Category: Nevin Manimala

JAMA Netw Open. 2025 Jul 1;8(7):e2521785. doi: 10.1001/jamanetworkopen.2025.21785.

ABSTRACT

IMPORTANCE: Hospital readmissions are associated with significant health care costs and poor patient outcomes. Despite the rapid adoption of electronic health record (EHR) systems, the use of EHR-based interventions to reduce the risk of hospital readmissions is unknown.

OBJECTIVE: To systematically review and estimate the association of EHR-based interventions vs controls with preventing 30-day all-cause hospital readmissions as tested in randomized clinical trials (RCTs).

DATA SOURCES: Ovid MEDLINE, Ovid Embase, CINAHL, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from database inception to July 5, 2024, using text words with analogous terms within concept areas of “randomized controlled trial,” “hospitalized adults,” and “readmissions.”

STUDY SELECTION: RCTs were included if they evaluated the effect of EHR-based interventions on hospital readmissions compared with a control arm without an EHR-embedded component. Studies were excluded if they involved nonhospitalized, pediatric, obstetric, or psychiatric populations or did not report readmission outcomes. Results were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guideline.

DATA EXTRACTION AND SYNTHESIS: Data were extracted independently by 3 reviewers in duplicate. A random-effects model was used to pool data, and the quality of studies was assessed using the Cochrane Risk of Bias tool. Heterogeneity was quantified using the I2 statistic and explored with prespecified subgroup analyses and univariable meta-regression by population demographics, intervention complexity, and publication year.

MAIN OUTCOMES AND MEASURES: The primary outcome was 30-day all-cause hospital readmission, and other readmission outcomes (eg, unplanned readmissions and readmissions at 3, 6, 12, and 24 months) were examined as secondary outcomes.

RESULTS: A total of 116 RCTs involving 204 523 participants (weighted mean [SD] males, 56% [16%]; weighted mean [SD] age, 68 [9] years) were included, with telemonitoring (76 studies [66%]) being the most common EHR-based intervention component followed by case management (45 studies [39%]) and medication reconciliation (33 [28%]). EHR-based interventions were associated with a statistically significant reduction in 30-day all-cause readmissions (OR, 0.83 [95% CI, 0.70-0.99]; I2 = 82%; τ = 0.44 [95% CI, 0.30-0.62]; prediction interval [PI], 0.34-2.06) and 90-day all-cause readmissions (OR, 0.72 [95% CI, 0.54-0.96]; I2 = 78%; τ = 0.34 [95% CI, 0.19-1.00]; PI, 0.33-1.55) compared with control arms.

CONCLUSIONS AND RELEVANCE: In this systematic review and meta-analysis of RCTs, the use of EHR-based interventions was associated with a reduction in 30-day and 90-day hospital readmissions. Future research should examine additional components of EHR interventions to understand and account for remaining gaps in effectiveness.

PMID:40674049 | DOI:10.1001/jamanetworkopen.2025.21785

JAMA Netw Open. 2025 Jul 1;8(7):e2521819. doi: 10.1001/jamanetworkopen.2025.21819.

ABSTRACT

IMPORTANCE: Alcohol advertising on television in China has the potential to target children and adolescents with harmful content. Understanding the extent of this advertising is critical for informing and improving current regulatory approaches.

OBJECTIVE: To measure the exposure of alcohol advertisements on television channels popular among children and adolescents in Beijing, China.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study of television advertisements used the 4 most popular television channels for viewers aged 3 to 18 years (2 children’s channels and 2 general channels) in Beijing and accessed advertisements recorded from October 19, 2020, to January 17, 2021. Television advertisements were recorded during 4 randomly selected weekdays and 4 randomly selected weekend days (from 6:00 am to 11:59 pm). Data were analyzed from October 1, 2023, to December 31, 2024.

EXPOSURES: Television alcohol advertisements, with food and nonalcoholic beverages (F&B) advertisements classified as not permitted in marketing to children included as comparison.

MAIN OUTCOMES AND MEASURES: Primary outcomes included frequency and distribution of alcohol advertisements, rate per channel-hour, and potential exposure during peak viewing times (PVT). Secondary outcomes included comparison with F&B advertisements classified as not permitted based on the World Health Organization Western Pacific Region Office Nutrient Profile Model integrated with the International Network for Food and Obesity/Non-communicable Diseases Research, Monitoring and Action Support (INFORMAS) food classification system and analysis of 6 marketing strategies.

