Category: Statistics

J Epidemiol Glob Health. 2023 Feb 3. doi: 10.1007/s44197-023-00086-4. Online ahead of print.

ABSTRACT

BACKGROUND: Lebanon endured its worst economic and financial crisis in 2020-2021. To minimize the impact of COVID-19 pandemic, it is important to improve the overall COVID-19 vaccination rate. Given that vaccine hesitancy among health care workers (HCWs) affects the general population’s decision to be vaccinated, our study assessed COVID-19 vaccine acceptance among Lebanon HCWs and identified barriers, demographic differences, and the most trusted sources of COVID-19 information.

METHODS: A cross-sectional study was conducted between January and May 2021 among HCWs across nine hospitals, the Orders of Physicians, Nurses, and Pharmacists in Lebanon. Descriptive statistics were performed to evaluate the COVID-19 vaccine acceptance, and univariate and multivariable to identify their predictors.

RESULTS: Among 879 participants, 762 (86.8%) were willing to receive the COVID-19 vaccine, 52 (5.9%) refused, and 64 (7.3%) were undecided. Males (226/254; 88.9%) and those ≥ 55 years (95/100; 95%) had the highest rates of acceptance. Of the 113 who were not willing to receive the vaccine, 54.9% reported that the vaccine was not studied well enough. Participants with a previous SARS-CoV-2 infection and those who did not know if they had a previous infection (p = 0.002) were less likely to accept the vaccine compared to those with no previous infection. The most trusted COVID-19 sources of information were WHO (69.3%) and healthcare providers (68%).

CONCLUSION: Lebanese HCWs had a relatively high acceptance rate for COVID-19 vaccination compared to other countries. Our findings are important in informing the Lebanese health care authorities to establish programs and interventions to improve vaccine uptake among HCWs and the general population.

PMID:36735184 | DOI:10.1007/s44197-023-00086-4

Qual Life Res. 2023 Feb 3. doi: 10.1007/s11136-023-03351-y. Online ahead of print.

ABSTRACT

PURPOSE: Preference-based measures are valuable tools for evaluating therapeutic interventions and for cost-effectiveness studies. Mapping procedures are useful when it is not possible to collect these kind of measures. The objective of this study was to evaluate which mapping method is the most appropriate to estimate the EQ-5D-5L index from the Spanish National Health Survey functional disability scale.

METHODS: The sample, formed by 5708 older adults (aged 65 years or older), was drawn from the Spanish National Health Survey (“Encuesta Nacional de Salud en España,” ENSE in Spanish 2011-2012). The predictions of EQ-5D-5L index were performed with response mapping using Bayesian network (BN), ordered logit (Ologit), and multinomial logistic (ML). The following direct methods were used: ordinary least squares (OLS) and Tobit regression. The intraclass correlation coefficient (ICC), absolute error (MAE), mean squared error (MSE), and root-mean squared error (RMSE) were calculated to compare all models. The predictions of response models were obtained through the expected value method.

RESULTS: BN model showed the highest ICC (0.756, 95% confidence interval, CI 0.733-0.777) and lowest MAE (0.110, 95% CI 0.104-0.115). OLS was the model with worse accuracy results with lowest ICC (0.621, 95% CI 0.553-0.681) and highest MAE (0.159, 95%CI: 0.145-0.173).

CONCLUSION: Indirect mapping methods (BN, Ologit, and ML) had a better accuracy than the direct methods. The response mapping approach provides a robust method to estimate EQ-5D-5L scores from the functional disability scale.

PMID:36735174 | DOI:10.1007/s11136-023-03351-y

CJEM. 2023 Feb 3. doi: 10.1007/s43678-023-00447-9. Online ahead of print.

ABSTRACT

PURPOSE: The most widely used prehospital strategy for the management of hemorrhagic shock or trauma accompanied by hypotension is fluid resuscitation. Though current guidelines suggest early and aggressive fluid resuscitation, contemporary literature suggests a more restrictive approach. Our objective was to evaluate the effectiveness of low/ no IV fluids in comparison to standard resuscitation in reducing mortality for trauma patients in the prehospital setting.

METHODS: Population-adults with blunt or penetrating trauma in the prehospital setting with severe injury (defined as SBP < 90 mm Hg and/or a shock index > (1). Intervention-low-dose/no IV fluids. Comparison-standard resuscitation. Outcome-mortality. A librarian-assisted search of five databases (Medline, Embase, Web of Science, and CINAHL, Cochrane trials) was completed in June 2021 (updated in November 2022). ROBINS-1 and ROB-2 tools were used to assess risk of bias in observational and randomized studies, respectively. An inverse variance method and random-effects model of statistical analysis were utilized, with data reported as risk ratios with related 95% confidence intervals. Heterogeneity of studies was assessed through analysis of the I² RESULTS: Seven studies (six observational and one randomized trial) were included, with three thousand and fifty study participants included for analysis. Four studies compared high- to low-dose fluids, and three compared fluids to no fluids. We found no difference in mortality when comparing standard resuscitation to restricted resuscitation (RR 0.99, 95% CI [0.80-1.22], I² = 54%).

