeV, respectively. The first uncertainties are statistical and the second are systematic. The significance of the resonance hypothesis is estimated to be 5.3 σ over the contributions only from the conventional charmed mesons. This is the first candidate for a charged hidden-charm tetraquark with strangeness, decaying into D_{s}^{-}D^{*0} and D_{s}^{*-}D^{0}. However, the properties of the excess need further exploration with more statistics.

PMID:33784133 | DOI:10.1103/PhysRevLett.126.102001

Phys Rev Lett. 2021 Mar 12;126(10):101601. doi: 10.1103/PhysRevLett.126.101601.

ABSTRACT

We study the holographic complexity conjectures for rotating black holes, uncovering a relationship between the complexity of formation and the thermodynamic volume of the black hole. We suggest that it is the thermodynamic volume and not the entropy that controls the complexity of formation of large black holes in both the complexity equals action and complexity equals volume proposals in general. Our proposal reduces to known results involving the entropy in settings where the thermodynamic volume and entropy are not independent, but has broader scope. Assuming a conjectured inequality is obeyed by the thermodynamic volume, we establish that the complexity of formation is bounded from below by the entropy for large black holes.

PMID:33784155 | DOI:10.1103/PhysRevLett.126.101601

Phys Rev Lett. 2021 Mar 12;126(10):104501. doi: 10.1103/PhysRevLett.126.104501.

ABSTRACT

The transitions between two states of a bistable system are investigated experimentally and analyzed in the framework of rare-event statistics. Considering a disk pendulum swept by a flow in a wind tunnel, bistability between two aerodynamic branches is observed, with spontaneous transitions from one branch to the other. The waiting times before spontaneous transition are distributed following a double exponential as a function of the control parameter, spanning 4 orders of magnitude in time, for both transitions. Inspired by a model originally applied to the transition to turbulence, we show that, for the disk pendulum, both transitions are controlled by rare events of the aerodynamic forces acting on the disk which we propose to link in particular to the vortex shedding-induced fluctuations. Beyond the aerodynamic aspects, this work has interesting fundamental outcomes regarding the broad field of rare events in out-of-equilibrium systems.

PMID:33784158 | DOI:10.1103/PhysRevLett.126.104501

Int J Biostat. 2021 Mar 30. doi: 10.1515/ijb-2020-0039. Online ahead of print.

ABSTRACT

A latent factor model for count data is popularly applied in deconvoluting mixed signals in biological data as exemplified by sequencing data for transcriptome or microbiome studies. Due to the availability of pure samples such as single-cell transcriptome data, the accuracy of the estimates could be much improved. However, the advantage quickly disappears in the presence of excessive zeros. To correctly account for this phenomenon in both mixed and pure samples, we propose a zero-inflated non-negative matrix factorization and derive an effective multiplicative parameter updating rule. In simulation studies, our method yielded the smallest bias. We applied our approach to brain gene expression as well as fecal microbiome datasets, illustrating the superior performance of the approach. Our method is implemented as a publicly available R-package, iNMF.

PMID:33783171 | DOI:10.1515/ijb-2020-0039

J Korean Med Sci. 2021 Mar 29;36(12):e80. doi: 10.3346/jkms.2021.36.e80.

ABSTRACT

BACKGROUND: Spinal cord injury (SCI) is a serious clinical condition that impacts a patient’s physical, psychological, and socio-economic status. The aim of this pilot study was to evaluate the effects of training with a newly developed powered wearable exoskeleton (Hyundai Medical Exoskeleton [H-MEX]) on functional mobility, physiological health, and quality of life in non-ambulatory SCI patients.

METHODS: Participants received 60 minutes of walking training with a powered exoskeleton 3 times per week for 10 weeks (total 30 sessions). The 6-minute walking test (6MWT) and timed-up-and-go test (TUGT) were performed to assess ambulatory function. The physiological outcomes of interest after exoskeleton-assisted walking training were spasticity, pulmonary function, bone mineral density, colon transit time, and serum inflammatory markers. Effects of walking training on subjective outcomes were estimated by the Korean version of the Falls Efficacy Scale-International and the 36-Item Short-Form Health Survey version 2.

RESULTS: Ten participants finished 30 sessions of training and could ambulate independently. No severe adverse events were reported during the study. After training, the mean distance walked in the 6MWT (49.13 m) was significantly enhanced compared with baseline (20.65 m). The results of the TUGT also indicated a statistically significant improvement in the times required to stand up, walk 3 m and sit down. Although not statistically significant, clinically meaningful changes in some secondary physiological outcomes and/or quality of life were reported in some participants.

CONCLUSION: In conclusion, this study demonstrated that the newly developed wearable exoskeleton, H-MEX is safe and feasible for non-ambulatory SCI patients, and may have potential to improve quality of life of patients by assisting bipedal ambulation. These results suggest that the H-MEX can be considered a beneficial device for chronic non-ambulatory SCI patients.

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04055610.

PMID:33783145 | DOI:10.3346/jkms.2021.36.e80

Anat Sci Educ. 2021 Mar 30. doi: 10.1002/ase.2078. Online ahead of print.