RESULTS: Among 13 864 total advertisements included in the analysis, 5368 were food advertisements. Among the food advertisements, 321 (6.0%; 95% CI, 5.4%-6.7%) were alcohol advertisements and 2001 (37.3%; 95% CI, 36.0%-38.6%) were F&B advertisements classified as not permitted. On general channels, a mean (SD) of 1.1 (1.7) alcohol advertisements per channel-hour were identified, with significantly higher rates during PVT compared with non-PVT (2.0 [2.4] vs 0.7 [0.9] per channel-hour; P < .001). The highest rate occurred between 9:00 and 9:59 pm, with a mean (SD) of 3.7 (2.8) advertisements per channel-hour and an estimated mean (SD) of 14 303 014 (11 659 096) impressions among children and adolescents. All 321 alcohol advertisements (100%; 95% CI, 98.9%-100%) and 1997 F&B advertisements classified as not permitted (99.8%; 95% CI, 99.5%-99.9%) used at least 1 marketing strategy, predominantly brand benefit claims, which were used in 307 alcohol advertisements (95.6%; 95% CI, 92.8%-97.4%) and 1915 F&B advertisements classified as not permitted (95.7%; 95% CI, 94.7%-96.5%).

CONCLUSIONS AND RELEVANCE: In this cross-sectional study of television advertising, alcohol advertisements on general channels exceeded regulatory limits, especially during PVT. These findings suggest that current regulations allow exposure of children and adolescents to alcohol marketing and should be strengthened.

PMID:40674047 | DOI:10.1001/jamanetworkopen.2025.21819

Psychol Trauma. 2025 Jul 17. doi: 10.1037/tra0001998. Online ahead of print.

ABSTRACT

OBJECTIVE: The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) is regarded as the state-of-the-art method for diagnosing Diagnostic and Statistical Manual of Mental Disorders, fifth edition, posttraumatic stress disorder (PTSD). To address the high demand for training in the CAPS-5, we developed the CAPS-5 Training Simulator (CAPSim), an online program in which learners administer the CAPS-5 to lifelike virtual PTSD patients and receive feedback on their performance.

METHOD: We created three virtual standardized PTSD patients who respond verbally to learners’ spoken or typed prompts. Complexity and availability of in-course feedback varied across patients. The program was then made available to interested learners, and data on program use and user performance were collected to determine acceptability and feasibility.

RESULTS: Over the first 4 years of the program, 4,484 users accessed the training. Of those who started the course (N = 3,022), most (83.6%) completed it. Although CAPS-5 familiarity varied, more than half of the users (58.3%) reported being moderately familiar with the CAPS-5 at baseline. Administration and scoring accuracy varied by virtual patient and by CAPS-5 item, with overall accuracy ranging from near perfect to 77.1% incorrect. Whereas the initial symptom prompts were delivered verbatim 76.2% of the time, in-sequence and additional required prompts were administered with less accuracy (46.0% and 39.2%, respectively).

CONCLUSIONS: The CAPSim is an innovative method for training CAPS-5 learners with various skill levels. The CAPSim can identify specific administrative and scoring challenges and provide personalized feedback in a manner that appears acceptable to learners. The CAPSim has promise to meet the high demand for CAPS-5 training. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

PMID:40674018 | DOI:10.1037/tra0001998

Emotion. 2025 Jul 17. doi: 10.1037/emo0001562. Online ahead of print.

ABSTRACT

A widely cited idea in the emotion regulation literature holds that expressive suppression impairs memory while cognitive reappraisal has no effect on or may enhance memory relative to control. However, empirical evidence for these effects has been inconsistent. To provide a definitive test, we conducted four well-powered experiments with more than 4,000 participants to examine the effects of reappraisal and suppression of negative emotion (Experiments 1 and 3) and positive emotion (Experiments 2 and 4) on verbal and nonverbal memory. Results showed no consistent evidence for an effect of reappraisal on either type of memory, though expressive suppression of negative emotion consistently impaired verbal memory relative to control. Obtained effect sizes were small given successful emotion regulation manipulations and adequate statistical power (ds < 0.11). Conclusions are constrained to English-speaking online samples, and may not generalize to other types of memory. These findings highlight the need to systematically test widely accepted assumptions as a field. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

PMID:40674016 | DOI:10.1037/emo0001562

J Fam Psychol. 2025 Jul 17. doi: 10.1037/fam0001378. Online ahead of print.