CONCLUSION: Weak, primarily observational evidence suggests that standard fluid resuscitation has no significant mortality benefit over restricting/withholding IV fluids in severe/hypotensive trauma. This review adds evidence to questioning the requirement for IV fluids in trauma given the lack of mortality benefit, in addition to demonstrating the need for more randomized studies in this area.

PMID:36735147 | DOI:10.1007/s43678-023-00447-9

Reprod Sci. 2023 Feb 3. doi: 10.1007/s43032-023-01177-0. Online ahead of print.

ABSTRACT

This study was to determine whether multiple vitrification-warming procedures and insemination method are associated with pregnancy and neonatal outcomes in preimplantation genetic testing for aneuploidy (PGT-A). This was a retrospective, single-center, observational study of 112 patients who underwent standard PGT-A practice and 154 patients who desired PGT-A for their vitrified unbiopsied blastocysts. A total of 97 euploid blastocysts biopsied and vitrified-warmed once and 117 euploid blastocysts biopsied once but vitrified-warmed twice (83 in vitro fertilization [IVF]-derived and 34 intracytoplasmic sperm injection [ICSI]-derived euploid blastocysts) were transferred. The primary outcome was the blastocyst survival rate for transfer, live birth rate, and neonatal outcomes. The results showed that an additional vitrification-warming procedure on blastocysts resulted in a lower but not statistically different survival rate for transfer. Compared with euploid blastocysts vitrified-warmed once, those vitrified-warmed twice provided statistically similar live birth rate. Neonatal outcomes, including the sex ratio, gestational age, birthweight, preterm birth rate, and low birthweight rate, did not differ between single and double vitrification. No significant differences were observed in rates of blastocyst survival, blastocyst euploid and live birth, and neonatal outcomes resulting from either conventional IVF or ICSI. The neonatal follow-up of babies live-born so far did not report any congenital malformations. In conclusion, an additional vitrification-warming on blastocysts had no detectable adverse impact on clinical outcomes after frozen-thawed single euploid blastocyst transfer in PGT-A cases; and ICSI did not confer any benefit in improving clinical outcomes compared with conventional IVF in cases requiring PGT-A on already vitrified nonbiopsied blastocysts.

PMID:36735146 | DOI:10.1007/s43032-023-01177-0

Environ Sci Pollut Res Int. 2023 Feb 3. doi: 10.1007/s11356-023-25693-3. Online ahead of print.

ABSTRACT

The current study aims to evaluate the associations between 10 urinary polycyclic aromatic hydrocarbon (PAH) metabolites and thyroid profiles. The levels of 10 PAH metabolites and thyroid profiles were obtained from National Health and Nutrition Examination Survey (NHANES) 2011-2012. Spearman analysis was utilized to evaluate the correlation coefficients among these 10 PAH metabolites. Multivariate linear and logistic regression models assessed the relationship between urinary PAH metabolite levels, thyroid hormones, and thyroid autoantibodies after adjusting potential confounders. Stratified analysis by gender was performed to evaluate sex-specific effect of urinary metabolites of PAH on thyroid profiles. One thousand six hundred forty-five eligible adult participants with complete research data were enrolled. Of note, the concentrations of the majority of urinary PAH metabolites were remarkedly higher in females compared with males. 2-hydroxyfluorene (2-FLU) was associated with higher total triiodothyronine (T3) levels in whole population (β = 2.113, 95% CI 0.339-3.888). In males, positive associations were observed in 1-hydroxynaphthalene (1-NAP) and free thyroxine (T4) (β = 0.0002, 95% CI 0.0000-0.0004). 2-FLU was also found positively associated with total T3 (β = 2.528, 95% CI 0.115-4.940) in male subjects. While in female participants, 2-hydroxynaphthalene (2-NAP) was associated with free T3 (β = 0.002, 95% CI 0.000-0.005). 2-FLU was associated with total T3 (β = 2.683, 95% CI 0.038-5.328), free T3 (β = 0.050, 95% CI 0.012-0.087), and total T4 (β = 0.195, 95% CI 0.008-0.382). 2-Hydroxyphenanthrene (2-OHP), 1-hydroxypyrene (1-HP), and 9-hydroxyfluorene (9-FLU) were all positively related to total T3 levels, and the corresponding coefficients were 16.504, 6.587, and 3.010. 9-FLU was also associated with free T3 (β = 0.049, 95% CI 0.008-0.090). No statistical significances were found between PAH metabolite levels and increased prevalence of increased thyroglobulin antibody (TgAb)/thyroid peroxidase antibody (TPOAb) when PAH metabolites were treated as continuous variables. Meanwhile, in the quartile analyses, increased prevalence of elevated TgAb was observed in participants with quartile 2 2-NAP compared with lowest quartile (OR = 1.753, 95% CI 1.021-3.008). Male subgroup analyses indicated that increased prevalence of elevated TgAb was observed in higher quartile of 1-NAP, 2-NAP, and 3-hydroxyfluorene (3-FLU). Increased prevalence of elevated TPOAb was associated with higher 2-NAP quartile. However, in subgroup analysis of females, no statistical significances were found between PAH quartiles and increased TgAb/TPOAb. Significant correlations were found among these 10 PAH metabolites. In conclusion, the cross-sectional study indicated that exposure to PAH might disturb the concentrations of thyroid hormones and thyroid autoantibodies. It is noteworthy that significant differences existed in males and females. Further prospective research is warranted to explore the causal relationship and underlying mechanism of PAH exposure on thyroid dysfunction.

