Category: Statistics

Adv Med Educ Pract. 2025 Feb 15;16:235-244. doi: 10.2147/AMEP.S503289. eCollection 2025.

ABSTRACT

OBJECTIVE: Interprofessional education (IPE) is widely recognized as an effective practice in healthcare education that helps healthcare students understand different professional roles, and values related to collaboration, teamwork, and leadership within healthcare teams. This study was conducted to measure attitudes and readiness for IPE among healthcare students at Taif University and to explore any differences in students’ attitudes in relation to their healthcare program, year of study and other related factors.

METHODS: Healthcare undergraduates participated in a cross-sectional study conducted from January 2024 to March 2024. Data was collected electronically by filling out an electronic version of The Readiness for Interprofessional Learning Scale (RIPLS), which was sent to students in advanced years of study, 3^rd year and higher, depending on the program. Data was analyzed descriptively and statistically using appropriate univariate and bivariate analyses.

RESULTS: A total of 263 healthcare students participated in the study (68.8% female, 31.2% male), and the majority were from pharmacy program (55.1%), followed by nursing (25.1%) and medicine (19.8%). The overall RIPLS score for all students was 76.58, indicating positive attitudes towards IPE. The RIPLS score differed significantly (P=0.01) in relation to the program of study, with nursing students showing the highest readiness (77.59), and medical students showed the least (73.56). For the other factors, no significant difference was found in RIPLS scores in relation to gender, clinical training experience, attending previous IPE sessions, or the year of study.

CONCLUSION: Attitudes and readiness for IPE among healthcare undergraduates at Taif University were positive, particularly among nursing students. The reasons behind differences in readiness for IPE among programs need further investigation by researchers and healthcare educators. Offering introductory sessions to introduce the concept of IPE to healthcare programs with lower readiness might be helpful to raise students’ awareness of the value of IPE.

PMID:39975809 | PMC:PMC11837851 | DOI:10.2147/AMEP.S503289

Front Public Health. 2025 Feb 5;13:1475357. doi: 10.3389/fpubh.2025.1475357. eCollection 2025.

ABSTRACT

BACKGROUND: Vaginal colonization by pathogenic bacteria increases the risk of bacterial infections such as sepsis, which is associated with high neonatal mortality. More than half a million newborn deaths occur globally each year due to infections that lead to sepsis. However, the problem is worsening in Ethiopia the evidence of vaginal colonization and vertical transmission is scarce.

METHODS: A healthcare facility-based cross-sectional study was conducted in Dessie town from April 1 to June 30, 2023, among 348 pregnant women and their newborns. Socio-demographic, clinical, and related data were collected using a pre-tested semi-structured questionnaire. Vaginal swab samples from pregnant women and pooled external ear, nasal area, and umbilical swab samples from the newborns were collected and transported using Amies transport media. Samples were inoculated into blood agar, Todd Hewitt selective enrichment broth, and MacConkey agar for bacterial isolation, and Sabouraud Dextrose Agar and CHROM Agar for Candida species isolation. The antimicrobial susceptibility was performed on isolates using the Kirby-Bauer disc diffusion technique. Data was analyzed by SPSS version 25.0. Logistic regression model was used to identify the associated factors. Finally, variables with p < 0.05 and their 95% confidence interval were considered statistically significant.

RESULTS: A total of 348 pregnant women attending vaginal delivery were included in the study. The maternal colonization and vertical transmission rates were 55.5% (193/348) and 53.9% (104/348), respectively. The most frequent potential pathogen among pregnant women was Escherichia coli (27.6%), followed by Candida spp. (14.1%), and Klebsiella spp. (6%). Similarly, the predominant isolates in the newborns were E. coli (16.4%), Candida spp. (6.3%), and Klebsiella spp. (3.6%). The overall multidrug resistance levels of potential pathogens were 37.3%. Living with domestic animals (p = 0.001), having premature rupture of membrane (p = 0.010) and history of urinary tract infection (p = 0.013) were significantly associated with maternal colonization. Potential pathogen colonization newborn was significantly associated with duration of labor (p = 0.024) and low birth weight (p < 0.001).

