Category: Nevin Manimala

J Psychosoc Oncol. 2026 May 10:1-10. doi: 10.1080/07347332.2026.2668705. Online ahead of print.

ABSTRACT

BACKGROUND: We adapted a previously-successful intervention, StoryListening, to a group setting for LGBTQ+ cancer survivors.

OBJECTIVE: Our goal was to assess the feasibility and acceptability of the QT (Queer/Trans) Cancer StoryListening Workshop.

METHODS: We conducted a single-arm pilot feasibility trial of QT Cancer StoryListening for LGBTQ+ cancer survivors in September, 2025. Feasibility was assessed by enrollment and questionnaire completion data. Acceptability was evaluated using self-report questionnaires with both closed-ended and open-ended items. We used a mixed methods analytic approach, including both descriptive statistics and deductive thematic content analysis.

RESULTS: Twelve individuals responded with interest in 5 wk of community outreach; 10 (83%) attended the workshop and 8 completed follow-up questionnaires (80%). Participants identified no emotional or logistical difficulty in participating and all identified value, particularly around the community aspect of the workshop. LGBTQ+ cancer survivors lack specifically-tailored support.

CONCLUSION: StoryListening is a brief, scalable intervention that is both feasible and acceptable to LGBTQ+ cancer survivors.

PMID:42107087 | DOI:10.1080/07347332.2026.2668705

Clin Chem Lab Med. 2026 May 11. doi: 10.1515/cclm-2026-0554. Online ahead of print.

NO ABSTRACT

PMID:42107068 | DOI:10.1515/cclm-2026-0554

Pharmaceut Med. 2026 May 10. doi: 10.1007/s40290-026-00610-4. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: Lagging pediatric safety and effectiveness data increase the risks to children associated with off-label drug use. The objective of this study was to delineate the frequency of, and reasons behind, delays in the completion of mandated pediatric postmarketing requirement (PMR) studies.

METHODS: Publicly accessible and internal US Food and Drug Administration (FDA) data were aggregated to characterize pediatric PMRs issued from 2012 to 2024, including relevant dates, durations, and deferral extension (DE) requests. Sponsor size, and clinical trial enrollment status were also examined.

RESULTS: There were 1160 pediatric PMRs identified, 459 of which were associated with 1176 DE requests. Despite a significant decline in the annual number of PMRs issued (slope [95% confidence interval]: – 3.64 [- 6.50, – 0.79] year^-1, p = 0.02), an increase in the annual number of DE requests (5.24 [2.16, 8.31] year^-1, p < 0.01) was observed. Declines in negotiated timelines for PMR completion and durations of time granted per request were also seen. Issues related to clinical trial conduct predominated DE rationale in every year and accounted for 48% of all requests. One in 10 delayed trials failed to initiate enrollment before the PMR due date and 1 in 5 cited problems with clinical trial conduct before enrollment began. Smaller companies (< 500 employees) exhibited higher DE request rates, lower PMR success rates, and accounted for an increasing proportion of PMRs over the review period (from 17% in 2012 to 72% in 2024).

CONCLUSIONS: Year-on-year increases in DE requests reinforce ongoing challenges to timely and successful pediatric trial completion. Difficulties with clinical trial conduct appear to be the primary driver for these delays although the underlying root causes have yet to be elucidated. Regulators, sponsors, and stakeholder partners should work cooperatively to remediate delayed pediatric drug development timelines and reduce the duration of off-label drug use in children.

PMID:42107033 | DOI:10.1007/s40290-026-00610-4

J Cancer Res Clin Oncol. 2026 May 10. doi: 10.1007/s00432-026-06469-x. Online ahead of print.

ABSTRACT

PURPOSE: The sensitivity of bladder cancer detection using a single biomarker from single sample type is limited. This study aimed to investigate whether a combined approach utilizing multiple biomarkers from different clinical samples could improve detection sensitivity.