PMID:36735133 | DOI:10.1007/s11356-023-25693-3

Environ Sci Pollut Res Int. 2023 Feb 3. doi: 10.1007/s11356-023-25701-6. Online ahead of print.

ABSTRACT

Bone mass increases rapidly in adolescence, and achieving higher bone mineral density (BMD) during this period can help prevent osteoporosis. However, the effects of metallic mercury on bone health remain controversial. Previous studies have discussed perimenopausal women and older adults, while the association of blood mercury with BMD in adolescents is yet to be studied. Date was collected from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. Weighted multiple linear regression models were used to explore the association of blood mercury levels with BMD in adolescents, while smooth curve fittings and weighted generalized additive models were used to identify the potential nonlinear association. We found that blood mercury levels were negatively associated with BMD in adolescents, though not significantly, based on the results of statistical analyses of 2818 participants. Additionally, the trend in BMD with changes in blood mercury was different in male and female adolescents. We also found an inverted U-shaped association between blood mercury and BMD in male and Mexican-American adolescents. This suggests that increased blood mercury levels within a range may benefit bone health in male adolescents (inflection point: 5.44 nmol/L) and Mexican-American adolescents (inflection point: 5.49 nmol/L), while higher blood mercury levels may harm bone health. More prospective research is needed to confirm our findings.

PMID:36735129 | DOI:10.1007/s11356-023-25701-6

Bull Math Biol. 2023 Feb 3;85(3):20. doi: 10.1007/s11538-023-01123-w.

ABSTRACT

Syphilis and HIV infections form a dangerous combination. In this paper, we propose an epidemic model of HIV-syphilis coinfection. The model always has a unique disease-free equilibrium, which is stable when both reproduction numbers of syphilis and HIV are less than 1. If the reproduction number of syphilis (HIV) is greater than 1, there exists a unique boundary equilibrium of syphilis (HIV), which is locally stable if the invasion number of HIV (syphilis) is less than 1. Coexistence equilibrium exists and is stable when all reproduction numbers and invasion numbers are greater than 1. Using data of syphilis cases and HIV cases from the US, we estimated that both reproduction numbers for syphilis and HIV are slightly greater than 1, and the boundary equilibrium of syphilis is stable. In addition, we observed competition between the two diseases. Treatment for primary syphilis is more important in mitigating the transmission of syphilis. However, it might lead to increase of HIV cases. The results derived here could be adapted to other multi-disease scenarios in other regions.

PMID:36735105 | DOI:10.1007/s11538-023-01123-w

Trop Anim Health Prod. 2023 Feb 3;55(2):64. doi: 10.1007/s11250-023-03488-5.