CONCLUSION: The finding of the present study revealed that vaginal colonization and vertical transmissions of potential pathogens and their antimicrobial resistance is still a significant problem. This alarms the urgency of evidence based-intervention to improve maternal and neonatal health.

PMID:39975790 | PMC:PMC11836021 | DOI:10.3389/fpubh.2025.1475357

Front Public Health. 2025 Feb 5;13:1524173. doi: 10.3389/fpubh.2025.1524173. eCollection 2025.

ABSTRACT

BACKGROUND: Computer vision syndrome refers to a range of eye and vision-related problems which may result from extended use of digital devices such as computers. It is a public health problem, affecting more than 70% of all computer users. In developing countries like Ethiopia, there is scarcity of studies on computer vision syndrome, particularly in the telecom industry making evidence-based interventions difficult. Hence, the study aims to identify the determinants and the prevalence of computer vision syndrome among Ethio telecom workers in Addis Ababa, Ethiopia.

OBJECTIVES: This study aimed to determine the prevalence of CVS and identify its factors among Ethio telecom workers in Addis Ababa, Ethiopia.

METHODS: Institution-based cross-sectional study was conducted among Ethio telecom employees in Addis Ababa, Ethiopia from March to June 2023. A total of 497 individuals participated in the study. Data were collected using an interviewer- administered questionnaire through Kobo Toolbox, observational checklist and an illuminance measuring instrument. The data were transferred to Statistical Package for the Social Sciences (SPSS) version 26 for analysis. Multivariable logistic regression was performed to assess the association and control for potential confounders.

RESULTS: The prevalence of CVS among Ethio telecom workers was 68.8% (95% CI: 64.5-72.9). Significant associations were observed with viewing distance <50 cm (AOR: 2.32, 95% CI: 1.24-4.33), improper task illumination (AOR: 1.78, 95% CI: 1.09-2.91), habit of taking breaks (AOR: 0.439, 95% CI: 0.281-0.686), and adjustment of brightness and contrast (AOR: 0.39, 95% CI: 0.22-0.68).

CONCLUSION: More than two-thirds of Ethio telecom workers in Addis Ababa suffer from CVS, with significant influences from viewing distance, task illumination, breaks, and monitor settings. These findings underscore the need for interventions to enhance working conditions and reduce CVS prevalence among computer users.

PMID:39975780 | PMC:PMC11835813 | DOI:10.3389/fpubh.2025.1524173

Front Public Health. 2025 Feb 5;13:1498450. doi: 10.3389/fpubh.2025.1498450. eCollection 2025.

ABSTRACT

INTRODUCTION: Women of reproductive age (18-44 years) are at an increased risk of developing obesity due to pregnancy, life-transitions, and marginalization. Obesity in women negatively affects women’s health and pregnancy outcomes and can increase risk their children will develop obesity. Less is known about obesity risk at the interpersonal and environmental levels for women of reproductive age. This study uses the socioecological model to explore women’s obesity risk across ecological levels.

MATERIALS AND METHODS: A secondary cross-sectional analysis was conducted using baseline data (March 2019-June 2022) from the cluster-randomized Healthy Eating and Active Living Taught at Home (HEALTH) Dissemination and Implementation study. Descriptive statistics and multivariate logistic regression models were used to determine associations between individual, interpersonal, and environmental level factors with weight status (overweight vs. obesity).

RESULTS: Among 221 participants (43% Hispanic/Latino, 51% High school or less), 37% were overweight and 63% had obesity. Interpersonal and environmental factors were not statistically significantly associated with obesity relative to overweight in bivariate analyses. In multivariate models, individual level factors of high/moderate physical activity (OR = 0.47, 95% CI: 0.26,0.84, p = 0.01) and food insecurity (OR = 2.51, 95% CI: 1.33,4.71, p = 0.00) were statistically significantly related to risk of having obesity compared to being overweight.

DISCUSSION: Physical activity and food insecurity were associated with obesity in this study. Associations with interpersonal and environmental level factors were not statistically significant, which may be due to limited sample size or measures available to assess these levels. Future studies should investigate structural determinants (e.g., economic, neighborhood and physical environment), which may drive physical activity and food insecurity.

