Category: Nevin Manimala

Dent Traumatol. 2021 Oct 13. doi: 10.1111/edt.12714. Online ahead of print.

ABSTRACT

BACKGROUND/AIMS: Up to 40% of dental injuries in children occur during sports and may be prevented by using mouthguards (MG). The use of mouthguards is mandatory in some sporting organizations. Knowledge of the benefits of protection does not always result in mouthguard use. The aim of this observational cross-sectional cohort study was to measure and compare knowledge of 9-16-year-old Gaelic football players and their parents on MG use and compliance with MG rules.

MATERIALS AND METHODS: A convenience sample of players and their parents was identified and were assessed at their sports facility. Parents completed a questionnaire while children were asked standardized questions and MG type was verified by a dentist. Data were analysed using descriptive statistics and binary logistic regression analysis for comparison.

RESULTS: One hundred and twenty-one children with 118 parents participated in the study. According to players, MG use during competition (N = 119, 99.2%) was greater than during training (N = 97, 80.8%). As age increased, children were less likely to comply with MG rules during training (OR =0.18, p < .001). Children played a median of 2 contact sports (IQR = 1). Only 32 parents (27.1%) and 17 children (14%) reported that the child wore a MG for all sports. Only four children (3.8%) had a custom MG even though most parents (N = 87, 73.7%) believed that they provided superior protection. Knowledge of players and their parents on how to care for the MG was variable.

CONCLUSION: Compliance with the Gaelic Atheletic Association’s MG rules was lower during training than competition. Children were less likely to comply with MG rules during training as they grew older. Most parents believed a custom MG would best protect their child’s teeth, yet few children had a custom MG. Players and parents had variable knowledge in relation to MG hygiene.

PMID:34643329 | DOI:10.1111/edt.12714

Neurourol Urodyn. 2021 Oct 13. doi: 10.1002/nau.24819. Online ahead of print.

ABSTRACT

AIMS: To determine the effects of oestrogen or oestrogen deprivation on vaginal wound healing. Impaired wound healing following prolapse surgery may increase the risk of recurrent prolapse in the future. Vaginal oestrogen therapy may improve wound healing, hereby possibly improving surgical outcomes.

METHODS: A systematic search of OVID MEDLINE, OVID Embase, and Web of Science was conducted up to January 28, 2020. We included original studies comparing wound healing-related outcomes of oestrogen exposed subjects (female animals and women) to hypo-oestrogenic subjects after vaginal surgery. Data on wound healing-related outcome measures were extracted. For each individual comparison, the standardised mean difference (Hedges’ g; SMD) and 95% confidence interval (CI) were calculated.

RESULTS: Of the 1474 studies reviewed, 14 studies were included for review, and 11 provided data for meta-analysis. Oestrogen improves neovascularisation (SMD: 1.13, 95% CI: 0.67-1.60), microscopic wound closure (SMD: 0.98, 95% CI: 0.66-1.29), collagen synthesis (SMD: 1.08, 95% CI: 0.42-1.74), and tissue strength (SMD: 1.26, 95% CI: 0.53-1.99) in animals. Oestrogen increases granulation (SMD: 1.67, 95% CI: 0.54-2.79) and accelerates macroscopic wound closure (SMD: 1.82, 95% CI: 1.22-2.42) in women and animals. Oestrogen decreases the inflammatory response (SMD: -0.58, 95% CI: -1.14 to -0.02) in women and animals and reduces levels of transforming growth factor (TGF)-β1 (SMD: -1.68, 95% CI: -2.52 to -0.83) in animals. All results were statistically significant.

CONCLUSIONS: Oestrogen therapy has a positive effect on vaginal wound healing. Future studies should determine whether oestrogen therapy has the potential to improve surgical outcomes.

PMID:34643282 | DOI:10.1002/nau.24819

Brief Bioinform. 2021 Oct 13:bbab426. doi: 10.1093/bib/bbab426. Online ahead of print.

