Category: Statistics

Cogn Sci. 2021 Mar;45(3):e12947. doi: 10.1111/cogs.12947.

ABSTRACT

Cognitive systems face a tension between stability and plasticity. The maintenance of long-term representations that reflect the global regularities of the environment is often at odds with pressure to flexibly adjust to short-term input regularities that may deviate from the norm. This tension is abundantly clear in speech communication when talkers with accents or dialects produce input that deviates from a listener’s language community norms. Prior research demonstrates that when bottom-up acoustic information or top-down word knowledge is available to disambiguate speech input, there is short-term adaptive plasticity such that subsequent speech perception is shifted even in the absence of the disambiguating information. Although such effects are well-documented, it is not yet known whether bottom-up and top-down resolution of ambiguity may operate through common processes, or how these information sources may interact in guiding the adaptive plasticity of speech perception. The present study investigates the joint contributions of bottom-up information from the acoustic signal and top-down information from lexical knowledge in the adaptive plasticity of speech categorization according to short-term input regularities. The results implicate speech category activation, whether from top-down or bottom-up sources, in driving rapid adjustment of listeners’ reliance on acoustic dimensions in speech categorization. Broadly, this pattern of perception is consistent with dynamic mapping of input to category representations that is flexibly tuned according to interactive processing accommodating both lexical knowledge and idiosyncrasies of the acoustic input.

PMID:33682208 | DOI:10.1111/cogs.12947

J Paediatr Child Health. 2021 Mar 8. doi: 10.1111/jpc.15337. Online ahead of print.

ABSTRACT

AIM: Despite being a common metabolic condition, the detection and care of neonatal hypoglycaemia in Germany largely depends on the infant’s health-care provider, rather than a national protocol. Therefore, this study aimed to evaluate midwives’ and nurses’ knowledge and management of neonatal hypoglycaemia and to determine the need for national guidelines.

METHODS: An anonymous online survey was developed and completed by 127 perinatal nurses and midwives. Descriptive statistics, Mann-Whitney-U, χ² and Fisher’s exact tests were used to summarise and analyse the results.

RESULTS: In total, 82% of respondents indicated using guidelines but routine blood glucose screening for neonates at risk for hypoglycaemia was rarely reported (44%). A blood glucose concentration of 2.5 mmol/L (45 mg/dL) was considered the treatment threshold by 52% of the respondents. However, the responses to clinical scenarios showed distinct differences regarding the management of neonatal hypoglycaemia. Finally, 49% of respondents reported insufficient knowledge regarding neonatal hypoglycaemia and 77% indicated that they would advocate the implication of enhanced national guidelines.

CONCLUSIONS: There is considerable variation in knowledge about the prevention, screening and management of neonatal hypoglycaemia among nurses and midwives in Germany. Enhanced guidelines and education of health-care professionals are urgently needed to provide the best possible care to all hypoglycaemic newborns.

PMID:33682210 | DOI:10.1111/jpc.15337

J Oral Rehabil. 2021 Mar 8. doi: 10.1111/joor.13163. Online ahead of print.

ABSTRACT

AIM: To evaluate the thermographic characteristics of orofacial structures and submental triangle of participants with obstructive sleep apnea (OSA), as well as to investigate its correlation with the anatomy, posture and functions of the orofacial structures.

METHOD: Eighteen patients diagnosed with OSA by polysomnography (OSA group; 57.4±15.8 years) and 13 healthy participants screened for OSA (Control group; 57.8±18.1 years) were included. All participants answered to questionnaires for OSA and excessive daytime sleepiness, and were submitted to infrared image thermography analysis of facial regions of interest (ROIs), orofacial myofunctional evaluation (OMES-E protocol) and masticatory performance. Statistical analysis included One-way ANOVA and Pearson/Spearman correlation test.

RESULTS: OSA group showed lower thermographic measures in many ROIs in the frontal and lateral views of the face, including the submental triangle region, and lower scores of aspect/posture and performance of orofacial structures, as well lower total score of OMES-E evaluation (p<0.05). Scores of aspect/posture and mobility were correlated to the temperature of some ROIs in the frontal and lateral views.

CONCLUSION: Lower facial skin and submental triangle region temperatures, measured by infrared thermography, and a worse orofacial myofunctional condition were identified in the group of individuals with OSA. The higher temperatures of the ROIs were correlated to the better status of aspect/posture and performance of the orofacial myofunctional structures.

PMID:33682155 | DOI:10.1111/joor.13163

J Oral Rehabil. 2021 Mar 7. doi: 10.1111/joor.13162. Online ahead of print.