PMID:39975777 | PMC:PMC11835867 | DOI:10.3389/fpubh.2025.1498450

BMC Oral Health. 2025 Feb 19;25(1):259. doi: 10.1186/s12903-025-05641-y.

ABSTRACT

BACKGROUND: To evaluate the frequency and radiodiagnostic characteristics of maxillary antroliths using cone beam computed tomography.

METHODS: A review of 1166 patients aged 11-85 years was conducted to assess the frequency of maxillary antroliths, considering sex, age, and location. The relationship between antroliths and sex, location, dental treatment status, and sinus inflammation was evaluated. The shape, size, and volume of the antroliths were also analyzed. Data were analyzed using descriptive statistics, Mann-Whitney U, Kruskal-Wallis, Spearman rank correlation, independent t-tests, and Pearson Chi-square tests.

RESULTS: Forty-eight antroliths were detected in 41 patients (3.5%), with 16 in males and 25 in females. The frequency of antroliths was higher in the 81-90- and 31-40-years age groups (p < 0.001). The most common locations were the sinus floor (56.3%) and molar region (87.5%), with an amorphous shape (47.9%). Regarding the sinus-mucosa relationship, 66.7% of patients had mucosal thickness completely covering the antroliths, and 72.9% had less than one-third of the sinus opacified. Tooth extraction was the most common dental status near the antrolith (45.8%). The shape, size, and volume of antroliths did not affect the surrounding mucosal thickness (p > 0.05), but sinuses containing antroliths had significantly thicker mucosa than those without (p = 0.036).

CONCLUSIONS: The findings indicate that although antroliths are relatively rare, predominantly located on the sinus floor and in the molar region, their presence is associated with increased mucosal thickening regardless of their shape, size, or volume. Understanding their radiographic features can aid in differential diagnosis and help anticipate potential complications during surgical interventions.

TRIAL REGISTRATION: The trial protocol was retrospectively registered ID NCT06765148 ( https://clinicaltrials.gov/ ); 09/01/2025.

PMID:39972501 | DOI:10.1186/s12903-025-05641-y

Nutr J. 2025 Feb 19;24(1):27. doi: 10.1186/s12937-025-01092-x.

ABSTRACT

BACKGROUND: Limited evidence exists about the relationship between serum carotenoid and mortality in metabolic syndrome (MetS) patients, and the effects of medication use on this association remains unclear.

METHODS: The study encompassed 2,521 MetS patients from the National Health and Nutrition Examination Survey (NHANES) 2001-2006 and 2017-2018. A total of 7 serum carotenoids were evaluated. Death data were sourced from the National Death Index, with causes assessed using ICD-10 codes. Bayesian kernel machine regression (BKMR) and random survival forest (RSF) were utilized to investigate serum carotenoid mixture on mortality and identify key carotenoids. “Qgcompint” R package was used to explore the modifying effects of medication use.

RESULTS: The serum carotenoid levels at baseline ranged from 0.04 to 1.37 µmol/L. During a follow-up of 15.1 years, there were 696 deaths (27.61%), with 247 (35.49%) by cardiovascular disease (CVD), 148 (21.26%) by cancer, and 301 (43.25%) by other diseases. Individual and combined serum carotenoids were negatively associated with all-cause mortality (HR range:0.70-0.88, 95%CI range:0.56-0.99, all P < 0.05). α-carotene (VIMP = 0.223 in RSF) and lutein/zeaxanthin (PIP = 1.000 in BKMR) emerged as the greatest contributors to all-cause mortality. Lipid-lowering drugs attenuate the negative effect of serum carotenoids on MetS patients’ mortality (P_int = 0.014).

CONCLUSION: The present study identified a protective effect of serum carotenoid on mortality in MetS patients, which was probably weakened by lipid-lowering drugs. Early dietary interventions for MetS patients taking lipid-lowering drugs, particularly those rich in carotenoids like α-carotene and lutein/zeaxanthin, could help reduce mortality.

PMID:39972496 | DOI:10.1186/s12937-025-01092-x

Diabetes Obes Metab. 2025 Feb 19. doi: 10.1111/dom.16257. Online ahead of print.

