Category: Statistics

JMIR Hum Factors. 2026 Apr 8;13:e86076. doi: 10.2196/86076.

ABSTRACT

BACKGROUND: Electronic health records (EHRs) play an essential role in modern health care, enabling data sharing and improving patient safety; however, even though vendors must adhere to International Organization for Standardization-related usability standards for EHR certification, persistent usability issues continue to undermine efficiency, contribute to clinician burden, and increase the risk of preventable errors.

OBJECTIVE: This scoping review synthesizes existing research on EHR adoption and usability, emphasizing theoretical models, measurement approaches, factors, and analytic methods used to assess or predict usability. We identify gaps and opportunities for integrating predictive analytics and artificial intelligence (AI) to advance research and improve the usability of EHRs.

METHODS: Following Joanna Briggs Institute and PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines, we systematically searched MEDLINE, Web of Science, IEEE Xplore, and Scopus library databases for studies published between January 1, 2009, and April 9, 2025. Inclusion criteria focused on empirical research using predictive methods or models related to EHR usability. Data were charted and synthesized thematically.

RESULTS: Of the 2323 screened papers, 47 studies met inclusion criteria. Most research examined or predicted EHR adoption (not usability) using dominant frameworks, such as the technology acceptance model, unified theory of acceptance and use of technology, and the information system success model, which comprised usability. Factors related to usability-particularly perceived usefulness, perceived ease of use, effort expectancy, and facilitating conditions via the EHR adoption models-appeared frequently. Regression-based methods and structural equation modeling were the most common analytic techniques. No studies applied predictive modeling or AI to predict EHR usability.

CONCLUSIONS: The focus of this study on the prediction of EHR usability and adoption for the past 15 years is distinctive in the literature. It extends prior usability reviews (mostly focusing on adoption, not prediction of usability). Predictive modeling for EHR usability remains underdeveloped throughout 2009 to 2025. Dominant frameworks in the EHR literature continue to prioritize predicting adoption over operational usability. These models rely heavily on self-reported, cross-sectional measures captured at a single postimplementation time point, embedding systematic bias and obscuring longitudinal usability dynamics. Despite the application of increasingly sophisticated predictive techniques-primarily variants of regression and structural equation modeling-usability has remained analytically subordinate to adoption and acceptance constructs for more than 15 years. As a result, widely used models, such as the technology acceptance model and unified theory of acceptance and use of technology, position usability merely as an antecedent to intention or use, rather than as an independent, system-level property that can be empirically measured, modeled, and predicted. Therefore, there is substantial opportunity to integrate predictive analytics, AI, and longitudinal usability measures to build dynamic models.

PMID:41950355 | DOI:10.2196/86076

JMIR Hum Factors. 2026 Apr 8;13:e78236. doi: 10.2196/78236.

ABSTRACT

BACKGROUND: Social media is one of the most accessible and extensive sources of data for tracking and understanding public reactions to COVID-19 policies. Cultural differences between the United States and Japan have resulted in highly distinctive policies and public reactions in each country.

OBJECTIVE: This study aims to analyze the public opinions surrounding COVID-19 mask mandate through 1,102,876 and 560,873 geo-tagged tweets from the United States and Japan during the period from 2020 to 2022. We conducted 3 stages of analysis-relevance to COVID-19 masks, stance for or against masking, and whether the tweets indicate users wearing masks-to understand individuals’ stance towards the mask mandate and their actual mask-wearing behavior.

METHODS: We adopted a semisupervised approach to enhance BERT (Bidirectional Encoder Representations from Transformers) classification results due to data imbalance, which were then visualized through time series and map representations.

RESULTS: In the United States, our data showed that individuals with a bachelor’s degree or higher, as well as those living in states with higher household incomes, are positively correlated with positive attitudes toward mask-wearing. In contrast, in Japan, those with higher education levels or individuals aged 65 years and older were positively correlated with tweets categorized as having a stance against the mask mandate. Key events in Japan, such as the announcement of the state of emergency and the Olympics, served as major triggers for the number boost in public opinion.

CONCLUSIONS: Our analysis of over 1.6 million tweets from the United States and Japan revealed that public opinion shifted notably in response to major events and policy changes during the COVID-19 pandemic. While some trends align with previous research, correlations with education, age, and income suggest that social media data may reflect underlying societal divisions and algorithm-driven biases.

PMID:41950353 | DOI:10.2196/78236

PLoS One. 2026 Apr 8;21(4):e0331831. doi: 10.1371/journal.pone.0331831. eCollection 2026.