ABSTRACT

INTRODUCTION: Clinical presentation of oromandibular dystonia (OMD) is variable that can be further complicated by the presence of temporomandibular disorder (TMD) symptoms. We sought to evaluate variations in the clinical presentation of OMD patients, particularly TMD-related characteristics, in two clinical settings.

METHODS: In a cross-sectional study design, a Web-based data collection survey was provided to eligible patients with OMD from movement disorder (MD) and oro-facial pain (OFP) clinics. The survey questionnaire was designed to collect information on demographic characteristics, clinical presentation particularly related to TMD, quality of life and treatment outcomes. Validated questionnaires were used when available such as the TMD Pain Screener, EuroQol 5-Dimensions 5-Levels (EQ-5D-5L), Jaw Functional Limitation Scale and Global Rating of Change Scale.

RESULTS: Of 53 eligible patients, 31 responded to the survey for a 58% response rate. Forty-eight per cent of patients in the MD clinic and 60% of patients in the OFP clinic reported jaw pain along with involuntary movements. Of those, 90% from the MD group and 83% from the OFP group screened positive with the TMD Pain Screener at the onset of symptoms based on recall. Positive TMD Pain Screener response was observed in about 40% of patients in both clinics within 30 days of questionnaire response. No statistically significant differences were observed between two groups for any measured variables.

CONCLUSION: Patients with OMD have features of TMD, irrespective of the clinical setting in which they seek and receive care. OMD patients from both clinics were similar in terms of clinical presentation, quality of life and treatment outcomes.

PMID:33682178 | DOI:10.1111/joor.13162

J Dent Educ. 2021 Mar 8. doi: 10.1002/jdd.12582. Online ahead of print.

ABSTRACT

OBJECTIVES: Community of practice (CoP) members develop cooperative learning history with shared cases, techniques, and concepts. A 2020 study was designed to explore participants’ perceptions toward learning in the dental education CoP.

METHODS: The Institutional Review Board exempted (AZ #1355) study involved an incidental population of third- and fourth-year dental students (N = 285) and resulted in a 43.5% response rate. The online Community of Practice Assessment Scale, consisted of Likert-style, check box items, and one open-ended question. Survey responses were categorized as Strongly Agree (1), Agree (2), No opinion (3), Disagree (4), and Strongly Disagree (5). Univariate analyses and descriptive statistics were used to analyze study variables (domain, community, and practice).

RESULTS: Overall the learning domain is most strongly perceived by participants with mean scores ranging from 1.59 to 1.61. Responses assessing practices within the CoP had mean scores ranging from 1.72 to 1.90. Similarly, responses assessing the community ranged from 1.65 to 1.81. “Builds Knowledge and Shared Learning” was the characteristic participants most strongly agreed as beneficial with a 1.58 mean score. Participants agree that the CoP “Captures and Stores Tacit and Explicit Knowledge” with a mean score of 1.90. There was a 25.6% response rate to the open-ended question. Two themes evolved: the need for calibration and more shared learning.

CONCLUSION: Based on study results, participants strongly agreed or agreed in opinions about CoP learning resources (faculty, staff, technology, and other students) benefitting their learning. The CoP provides an optimal environment for preparing competent new dental professionals.

PMID:33682132 | DOI:10.1002/jdd.12582

Zhonghua Bing Li Xue Za Zhi. 2021 Mar 8;50(3):229-235. doi: 10.3760/cma.j.cn112151-20200617-00479.

