Category: Nevin Manimala

Afr J Prim Health Care Fam Med. 2021 Apr 28;13(1):e1-e6. doi: 10.4102/phcfm.v13i1.2424.

ABSTRACT

BACKGROUND: Episiotomy was introduced into clinical practice without clear evidence of its benefits.The knowledge and understanding of episiotomy guidelines and practice by healthcare workers is substandard in our setting; hence, the injudicious use of this procedure have led to high rates.

AIM: To assess the knowledge, perception and practice of episiotomy by healthcare workers.

SETTING: Research was conducted in a Pietermaritzburg complex, South AfricaMethods: A questionnaire-based survey was conducted amongst healthcare workers regarding episiotomy practice. In addition to providing demographic data, the participants were requested to respond to 35 proposed statements regarding episiotomy practice. Data were analysed using SPSS (Statistical Package for the Social Sciences) software.

RESULTS: One hundred and forty-two midwives and 66 medical practitioners completed the questionnaires. There were variations in responses to several statements on episiotomy practice by medical practitioners and nurses based on their level of experience. This study found that the majority of HCWs did not have access to a protocol or policy on episiotomy practice in their units; furthermore, nor knowledge of the South African guidelines for maternity care on episiotomy practice. Significantly, more medical practitioners felt a need for more in-service training and an increase in the number of episiotomies performed under supervision. The commonly reported reason for performing an episiotomy by both medical practitioners and midwives was to reduce 3rd – 4th degree perineal tears.

CONCLUSION: Healthcare workers in our setting displayed poor knowledge about the practice of episiotomy and were not aware of existing national guidelines on episiotomy practice.

PMID:33970009 | DOI:10.4102/phcfm.v13i1.2424

Afr J Prim Health Care Fam Med. 2021 Apr 30;13(1):e1-e6. doi: 10.4102/phcfm.v13i1.2664.

ABSTRACT

BACKGROUND: The prevalence of diabetes mellitus is increasing dramatically in developing countries, where diabetic patients usually present with poor glycaemic control, leading to complications and worsening the prognosis.

AIM: The aim of this study was to determine the extent of poor glycaemic control and its determinants in diabetic patients.

SETTING: The study was conducted in a rural area of the province of Kwilu, Democratic Republic of the Congo.

METHODS: This research comprised a cross-sectional study involving 300 Type 1 and 2 diabetic patients attending Vanga Evangelical Hospital in the Democratic Republic of the Congo from January 2018 to March 2018. Patients’ sociodemographic, clinical and biological characteristics, accessibility to the health structure and treatment were described. The determinants of poor glycaemic control were identified using multivariate logistic regression at the p 0.05 level of statistical significance.

RESULTS: The mean age of participants was 46.9 ± 16.3 years, 68.4% were men, and 62.3% had Type 2 diabetes mellitus. Poor glycaemic control was present in 78% of patients. The independent determinants of poor glycaemic control were tobacco use (adjusted odds ratio [aOR]: 2.01 [1.77-5.20], p = 0.015), the presence of comorbidities (aOR: 2.86 [1.95-6.65], p = 0.007), the presence of a factor contributing to hyperglycaemia (aOR: 2.74 [1.83-3.67], p = 0.014), missing scheduled appointments (aOR: 2.59 [1.94-7.13], p = 0.006) and non-adherence to treatment (aOR: 4.09 [1.35-6.39], p = 0.008).

CONCLUSION: This study shows that more than three-quarters of diabetics undergoing treatment are not controlled, with mainly patient-related factors as the main explanatory factors for this poor glycaemic control. Therefore, the establishment of a therapeutic education programme and wider integration of diabetes care services, mainly at the primary level of the healthcare pyramid, should contribute to improved diabetes treatment.

PMID:33970011 | DOI:10.4102/phcfm.v13i1.2664

Afr J Prim Health Care Fam Med. 2021 Apr 30;13(1):e1-e7. doi: 10.4102/phcfm.v13i1.2653.

ABSTRACT

BACKGROUND: Umbilical cord infection contributes significantly to neonatal mortality rate in sub-Saharan Africa. Studies have shown low knowledge of chlorhexidine (CHX) gel for umbilical cord management amongst mothers in low-resource settings, including Nigeria.

OBJECTIVE: The objective of this study was to assess the effectiveness of a supportive-educative nursing intervention programme on knowledge of CHX gel amongst mothers in Cross River State, Nigeria.

METHODS: A quasi-experimental study design was used, and study participants comprised 168 expectant mothers, who were purposely selected and assigned to randomised control and intervention groups. The instrument for data collection was a researcher-developed structured questionnaire. The data were analysed using Statistical Package for Social Sciences version 23 for descriptive and inferential statistics at significant level was set at p 0.05.

RESULTS: The result showed that at post-test the knowledge score of mothers on CHX gel improved significantly in the intervention group (t 77 = 24.394; p 0.05). The result showed no significant difference between mothers’ demographic variables and knowledge of CHX gel.