ABSTRACT

Complex computation and approximate solution hinder the application of generalized linear mixed models (GLMM) into genome-wide association studies. We extended GRAMMAR to handle binary diseases by considering genomic breeding values (GBVs) estimated in advance as a known predictor in genomic logit regression, and then reduced polygenic effects by regulating downward genomic heritability to control false negative errors produced in the association tests. Using simulations and case analyses, we showed in optimizing GRAMMAR, polygenic effects and genomic controls could be evaluated using the fewer sampling markers, which extremely simplified GLMM-based association analysis in large-scale data. Further, joint association analysis for quantitative trait nucleotide (QTN) candidates chosen by multiple testing offered significant improved statistical power to detect QTNs over existing methods.

PMID:34643219 | DOI:10.1093/bib/bbab426

Kardiol Pol. 2021 Oct 13. doi: 10.33963/KP.a2021.0133. Online ahead of print.

ABSTRACT

BACKGROUND: Despite optimizing treatment of ST-segment elevation myocardial infarction (STEMI) a lot of patients die during the invasive procedure or experience sudden cardiac arrest (SCA) that complicates further hospitalization.

AIMS: The aim of the study was to identify the most important risk factors leading to SCA and death in the cath lab among STEMI patients.

METHODS: We used the National Registry of Invasive Cardiology Procedures (ORPKI) between 2014 and 2019. The study population consisted of 113 465 patients. Descriptive statistics univariate and multiple logistic regression analysis of factors affecting perioperative mortality (PM) and SCA in the cath lab were performed.

RESULTS: Death and SCA occurred in 1549 (1.4%) and 945 (0.8%) patients, respectively. Diabetes (odds ratio [OR] 1.76; P <0.0001), previous brain stroke (OR 2.26; P <0.0001), prior myocardial infarction (OR 1.81; P <0.0001), psoriasis (OR 1.79; P = 0.04) and chronic renal failure (OR 2.79; P <0.0001) were the strongest predictors of PM. The occurrence of SCA was dependent mainly on diabetes (OR 1.37; P = 0.0001), previous brain stroke (OR 2.23; P <0.0001), prior myocardial infarction (OR 1.73; P <0.0001), psoriasis (OR 2.03; P = 0.04), chronic renal failure (OR 2.79; P <0.0001). Of the pre-hospital factors, the Killip-Kimball class showed the strongest relationship with the two endpoints (OR 3.53; P <0.0001 and OR 2.65; P <0.0001).

CONCLUSIONS: Diabetes, previous brain stroke and myocardial infarction, psoriasis, chronic renal failure and the Killip-Kimball class were the strongest predictors of PM and SCA in the cath lab.

PMID:34643263 | DOI:10.33963/KP.a2021.0133

Virulence. 2021 Oct 13. doi: 10.1080/21505594.2021.1989252. Online ahead of print.

ABSTRACT

Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH), encoded by gapC, is a glycolytic enzyme that is associated with virulence and immune-mediated protection. However, the role of GAPDH in cellular cytokine responses to S. agalactiae, bacterial phagocytosis and colonization of the female reproductive tract, a central host niche, is unknown. We expressed and studied purified recombinant GAPDH (rGAPDH) of S. agalactiae in cytokine elicitation assays with human monocyte-derived macrophage, epithelial cell, and polymorphonuclear leukocyte (PMN) co-culture infection models. We also generated a S. agalactiae mutant that over-expresses GAPDH (oeGAPDH) from gapC using a constitutively active promoter, and analysed the mutant in murine macrophage antibiotic protection assays and in virulence assays in vivo, using a colonization model that is based on experimental infection of the reproductive tract in female mice. Human cell co-cultures produced interleukin (IL)-1β, IL-6, macrophage inflammatory protein (MIP)-1, tumour necrosis factor (TNF)-α and IL-10 within 24 h of exposure to rGAPDH. PMNs were required for several of these cytokine responses. However, over-expression of GAPDH in S. agalactiae did not significantly affect measures of phagocytic uptake compared to an empty vector control. In contrast, oeGAPDH-S. agalactiae showed a small but statistically significant attenuation for persistence in the reproductive tract of female mice during the chronic phase of infection (10-28 days post-inoculation), relative to the vector control. We conclude that S. agalactiae GAPDH elicits production of multiple cytokines from human cells, and over-expression of GAPDH renders the bacterium more susceptible to host clearance in the female reproductive tract.

