Category: Nevin Manimala

ESMO Open. 2021 May 10;6(3):100151. doi: 10.1016/j.esmoop.2021.100151. Online ahead of print.

ABSTRACT

BACKGROUND: Prognostic impact of lymph node micro-metastases (pN1mi) has been discordantly reported in the literature. The need to clarify this point for decision-making regarding adjuvant therapy, particularly for patients with endocrine receptor (ER)-positive status and HER2-negative tumors, is further reinforced by the generalization of gene expression signatures using pN status in their recommendation algorithm.

PATIENTS AND METHODS: We retrospectively analyzed 13 773 patients treated for ER-positive breast cancer in 13 French cancer centers from 1999 to 2014. Five categories of axillary lymph node (LN) status were defined: negative LN (pN0i-), isolated tumor cells [pN0(i+)], pN1mi, and pN1 divided into single (pN1 = 1) and multiple (pN1 > 1) macro-metastases (>2 mm). The effect of LN micro-metastases on outcomes was investigated both in the entire cohort of patients and in clinically relevant subgroups according to tumor subtypes. Propensity-score-based matching was used to balance differences in known prognostic variables associated with pN status.

RESULTS: As determined by sentinel LN biopsy, 9427 patients were pN0 (68.4%), 546 pN0(i+) (4.0%), 1446 pN1mi (10.5%) and 2354 pN1 with macro-metastases (17.1%). With a median follow-up of 61.25 months, pN1 status, but not pN1mi, significantly impacted overall survival (OS), disease-free survival (DFS), metastasis-free survival (MFS), and breast-cancer-specific survival. In the subgroup of patients with known tumor subtype, pN1 = 1, as pN1 > 1, but not pN1mi, had a significant prognostic impact on OS. DFS and MFS were only impacted by pN1 > 1. Similar results were observed in the subgroup of patients with luminal A-like tumors (n = 7101). In the matched population analysis, pN1macro, but not pN1mi, had a statistically significant negative impact on MFS and OS.

CONCLUSION: LN micro-metastases have no detectable prognostic impact and should not be considered as a determining factor in indicating adjuvant chemotherapy. The evaluation of the risk of recurrence using second-generation signatures should be calculated considering micro-metastases as pN0.

PMID:33984674 | DOI:10.1016/j.esmoop.2021.100151

Sci Total Environ. 2021 May 6;786:147534. doi: 10.1016/j.scitotenv.2021.147534. Online ahead of print.

ABSTRACT

The presence of SARS-CoV-2 in wastewater pose the question of whether this new pandemic virus could be released into watercourses and potentially continue to finally reach coastal waters. In this study, we employed two bivalve molluscan species from the genus Ruditapes as sentinel organisms to investigate the presence of SARS-CoV-2 signals in the marine coastal environment. Estuarine sediments from the natural clam banks were also analyzed. Viral RNA was detected by RT-qPCR, targeting IP4, E and N1 genomic regions. Positive samples were also subjected to a PMAxx-triton viability RT-qPCR assay in order to discriminate between intact and altered capsids, obtaining indirect information about the viability of the virus. SARS-CoV-2 RNA traces were detected in 9/12 clam samples by RT-qPCR, from which 4 were positive for two different target regions. Viral quantification ranged from <LoQ to 4.48 Log genomic copies/g of digestive tissue. Regarding the sediment samples, 3/12 were positive by RT-qPCR, but only IP4 region was successfully amplificated. Quantification values for sediment samples ranged from <LoQ to 3.60 Log genomic copies/g of sediment. RNA signals disappeared in the PMAxx-triton viability RT-qPCR assay, indicating non-infectious potential. In addition, the recently discovered human-specific gut associated bacteriophage crAssphage was also quantified as a biomarker for the presence of human-derived wastewater contamination on the study area. CrAssphage was detected in 100% of both types of samples with quantification values ranging from <LoQ to 5.94 Log gc/g digestive tissue and from <LoQ to 4.71 Log gc/g sediment. Statistical analysis also showed that quantification levels for the crAssphage in clams are significantly higher than in sediments. These findings represent the first detection of SARS-CoV-2 RNA in the marine environment, demonstrating that it can reach these habitats and make contact with the marine life.

PMID:33984699 | DOI:10.1016/j.scitotenv.2021.147534

Sci Total Environ. 2021 Apr 29;786:147415. doi: 10.1016/j.scitotenv.2021.147415. Online ahead of print.

ABSTRACT

Depletion of groundwater aquifers along with all of the associated quality and quantity problems which affect profitability of direct agricultural and urban users and linked groundwater-ecosystems have been recognized globally. During recent years, attention has been devoted to land subsidence-the loss of land elevation that occurs in areas with certain geological characteristics associated with aquifer exploitation. Despite the large socioeconomic impacts of land subsidence most of these effects are still not well analyzed and not properly recognized and quantified globally. In this paper we developed a land subsidence impact extent (LSIE) index that is based on 10 land subsidence attributes, and applied it to 113 sites located around the world with reported land subsidence effects. We used statistical means to map physical, human, and policy variables to the regions affected by land subsidence and quantified their impact on the index. Our main findings suggest that LSIE increases between 0.1 and 6.5% by changes in natural processes, regulatory policy interventions, and groundwater usage, while holding all other variables unchanged. Effectiveness of regulatory policy interventions varies depending on the lithology of the aquifer system, in particular its stiffness. Our findings suggest also that developing countries are more prone to land subsidence due to lower performance of their existing water governance and institutions.