ABSTRACT

The association between prenatal stress factors and infant sleep has been examined in the literature, however, the mechanisms explaining this association remain unclear. The present study examined the indirect association between prenatal stress and infant sleep problems via maternal emotional distress and maternal sensitivity in distress-eliciting context in a three-wave longitudinal study that followed 299 mothers from pregnancy until the infants were 6 months old. Expectant mothers reported demographics, prenatal stress (i.e., stressful life events, neighborhood violence, income) and emotional distress (i.e., depressive symptoms, trait anxiety, emotion regulation difficulties, and personality characteristics) Prior to the 2-month laboratory visit, mothers reported their depressive symptoms and state anxiety. During the 2- and 6-month laboratory visits, maternal sensitivity in distress-eliciting context was assessed during the still-face episode of the still-face paradigm. Mothers reported infant sleep problems at 6 months. Consistent with hypotheses, prenatal stress predicted higher perinatal emotional distress which in turn was significantly associated with lower maternal sensitivity. Further, maternal sensitivity was significantly associated with fewer infant sleep problems. The indirect pathway from prenatal stress to infant sleep problems via elevated maternal emotional distress and compromised maternal sensitivity was statistically significant. The findings affirm the need for policies and interventions to better support mothers exposed to prenatal stress and/or experiencing emotional distress to ensure optimal infant sleep outcomes. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

PMID:40674011 | DOI:10.1037/fam0001378

Health Psychol. 2025 Jul 17. doi: 10.1037/hea0001532. Online ahead of print.

ABSTRACT

OBJECTIVE: Ambivalence in relationships is related to health-relevant biological outcomes. However, the antecedent processes that contribute to this association are unknown. The primary aim of this study was to test the prediction of the social ambivalence and disease model, which highlights the potential role of childhood trauma as an antecedent factor linking spousal ambivalence to inflammation.

METHOD: A sample of 107 heterosexual couples who had been married for at least 10 years was recruited. Participants completed the social relationship index to assess spousal ambivalence and the Childhood Trauma Questionnaire. Blood was drawn to determine levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 as measures of inflammation.

RESULTS: Consistent with the social ambivalence and disease model, there was a significant indirect effect in which childhood trauma was related to greater spousal ambivalence which in turn was associated with higher hs-CRP levels. No evidence for the statistical mediational model was found for interleukin-6.

CONCLUSIONS: These results highlight the potential role of childhood trauma as an antecedent factor linking spousal ambivalence to hs-CRP. It also highlights potential pathways that might be targeted for interventions pending further work. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

PMID:40673997 | DOI:10.1037/hea0001532

Health Psychol. 2025 Jul 17. doi: 10.1037/hea0001534. Online ahead of print.

ABSTRACT

OBJECTIVE: To use a recently developed methodology, z-curve analysis, to estimate the likelihood of replication success for recently published studies in three leading health psychology journals with high impact factors that involved some form of a moderation analysis.

METHOD: Utilizing a z-curve analysis, we estimated the replicability, false positives, publication bias, and “file drawer ratio” of 124 independent tests of moderation with significant results published in recent issues of three leading journals in the field of health psychology. z-curve analyses were conducted for all the journals combined and each journal separately.

RESULTS: The distribution of z scores derived from all 124 studies indicated that the estimation of the expected replication rate and false positive ratio were 46.0% and 8.3%, respectively. The estimated file drawer ratio was 1.6, indicating that for every statistically significant interaction reported, nearly two nonsignificant interactions go unreported. In comparing the three journals, Health Psychology had the best overall results (expected replication rate = 52.3%, Soric false discovery rate = 4.8%, file drawer ration = 0.9). Of the 124 studies examined, 23 conducted power analyses to determine sample size, seven preregistered hypotheses, and three conducted a replication analysis.

CONCLUSION: Results suggest a need for change regarding both the methodological practices used and the publication processes in place to improve the validity and efficacy of research regarding moderation effects in behavioral medicine-this includes preregistering hypotheses, using formalized methods to determine sample size, and utilizing attention checks. Journals can encourage or require these practices and foster acceptance of nonsignificant results to limit publication biases. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

PMID:40673996 | DOI:10.1037/hea0001534

Neurosurg Rev. 2025 Jul 17;48(1):571. doi: 10.1007/s10143-025-03726-4.

ABSTRACT

BACKGROUND AND PURPOSE: The Maurora stent (Drug eluting stent) is the first rapamycin-eluting vertebral artery stent system, and currently, there are no studies on the one-year outcomes of the Maurora stent in the treatment of severe vertebral artery ostium stenosis. Therefore, this study utilizes Cumulative sum (CUSUM) curve analysis to evaluate the one-year prognosis and restenosis rate of the Maurora stent in patients with severe stenosis at the vertebral artery origin.