ABSTRACT

This study assessed the effect of course cycle on theoretical knowledge of dental morphology and the dental carving ability of dental students. Thirty-two dental students from the third semester (initial cycle) and 30 students from the eighth and tenth semesters of the dental course (end cycle) had their theoretical knowledge on dental morphology assessed using a questionnaire with ten closed questions. Their dental carving ability was also assessed using wax carvings in macro models of plaster (for the third [S3] and eight [S8] semesters) and natural-sized artificial teeth (for the tenth [S10] semester). The teeth chosen for the dental carving activity were #16 and #47. The scores were statistically analyzed using the t-test, Kruskal-Wallis test, and Mann-Whitney test (α = 0.05). Students from the initial cycle presented better theoretical knowledge than the other groups did (P < 0.007). No significant differences in carving score were found between the initial and end cycles (P > 0.05), although S10 students obtained a higher score for teeth #16 and #47 (P < 0.05). Natural-sized artificial teeth received a higher evaluation score in dental carvings than the macro models (P < 0.001). Within the limits of this study, it was possible to conclude that students from the initial cycle (S3) presented higher theoretical knowledge, whereas no difference in carving ability was observed between the initial and end cycles. The tenth semester (S10) students performed dental carvings with better quality. Furthermore, carvings in natural-sized artificial teeth presented better quality compared with the macro models.

PMID:33783136 | DOI:10.1002/ase.2078

Clin Exp Dent Res. 2021 Mar 29. doi: 10.1002/cre2.422. Online ahead of print.

ABSTRACT

OBJECTIVES: To assess if wearing a mouth guard impacts maximal aerobic capacity in amateur boxers.

MATERIALS AND METHODS: A prospective crossover cohort (pilot) study was conducted to assess maximal aerobic capacity in amateur boxers using the 20 m multi stage fitness test (MSFT). Two primary outcomes measures were recorded: (1) the maximum oxygen uptake (peak VO₂ -mL/kg/min) and (2) distance run (meters-m). Thirteen amateur boxers completed the MSFT 7 days apart under control (no mouth guard-C) and intervention conditions (mouth guard-MG). Participants also submitted data on height, weight, type of mouth guard and Rate of Perceived Exertion (RPE) during the test.

STATISTICS: Paired T-test.

RESULTS: Mouth guard use was shown to reduce peak VO₂ and distance run during the 20 m MSFT from 56.31 to 54.12 mL/kg/min and 2572 to 2380 m respectively (p < 0.05). Twelve out of 13 participants wore a Boil & Bite mouthguard and recorded lower peak VO₂ scores (-4.38%) when wearing a mouth guard compared to control conditions, (Mean = -2.46 mL/kg/min, Range of decrease = 4.2-0.9 mL/kg/min; p < 0.05). Ten participants submitted data on RPE-One participant with a custom made mouthguard reported no change in RPE in mouthguard conditions, while nine participants reported an average (+30.5%) increase in mean RPE in Boil & Bite mouthguard conditions compared to control conditions.

CONCLUSIONS: Boil & Bite mouth guard use was shown to significantly reduce aerobic performance in amateur boxers and increase the perceived rate of exertion during the 20 m MSFT.

PMID:33783141 | DOI:10.1002/cre2.422

J Magn Reson Imaging. 2021 Mar 29. doi: 10.1002/jmri.27611. Online ahead of print.

ABSTRACT

BACKGROUND: Chemical shift encoded magnetic resonance imaging (CSE-MRI)-based tissue fat quantification is confounded by increased R2* signal decay rate caused by the presence of excess iron deposition.

PURPOSE: To determine the upper limit of R2* above which it is no longer feasible to quantify proton density fat fraction (PDFF) reliably, using CSE-MRI.

STUDY TYPE: Prospective.

POPULATION: Cramér-Rao lower bound (CRLB) calculations, Monte Carlo simulations, phantom experiments, and a prospective study in 26 patients with known or suspected liver iron overload.

FIELD STRENGTH/SEQUENCE: Multiecho gradient echo at 1.5 T and 3.0 T.

ASSESSMENT: CRLB calculations were used to develop an empirical relationship between the maximum R2* value above which PDFF estimation will achieve a desired number of effective signal averages. A single voxel multi-TR, multi-TE stimulated echo acquisition mode magnetic resonance spectroscopy acquisition was used as a reference standard to estimate PDFF. Reconstructed PDFF and R2* maps were analyzed by one analyst using multiple regions of interest drawn in all nine Couinaud segments.

STATISTICAL TESTS: None.

RESULTS: Simulations, phantom experiments, and in vivo measurements demonstrated unreliable PDFF estimates with increased R2*, with PDFF errors as large as 20% at an R2* of 1000 s^-1 . For typical optimized Cartesian acquisitions (TE1 = 0.75 msec, ΔTE = 0.67 msec at 1.5 T, TE1 = 0.65 msec, ΔTE = 0.58 msec at 3.0 T), an empirical relationship between PDFF estimation errors and acquisition parameters was developed that suggests PDFF estimates are unreliable above an R2* of ~538 s^-1 and ~779 s^-1 at 1.5 T and 3 T, respectively. This empirical relationship was further investigated with phantom experiments and in vivo measurements, with PDFF errors at an R2* of 1000 s^-1 at 3.0 T as large as 10% with TE1 = 1.24 msec, ΔTE = 1.01 msec compared to 3% with TE1 = 0.65 msec, ΔTE = 0.58 msec.

DATA CONCLUSION: We successfully developed a theoretically-based empirical formula that may provide an easily calculable guideline to identify R2* values above which PDFF is not reliable in research and clinical applications using CSE-MRI to quantify PDFF in the presence of iron overload.

LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY STAGE: 1.

PMID:33783066 | DOI:10.1002/jmri.27611