Category: Statistics

Int J Occup Saf Ergon. 2021 May 17:1-18. doi: 10.1080/10803548.2021.1928390. Online ahead of print.

ABSTRACT

We investigated the awareness of occupational hazards, attitudes and practices towards the use of personal protective equipment (PPE) among informal woodworkers of the Sokoban Wood Village in Ghana. Structured questionnaires were used to collect primary data from 355 woodworkers and analysed using descriptive statistics and logistic regression model. The results showed that the workers are aware of PPE and knew about injuries they are exposed to. Most woodworkers had a positive attitude in terms of their perception on the necessity to use PPE but had a low frequency of PPE usage. Educational level, job type, length of service and marital status are the socio-demographic characteristics which significantly influence woodworkers’ compliance with health and safety regulations. We recommend that institutions charged with enforcement of occupational health and safety regulations should extend their monitoring roles to informal workers and liaise with local companies to supply PPE to informal woodworkers at subsidised costs.

PMID:33998973 | DOI:10.1080/10803548.2021.1928390

J Aging Health. 2021 May 17:8982643211019499. doi: 10.1177/08982643211019499. Online ahead of print.

ABSTRACT

Objective: We explore how upper and lower body functional ability of older adults and their partners relate to affect in later life. Methods: Data regarding own and partner’s upper and lower body functional abilities were reported by 1767 married/partnered persons aged 57-83. Using multilevel modeling to account for nesting within couples, we examined the impact of a respondent’s own functional abilities, their perception of their partner’s abilities, and the interaction of respondent’s and perceived partner’s abilities on respondent’s positive and negative affect. Results: Higher upper and lower body ability of both respondents and partners were associated with higher positive and lower negative affect. Moderating effects demonstrated a protective role of respondents’ ability on affect when their partners experienced lower ability. Discussion: There is a potential compensatory relationship between older couples adapting to functional changes; it is important to support the functional abilities of both partners in couples to maximize psychological well-being.

PMID:33998913 | DOI:10.1177/08982643211019499

Int J Phytoremediation. 2021 May 12:1-9. doi: 10.1080/15226514.2021.1920571. Online ahead of print.

ABSTRACT

Hyperaccumulator-cash crop intercropping remediation is a research hotspot for heavy metal contaminated farmland, but few studies evaluated its feasibility based on practice. Field experiments and survey statistics were conducted to obtain parameters of Pteris vittata-Citrus reticulata/Zea mays intercropping, and potential of intercropping remediation was evaluated based on remediation efficiency and economic benefits. The results showed that intercropping hyperaccumulator with cash crop (especially herbs) had a certain negative effect on remediation efficiency because of the influence on planting density and harvest times of hyperaccumulator; while trees could partly alleviate this effect. Until achieving the predetermined target, the net remediation cost of P. vittata-Z. mays was 18.2 $/g As, followed by P. vittata monoculture (13.3 $/g) and P. vittata-C. reticulata (8.6 $/g). Based on the proposed evaluation model, nealy half of the P. vittata intercropping modes had low economic benefits, insufficient to compensate the cost of sacrificing remediation efficiency. Based on the data from two soil remediation projects, when net income of cash crops intercropped with As-hyperaccumulators exceeded 5865/1607 $/hm² (herbs/trees), the economic benefit of intercropping will be relatively obvious. Therefore, cash crops should be considered from three aspects: planting conditions, spatial allocation and economic benefits. Novelty statement: This work analyzed remediation efficiency and economic benefits of intercropping remediation. An economic benefit evaluation model was established to evaluate intercropping remediation modes. The selection principle and net income threshold of cash crops in intercropping was put forward for the first time.[Figure: see text]HighlightsThe selection principle of cash crops in intercropping remediation was put forward.An evaluation model of P. vittata intercropping remediation was established.The net cost of extracting 1.0 g of soil As in each remediation mode was proposed.Net income of herb/tree intercropped with P. vittata should exceed 5865/1607 $/hm².

PMID:33998931 | DOI:10.1080/15226514.2021.1920571

Cleft Palate Craniofac J. 2021 May 17:10556656211002675. doi: 10.1177/10556656211002675. Online ahead of print.