PMID:33984701 | DOI:10.1016/j.scitotenv.2021.147415

Ecotoxicol Environ Saf. 2021 May 10;218:112294. doi: 10.1016/j.ecoenv.2021.112294. Online ahead of print.

ABSTRACT

In China, studies on lead exposure to grownup are scarce compared to children, although relevant disease burdens for adults are much severe than that in developed countries. The present study evaluated blood lead levels (BLLs) in Chinese adults by data mining using Monte Carlo simulation. A total of 115 scientific studies published between January 1980 and March 2021 reflecting 45,514 Chinese adults were included in the study. After a continuous increase in Chinese adult BLLs from 1980-1983 (GM 74.84 μg/L) to 1994-1996 (GM 92.27 μg/L), BLLs began to decline from 2000–2002 (GM 80.32 μg/L) to 2016-2018 (GM 21.57 μg/L). This decline implied that the lead phase-out policy in gasoline was effective over the past two decades. The study indicated that North, South, and Southwest China were still relatively high compared to other regions in the past decade. Statistical analysis showed that BLLs of males (GM 68.45 μg/L) were higher than females (GM 56.51 μg/L), smokers (GM 80.96 μg/L) higher than nonsmokers (GM 58.95 μg/L), and populations over 40 (GM 40.43 μg/L) higher than younger populations (GM 40.37 μg/L). The significantly positive correlation between the concentrations of PM2.5 and topsoil lead and BLLs in Chinese adults indicated that air and soil pollution affect adult BLLs. Taken together, our results showed that strict lead control strategies and regular bio-monitoring are needed to maintain low BLLs in the population.

PMID:33984660 | DOI:10.1016/j.ecoenv.2021.112294

Clin Imaging. 2021 Apr 29;77:194-201. doi: 10.1016/j.clinimag.2021.04.033. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of this study was to quantify COVID-19 pneumonia features using CT performed at time of admission to emergency department in order to predict patients’ hypoxia during the hospitalization and outcome.

METHODS: Consecutive chest CT performed in the emergency department between March 1st and April 7th 2020 for COVID-19 pneumonia were analyzed. The three features of pneumonia (GGO, semi-consolidation and consolidation) and the percentage of well-aerated lung were quantified using a HU threshold based software. ROC curves identified the optimal cut-off values of CT parameters to predict hypoxia worsening and hospital discharge. Multiple Cox proportional hazards regression was used to analyze the capability of CT quantitative features, demographic and clinical variables to predict the time to hospital discharge.

RESULTS: Seventy-seven patients (median age 56-years-old, 51 men) with COVID-19 pneumonia at CT were enrolled. The quantitative features of COVID-19 pneumonia were not associated to age, sex and time-from-symptoms onset, whereas higher number of comorbidities was correlated to lower well-aerated parenchyma ratio (rho = -0.234, p = 0.04) and increased semi-consolidation ratio (rho = -0.303, p = 0.008). Well-aerated lung (≤57%), semi-consolidation (≥17%) and consolidation (≥9%) predicted worst hypoxemia during hospitalization, with moderate areas under curves (AUC 0.76, 0.75, 0.77, respectively). Multiple Cox regression identified younger age (p < 0.01), female sex (p < 0.001), longer time-from-symptoms onset (p = 0.049), semi-consolidation ≤17% (p < 0.01) and consolidation ≤13% (p = 0.03) as independent predictors of shorter time to hospital discharge.

CONCLUSION: Quantification of pneumonia features on admitting chest CT predicted hypoxia worsening during hospitalization and time to hospital discharge in COVID-19 patients.

PMID:33984670 | DOI:10.1016/j.clinimag.2021.04.033

J Opt Soc Am A Opt Image Sci Vis. 2021 May 1;38(5):654-662. doi: 10.1364/JOSAA.412972.

ABSTRACT

In previous studies, the receivers in indoor visible light communication (VLC) were usually fixed. However, in reality, the receivers in VLC have random locations and orientations. Therefore, it is important to consider these random factors for performance analysis in VLC. In this paper, we consider a typical VLC system with a fixed transmitter and a random receiver. Two types of receivers are investigated: (1) those with random location and (2) those with random orientation. Based on the established system model, the statistical characteristics of the channel were obtained, and closed-form expressions of the average channel capacity and the outage probability were derived, respectively. Finally, numerical results verified the accuracy of derived theoretical expressions. Moreover, the effects of the nominal optical intensity, the dimming target, the transmitter height, the receiver zone’s radius, the outage threshold, and the Lambertian emission order on system performance were also provided.

PMID:33983270 | DOI:10.1364/JOSAA.412972

Appl Opt. 2021 May 1;60(13):3936-3946. doi: 10.1364/AO.419594.

