Category: Statistics

J Oral Biol Craniofac Res. 2025 May-Jun;15(3):638-644. doi: 10.1016/j.jobcr.2024.12.008. Epub 2025 Apr 10.

ABSTRACT

INTRODUCTION: Oral squamous cell carcinoma is a malignancy that is biologically aggressive.

OBJECTIVE: To investigate the correlation between various histopathological factors and the worst patterns of invasion at the tumor-host interface, which were classified as cohesive (1-3) and non-cohesive (4&5).

METHODS: Neck dissections were performed on 81 cases of oral squamous cell carcinoma those had been diagnosed. The selection was limited to paraffin-embedded blocks that contained sections from the tumor. Tumor staging, nodal staging and other factors such as lymphovascular invasion, perineural invasion, extra nodal extension, depth of invasion, margin status and tumor differentiation grades were documented.

RESULTS: The findings indicate a higher frequency of non-cohesive worst invasion patterns in numerous anatomical sites. A prediction accuracy of 69.1 % was obtained from the logistic regression analysis, suggesting that the predictive performance has also improved. The chi square test results demonstrated a statistically significant correlation between the variable of interest and extranodal extension showing a p value of 0.008 while lymph node status also showed significant with a p value of 0.000. Another factor that depicted a significance with worst pattern of invasion was tumor margin status having a p value of 0.046. Lymphovascular invasion and the worst pattern of invasion also exhibited a statistically significant correlation, with a p-value of 0.013.

CONCLUSION: The results of this investigation indicate that aggressive tumor biology is associated with non-cohesive worst pattern of invasion. Non-cohesive worst pattern of invasion is associated with moderate differentiation grade, lymphovascular invasion, perineural invasion, extranodal extension, closed or involved tumor margins and nodal metastases.

PMID:40265143 | PMC:PMC12013481 | DOI:10.1016/j.jobcr.2024.12.008

J Phys Chem C Nanomater Interfaces. 2025 Apr 4;129(15):7377-7386. doi: 10.1021/acs.jpcc.4c05199. eCollection 2025 Apr 17.

ABSTRACT

An Fe-deficient iron sulfide thin film with a nickeline (NiAs) type structure has been reported with a stoichiometry close to greigite (Fe₃S₄) [Davis E. M.; Phys. Chem. Chem. Phys.2019, 21, 20204-20210]. We have investigated the Fe-vacancy ordering in the nonstoichiometric iron sulfide with the NiAs-like structure using density functional theory calculations with a Hubbard Hamiltonian and long-range dispersion corrections [DFT + U – D3(BJ)]. We applied canonical statistical mechanics to study the thermodynamics of ordering and in the most stable configuration we found the same concentration of Fe deficiencies in each layer along the c axis. We discuss the probabilities of the configurations and the averages of observables, such as lattice parameters and magnetic moments, as a function of temperature. At equilibrium, the Fe-deficient iron sulfide is expected to be fully ordered. The predicted electronic properties of the most stable configuration suggest that this material is antiferromagnetic. The simulated electronic structure shows that the most stable configuration of the Fe-deficient iron sulfide has semimetallic properties.

PMID:40265134 | PMC:PMC12010426 | DOI:10.1021/acs.jpcc.4c05199

J Blood Med. 2025 Apr 17;16:187-195. doi: 10.2147/JBM.S521698. eCollection 2025.

ABSTRACT

PURPOSE: Blood transfusion is an essential component of healthcare systems, and blood donors play a critical role in saving lives and enhancing the well-being of others. This study explored blood donation practices among health profession students in northern Uganda.

PARTICIPANTS AND METHODS: We conducted an institutional-based, cross-sectional study with a quantitative approach from November 2023 to July 2024 across five healthcare institutions in Gulu. Attitude toward blood donation was assessed with seven questions, each scored from 0 (negative) to 2 (positive), yielding a total score per participant ranging from 0 to 28. The mean of these total scores across all 408 participants was calculated, with a mean total score of ≥5.0 indicating a positive group attitude, reflecting moderate favorability on average. Knowledge of blood donation practices was evaluated with 16 questions, each scored from 0 (incorrect) to 4 (fully correct), yielding a total score per participant ranging from 0 to 64. The mean of these total scores across all 408 participants was computed, with a mean total score of ≥12.0 signifying adequate group knowledge, representing a basic proficiency level. Willingness to donate blood was determined by a single question, with a “YES” response indicating willingness. Data were cleaned and analyzed using STATA 18.0, with descriptive statistics presented in tables. This study was approved by the Gulu University Research and Ethics Committee (GUREC-2023-619) on 11/11/2023.