ABSTRACT

Wildfires pose a major challenge for many nations. Rapid mapping of their extent is key to evaluating their impacts. We present the first operational monthly burned-area processing chain for Indonesia, based on largely automated processing of Sentinel-2 imagery in Google Earth Engine. Our approach uses a Random Forest applied to Sentinel-2 imagery and integrates FIRMS fire hotspots to reduce false positives. The resulting 20-m monthly burned-area maps cover the entire country. From January 2019 to December 2024, fires burned a cumulative 5.62 million hectares (Mha), including 2.92 Mha that burned once and 1.12 Mha that burned multiple times. This represents a total burned extent of 4.04 Mha. Compared to the MCD64A1 product, our dataset detects more burns with higher spatial detail and accuracy. In total, 122,164 hectares of primary humid forest burned, representing 2.2% of the burned area. In 2019 and 2023, fire activity accelerated around July and peaked in September-October, coinciding with Oceanic Niño Index (ONI) values ≥ +0.5 °C and Indian Ocean Dipole (IOD) values ≥ +1.5°C. In contrast, neutral or negative phases from 2020 to 2022 corresponded with minimal burning. The year 2024 recorded intermediate fire activity without strong climatic anomalies. These findings confirm that climatic anomalies are associated with fire activity in Indonesia, reaffirming the importance of ONI and IOD for early warning. Our results suggest that prevention efforts are limiting forest fires, as burns in 2019 and 2023 remained lower than during earlier events. Monthly burn-scar updates are available on Nusantara Atlas (www.nusantara-atlas.org), an open-access platform for monitoring deforestation in Southeast Asia.

PMID:41950337 | DOI:10.1371/journal.pone.0331831

Sci Adv. 2026 Apr 10;12(15):eaec2739. doi: 10.1126/sciadv.aec2739. Epub 2026 Apr 8.

ABSTRACT

Despite the common perception, most fatal landslides occur in human-transformed environments. Even on steep terrain, anthropogenic disturbances may fundamentally modulate landslides. Most of our knowledge regarding landslide-human interaction is restricted to local models or regional heuristic assessments based on empirical evidence. In this study, we used land-use-land-cover change as a metric to explain human pressure as a preconditioning factor for fatal landslide occurrences to provide a global overview. We addressed countries’ income levels, populations, exposure, and a dataset of ≈60 years of land-use-land-cover changes with mountainous landmasses to compare landslides and fatalities across 46 countries. Our statistical analyses show that land-use-land-cover changes have a substantially greater influence on the density of fatal landslides and landslide fatalities than physical factors such as topography and precipitation, especially in lower-income countries. We observed a marginal landslide impact when the land-use-land-cover change was low, regardless of the income class. Our results emphasize that effective land-use-land-cover planning is critical to decreasing landslide fatalities, especially in low- and lower-middle-income countries.

PMID:41950326 | DOI:10.1126/sciadv.aec2739

Sci Adv. 2026 Apr 10;12(15):eaec3183. doi: 10.1126/sciadv.aec3183. Epub 2026 Apr 8.

ABSTRACT

Influenza viruses encountered in childhood can leave a lasting immunological imprint. To disentangle the mortality effects of age, the circulating seasonal strain, and immune history, we fit statistical mortality models to 54 years of influenza mortality data from the United States. We find strong signatures of subtype-level imprinting in H1N1-dominated seasons following the 2009 pandemic-cohorts imprinted with more similar H1N1 strains experience greater protection. Furthermore, we find large differences in age-specific mortality risk across cohorts based on their imprinted strain and the seasonal strains that were dominant throughout their lifetime. In contrast to older H1N1- and H2N2-imprinted cohorts, our results show that more recent cohorts imprinted with H3N2 have experienced substantially higher mortality through most of their lifetime. Our results highlight the long-term consequences of immune imprinting and its impact on period and cohort influenza mortality. Overall, our findings have important implications for vaccination efforts and future influenza mortality burden.

PMID:41950318 | DOI:10.1126/sciadv.aec3183

JMIR Diabetes. 2026 Apr 7. doi: 10.2196/87364. Online ahead of print.

ABSTRACT

BACKGROUND: The prevalence of diabetes in the US necessitates investigations into how to better enable adults with type 2 diabetes to manage their health using easy to access and personally adaptable technologies. The ubiquity of digital content further justifies the need to consider the impact of different digital intervention modalities in diabetes self-care activities.

OBJECTIVE: The purpose of this study is to compare the impact of two digital diabetes self-care education programs delivered separately, and in combination, to adults with type 2 diabetes across various settings in Texas.

METHODS: We conducted a randomized control trial (RCT) in Texas with 188 adults with T2DM to assess whether two different interventions alone (vMMWD or TBES) or in combination (vMMWD followed by TBES) improved multiple outcomes associated with diabetes self-management. We employed several estimation techniques including generalized estimating equations (GEE), to account for multiple factors simultaneously.

RESULTS: All three digital intervention modalities led to significant improvements (p<.05) in diabetes-related confidence, distress, and self-care behaviors, with significant effects from baseline through 6 months and supported by moderate to strong effect sizes for the total population (ranging from .446 to .827 at 3 months and .538 to .888 at 6 months). No statistically significant superiority was observed among the intervention modalities. Higher self-care behaviors were significantly associated with higher baseline confidence and lower distress. Those in the most disadvantaged positions (less education, less financial stability, and no health insurance) showed significantly larger improvement in selfcare behaviors.

CONCLUSIONS: Given the benefits associated with the current study’s interventions, we suggest future work to further develop digital content that can be tailored to individuals with T2DM to help them manage their chronic condition(s) in a cost-effective manner.