ABSTRACT

Objective: To investigate the clinicopathological and molecular characteristics of the epithelioid glioblastoma (eGBM) with BRAF V600E mutation. Methods: Sixteen cases of eGBM with BRAF V600E mutation diagnosed at the West China Hospital of Sichuan University, China from 2012 to 2019 were collected. Their clinicopathological and molecular characteristics were analyzed. Results: The range of patients’ age was from 7 to 61 years (median 31.5 years). There were 4 males and 12 females, with a male to female ratio of 1∶3. Eleven cases were newly diagnosed eGBM and five cases had a previous history of astrocytomas. Most of the tumors were located in the cerebral hemisphere, often in the frontal lobe, with an average diameter of 4.6 cm (2.0-8.0 cm). The tumors were composed of relatively uniform, closely packed epithelioid cells, some showing discohesion, with distinct cell membrane, eosinophilic cytoplasm, eccentric nuclei, distinct nucleoli and mitotic activity. Palisaded/coagulative necrosis was seen in all cases. Glomerular microvascular proliferation was seen in most of the cases, while mono-or multi-nucleated tumor giant cells were seen in some cases. Focal sarcomatoid area was seen in 2 cases, and focal pleomorphic xanthoastrocytoma (PXA)-like area was seen in 3 cases. Immunohistochemistry showed variable positivity for GFAP, Olig2 and p53. The median Ki-67 index was 30% (10%-50%). Only one case lost ATRX protein expression. Sanger sequencing identified the BRAF V600E mutation in all sixteen patients. Five cases also had mutations in the TERT gene promoter. No IDH1 (R132) or IDH2 (R172) mutation was detected. Surgical resection of the tumors was performed for all patients, and 3 patients also received adjuvant radiotherapy and chemotherapy. Follow-up data were available for 15 patients, with a follow-up time of 1-89 months (median 10 months). Among the 15 patients, 7 patients died of disease and another 5 patients had recurrences. The overall survival time of the patients under 35 years of age was significantly longer than that of the patients aged 35 years or older (P=0.014), but their progression-free survival was not statistically different (P=0.232). Conclusions: eGBM with BRAF V600E mutation is more commonly detected in young women than other the populations (i.e. elderly or male). The epithelioid morphology should include rhabdoid meningioma, anaplastic PXA, atypical teratoid/rhabdoid tumor, metastatic tumors, and melanoma in its differential diagnosis. PXA-like area is observed in some eGBM cases, suggesting a relationship of these two types of tumor. eGBM is a high-grade malignant tumor and most of the cases show recurrences or deaths in a short-period time. The younger patients have a relatively better prognosis than the older ones.

PMID:33677887 | DOI:10.3760/cma.j.cn112151-20200617-00479

Zhonghua Bing Li Xue Za Zhi. 2021 Mar 8;50(3):207-212. doi: 10.3760/cma.j.cn112151-20200513-00379.

ABSTRACT

Objective: To evaluate the expression of LEF1 protein in lymphoblastic lymphoma/acute lymphoblastic leukemia (LBL/ALL) and small B-cell lymphomas, and its value in pathologic diagnosis and differential diagnosis of LBL/ALL. Methods: 53 cases of LBL/ALL were collected at shanghai Tongji Hospital from January 2012 to December 2019. The protein expression of LEF1 and TdT was detected by immunohistochemistry in 53 paraffin-embedded tissue samples of LBL/ALL. The specificity and sensitivity of LEF1 and TdT in the diagnosis of LBL/ALL were compared. The expression of LEF1 protein in 77 cases of small B-cell lymphomas including chronic lymphocytic leukemia/small lymphoid lymphoma (CLL/SLL), follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma and Waldenstrom’s macroglobulinemia/lymphoplasmacytic lymphoma was studied. The correlation between LEF1 expression and overall survival (OS) and progression-free survival (PFS) was performed by univariate analysis. Results: The expression of LEF1 in LBL/ALL was 100% (53/53), the median value was 90%; the expression of TdT was 84.9% (T-LBL/ALL 78.1%, B-LBL/ALL 95.2%), the median value was 80%; the expression rate and median value of LEF1 and TdT were significantly different (P=0.008 and 0.001 respectively). The expression of LEF1 in CLL/SLL was 14/18, the median value was 45%; LEF1 was not expressed in follicular lymphoma (0/16), mantle cell lymphoma (0/16), marginal zone lymphoma (0/19), and Waldenstrom’s macroglobulinemia/lymphoplasmacytic lymphoma (0/8). LEF1 expression was significantly different between B-LBL/ALL and small B-cell lymphomas. The median follow-up time of LBL/ALL cases in this group was 16 months. There was no statistical difference between LEF1 expression and the OS and PFS in LBL/ALL patients. Conclusions: Immunohistochemical staining of LEF1 has high sensitivity and good specificity in the diagnosis of LBL/ALL, and its combination with TdT can improve the diagnostic rate of LBL/ALL.

PMID:33677883 | DOI:10.3760/cma.j.cn112151-20200513-00379

Breast J. 2021 Mar 6. doi: 10.1111/tbj.14216. Online ahead of print.

ABSTRACT

In the last few years, ultrasound-guided vacuum-assisted breast biopsy (US-VABB) has replaced surgical biopsy due to higher diagnostic accuracy and lower patient discomfort, and, at present, an even greater possibility is represented by the new wireless ultrasound-guided VAB device (Wi-UVAB). The purpose of our study is to determine the diagnostic accuracy of this new device in a sizeable representative number of patients. From January 2014 to June 2018, 168 biopsies were performed in our institution using the new Wi-UVAB device. We analyzed sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of biopsies obtained with the new device using surgical results as reference point, following patients for at least one year. In our cohort, we obtained a complete sensitivity of 97.5%, an absolute sensitivity of 94.3%, a complete specificity of 98%, and an absolute specificity of 98%. The positive predictive value of the procedure was 97.5% while the negative predictive value was 98%. The diagnostic accuracy was 98%. The Wi-UVAB is a safe procedure with high diagnostic accuracy, comparable to that of the traditional vacuum-assisted breast biopsy and even higher than that of core needle biopsy (CNB). Moreover, the Wi-UVAB is easy to use and shows low costs as core needle biopsy (CNB).