CONCLUSION: A supportive-educative nursing intervention programme could effectively improve knowledge of CHX gel for umbilical cord management amongst mothers. This underscores the need to improve mothers’ knowledge of CHX gel by healthcare personnel.

PMID:33970012 | DOI:10.4102/phcfm.v13i1.2653

Geospat Health. 2021 May 5;16(1). doi: 10.4081/gh.2021.964.

ABSTRACT

This study examines the relationship between the suicide mortality rate and structural covariates in South Korea from 2008 to 2017 under Durkheim’s theory of suicide. It applies the dynamic spatial panel data model to explore both spatial and temporal aspects of the suicide phenomena recognising statistical limitations in previous suicide research based on either cross-sectional or longitudinal methodology. The results demonstrate that the suicide mortality rates in South Korea are spatially and temporally dependent on those of neighbouring units or its own time-lagged suicide mortality rates. Moreover, this study estimates that the divorce rate, unemployment rate and land price index, which are assumed to be proxies of social integration and regulation, significantly impact the suicide mortality rates. The results imply that deteriorating socioeconomic conditions are risk factors for the suicide mortality rate and suggests implementing policies to alleviate the high level of social disintegration caused by Korea’s deteriorating socioeconomic conditions.

PMID:33969967 | DOI:10.4081/gh.2021.964

Geospat Health. 2021 May 5;16(1). doi: 10.4081/gh.2021.966.

ABSTRACT

The number of homicides in Brazil has reached record numbers, and when the race/colour of the victims is considered-an extreme inequality is evident- with a particularly high number of deaths in black and brown populations. The goal of this work was to analyse homicide rates of black people in Brazil from the years 2000 to 2016, using generalized additive regression models, with a geo-spatial component. The statistics were applied to understand the social reasons for homicide risks in the black population in Brazil’s 26 states and Federal District with reference to the human development index and its components (education, longevity and income) as well as social inequality indices (Gini and Theil). This socioecological, epidemiological study to estimate the risk of homicide in the black population with a time series component, shows that this risk has increased linearly over time. Less longevity and low income correlated with a greater risk of homicide-while the Gini and Theil indices showed that in places where there are greater inequalities, there is also a higher risk of homicide in both black and non-black populations. The results – regarding the possibility of relating social indicators to homicide risk in the regional units under study, would support implementation of interventional public policy measures.

PMID:33969968 | DOI:10.4081/gh.2021.966

J Agric Food Chem. 2021 May 10. doi: 10.1021/acs.jafc.1c00878. Online ahead of print.

ABSTRACT

This work involved a systematic comparison between serum and urine for the monitoring of anabolic androgenic steroids in livestock. Incurred samples were collected over 120 days from crossbred steers treated with intramuscular injections containing boldenone undecylenate. Independent high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods were used for the assessment of the respective detection windows, which were larger for serum samples. Both matrices presented adequate performance in terms of long-term stability, assessed using an isochronous approach during 196 days at -20 °C and for five freeze-thaw cycles. The effectiveness of the enzymatic hydrolysis reaction using Helix pomatia juice was also compared. The calculated concentrations in serum samples were not statistically influenced by the deconjugation reaction. On the other hand, urine hydrolysis conditions were studied using a 3³ Box-Behnken Design, in which a central point condition led to a satisfactory deconjugation performance. It could be observed that serum exhibited equivalent or better performance than urine for most of the evaluated criteria; thus, its inclusion in the regulatory analysis of boldenone in cattle is supported.

PMID:33970002 | DOI:10.1021/acs.jafc.1c00878

J Epidemiol Glob Health. 2021 Apr 26. doi: 10.2991/jegh.k.210420.002. Online ahead of print.

ABSTRACT

OBJECTIVE: Little information is available about the etiology, pathophysiology, risk factors, and epidemiologic features of Bone Tuberculosis (Bone-TB). In this work, we present the epidemiological data about the Bone-TB in the Sultanate of Oman.

METHODS: Retrospectively, we identified and assessed those patients who were diagnosed with Bone-TB between January 2002 and December 2019 at Khoula Hospital. The following data were collected: demographics, clinical presentation, anatomical location, diagnosis, and treatment of the Bone-TB.

RESULTS: During the study period, 115 cases of Bone-TB were diagnosed. Males were affected more than females (57.4% and 42.6%, respectively). About 30% of Bone-TB cases were primary diagnosed in other organs particularly the lungs and then after disseminated to the bone. However, the Bone-TB was detected in hip, leg, hand, shoulder, and skull bones, the most detected Bone-TB was in spine (66% of cases). After vaccination the Bacillus Calmette-Guérin (BCG) strains were identified in the bones of eight babies. Tubercle bacilli were detected by Acid-Fast Stain (AFS) in 59% of cases, and the rest of cases were confirmed using polymerase chain reaction (PCR) tests. There are two used treatment regimens, with 12.4% relapse. The gastrointestinal tract (GIT) disturbances were the most related side effects. The resistance has been detected to pyrazinamide in six cases, rifampicin in three cases, and isoniazid, streptomycin and kanamycin were detected in one case.