METHODS: A total of 85 patients with bladder cancer and 30 healthy individuals were enrolled in this study. Urine and blood samples were collected for the isolation of urine-derived epithelial cells (UDECs) and circulating tumor cells (CTCs). These cells were then analyzed via PD-L1 assay and fluorescence in situ hybridization (FISH) targeting chromosomes 7 and 8. In parallel, matched urine samples from patients underwent conventional urine exfoliation cytology testing (UEC). All data were analyzed in conjunction with pathological information using specialized statistical software.

RESULTS: Analysis of CTCs demonstrated a significantly higher bladder cancer detection rate (78.6%) compared to UEC (36.7%). The combination of UDEC-FISH and CTC analysis utilizing urine and blood samples achieved a higher detection rate (94.1%) than the combination of UDEC-FISH with UEC performed on the same urine sample (79.8%). Furthermore, combined analysis of three markers of CTC, UEC, and UDEC-FISH (96.5%) or CTC, UEC, and UDEC-PD-L1 (90.6%) yielded significantly higher detection rates than any single biomarker analysis alone.

CONCLUSION: Integrating multiple biomarkers from distinct sample types significantly enhances the detection sensitivity for bladder cancer.

PMID:42107019 | DOI:10.1007/s00432-026-06469-x

JAMA. 2026 May 10. doi: 10.1001/jama.2026.7886. Online ahead of print.

ABSTRACT

IMPORTANCE: Digitalis glycosides may be used as additional therapy in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or HF with reduced EF (HFrEF).

OBJECTIVE: To assess the effect of digitalis glycosides on clinical outcomes in patients with HFmrEF or HFrEF.

DATA SOURCES AND STUDY SELECTION: PubMed was searched from inception to March 1, 2026, using medical subject headings and keywords related to digitalis glycosides and HF. The review was restricted to placebo-controlled randomized clinical trials including more than 1000 patients and articles published in the English language.

DATA EXTRACTION AND SYNTHESIS: Data were extracted by 2 reviewers who followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline. Risk of bias was assessed with the Cochrane Risk of Bias tool (version 2). A fixed-effects model was used to estimate the hazard ratios (HRs) with 95% CIs.

MAIN OUTCOMES AND MEASURES: The primary end point was the composite of time to cardiovascular death or first worsening HF event. Secondary outcomes included individual components of the composite outcome and time to all-cause death.

RESULTS: A total of 3 studies met the inclusion criteria and included 9013 patients with HFmrEF or HFrEF (weighted mean age, 64.5 [weighted SD, 11.2] years; 22% female and 78% male). The composite outcome of cardiovascular death or first worsening HF event occurred in 1852 of 4510 patients (41%) in the digitalis glycoside group vs 2037 of 4503 patients (45%) in the placebo group (HR, 0.85 [95% CI, 0.80-0.90]; P < .001). First worsening HF event occurred in 1183 (26%) patients in the digitalis glycoside group vs 1474 (33%) patients in the placebo group (HR, 0.75 [95% CI, 0.69-0.81]; P < .001). There were 1224 cardiovascular events in the digitalis glycoside group vs 1224 in the placebo group (27% of participants in each group; HR, 0.99 [95% CI, 0.92-1.07]; P = .81) and there were 1466 vs 1497, respectively, all-cause deaths (32% of participants vs 33%; HR, 0.97 [95% CI, 0.90-1.04]; P = .41). There was no statistically significant heterogeneity by trial, type of digitalis glycoside treatment, or extent of background HF therapy.

CONCLUSIONS AND RELEVANCE: Treatment with digitalis glycosides was associated with a lower risk of the composite of cardiovascular death or first worsening HF event in patients with HFmrEF or HFrEF, mainly through a lower risk of worsening HF events. There was no statistically significant interaction with important study characteristics, including the extent of HF background therapy or type of digitalis glycosides treatment. These results suggest digitalis glycosides may be used as additional medical therapy to reduce worsening HF events in patients with HFmrEF or HFrEF.

PMID:42106991 | DOI:10.1001/jama.2026.7886

Psychol Rep. 2026 May 10:332941261450508. doi: 10.1177/00332941261450508. Online ahead of print.