ABSTRACT

INTRODUCTION: Type 2 diabetes is associated with excess hospital admissions and increased mortality. Structured diabetes self-management education (DSME) is recommended internationally and is associated with improved self-management skills, well-being and minor improvements in glycated haemoglobin (HBA1c), but does it reduce hospital admissions or prevent premature mortality? Our aim is to examine the relationship between DSME attendance, hospitalisations, mortality and 3-point major adverse cardiovascular events (MACE) in people with type 2 diabetes to inform future healthcare policy and diabetes care.

METHODS AND ANALYSIS: This protocol details a 10-year retrospective open cohort study of patients aged over 18 years old who have a clinical diagnosis of type 2 diabetes and were registered to an English GP practice from 29 March 2011 to 29 March 2021 and have attended DSME. Patients in the ‘ever’ cohort will be matched at baseline for age, sex, age at diagnosis and diabetes duration, to those who have ‘never’ attended DSME. Data will be identified via the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics Admitted Patient Care data, Office for National Statistics death registrations and patient Index of Multiple Deprivation deciles. Patients will be followed-up through serial cross-sections. Multiple imputation will be considered to manage covariates where data are >12-months from baseline or are not expected to be missing at random. Cox proportional hazard regression and time to event modelling adjusted a priori for cofounding during multivariate analysis will be used.

ETHICS AND DISSEMINATION: This study was approved by CPRD (24_003744). Study findings will be disseminated through peer-reviewed publications and international conferences.

PMID:39972494 | DOI:10.1111/dom.16257

Virol J. 2025 Feb 19;22(1):42. doi: 10.1186/s12985-025-02630-z.

ABSTRACT

Encephalitis, a severe brain inflammation, can arise due to various infectious agents, including viruses like Parvovirus B19 (B19V). Previously linked to mild neonatal and young one’s illnesses and some haematological diseases, recent evidence associates B19V with encephalitis, with no clear prevalence and mechanisms in place. This systematic review and meta-analysis aim to determine the prevalence of B19V in cases of encephalitis, exploring variations associated with diagnostic approaches, and identifying gaps in existing research to enhance clinical comprehension and diagnostic methods. An extensive search (1994-2024) was performed through PubMed, Scopus, ScienceDirect, and Cochrane databases for research and epidemiological investigations related to B19V in cases of encephalitis. Inclusion criteria focused on studies that verified B19V using molecular (PCR, NGS) or serological (IgM/IgG) techniques in cerebrospinal fluid or serum. Data analysis was done to pool the prevalence data of included studies using a random-effects model. Heterogeneity was evaluated using I² statistics. Sensitivity and meta-regression analyses were conducted to evaluate variability and the effects of moderators. A total of fourteen studies involving 3,135 encephalitis patients resulted in a combined prevalence of 3% (95% CI: 2-4%). Studies using PCR indicated a greater prevalence (3%) in comparison to ELISA (1%) and NGS (2%). A moderate level of heterogeneity (I² = 57.4%) was attributed to the variability in diagnostic methods and geographic distribution. Sensitivity analyses validated strong estimates, while meta-regression revealed country as a key moderator accounting for heterogeneity. Publication bias was modest. The research indicates that B19V may be involved in certain encephalitis instances, with an overall prevalence of 3%. The differences observed in the studies emphasize the need for standardized diagnostic procedures and more extensive multicentric epidemiological research.

PMID:39972487 | DOI:10.1186/s12985-025-02630-z

Int J Equity Health. 2025 Feb 19;24(1):49. doi: 10.1186/s12939-025-02403-8.

ABSTRACT

BACKGROUND: The increasing use of anxiolytics, hypnotics, and sedatives (AHS) among adolescents is a growing public health concern. Social determinants such as gender or socioeconomic status have a significant influence on consumption levels. However, whether trends in adolescent AHS use show socioeconomic and gender disparities is unknown. The aim of this study is to examine the trends in gender and socioeconomic inequalities in secondary school students’ AHS use in Spain from 2010 to 2021.

METHODS: A repeated cross-sectional analysis was conducted using data from the Survey on Drug Use in Secondary Education in Spain (n = 192,656), targeting students aged 14-18 years during 2010-2021. Gender-specific prevalences of AHS use were calculated according to the educational and occupational status of the mother, the father, and both parents. Chi-squared tests assessed statistical significance of the observed social gradients. The Relative Index of Inequality (RII) and Slope Index of Inequality (SII) with 95% confidence intervals were used to measure inequality magnitudes. Consumption trends were examined through prevalence ratios (PR) derived from age-adjusted robust variance Poisson models.