RESULTS: A total of 408 participants were recruited, with a median age of 23 years (IQR: 21-24). Half of the participants identified as male, comprising 56.4% (n=230). Most participants demonstrated adequate knowledge about blood donation 73% (n=298). The overall positive attitude towards blood donation was 93.6% (n=382). Nearly all participants considered donating blood (99.0%, n=404), and 83.8% (n=342) expressed a willingness to donate blood in the future. However, only 48.8% (n=199) of respondents reported having donated blood in the past.

CONCLUSION: While health profession students in northern Uganda exhibit adequate knowledge and positive attitudes towards blood donation, actual blood donation practices remain suboptimal. These findings highlight the need for interventions to translate knowledge and attitudes into consistent donation practices among this population.

PMID:40265123 | PMC:PMC12012627 | DOI:10.2147/JBM.S521698

Acta Med Indones. 2025 Jan;57(1):11-17.

ABSTRACT

BACKGROUND: Inflammation plays a role in ST-segment elevation myocardial infarction (STEMI), especially in reperfusion injury (RI). Colchicine, an anti-inflammatory drug, can suppress inflammation during RI. We assessed the effectiveness of administering colchicine to STEMI patients undergoing primary percutaneous coronary intervention (PPCI) in suppressing RI events.

METHODS: This study was a randomized, double-blind, placebo-controlled clinical trial conducted in a multicenter manner at two hospitals in Jakarta with IKPP facilities from December 2022 to April 2023. STEMI patients that underwent PPCI received 2 mg of colchicine as a loading dose and a maintenance dose of 0.5 mg every 12 hours for two days or amylum at a similar dose. Patients were observed for RI events (low-flow thrombolysis in myocardial infarction (0-2) during angiography procedure, reperfusion arrhythmia, cardiogenic shock, or persistent chest pain).

RESULTS: Seventy-seven STEMI patients with a mean age of 55.2 ± 9.9 years underwent PPCI. Of these patients, 37 received colchicine, and 40 received a placebo. Most subjects were male (77.5%), suffered three-vessel disease (44.15%), and occlusion in left anterior descending coronary artery (53.24%). Colchicine was found to fail to reduce the incidence of ischemia-RI (51.5% vs. 42.4%; p = 0.437). Analysis of comorbidities (hypertension, chronic kidney disease, diabetes mellitus, and obesity) and angiography results (vessel disease, lesion diameter, and culprit artery) failed to demonstrate a statistical difference in RI. Side effects were similar in the colchicine and placebo groups (21.6% vs. 15%).

CONCLUSION: Colchicine administration in STEMI patients undergoing PPCI failed to reduce RI.

PMID:40263680

Acta Med Indones. 2025 Jan;57(1):3-10.

ABSTRACT

BACKGROUND: Heart disease is one of the non-communicable diseases that cause the highest mortality. Its symptoms affect the patient’s functional capacity and activities. The six-minute walking test can be done to assess a person’s functional ability, response to therapy, and prognosis of chronic heart-lung conditions. The study aims to determine the safety of the six-minute walking test in inpatients after percutaneous coronary intervention by assessing the response of vital signs, Borg scale, and angina scale.

METHODS: This study was a one-group pre-and post-test design study with subjects of inpatients after percutaneous coronary intervention at the Integrated Cardiac Service in Cipto Mangunkusumo General Hospital Jakarta. Research subjects conducted a six-minute walking test twice with a five-minute break in between. Examination of vital signs, Borg scale, and angina scale before and after walking test. The number of subjects was 30 (27 male and 3 female) with the majority classified as a low-risk stratification.

RESULTS: The six-minute walking test was performed over two days or more in 56.7% of the subjects. The mean covered distance was 294.68 ± 57.02 meters. Vital signs of systolic and diastolic blood pressure, pulse rate, respiratory rate, and Borg rating of perceived exertion (RPE) scale increased during the test. They decreased to baseline after resting for five minutes with p-value <0.05 in the Wilcoxon Signed Rank test. Changes in saturation, dyspnea, and leg fatigue of the Borg scale, and angina scale were not statistically significant. All study subjects did not have major adverse events.

CONCLUSION: The six-minute walking test is safe to do in inpatients after percutaneous coronary intervention with vital signs, Borg scale, and angina scale change accordingly to physiological response.

PMID:40263674

Nurs Open. 2025 Apr;12(4):e70232. doi: 10.1002/nop2.70232.

ABSTRACT

AIM: Bilevel positive airway pressure (BiPAP) management is a cornerstone in treating acute hypercapnic respiratory failure, with varying outcomes depending on the care model. This retrospective cohort study aims to compare the effectiveness of nurse-led versus physician-led BiPAP management in this context.