CLINICALTRIAL: This trial was registered at ClinicalTrials.gov under ID number NCT06370494.

PMID:41949910 | DOI:10.2196/87364

J Pharm Pract. 2026 Apr 8:8971900261441524. doi: 10.1177/08971900261441524. Online ahead of print.

ABSTRACT

In 2021, North Carolina (NC) authorized pharmacists to initiate hormonal contraceptives. The objectives of this pilot study were to: (1) determine where hormonal contraception (HC) services were provided; (2) evaluate patient characteristics; and (3) describe pharmacist interventions. Pharmacists who completed training and prescribed HC between April 2022 and December 2023 were invited to participate. Participants completed an online survey about pharmacy demographics and descriptive statistics were used to summarize characteristics. De-identified patient encounters were uploaded into a secure website and data was analyzed using descriptive statistics. 1309 pharmacists completed HC training. Seventeen pharmacists (1.3%) participated in the study and completed demographic surveys. Four pharmacists (24%) saw 34 patients during the study period and provided intervention data for 21 patients. Seventy percent of pharmacists worked in independent pharmacies, and 47% of pharmacies were in rural communities. Seventy percent of patients had commercial insurance (50%) or NC Medicaid (20%). Fifty-three percent of patients reported that they had a primary care provider (PCP). Pharmacists prescribed a hormonal contraceptive in 95% of patient encounters, most frequently the combined HC pill (70%). One patient was referred to a primary care clinic due to elevated blood pressure. All pharmacists in this early-adopter pilot study of contraception pharmacists practiced in independent pharmacies. Seventy percent of patients who sought care from a pharmacist were insured, approximately half did not have a primary care provider, and pharmacists initiated HC for 95% of patients. The most common HC prescribed was the combined HC pill.

PMID:41949905 | DOI:10.1177/08971900261441524

Clin Transl Sci. 2026 Apr;19(4):e70537. doi: 10.1111/cts.70537.

ABSTRACT

Pharmacogenomics (PGx) offers patients personalized treatment by guiding medication selection and dosing based on their genetic profiles. However, widespread clinical implementation remains limited, in part due to patient and provider concerns about cost and willingness to pay (WTP). This study evaluated whether an outpatient clinical consultation that educates patients on their PGx results influences their WTP for PGx testing. As part of the PROTECT-Rx trial at the University of Chicago, high-risk patients received free PGx testing and a virtual consultation at the Personalized Therapeutics Clinic (PTC). Patients completed pre- and post-visit surveys assessing PGx knowledge and WTP. Of 129 patients who had completed a PTC visit as of 1/2025, 76 completed both the PTC visit and surveys. WTP for PGx testing increased significantly from 68% pre-visit to 83% post-visit (p = 0.029). After controlling for social vulnerability, patients who had at least one cautionary or high-risk PGx result were nearly 3 times more likely to report higher willingness-to-pay (OR 2.76, p = 0.037). A single PGx consultation with review of personal results significantly increases patients’ WTP for testing, particularly among those with actionable PGx results. Understanding individual risk and the relevance of PGx enhances perceived value, suggesting that patient education is an important component in the broader adoption of pharmacogenomic testing.

PMID:41949895 | DOI:10.1111/cts.70537

Lupus. 2026 Apr 8:9612033261441392. doi: 10.1177/09612033261441392. Online ahead of print.

ABSTRACT

ObjectiveTo determine the long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus (pSLE) treated with systematic administration of combination rituximab (RTX) and cyclophosphamide (CYC) at our institution.MethodsPatients with moderate-severe pSLE treated with the combination RTX/CYC therapy between 2013 and 2023 at a single center were included. Steroid exposure, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores, and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage indices were collected as primary outcomes. We also reviewed the literature of the use of RTX/CYC therapy in pSLE.ResultsEleven patients received RTX/CYC therapy in our cohort. Six of 11 patients (55%) were Black. All patients achieved sustained low disease activity as defined by SLEDAI score less than 4 and prednisone dose less than 8 mg/day. There was no statistically significant change in the SLICC/ACR damage index over time. Positive clinical outcomes were observed in all racial groups. Two of 11 patients (18%) required hemodialysis, with one requiring a transplant. Other adverse effects included anaphylaxis and cytopenias. Several reports of use of RTX/CYC therapy were identified in our literature search. Our cohort had a more racially diverse cohort compared to other studies identified in our literature review.ConclusionsOur study supports the use of rituximab and cyclophosphamide use in patients with pSLE and demonstrates its efficacy among a racially diverse cohort over the long-term follow-up period. Our study has important limitations, and larger, prospective randomized clinical trials would allow for improved protocol evaluation and comparison.

PMID:41949877 | DOI:10.1177/09612033261441392

JAMA Netw Open. 2026 Apr 1;9(4):e265775. doi: 10.1001/jamanetworkopen.2026.5775.

NO ABSTRACT

PMID:41949868 | DOI:10.1001/jamanetworkopen.2026.5775