ABSTRACT

OBJECTIVE: To identify differences between asymptote- and rate-based methods for estimating age and size at growth cessation in linear craniofacial measurements.

DESIGN: This is a retrospective, longitudinal study. Five linear measurements were collected from lateral cephalograms as part of the Craniofacial Growth Consortium Study (CGCS). Four estimates of growth cessation, including 2 asymptote- (GC_asym, GC_err) and 2 rate-based (GC_abs, GC_10%) methods, from double logistic models of craniofacial growth were compared.

PARTICIPANTS: Cephalometric data from participants in 6 historic longitudinal growth studies were included in the CGCS. At least 1749 individuals (870 females, 879 males), unaffected by craniofacial anomalies, were included in all analyses. Individuals were represented by a median of 11 images between 2.5 and 31.3 years of age.

RESULTS: GC_asym consistently occurred before GC_err and GC_abs consistently occurred before GC_10% within the rate-based approaches. The ordering of the asymptote-based methods compared to the rate-based methods was not consistent across measurements or between males and females. Across the 5 measurements, age at growth cessation ranged from 13.56 (females, nasion-basion, GC_asym) to 24.39 (males, sella-gonion, GC_err).

CONCLUSIONS: Adolescent growth cessation is an important milestone for treatment planning. Based on our findings, we recommend careful consideration of specific definitions of growth cessation in both clinical and research settings since the most appropriate estimation method may differ according to patients’ needs. The different methods presented here provide useful estimates of growth cessation that can be applied to raw data and to a variety of statistical models of craniofacial growth.

PMID:33998905 | DOI:10.1177/10556656211002675

Comput Methods Biomech Biomed Engin. 2021 May 17:1-13. doi: 10.1080/10255842.2021.1927000. Online ahead of print.

ABSTRACT

A diffusion tensor imaging (DTI) -based statistical micromechanical model was developed to study the effect of axonal fiber architecture on the inter- and intra-regional mechanical heterogeneity of the white matter. Three characteristic regions within the white matter, i.e., corpus callosum, brain stem, and corona radiata, were studied considering the previous observations of locations of diffuse axonal injury. The embedded element technique was used to create a fiber-reinforced model, where the fiber was characterized by a Holzapfel hyperelastic material model with variable dispersion of axonal orientations. A relationship between the fractional anisotropy and the dispersion parameter of the hyperelastic model was used to introduce the statistical DTI data into the representative volume element. The FA-informed statistical micromechanical models of three characteristic regions of white matter were developed by deriving the corresponding probabilistic measures of FA variations. Comparison of the model predictions and experimental data indicated a good agreement, suggesting that the model could reasonably capture the inter-regional heterogeneity of white matter. Moreover, the standard deviations of experimental results correlated well with the model predictions, suggesting that the model could capture the intra-regional mechanical heterogeneity for different regions of white matter.

PMID:33998911 | DOI:10.1080/10255842.2021.1927000

Cannabis Cannabinoid Res. 2021 May 11. doi: 10.1089/can.2021.0014. Online ahead of print.

ABSTRACT

Background: Beside others, neuroinhibitory and sedative effects of CBD were documented. Aim and Methods: The aim of the study was to assess the dose-related effects of CBD premedication on the course of isoflurane anesthesia. Wistar rats were pretreated with different doses of CBD 1 h before isoflurane anesthesia. In the pretreatment, animals were given CBD at doses of 100, 20, 10, or 2 mg kg^-1. Before the fifth (control) anesthesia, the animals were given only mid-chain triglyceride oil, which served as a solvent in the CBD formulation. The induction time was determined, and on awakening, the time to appearance of the flexion reflex and the recovery from anesthesia were determined. Results: Statistical analysis showed a significantly shorter induction time if animals were pretreated with 20 mg kg^-1 CBD. In addition, pretreatment with 100 mg kg^-1 CBD resulted in a prolonged induction time, while on awakening, delayed appearance of reflexes and prolonged recovery from anesthesia compared to pretreatment with 20 mg kg^-1 CBD were observed. Conclusions: The results indicate that the influence of CBD on the course of isoflurane anesthesia depends on the dose and can reduce the induction time. Although this study was performed in laboratory rats, in clinical practice, these data should be considered when CBD-treated patients undergo isoflurane anesthesia.