RESULTS: Statistically significant social inequalities in AHS use were identified among girls, which increased over time. These inequalities were particularly pronounced when considering maternal educational level (e.g. 2021: 21.5% vs. 16.3%; RII₂₀₂₁ = 1.37 [1.16-1.62]) and paternal occupational status (e.g. 2021: 23.2% vs. 16.5%). Trends showed a significant increase among all groups in both male and female students (e.g. both parents with primary education: PR₂₀₂₁ = 1.74 [1.23-2.47] and PR₂₀₂₁ = 1.83 [1.49-2.25], respectively).

CONCLUSIONS: The findings highlight the necessity for developing equity-focused public health policies addressing adolescent AHS use, especially among disadvantaged female students. Further research is needed to explore the social determinants of adolescent AHS use, considering inequalities from an intersectional perspective.

PMID:39972485 | DOI:10.1186/s12939-025-02403-8

Radiat Oncol. 2025 Feb 19;20(1):24. doi: 10.1186/s13014-025-02601-2.

ABSTRACT

OBJECTIVE: This study aimed to analyze the effect of target volumes for radiotherapy and dose on the prognosis of high-grade glioma (HGG) patients when the tumor involves the subventricular zone (SVZ), and to provide a reference for postoperative target volume delineation in HGG patients with SVZ involvement.

METHODS: The clinical and pathological data were collected from 50 HGG patients with SVZ involvement were collected in the Department of Neurosurgery of the First Affiliated Hospital of Soochow University during the period from January 1, 2017 to December 31, 2020. The average dose (Dmean) of the whole ipsilateral and contralateral SVZs as well as the V45Gy and V60Gy of the whole ipsilateral SVZs of the tumor were derived from the dose-volume histograms (DVH). The Kaplan-Meier analysis was applied to compare the survival differences between groups under different factors. The Cox proportional risk regression model was used to analyze the influencing factors of progression-free survival (PFS) and overall survival (OS). The correlation between the size of the ipsilateral SVZ target area range and the progression pattern was tested by chi-square test.

RESULTS: Univariate analysis revealed that the potential predictors of PFS of HGG patients with tumor involvement in SVZ were as follows: multiple lesions, tumor size > 3.5 cm and total resection; the potential predictors of OS were multiple lesions, surgical approaches to the lateral ventricles and the dose of contralateral SVZ > 37.33 Gy. Multibariate analysis showed that tumor size > 3.5 cm and total resection were the independent prognostic factors of PFS; multiple lesions was the independent prognostic factors of OS. The Kaplan-Meier method showed that the median PFS and OS of HGG patients with V60Gy ≥ 50% was higher than that of patients with V60Gy < 50% but the difference was not statistically significant. Subgroup analysis showed that patients with V60Gy ≥ 50% had significantly higher PFS in the age < 60 years subgroup (P = 0.006), WHO IV grade (P = 0.006), and surgical penetration of the lateral ventricle subgroup (P = 0.034) than in the V60Gy < 50%. Patients with V60Gy ≥ 50% had significantly higher OS in the WHO IV grade subgroup (P = 0.035), surgically penetrated lateral ventricle subgroup (P = 0.008), IDH1 wild-type subgroup (P = 0.012), and MGMT unmethylated subgroup (P = 0.047) than in V60Gy < 50%. A volume of ≥ 50% of the ipsilateral SVZ receiving a 60 Gy irradiation dose improves local control and reduces the risk of local recurrence in patients with SVZ involvement in HGG.

CONCLUSIONS: For SVZ-involved HGG patients, the whole ipsilateral SVZ receiving 60 Gy irradiation dose in ≥ 50% of the volume prolonged PFS in those with age < 60 years, WHO IV grade and surgically penetrating lateral ventricles and prolonged OS in those with WHO IV grade, surgically penetrating lateral ventricles, IDH1 wild-type and MGMT unmethylated.

PMID:39972483 | DOI:10.1186/s13014-025-02601-2