ABSTRACT

This study examined whether the relationship between impulsivity and Internet addiction (IA) levels among university students varies depending on the indirect pathway mediated by the meaning-seeking in life and whether this indirect pathway is dependent on self-esteem levels. The study was conducted using data collected from 500 university students in Türkiye via valid self-report measures, employing a cross-sectional, correlational design. Controlling for daily internet usage time, the assumed direct, indirect, and conditional associations were tested using Hayes’ PROCESS macro (Model 14). Correlation analyses found that impulsivity was negatively related to meaning-seeking in life (r = -.120, p < .01) and positively related to IA (r = .261, p < .001). In the conditional process analysis, impulsivity was negatively associated with meaning-seeking in life (B = -0.180, p = .003) and positively associated with IA (B = 0.592, p < .001). The interaction between meaning-seeking in life and self-esteem was significantly associated IA (B = 0.180, p = .009) and contributed additional explanatory power to the model (ΔR² = 0.0125, p < .01; total R² = .117). The direct association between meaning-seeking in life and IA in the regression model was statistically significant (B = 0.214, p = .004); however, the indirect pathway through meaning-seeking in life was moderated by self-esteem. The moderated mediation index was significant (Index = -0.032, 95% CI [-0.076, -0.007]), and the findings indicate that the indirect component of the relationship between impulsivity and IA level, mediated by meaning-seeking in life, varies according to self-esteem level; the indirect association is more pronounced at lower self-esteem scores. These findings were interpreted within a cross-sectional design framework and suggest that impulsivity is related to IA levels and that the conditional indirect mechanism is present, although its magnitude appears modest.

PMID:42106983 | DOI:10.1177/00332941261450508

Am J Addict. 2026 May 10. doi: 10.1111/ajad.70172. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: To describe provider preparedness and experiences engaging families after a patient overdose death.

METHODS: We used descriptive statistics to summarize responses to a national survey of interdisciplinary providers.

RESULTS: Participants (n = 524; 47,937 invited) agreed that providers should communicate with a patient’s family after an overdose death (78.2% agreed), yet few felt very well prepared to do so (22.6%).

DISCUSSION AND CONCLUSIONS: Providers inconsistently contacted families despite believing these interactions are opportunities to improve family and provider coping.

SCIENTIFIC SIGNIFICANCE: There is a potential need for interventions addressing this discrepancy between providers’ desired behaviors and practice contacting families following a patient death.

PMID:42106972 | DOI:10.1111/ajad.70172

Am J Ind Med. 2026 May 10. doi: 10.1002/ajim.70088. Online ahead of print.

ABSTRACT

BACKGROUND: We used national-level data to compare worker demographic and socioeconomic characteristics, work arrangements, psychosocial working conditions, safety and health, job security, wages and benefits, and worker health and well-being before the COVID-19 pandemic, in 2018, and in the late stage of the pandemic, in 2022. Understanding these changes helps inform some of the potential ways these factors may shape the future of work.

METHODS: We analyzed self-reported and publicly available data from the 2018 and 2022 waves of the General Social Survey (GSS)-Quality of Worklife (QWL) module, focusing on adults working part-time or full-time. We describe differences in the broad categories of interest mentioned above, as well as subcategories within each. For example, we assessed changes in psychosocial working conditions by focusing on subcategories that included job demands, job control, role conflict, resource adequacy, job support, work flexibility, and work and family interface, that is, the boundaries between work and family life. We used Mann-Whitney tests to assess statistically significant changes, using weighted, nationally representative worker samples (N = 1473 in 2018; N = 2112 in 2022).

RESULTS: Between 2018 and 2022, we observed two changes in work arrangements; the share of independent contractors increased (from 12.4% to 14.4%) while the share of those working full-time decreased (from 81.3% to 78.5%). Psychosocial conditions exhibited mixed trends; job demands and control showed marginal improvement, while role conflict, resource adequacy, and job support worsened. The share of workers who mainly worked at home increased (6.6%-17.2%), alongside those experiencing family-work conflict (from 26% to 32%). Health and well-being also worsened, with more workers reporting lower job satisfaction and very often feeling used up (from 13.1% to 16.0%). In addition, workers reported more days in poor mental health (from 3.6 to 4.4 days) and days with activity limitations (from 1.6 to 2.2) in the past 30 days.