PMID:33998903 | DOI:10.1089/can.2021.0014

Cannabis Cannabinoid Res. 2021 Apr 16. doi: 10.1089/can.2020.0107. Online ahead of print.

ABSTRACT

Background: The endocannabinoid system is present in multiple organ systems and is involved in smooth muscle regulation, immune function, neuroendocrine modulation, and metabolism of tissues. Limited data are available regarding the presence and role of this system in reproductive tissues. Components of the endocannabinoid system have been identified in myometrial and placental tissues. However, no study has investigated differential expression of the endocannabinoid system in labor. Objectives: The purpose of this study was to identify and quantify two components of the endocannabinoid system, the CB₁ cannabinoid receptor and cannabinoid receptor interacting protein 1a (CRIP1a) in uterine and placental tissues, and to determine if there is differential expression in tissues exposed to labor. We hypothesized that CB₁ cannabinoid receptor concentration would be altered in uterine and placental tissue exposed to labor compared with tissues not exposed to labor. Study Design: Uterine and placental tissue samples were collected in nine laboring and 11 nonlaboring women undergoing cesarean delivery. CB₁ cannabinoid receptor and CRIP1a presence and quantification were evaluated using western blot, immunohistochemistry, and real-time quantitative polymerase chain reaction. Statistical comparisons of laboring and nonlaboring subjects were made for uterine and placental tissue using a Mann-Whitney test. Results: Immunohistochemistry demonstrated positive staining for CB₁ cannabinoid receptors and CRIP1a in uterine tissue. The protein abundance of CB₁ cannabinoid receptor in uterine tissue was significantly lower in tissues exposed to labor (p=0.01). The protein abundance of CRIP1a was lower in uterine tissue exposed to labor but did not reach statistical significance (p=0.06). mRNA expression of CB₁ cannabinoid receptor (p=0.20) and CRIP1a (p=0.63) did not differ in labored compared with nonlabored uterine tissues. Conclusions: Our findings of diminished protein density of CB₁ cannabinoid receptor in uterine tissue exposed to labor support the hypothesis that the endocannabinoid system plays a role in parturition. Our data add to the growing body of evidence indicating the endocannabinoid system is of importance for successful reproduction and support the need for additional research investigating this complex system as it pertains to labor. ClinicalTrials.gov ID: NCT03752021.

PMID:33998898 | DOI:10.1089/can.2020.0107

Cannabis Cannabinoid Res. 2020 Aug 21. doi: 10.1089/can.2019.0095. Online ahead of print.

ABSTRACT

Introduction: Cannabis smoke contains carcinogens similar to tobacco, in addition to compounds with antitumor activity. Cannabis use reduces the risk of obesity and cannabinoids inhibit chronic inflammation, known causes of cancer. The net effect of Cannabis use on cancer risk is not known. Objective: To examine the association between Cannabis use and cancer risk in the United States. Methods: Identify and analyze published data on cancer risk in Cannabis users. Results: A total of 55 data points, consisting of risk ratios of cancer in Cannabis users and nonusers, were identified from 34 studies. Of these, 5 did not contain data essential for inclusion in the meta-analysis. The remaining data showed a nonsignificant trend to an association with reduced risk (relative risk [RR]=0.90, p>0.06, N=50) although heterogeneity is high (I²=72.4%). Removal of data with high risk of selection bias (defined as those from North Africa and those that failed to adjust for tobacco) and data with high risk of performance bias (defined as those with fewer than 20 cases or controls among Cannabis users) resulted in an RR <1.0 (RR=0.86, p<0.017, N=24) and large effect size (Hedges g=0.66), but did not decrease heterogeneity (I²=74.9). Of all cancer sites, only testicular cancer showed an RR value >1, although this was not significant and had a negligible effect size (RR=1.12, p=0.3, Hedges g=0.02). Following removal of testicular cancers the remaining data showed a decrease in risk (RR=0.87, p<0.025, N=41). Cancers of the head and neck showed a negative association with cancer risk (RR=0.83, p<0.05), with a large effect size (Hedges g=0.55), but high heterogeneity (I²=79.2%). RR did not reach statistical significance in the remaining cancer site categories (lung, testicular, obesity-associated, other). The data are consistent with a negative association between Cannabis use and nontesticular cancer, but there is low confidence in this result due to high heterogeneity and a paucity of data for many cancer types.