CONCLUSION: The most predominant Bone-TB cases were spine-TB that were mainly disseminated from the lungs. AFS failed to detect tubercle bacilli in 40% of cases. There is no statistical significance in relapse between the used two regimens. The death was predominant among skull-TB cases.

PMID:33969946 | DOI:10.2991/jegh.k.210420.002

J Sports Med Phys Fitness. 2021 May 10. doi: 10.23736/S0022-4707.21.12484-3. Online ahead of print.

ABSTRACT

BACKGROUND: A paucity of research exists examining whether resistance training with a greater number of sets per exercise enhances the development of muscular endurance. The aim of this study was to investigate the effects of ten sets versus five sets of resistance training on muscle endurance.

METHODS: Fifteen healthy males (age 23.7 ± 4.6 y) with at least 1 year resistance training experience were randomly assigned to 6 weeks of 10 sets (10-SET) or 5 sets (5-SET) of 10 repetitions at 60-80% one-repetition maximum (1RM) for specific compound resistance exercises with rest intervals between sets of 60-90 s and 60 s between exercises, performed 3 times per week. Relative muscle endurance test was assessed via maximal repetitions using 70% 1RM for the bench press, lat pulldown and leg press.

RESULTS: There was a significant increase in the number of repetitions to failure in the muscle endurance test for the leg press in 10-SET (40.9%, p = 0.04) and 5-SET (27.9%; p = 0.03), although no statistical differences between groups in the post-intervention results. Both groups increased volume-load in the muscle endurance test for the bench press (≥14.3%, p<0.05) and leg press (≥36.7%, p<0.05), but there were no statistical differences between groups in the post-intervention results.

CONCLUSIONS: Findings suggest that performing 10 sets compared to 5 sets of resistance training does not enhance the development of relative muscle endurance. The volume-load accrued within an individual set rather than across sets may be of greater importance when targeting muscular endurance.

PMID:33969958 | DOI:10.23736/S0022-4707.21.12484-3

Geospat Health. 2021 May 5;16(1). doi: 10.4081/gh.2021.961.

ABSTRACT

Coronavirus disease 2019 (COVID-19) is the current worldwide pandemic as declared by the World Health Organization (WHO) in March 2020. Being part of the ongoing global pandemic, Malaysia has recorded a total of 8639 COVID-19 cases and 121 deaths as of 30th June 2020. This study aims to detect spatial clusters of COVID-19 in Malaysia using the Spatial Scan Statistic (SaTScan™) to guide control authorities on prioritizing locations for targeted interventions. The spatial analyses were conducted on a monthly basis at the state-level from March to September 2020. The results show that the most likely cluster of COVID-19 occurred in West Malaysia repeatedly from March to June, covering three counties (two federal territories and one neighbouring state) and moved to East Malaysia in July covering two other counties. The most likely cluster shows a tendency of having moved from the western part to the eastern part of the country. These results provide information that can be used for the evidence- based interventions to control the spread of COVID-19 in Malaysia.

PMID:33969966 | DOI:10.4081/gh.2021.961

Proteomics. 2021 May 10:e2100037. doi: 10.1002/pmic.202100037. Online ahead of print.

ABSTRACT

Rheumatoid arthritis (RA) is a common autoimmune and inflammatory disease worldwide, but understanding its pathogenesis is still limited. In this study, plasma untargeted metabolomics of a discovery cohort and targeted analysis of a verification cohort were performed by gas chromatograph mass spectrometry (GC/MS). Univariate and multivariate statistical analysis were utilized to reveal differential metabolites, followed by the construction of biomarker panel through random forest (RF) algorithm. The pathways involved in RA were enriched by differential metabolites using Ingenuity Pathway Analysis (IPA) suite. Untargeted metabolomics revealed eighteen significantly altered metabolites in RA. Among these metabolites, a three-metabolite marker panel consisting of L-cysteine, citric acid and L-glutamine was constructed, using random forest algorithm that could predict RA with high accuracy, sensitivity and specificity based on a multivariate exploratory receiver operator characteristic (ROC) curve analysis. The panel was further validated by support vector machine (SVM) and partial least squares discriminant analysis (PLS-DA) algorithms, and also verified with targeted metabolomics using a verification cohort. Additionally, the dysregulated taurine biosynthesis pathway in RA was revealed by an integrated analysis of metabolomics and transcriptomics. Our findings in this study not only provided a mechanism underlying RA pathogenesis, but also offered alternative therapeutic targets for RA. This article is protected by copyright. All rights reserved.

PMID:33969925 | DOI:10.1002/pmic.202100037