DESIGN: Retrospective cohort study.

METHODS: We analysed medical records of 189 patients with acute hypercapnic respiratory failure treated with BiPAP between January 2020 and December 2022. Patients were divided into nurse-led (n = 101) and physician-led (n = 88) groups based on their BiPAP management leadership. Outcomes measured included arterial blood gas (ABG) parameter improvements, intubation rates, length of hospital stay and 30-day readmission rates. Statistical analysis involved chi-squared tests, t-tests, Mann-Whitney U tests and multivariable regression to adjust for confounders.

RESULTS: Both groups demonstrated significant improvements in ABG parameters, with no significant differences between groups. The nurse-led group exhibited a lower intubation rate (9.9% vs. 21.6%, p = 0.026) and higher patient satisfaction scores (median 8 vs. 6, p < 0.001). Mortality rates, complication rates and 30-day readmission rates were similar between the groups. Multivariable logistic regression confirmed the nurse-led group had a lower likelihood of intubation (AOR: 0.401, p = 0.032) and higher patient satisfaction (AOR: 7.770, p < 0.001).

PATIENT OR PUBLIC CONTRIBUTION: Our findings indicate that nurse-led and physician-led BiPAP management strategies for acute hypercapnic respiratory failure are equally effective in terms of ABG improvement, intubation rates, hospital stay length, and readmission rates. This suggests that with adequate training and supervision, nurse-led BiPAP management can be as effective as physician-led management, offering a viable alternative in healthcare settings where physician resources are limited.

PMID:40263671 | DOI:10.1002/nop2.70232

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 May;39(5):476-481. doi: 10.13201/j.issn.2096-7993.2025.05.015.

ABSTRACT

Objective:To analyze the clinical characteristics of malignant lymphoma of the head and neck in children, and to improve the understanding and diagnosis and treatment of this type of disease by otolaryngologists. Methods:Clinical data of 49 children with malignant lymphoma of the head and neck hospitalized in the Department of Otorhinolaryngology, Head and Neck Surgery of Kunming Children’s Hospital from 2013-2021 were retrospectively analyzed and statistically analyzed according to gender, age distribution, duration of the disease, site of onset, type of pathology and survival status. Results:A total of 49 cases of malignant lymphoma of the head and neck in children were collected, of which, 39 were male and 10 female. The minimum age was 3 years, the maximum was 14 years and 4 months, the median age of onset was 7 years, and the largest percentage （51.02%） of children was in the school age（6-12 years）. The duration of the disease ranged from 5 days to 2 years, with a median of 1 month, and the site of the lesion was located in the neck in the majority of cases, 41（83.67%）. The pathologic types of hodgkin lymphoma（HL） were 25 cases（51.02%） and non-hodgkin lymphoma（NHL） were 24 cases（48.98%）, and among hodgkin lymphomas, mixed-cell classical hodgkin lymphoma was the most common, with 9 cases（18.37%）; among non-hodgkin lymphomas,originated from B-cells in 16 cases （32.65%） and from T-cells in 7 cases （14.29%）, with Burkitt’s lymphoma being the most numerous of B-cell origin in 13 cases （26.53%）, and T-cell lymphoblastoid lymphoma being the most common of T-cell origin in 4 cases （8.16%）. The follow-up period was from 22 days to 6 years and 10 months, with 3 cases losing, 43 cases surviving, 3 cases dying, with a survival rate of 93<unk> 5%, and 3 cases relapsing, with a relapse rate of 6<unk> 5%. Conclusion:Children’s head and neck malignant lymphoma has its own characteristics in terms of age of onset, gender distribution, site of onset, pathological type and treatment prognosis, which should be comprehensively assessed, diagnosed as early as possible, and multidisciplinary joint treatment actively carried out to propose personalized treatment plans.

PMID:40263660 | DOI:10.13201/j.issn.2096-7993.2025.05.015

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 May;39(5):457-461;469. doi: 10.13201/j.issn.2096-7993.2025.05.012.