PMID:34643172 | DOI:10.1080/21505594.2021.1989252

Rev Esp Salud Publica. 2021 Oct 13;95:e202110132.

ABSTRACT

OBJECTIVE: Low back pain in childhood and adolescence is considered a predictor of low back pain in adulthood. Sedentary lifestyle is associated with low back pain. This study evaluated the relationship between low back pain and screen time in adolescents 10 to 15 years.

METHODS: Cross-sectional study involving schoolchildren 10 and 15 years from school centers of the urban area in Talavera de la Reina. Chi-square test was used to analyze the relationship between low back pain and time spent watching. A logistic regression adjusted for confounding variables was performed and represented by the Odds Ratio. Statistical significance was considered for p<0.05.

RESULTS: A total of 1,278 surveys were completed. 31% of schoolchildren reported low back pain in the last 3 months. Statistically significant differences were observed between low back pain with respect to sex and sleep time. Moreover, differences were noticed in the proportion of school-children who report low back pain during the week and use screens more than 2 hours compared to those who report using screens less than 2 hours. These differences were not observed on weekends.

CONCLUSIONS: Although adolescents spend more time in front of screens on weekends, the proportion of adolescents who report low back pain is higher during the week.

PMID:34643186

Int J Neurosci. 2021 Oct 13:1-13. doi: 10.1080/00207454.2021.1986492. Online ahead of print.

ABSTRACT

Background: Despite the increase in ventriculoperitoneal shunt surgeries performed for children with hydrocephalus, the potential complications and survival of patients after the procedure remains the major challenge for both clinical and public health aspects. This study intends to assess the survival status and scrutinize the predictive factors of mortality among children after a ventriculoperitoneal shunt.Methods: A retrospective cohort study was employed by reviewing charts of 337 systematically selected children who have undergone a ventriculoperitoneal shunt from 2016 to 2018 in Addis Ababa. The extraction tool was used for data collection, Epi-data version 4.4.2 for data entry, and Stata version-14 for cleaning and analysis. Kaplan-Meier curve, log-rank test, and life table were used to describe the data. Cox proportional hazard regression model was used for analysis. Any variable at p < 0.25 in the bi-variable analysis was fitted to multivariate analysis, and significance was declared at p ≤ 0.05. Then, AHR with 95% CI was used to report the association and test the statistical significance. Finally, texts and tables were used to present the results.Results and Conclusion: The incidence rate of mortality was 58.4 per 1000 child-months of observation with a median survival time of 12 months (95%CI: 9.04-14.96). Communicative hydrocephalus (AHR: 1.99, 95% CI: 1.18-3.36), post-traumatic brain injury (AHR: 7.43, 95% CI: 3.21-16.88), emergency surgery (AHR: 1.86, 95% CI: 1.17-3.13) as well as revised shunt procedure (AHR: 8.01, 95% CI: 6.12-13.43) were independent predictors of death. Besides, sunset eye (ARH: 2.01; 95% CI: 1.17-3.47), rapidly increased head size (ARH: 2.05, 95% CI: 1.14-3.37), prolonged antibiotics treatment (AHR: 2.46, 95% CI: 1.82-7.37), and gram-negative infections (AHR: 1.95, 95% CI: 1.60-12.64) were also significantly associated. Hence, health professionals ought to give special attention to patients with identified predictors.

PMID:34643151 | DOI:10.1080/00207454.2021.1986492

Health Psychol Rev. 2021 Oct 13:1-67. doi: 10.1080/17437199.2021.1987953. Online ahead of print.