METHODS: All patients were arranged in chronological order according to the sequence of their surgeries. CUSUM analysis was employed to assess the surgical learning curve. The point at which the CUSUM learning curve begins to descend marks the number of cases required to achieve procedural proficiency; this point delineates the transition from the initial stable phase to the mature phase. Postoperative Modified Rankin Scale(mRS) and NIHSS scores are visualized using histograms.

RESULTS: Ultimately, 38 patients met the inclusion and exclusion criteria and were included in the analysis. At the 1-year follow-up, 89.47% of patients had an MRS score of 0, showing a statistically significant improvement compared to preoperative values (p < 0.05). The MRS scores at 1year post-procedure showed a statistically significant difference between the mature and stable groups (P < 0.05).

CONCLUSIONS: The study showed that the Maurora stent (Drug eluting stent) is safe and effective in treating severe vertebral artery ostium stenosis, offering significant clinical value.

PMID:40673988 | DOI:10.1007/s10143-025-03726-4

Hum Genet. 2025 Jul 17. doi: 10.1007/s00439-025-02763-9. Online ahead of print.

ABSTRACT

The human leukocyte antigen (HLA) region is a critical genetic locus associated with diverse complex traits, yet its intricate genetic architecture poses significant challenges to elucidation. Leveraging recent advances in regional heritability estimation and extensive datasets from the Million Veteran Program (MVP), we conducted a comprehensive investigation of the HLA region’s genetic architecture. This involved heritability estimation and genetic correlation analyses within the HLA region across European Americans (EAs) and African Americans (AAs). Our analyses demonstrated that in EAs, the HLA region exhibited significantly greater local heritability than other genomic regions of comparable length for lipid metabolic traits (triglycerides [TG], total cholesterol [TC], high-density lipoprotein [HDL], low-density lipoprotein [LDL]), anthropometric measures (body mass index [BMI]), and suicide-related traits (suicidal ideation without suicide attempts [IDE] and suicidal thoughts and behaviors [SITB]) (false discovery rate [FDR]-adjusted empirical p-values < 0.05). Notably, this enrichment was not observed in AAs. Genetic correlation analyses revealed disparities between local HLA and genome-wide findings. EAs exhibited 16 significant local HLA correlations and 32 genome-wide correlations. Conversely, AAs displayed more significant local genetic correlations within the HLA region (14 pairs) than genome-wide (3 pairs), with two pairs (IDE-SITB, LDL-TC) concordantly significant. These findings underscore the HLA region’s substantial contribution to the variance of these lipid metabolic traits, BMI, and suicide-related traits. Further investigation into the genetic mechanisms by which HLA-mediated pathways influence these phenotypes is crucial for elucidating the complex role of this region, particularly concerning lipid metabolism and suicidal behaviors.

PMID:40673980 | DOI:10.1007/s00439-025-02763-9

Oral Maxillofac Surg. 2025 Jul 17;29(1):135. doi: 10.1007/s10006-025-01430-7.

ABSTRACT

INTRODUCTION: One of the challenges of orthognathic surgery (OS) is maintaining condylar position during osteosynthesis. It is believed that the post-surgical condylar position is related to postoperative morphological changes in the temporomandibular joint (TMJ), as well as surgical stability.

OBJECTIVE: The aim of this study is to perform fractal analysis of the mandibular ramus in class II and class III patients undergoing OS, analyzing cone beam computed tomography (CBCT) images one month before surgery (T0), one month after surgery (T1), and six to eight months after surgery (T2).

MATERIALS AND METHODS: Fractal analysis was performed on coronal and sagittal reconstructions. Regions of interest (ROIs) were selected for each patient and evaluated region. The ROIs underwent a processing method described by White & Rudolph in 1999. After processing, fractal analysis calculation was performed using the box-counting method by the “Fractal Box Count” function of the ImageJ software.

RESULTS: When examining the different periods (T0, T1, and T2) among class II and class III patients, no statistically significant differences were identified (p > 0.05). This finding suggests stability in the fractal characteristics of the analyzed region, regardless of skeletal class.

CONCLUSION: OS for correction of Class II and Class III malocclusions did not demonstrate a significant impact on the microstructure of the mandibular ramus over time.

PMID:40673961 | DOI:10.1007/s10006-025-01430-7