Category: Statistics

J Robot Surg. 2026 Feb 16;20(1):260. doi: 10.1007/s11701-026-03161-7.

ABSTRACT

OBJECTIVE: To compare the outcomes between the traditional hospitalization care model and an ambulatory surgery model with integrated continuity of care for patients undergoing robot-assisted partial nephrectomy (RPN).

METHODS: This retrospective cohort study analyzed the clinical data of 120 consecutive patients who underwent robot-assisted partial nephrectomy at our hospital between June 2021 and June 2024. Patients were divided into two groups based on the perioperative care model they received: a control group (n = 55) receiving routine care within the traditional hospitalization model and an observation group (n = 65) managed under the ambulatory surgery model with integrated continuity of care. A propensity score-matched analysis was performed to control for potential selection bias. The OAS CAHPS was used to investigate patient evaluations regarding medical care, preoperative preparation, postoperative education, and discharge guidance. Based on the characteristics of the statistical data, analysis was performed using statistical packages in R software. Outcome measures included wound healing status, pain scores, ability to perform activities of daily living (ADL), and patient satisfaction.

RESULTS: Groups were comparable at baseline and after matching. The intervention group demonstrated a significantly shorter median postoperative stay (29 vs. 94 h), time to first ambulation (8 vs. 25 h), and lower hospitalization costs (all P < 0.05). They also had superior functional recovery, lower pain scores, and higher satisfaction (all P < 0.05). An initial association with improved wound healing at 1 month was attenuated in the matched analysis.

CONCLUSION: For patients undergoing RPN, the ambulatory surgery model with integrated continuity of care was associated with accelerated recovery, improved functional outcomes, and higher patient satisfaction compared to the traditional hospitalization care model. Its association with improved wound healing requires further validation. This integrated care approach is worthy of further prospective validation and application.

PMID:41692927 | DOI:10.1007/s11701-026-03161-7

J Robot Surg. 2026 Feb 16;20(1):254. doi: 10.1007/s11701-026-03217-8.

NO ABSTRACT

PMID:41692915 | DOI:10.1007/s11701-026-03217-8

Prostate Cancer Prostatic Dis. 2026 Feb 15. doi: 10.1038/s41391-026-01088-6. Online ahead of print.

NO ABSTRACT

PMID:41692906 | DOI:10.1038/s41391-026-01088-6

Eur Radiol. 2026 Feb 16. doi: 10.1007/s00330-026-12326-9. Online ahead of print.

NO ABSTRACT

PMID:41692898 | DOI:10.1007/s00330-026-12326-9

Eur Radiol. 2026 Feb 16. doi: 10.1007/s00330-025-12197-6. Online ahead of print.

NO ABSTRACT

PMID:41692897 | DOI:10.1007/s00330-025-12197-6

Sci Rep. 2026 Feb 15. doi: 10.1038/s41598-026-37791-6. Online ahead of print.

ABSTRACT

The purpose of this study was to evaluate the predictive value of monocyte-to-lymphocyte ratio (MLR) on the short-term (28 days) and long-term (365 days) mortality risk in patients with acute pancreatitis (AP) using multiple statistical and machine learning (ML) models. Studies selected 1,044 eligible AP patients from the MIMIC-IV database and divided them into four groups based on their MLR values (MLR<0.32; 0.32 ≤ MLR<0.57; 0.57 ≤ MLR<1; MLR ≥ 1). Findings revealed that MLR demonstrated a U-shaped relationship with patient mortality risk, with the minimal mortality risk occurring at an MLR of approximately 0.57. Cox regression model analysis showed that after adjusting for multiple parameters, MLR was still significantly associated with the risk of death. Moreover, ML model analysis identified that MLR has potential value in predicting AP patient outcomes. This study suggests that MLR can be used as a potential indicator to assess prognostic risk in critically ill patients with AP to support clinical decision-making.

PMID:41692893 | DOI:10.1038/s41598-026-37791-6

Commun Biol. 2026 Feb 16. doi: 10.1038/s42003-026-09715-7. Online ahead of print.

ABSTRACT

Our thoughts fluctuate dynamically, driven either by external stimuli and tasks (on-task thoughts) or drifting to task-unrelated contents (off-task thoughts or mind wandering). Although research has identified neural markers distinguishing different thought types, the temporal signature (dynamics) of on- and off-task thoughts remains poorly understood. This EEG study investigated different neurodynamical features-autocorrelation window (ACW), Lempel-Ziv complexity (LZC), power-law exponent (PLE), and median frequency (MF)-to differentiate these thoughts in their underlying dynamics during a signal-response task. Off-task thoughts exhibited prolonged ACW, reduced LZC, increased PLE, and smaller MF compared to on-task thoughts, establishing a distinct neurodynamic signature. Through statistical modeling, we identified a hierarchical background-foreground structure among these measures that unfolds along a temporal continuum, transitioning from longer block-level (17-second) to shorter trial-level (3-second) timescale. Notably, the longer background (block-level ACW) and shorter foreground (trial-level ACW and LZC) layers are tightly coupled during the “faster and shorter” on-task thoughts whereas they are more loosely related during “slower and longer” off-task thoughts. These findings, replicated in an independent dataset, demonstrate how the organization of our brain’s dynamics, along a temporal continuum of longer background durations to shorter foreground durations, shapes on-task and off-task thoughts thereby yielding their distinct signatures.