CONCLUSIONS: The quality of worklife in 2022 differed meaningfully from 2018, though not uniformly for better or worse. For example, increases in working at home and the share of independent contractor arrangements suggest different potential long-term consequences for worker well-being. Continued monitoring and more nuanced analyses are essential to understanding the evolving future of work.

PMID:42106970 | DOI:10.1002/ajim.70088

Knee Surg Sports Traumatol Arthrosc. 2026 May 10. doi: 10.1002/ksa.70420. Online ahead of print.

ABSTRACT

PURPOSE: To compare the career longevity of professional soccer players after achilles tendon rupture (ATR) with that of an uninjured matched control cohort.

METHODS: A retrospective analysis of ATR cases in professional male athletes from the English Premier League and English Championship was performed. Each athlete with ATR was matched to three control athletes who had not sustained ATR. The analysis included all identified ATR cases, including those who failed to return to professional competition. Statistics were compiled for each year until retirement or study end.

RESULTS: A total of 36 players with ATR were matched to 108 controls. The return-to-professional play rate following ATR was 91.7%. The mean career length after ATR was 4.9 ± 3.3 years, while that of the matched control athletes was 3.4 ± 3.5 years (p = 0.045). After ATR, an athlete had a 33% lower risk of retirement compared with the matched control athlete, which approached statistical significance (hazard ratio [HR] = 0.67; 95% confidence interval [CI], 0.45-1.00; p = 0.051). Significant subsequent non-ATR injuries were documented in 24.1% of control athletes during the follow-up period. At 5 years after ATR, 58.3% of athletes had retired from professional soccer, while 70.4% of the matched cohort were retired (p = 0.259). By 10 years, 83.3% of the ATR cohort had retired compared with 91.7% of the matched cohort (p = 0.270). Within the ATR cohort, re-rupture occurred in seven players (19.4%) but did not significantly affect career length (HR = 0.80; p = 0.622). Age at ATR remained the strongest predictor of retirement (HR = 1.27 per year; p < 0.001).

CONCLUSION: Professional male soccer players who sustained ATR demonstrated comparable career longevity to a matched player cohort, with a trend toward longer survival in those who successfully return to play. ATR did not significantly shorten professional careers in this elite population. This likely reflects the efficacy of modern rehabilitation, a potential selection effect, and the high non-ATR injury burden observed in the control group.

LEVEL OF EVIDENCE: Level III.

PMID:42106965 | DOI:10.1002/ksa.70420

Psychiatr Pol. 2026 Feb 28;60(1):91-104. doi: 10.12740/PP/199519. Epub 2026 Feb 28.

ABSTRACT

OBJECTIVES: The aim of the study was to search for the relationship between insomnia, stress, and occupational burnout and to identify factors influencing their severity among health care workers.

METHODS: This survey-based study was conducted among 216 health care workers. It was performed using the author questionnaire, the Perceived Stress Scale (PSS-10), the Athens Insomnia Scale (AIS), and the Maslach Burnout Inventory (MBI).

RESULTS: Analysis of the effects of stress (PSS-10) and insomnia (AIS) on occupational burnout showed that stress correlated significantly (p ˂ 0.05) and positively (r ˃ 0) with all MBI subscales; that is, the more severe the stress, the higher the levels of emotional exhaustion, depersonalization, but also personal accomplishment. Insomnia correlated significantly (p ˂ 0.05) and positively (r ˃ 0) with all MBI subscales – the more severe the insomnia, the higher the levels of emotional exhaustion, depersonalization, but also personal accomplishment.

CONCLUSIONS: (1) Age and work experience were the sociodemographic variables that determined the occurrence of insomnia among the surveyed participants. (2) The form of employment may be an important factor that determines the level of stress, insomnia, and job burnout. Those employed under permanent contracts had lower levels of stress and job burnout, more often suffered from insomnia, and had higher levels of personal accomplishment. (3) In the study group, stress and insomnia influenced all aspects of job burnout. As stress and insomnia increased, so did levels of depersonalization, emotional exhaustion, but also personal accomplishment.

PMID:42106944 | DOI:10.12740/PP/199519