ABSTRACT

The objective of this study was to understand and predict the intake and performance of Nellore cattle finished in the feedlot. Individual data from 144 non-castrated male Nellore steers finished in the feedlot between the years 2016 and 2020 were used. Descriptive statistical analyses and Pearson’s correlation were performed. The outliers were tested by evaluating the studentized residuals in relation to the values predicted by the equations. Residues that were outside the range of – 2.5 to 2.5 were removed. The goodness of fit of the developed equations was evaluated by the coefficients of determination (r²) and root mean square error (RMSE). The mean dry matter intake (DMI) was 10.2 kg/day, neutral detergent fiber intake (NDFI) was 3.4 kg/day, corresponding to 33.3% of DMI, crude protein intake (CPI) was 1.6 kg/day, and total digestible nutrient intake (TDNI) was 7.1 kg/day. The CPI to ADG ratio was 1.3 kg CPI/kg ADG and the TDNI to CPI ratio was 4.5 kg TDNI/kg CPI. The averages of productive performance were 1.3 kg/day for average daily gain (ADG), 152.6 kg for total weight gain (TWG), and 497.8 kg for final body weight (FBW) in average days in the confinement of 115.7 days. The intake measures correlated significantly with the performance measures, except for carcass yield and days in the feedlot. TWG had a high positive correlation with ADG (r = 0.84), while FBW had a positive correlation (r = 0.86) with hot carcass weight (HCW). Measures of intake, performance, and days in the feedlot can be used as predictors of DMI, FBW, HCW, TWG, and ADG. The prediction equations had satisfactory precision and accuracy for non-castrated Nellore cattle finished in feedlot systems under tropical conditions.

PMID:36735099 | DOI:10.1007/s11250-023-03488-5

Environ Monit Assess. 2023 Feb 3;195(3):359. doi: 10.1007/s10661-023-10969-5.

ABSTRACT

Zinc (Zn) is an essential micronutrient for plants and an important component for maintaining soil quality. Commonly found in the soil due to anthropogenic activities, such as industrialization and application of organic waste as fertilizers, in high concentrations, Zn may induce soil toxicity, affecting important communities, such as edaphic fauna. Despite its high concentrations found in the environment, Zn bioavailability can be affected by the type of soil, organic matter content and pH. In this work, Zn had its toxicity evaluated in a natural tropical soil, sampled in São Paulo-Brazil, for two soil invertebrates (Folsomia candida, Enchytraeus crypticus) and two seeds (Lactuca sativa and Phaseolus vulgaris), through ecotoxicological tests. The invertebrate E. crypticus was exposed to Zn concentrations of 10.0 (T1); 100.0 (T2); 150.0 (T3); 200.0 (T4); 400.0 (T5) mg Zn kg^-1 of dry soil, while F. candida, L. sativa and P. vulgaris were exposed to Zn concentrations of 100.0; 200.0; 400.0; 800.0 (t6); 1600.0 (t7); and 2000.0 (t8) mg Zn kg^-1 of dry soil. The outcome evaluated were seed germination, for L. sativa and P. vulgaris, and reproduction, for F. candida and E. crypticus. The EC50 obtained for E. crypticus, F. candida, L. sativa, and P. vulgaris were 261.5, 1089.7, 898.5, and 954.5 mg Zn kg^-1 of dry soil, respectively, being E. crypticus the most sensitive organism, and only at the highest Zn’s concentrations the organisms’ reproduction and seeds’ germination showed a statistically significant inhibitory effect (p < 0.05). Therefore, this work’s results showed that Zn does not present significant toxicity for the tested soil organisms and seeds and that at 100 mg Zn kg^-1 of dry soil it can be beneficial to F. candida and E. crypticus’ reproduction and L. sativa’s germination. These results imply that the presence of Zn in low concentrations, both in soil and biofertilizers, such as sewage sludge, not only is not a concern, but it can even benefit certain crops and functions of edaphic organisms, which may contribute to the engagement of sustainable agricultural practices and the quest for food security.

PMID:36735091 | DOI:10.1007/s10661-023-10969-5

J Forensic Sci. 2023 Feb 3. doi: 10.1111/1556-4029.15206. Online ahead of print.

ABSTRACT

TASER® weapons are conducted energy weapons (CEWs) that are frequently used by police departments around the world. CEWs can be deployed in two methods: drive stun application and probe deployment. This study aims to examine damages caused by TASER devices on fabrics and whether types of fabric material and TASER models could contribute to different damage features. Three types of white fabric were used, including 100% cotton, 100% polyester, and 65:35 polyester-cotton blend. Three models: TASER X26P, TASER X2, and TASER 7 were shot onto each type of fabric, with five repetitions each. Each damaged area on the fabric caused by a probe is a sample (n = 90) and was examined with a Keyence digital microscope. Images were captured by the Keyence microscope and measurements were recorded, including damage dimensions, fabric condition, evidence of burning, and extra findings. The presence of fused yarn ends was found to be statistically significant across the fabric types, and no damage features were found that may assist in the identification of TASER models. Other damage features including damage dimensions, discoloration, and fiber deformation were not found to be showing apparent differences according to statistical analysis. The conclusions made by this research should be used with caution due to the small sample size.

PMID:36734305 | DOI:10.1111/1556-4029.15206