PMID:41692886 | DOI:10.1038/s42003-026-09715-7

J Robot Surg. 2026 Feb 16;20(1):255. doi: 10.1007/s11701-026-03228-5.

ABSTRACT

The objective of this study was to evaluate the efficacy of an integrated whole-process nursing approach grounded in smart healthcare principles for perioperative care in patients undergoing Mako robot-assisted total knee arthroplasty (RA-TKA), thereby proposing an innovative nursing protocol for clinical use. A total of 445 patients who received Mako robot-assisted TKA between January 2022 and May 2025 were retrospectively analyzed. Participants were divided into two groups: a control group received conventional nursing interventions and an observation group received the smart healthcare-based whole-process nursing model. Outcome variables compared between the groups included postoperative pain levels, hematological indices (erythrocyte sedimentation rate [ESR], albumin, hemoglobin, and D-dimer), Hospital for Special Surgery (HSS) scores, length of stay (LOS), and complication rates. Results indicated that, compared to the control group, the observation group exhibited significantly improved postoperative hemoglobin and albumin concentrations (P < 0.01), along with notably lower pain scores, D-dimer levels, and complication incidences (P < 0.01). Additionally, significant enhancements in knee joint function scores were observed following implementation of the smart healthcare-based nursing model (P < 0.001 or P < 0.05). Thus, applying a whole-process nursing model integrated with smart healthcare effectively mitigates hemoglobin depletion, reduces postoperative pain, decreases D-dimer elevation, shortens hospital stays, enhances knee functionality, and lowers the rate of complications, demonstrating substantial clinical value and potential for broader implementation.

PMID:41692876 | DOI:10.1007/s11701-026-03228-5

J Robot Surg. 2026 Feb 16;20(1):256. doi: 10.1007/s11701-026-03218-7.

ABSTRACT

Uniportal video-assisted thoracoscopic surgery (uVATS) is an established minimally invasive approach for lung cancer. Uniportal robotic-assisted thoracoscopic surgery (uRATS) is a recent innovation integrating robotic technology with single-incision access. Comparative data between these techniques remain scarce. We retrospectively analyzed patients who underwent anatomic pulmonary resection via uVATS or uRATS at Chang Gung Memorial Hospital between July 2023 and July 2025. Propensity score matching (1:1) was applied using key baseline variables. Perioperative outcomes and cost-effectiveness were assessed. A total of 356 patients (251 uVATS, 105 uRATS) were included; 98 matched pairs were analyzed. Operative time was longer with uRATS (median 179.50 vs. 117.00 min, p < 0.001). uRATS was associated with shorter hospital stay (2.70 vs. 3.00 days, p < 0.001), reduced chest drainage duration (1.45vs. 2.00 days, p < 0.001), and lower postoperative day 1 pain scores (p = 0.04). Median N1 and N2 lymph node counts were similar in uRATS and uVATS. Postoperative complication rates did not differ significantly between groups (2.04% vs. 9.18%, p = 0.06). Cost analyses quantified the incremental costs associated with short-term recovery benefits of uRATS. uRATS was associated with modest, short-term differences in selected early postoperative recovery parameters compared with uVATS, accompanied by longer operative time and higher cost. Oncologic surrogate outcomes were comparable between groups, while definitive conclusions regarding long-term oncologic and economic benefits require confirmation in larger, multicenter studies with extended follow-up.

PMID:41692862 | DOI:10.1007/s11701-026-03218-7

Support Care Cancer. 2026 Feb 16;34(3):206. doi: 10.1007/s00520-026-10434-2.

ABSTRACT

PURPOSE: Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for hematological disorders but often results in micronutrients deficiency and complications. Vitamin C, a potent antioxidant, may improve endothelial function, tissue protection, and immune recovery. This study evaluated the effects of early high-dose vitamin C supplementation on plasma vitamin C levels and post-HSCT complications.

METHODS: In this pilot, triple-blind, placebo-controlled trial, 31 adult allo-HSCT patients were randomized to receive intravenous vitamin C (50 mg/kg/day) or placebo from day + 1 to + 14, followed by oral vitamin C (500 mg/day) or placebo until day + 100. Plasma vitamin C levels were measured at days 0, + 7, + 15, and discharge. Patients were monitored for post-HSCT complications until day + 100.

RESULTS: Plasma vitamin C levels were significantly higher in the vitamin C group at all time points (P < 0.001). Trends toward reduced acute graft-versus-host disease (33% vs. 44%), lower oral mucositis severity (46.6% vs. 62.5%), and shorter duration (7.5 ± 3.6 vs. 9.1 ± 3.7 days) were observed, though not statistically significant. No significant adverse events were reported.

CONCLUSION: High-dose vitamin C effectively corrected plasma levels, and while trends toward reduced complications were observed in allo-HSCT patients, larger trials are needed to confirm these findings.

PMID:41692856 | DOI:10.1007/s00520-026-10434-2