ABSTRACT

Objective:To compare the clinical characteristics of nasal NK/T-cell lymphoma（NKTL） and diffuse large B-cell lymphoma（DLBCL） to improve the diagnosis and differential diagnosis of nasal lymphomas. Methods:A retrospective analysis of cases of nasal NKTL and DLBCL was conducted. The clinical symptoms, signs, and imaging features of both groups were compared and statistically analyzed. Results: The DLBCL group showed more symptoms like exophthalmos/diplopia and epiphora compared to the NKTL group （both P=0.040）. NKTL cases were more likely to be misdiagnosed as sinusitis（P=0.007）. In NKTL cases, nasal mucosal swelling（P<0.01）, destruction of nasal structures（P=0.002）, and external nasal structural abnormalities（P=0.003） were more prevalent. In imaging, the DLBCL group more commonly demonstrated worm-eaten destruction of sinus bones （P=0.004）, sinus masses （P=0.018）, and invasion of adjacent structures including the pterygopalatine fossa, infratemporal fossa （P<0.01）, orbit （P=0.039）, and skull base （P=0.011）. NKTL involved the turbinates（P=0.001）, nasal cavity and septum（P=0.016）, nasopharynx（P<0.01）, and “skip” infiltration of external nasal tissues（P=0.042） more frequently. No statistically significant differences were found in other clinical features between the two groups. Conclusion:For patients with nasal obstruction and discharge, it is essential to inquire about systemic B symptoms, such as fever, and eye symptoms, such as periorbital swelling, diplopia, and lacrimation. Lymphoma should be suspected if local examination reveals diffuse nasal swelling, destruction of turbinates or septum, and external nasal structural abnormalities. Worm-eaten bone destruction and “cast-like” changes of the turbinates, septum, and nasal cavity, as well as “skip” infiltration of the external nose, are more common in NKTL. Sinus masses with invasion of the pterygopalatine fossa, infratemporal fossa, skull base, and orbit are more typical of DLBCL.

PMID:40263657 | DOI:10.13201/j.issn.2096-7993.2025.05.012

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 May;39(5):439-442. doi: 10.13201/j.issn.2096-7993.2025.05.008.

ABSTRACT

Objective:To study whether the auditory rehabilitation effect and quality of life of elderly patients have improved after cochlear implantation. Methods:Selected 36 elderly deafness patients over 60 years during the period January 2020 to December 2022, After exclusion of surgical contraindications, a minimally invasive cochlear implant was performed. Using the auditory behavior grading-Ⅱ（CAP-Ⅱ）, the Nijmegen cochlear implant scale（NCIQ）, the scores of preoperative, postoperative 6 months and postoperative 18 months of cochlear implantation in 36 elderly deafness patients were collected through questionnaire survey, and statistical analysis was conducted, compare the auditory ability and quality of life of elderly patients after cochlear implantation. Results:The preoperative score of CAP-Ⅱ （2.50±0.85） and the total score of NCIQ （23.73±2.12）; the CAP-Ⅱ score at the sixth postoperative month was （4.39±1.02） and the NCIQ total table score （40.55±3.52）. The CAP-Ⅱ score at the eighteen postoperative months was （5.97±1.28）, NCIQ total table （57.36±4.02）, and the highest score. Statistically significant difference per group（P<0.05）. Conclusion:After cochlear implantation in elderly patients with deafness, their auditory ability, basic sound perception, social ability, self-confidence and other quality of life were significantly improved.

PMID:40263653 | DOI:10.13201/j.issn.2096-7993.2025.05.008

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 May;39(5):433-438;442. doi: 10.13201/j.issn.2096-7993.2025.05.007.

ABSTRACT

Objective:To compare the outcomes of multiple scales, primarily the speech, spatial, and other qualities of hearing scale for parents（SSQ-P）, in children with ipsilateral vs. Contralateral cochleareimplantat ion（CRI）. Methods: A total of 69 children who received cochlear implantation surgery from April 1999 to June 2024 were included. Patients were divided into two groups based on whether the implantation was on the same side. General information such as gender, age, age at initial implantation and reimplantation was collected. The primary caregivers of the children were followed up by telephone using the categories of auditory performance（CAP）, speech intelligibility rating（SIR）, and SSQ-P questionnaires. Statistical methods including stepwise regression, linear regression, and permutation tests were employed to investigate if there were any statistically significant differences in the scores of CAP, SIR, SSQ-P total, SSQ-P speech perception, SSQ-P spatial hearing, and SSQ-P auditory quality dimensions between the ipsilateral and contralateral reimplantation groups. Results:Of the 69 children included, 62 were in the ipsilateral reimplantation group with a mean age of 11.1 years, and 7 were in the contralateral reimplantation group with a mean age of 11.7 years. Statistical analysis showed that patients in the contralateral reimplantation group had significantly lower SSQ-P total scores （P<0.05） and spatial hearing dimension scores （P<0.05） than those in the ipsilateral reimplantation group after controlling for the corresponding confounders. Conclusion:The effect of ipsilateral reimplantation of cochlear implants is superior to that of contralateral reimplantation in terms of overall auditory function and spatial hearing in daily life for children, but the mechanisms require further investigation.

PMID:40263652 | DOI:10.13201/j.issn.2096-7993.2025.05.007