ABSTRACT

Physical activity behaviour displays temporal variability, and is influenced by a range of dynamic psychological processes (e.g., affect) and shaped by various co-occurring events (e.g., social/environmental factors, interpersonal dynamics). Yet, most physical activity research tends not to examine the dynamic psychological processes implicated in adopting and maintaining physical activity. Intensive longitudinal methods (ILM) represent one particularly salient means of studying the complex psychological dynamics that underlie and result from physical activity behaviour. With the increased recent interest in using intensive longitudinal data to understand specific dynamic psychological processes, the field of exercise and health psychology is well-positioned to draw from state-of-the-art measurement and statistical approaches that have been developed and operationalized in other fields of enquiry. The purpose of this review is to provide an overview of some of the fundamental dynamic measurement and modelling approaches applicable to the study of physical activity behaviour change, as well as the dynamic psychological processes that contribute to such change.

PMID:34643154 | DOI:10.1080/17437199.2021.1987953

Int J Artif Organs. 2021 Oct 13:3913988211051395. doi: 10.1177/03913988211051395. Online ahead of print.

ABSTRACT

OBJECTIVE: This was a pilot study to determine the utility of daily lung ultrasound (LUS) in patients requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) for acute respiratory distress syndrome (ARDS).

DESIGN: This was a prospective, observational study.

SETTING: The study took place in the intensive care unit at Royal Papworth Hospital in Cambridge, UK.

PARTICIPANTS: We recruited adult patients receiving VV-ECMO for ARDS.

INTERVENTIONS: All patients received a lung computed tomography (CT) scan and LUS on admission. Bedside chest radiography (CXR) and LUS were done on a daily basis until patients were decannulated.

MEASUREMENTS AND MAIN RESULTS: Daily LUS aeration scores were calculated according to the appearance of four defined patterns. An independent radiologist calculated corresponding scores for CT and CXR, retrospectively. These were checked for correlation with LUS aeration scores. There were statistically significant correlations between LUS versus CT (r = 0.868, p = 0.002) and LUS versus CXR (r = 0.498, p = 0.018) with good agreement and no evidence of proportional bias. LUS was able to detect 13.5% of pleural effusions and 54.2% of pneumothorax that were not picked up on CXR.In most of the patients who were weaned off VV-ECMO, a progressive reduction of LUS aeration scores corresponding to lung re-aeration was observed.

CONCLUSIONS: LUS correlated with findings on CT and CXR for quantifying lung aeration and the clinical presentation of patients. LUS also picked up more pleural effusions and pneumothorax than CXR. Together with traditional imaging techniques, the routine use of LUS should be considered for this patient group.

PMID:34643145 | DOI:10.1177/03913988211051395

OTJR (Thorofare N J). 2021 Oct 13:15394492211050634. doi: 10.1177/15394492211050634. Online ahead of print.

ABSTRACT

The rehabilitation strategies used by occupational therapy driver assessors with older drivers with age-related decline or health conditions are not well understood. The objective of the study was to describe driver rehabilitation interventions used by Australian driver assessors, identify factors that guide rehabilitation choices, and identify barriers and facilitators encountered. An online survey was emailed to 300 driver assessors. Descriptive statistics were used to summarize and to rank order participant responses. A total of 148 respondents selected from a combined total of 655 interventions. The four most common rehabilitation methods were (a) graded driving (18%, n = 118), (b) practicing specific maneuvers (17.7%, n = 116), (c) using a modified vehicle (16.9%, n = 111), and (d) graded driving in local areas only (15.1%, n = 99). The most common barrier limiting driver rehabilitation was cost (M = 2.92, SD = 1.24). The most frequently used driver rehabilitation method was on-road training. Practice can be enhanced by collating and evaluating resources, and ensuring effective interventions are more accessible.

PMID:34643144 | DOI:10.1177/15394492211050634