PMID:33677844 | DOI:10.1111/tbj.14216

Epidemiol Health. 2021 Feb 28:e2021017. doi: 10.4178/epih.e2021017. Online ahead of print.

ABSTRACT

OBJECTIVES: The effect of age, gender and other demographic factors on relationship between smoking and dry mouth remained unknown. The aim of this study was to measure the relationship between dry mouth and smoking specifically by considering demographic characteristics.

METHODS: In this case-control study, 5640 subjects who were randomly selected from 10000 participants of the second phase of Kerman coronary artery disease risk factors study (KERCADRS) during 2014-2018, were included. Demographic characteristics and smoking frequency in the participants were recorded by a checklist. Six-item Fox questionnaire was filled out by the participants to determine dry mouth as a dependent variable. The interaction terms of daily cigarette smoking with sex, age, educational level, and marital status were entered to the model and non-significant terms were removed by the hierarchical model selection.

RESULTS: It was revealed that 3429 (60.8%) of controls had not dry mouth and 2211 (39.2%) of cases had xerostomia. Statistical analysis revealed that smokers are more likely to have dry mouth in all ages and both sexes (p<0.001). As men get older, the chance of having dry mouth increases more rapidly among them than female smokers (p<0.001). In addition, female smokers have more chance to have dry mouth compared to male smokers (p<0.001).

CONCLUSION: Age, sex, and daily cigarette smoking affect the prevalence of dry mouth in the very complex way. Cigarette smoking was associated with more chance of having dry mouth especially in female smokers.

PMID:33677858 | DOI:10.4178/epih.e2021017

Zhonghua Xue Ye Xue Za Zhi. 2021 Jan 14;42(1):45-51. doi: 10.3760/cma.j.issn.0253-2727.2021.01.009.

ABSTRACT

Objective: To investigate the clinical features and prognosis of ETV6-RUNX1-positive childhood B-precursor acute lymphocyte leukemia (B-ALL) . Methods: The clinical data of 927 newly diagnosed children with B-ALL admitted to the Fujian Medical University Union Hospital from April 2011 to May 2020 were retrospectively analyzed. According to the results of ETV6-RUNX1 gene, the patients were divided into ETV6-RUNX1(+) and ETV6-RUNX1(-) groups. The clinical features and prognosis between the two groups were compared. Among the 182 children with ETV6-RUNX1(+), 144 patients received the Chinese Childhood Leukemia Collaborative Group (CCLG) -ALL 2008 protocol (CCLG-ALL 2008 group) and 38 received the China Childhood Cancer Collaborative Group (CCCG) -ALL2015 protocol (CCCG-ALL 2015 group) . The efficacy, serious adverse effects (SAE) incidence, and treatment-related mortality (TRM) of the two groups were also compared. Results: Of the 927 B-ALL patients, 189 (20.4% ) were ETV6-RUNX1(+). The proportion of patients with risk factors (age ≥10 years or <1 year, white blood cell count ≥50×10(9)/L) in the ETV6-RUNX1(+) group was significantly lower than that in the ETV6-RUNX1(-) group (P=0.000, 0.001, respectively) , while the proportion of patients with good early response (good response to prednisone, d15 or d19 MRD <1% , and d33 or d46 MRD<0.01% in induction chemotherapy) in the ETV6-RUNX1(+) group was significantly higher than that in the ETV6-RUNX1(-) group (P=0.028, 0.004, respectively) . The 5-year EFS and OS of the ETV6-RUNX1(+) group were significantly higher than those of the ETV6-RUNX1(-) group (EFS: 89.8% vs 83.2% , P=0.003; OS: 90.2% vs 86.3% , P=0.030) . The incidence of infection-related SAE and TRM was significantly higher than that of CCCG-ALL 2015 group. A statistical difference was observed between the incidence of infection-related SAE of the two groups (27.1% vs 5.3% , P=0.004) , but no difference in TRM (4.9% vs 0, P=0.348) . Conclusion: ETV6-RUNX1(+)B-ALL children have fewer risk factors at diagnosis, better early response, lower recurrence rate, and good prognosis than that of ETV6-RUNX1(-)B-ALL children. Reducing the intensity of chemotherapy appropriately can lower the infection-related SAE and TRM and improve the long-term survival in this subtype.

PMID:33677868 | DOI:10.3760/cma.j.issn.0253-2727.2021.01.009