PMID:33998861 | DOI:10.1089/can.2019.0095

Cannabis Cannabinoid Res. 2021 Feb 11. doi: 10.1089/can.2020.0087. Online ahead of print.

ABSTRACT

Background: Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. Its pathophysiology is diverse and variable, involving disturbed gut-brain interactions, altered motility and secretion, visceral hypersensitivity, increased intestinal permeability, immune activation, and changes in gut microbiota. Complaints experienced by patients suffering from IBS and its co-morbidities strongly impair quality of life (QoL), and available treatments are often unsatisfactory. Anecdotal reports and preclinical data suggest that the endocannabinoid system and functionally related mechanisms could offer treatment targets. Cannabidiol (CBD) is a candidate agent of interest with a broad molecular target profile and the absence of psychoactive properties. Materials and Methods: In 32 female IBS patients, we explored the effect of a chewing gum formulation containing 50 mg CBD on abdominal pain and perceived well-being in a randomized, double-blinded, placebo-controlled cross-over trial. Chewing gums were used on-demand guided by pain symptoms with a maximum of six per day. Pain intensity was assessed by a visual analogue scale (scale 0.0-10.0), and QoL was evaluated with the IBS-36 questionnaire. Results: There was no statistically significant difference in pain scores between CBD and placebo at a group level. Subgroup and individual analyses showed a highly variable picture. No indications were found for symptom-driven intake, which also remained lower than expected overall. Conclusions: With the current design, based on the assumption that IBS patients would adjust their intake to their perceived symptom relief, no differences at the group level were found between CBD and placebo gum in pain scores and the number of gums used. The low use of the gums also indicates that the benefits experienced by these patients generally did not outweigh practical disadvantages such as prolonged chewing throughout the day. The very high intra- and inter-individual variation in IBS symptoms warrant future trials that are more personalized, for example by applying an N-of-1 (rotating) design with individualized dose titration.

PMID:33998882 | DOI:10.1089/can.2020.0087

Cannabis Cannabinoid Res. 2021 Feb 15. doi: 10.1089/can.2020.0133. Online ahead of print.

ABSTRACT

Background: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality in the United States. Due to the ongoing legalization of cannabis, its acceptance, availability, and use in the in-patient population are on the rise. In this retrospective study, we investigated the association of cannabis use with important outcomes in COPD hospitalizations. Methods: The National Inpatient Sample (NIS) data were analyzed from 2005 to 2014. The primary outcome of interest was the trends and outcomes of cannabis use among COPD hospitalizations, including in-hospital mortality, pneumonia, sepsis, and respiratory failure. Results: We identified 6,073,862 hospitalizations, 18 years of age or older, with COPD using hospital discharge codes. Of these, 6,049,316 (99.6%) were without cannabis use, and 24,546 (0.4%) were admitted with cannabis use. The majority of COPD hospitalizations with cannabis use were aged 50-64 (60%). Cannabis use was associated with lower odds of in-hospital mortality (odds ratio [OR] 0.624 [95% confidence interval (CI) 0.407-0.958]; p=0.0309) and pneumonia (OR 0.882 [95% CI 0.806-0.964]; p=0.0059) among COPD hospitalizations. Cannabis use also had lower odds of sepsis (OR 0.749 [95% CI 0.523-1.071]; p=0.1127) and acute respiratory failure (OR 0.995 [95% CI 0.877-1.13]; p=0.9411), but it was not statistically significant. Conclusions: Among hospitalized patients with a diagnosis of COPD, cannabis users had statistically significant lower odds of in-hospital mortality and pneumonia compared to noncannabis users. The association between cannabis use and these favorable outcomes deserves further study to understand the interaction between cannabis use and COPD.

PMID:33998884 | DOI:10.1089/can.2020.0133