ABSTRACT

We discuss various methods for acquiring optical links in space using a dedicated acquisition sensor. Statistical models are developed and simple analytical equations derived that compare the performance between a single- and dual-spiral scan approach as well as between sequential and parallel acquisition of link chains. Simple derived analytical equations allow relating essential search parameters such as track width, variance of the uncertainty distribution, capture radius, and scan speed to the probabilities of acquiring the links within a specific time. We also assess the probability of failing to acquire a link due to beam jitter and derive a simple analytical model that allows determining the maximum tolerable jitter for a given beam overlap and required probability of success. All results are validated by Monte Carlo simulations and applied to the concrete example of the GRACE FO mission.

PMID:33983332 | DOI:10.1364/AO.419594

Appl Opt. 2021 May 10;60(14):4154-4164. doi: 10.1364/AO.419746.

ABSTRACT

The LiDAR sensor has been widely used for reconstruction in urban scenes. However, the current registration method makes it difficult to find stable 3D point correspondences from sparse and low overlapping LiDAR point clouds. In the urban situation, most of the LiDAR point clouds have a common flat ground. Therefore, we propose a novel, to the best of our knowledge, multi-level height (MH) maps-based coarse registration method. It requires that source and target point clouds have a common flat ground, which is easily satisfied for LiDAR point clouds in urban scenes. With MH maps, 3D registration is simplified as 2D registration, increasing the speed of registration. Robust correspondences are extracted in MH maps with different height intervals and statistic height information, improving the registration accuracy. The solid-state LiDAR Livox Mid-100 and mechanical LiDAR Velodyne HDL-64E are used in real-data and dataset experiments, respectively. Verification results demonstrate that our method is stable and outperforms state-of-the-art coarse registration methods for the sparse case. Runtime analysis shows that our method is faster than these methods, for it is non-iterative. Furthermore, our method can be extended for the unordered multi-view point clouds.

PMID:33983168 | DOI:10.1364/AO.419746

Appl Opt. 2021 Apr 10;60(11):3257-3265. doi: 10.1364/AO.417344.

ABSTRACT

This paper continues a series of studies on using underwater solar path imagery (USPI) to retrieve characteristics of wind-driven waves and their variations in the field of near-surface hydrophysical processes under the influence of surfactant films. Research is based on previously developed mathematical models of USPI and its statistical moments, the Elfouhaily spectrum of wind-driven waves, the Ermakov model of wave damping by a thin film, and the Cox-Munk result for a thick oil film. A high sensitivity of two statistical moments of USPI to variations of wind-wave conditions and viscoelastic characteristics of oil films was shown. The presented examples demonstrated 20%-40% narrowing of the statistically average image (the first statistical moment) for thin films and more than 2 times narrowing for thick films. The film presence also leads to significant changes in the autocorrelation function of USPI. The characteristic scales and magnitudes of changes in the considered statistical moments fit into the ranges of values that can be recorded in practice using even inexpensive video cameras. At the same time, there are cases in which these moments are close. For example, for a clean sea surface in weak winds and for a surface covered by a thin film in stronger winds. These cases can be distinguished by analyzing a series of instant images. As an example, a series of real underwater images demonstrating changes in the glint structure with the surfactant film spot passing through the observed sea surface area were analyzed. This example is intended to help researchers to distinguish cases of wind weakening and a surfactant film presence.

PMID:33983227 | DOI:10.1364/AO.417344

Br J Neurosurg. 2021 May 13:1-5. doi: 10.1080/02688697.2021.1923651. Online ahead of print.

ABSTRACT

BACKGROUND AND OBJECTIVES: Understanding the biomechanical relationship between the spine and the pelvis is important for the management of symptomatic lumbar disease. There are several different metrics that may be used to evaluate the spine in the sagittal plane. The aim of this study is to compare spinopelvic parameters and global sagittal angle (GSA) in a cohort of patients with upper lumbar disc herniations (ULDH) to identify a correlation between the pelvic incidence (PI) and GSA with ULDH.

MATERIAL AND METHODS: Eighty-six patients with ULDH and 86 asymptomatic control group underwent whole body biplanar stereographs- and magnetic resonance imaging . The spinopelvic parameters and GSA were measured.

RESULTS: PI, sacral slope (SS), lumbar lordosis (LL), and thoracic kyphosis (TK) were all significantly lower than in the control group (p < 0.01) but there was no difference in the pelvic tilt (PT). The two groups were divided into subgroups. PI in the T12-L1 and L1-L2 level groups were significantly smaller than in the control group (p < 0.05). Also, there was a significant difference in TK and LL between the L3-L4 level and control group (p < 0.05), but there was no statistically significant difference in PT between all levels and the control group.

CONCLUSION: This study demonstrated a unique correlation between several spinopelvic parameters and GSA and the occurrence of ULDH. Lower PI, SS, and LL in T12-L1 and L1-L2 levels indicates a flat lumbar spine which may increase mechanical stress at these levels, thereby leading to disc herniation.

PMID:33983097 | DOI:10.1080/02688697.2021.1923651