Nevin Manimala

Clin Exp Dent Res. 2025 Oct;11(5):e70207. doi: 10.1002/cre2.70207.

ABSTRACT

OBJECTIVES: The aim of this study is to evaluate the buccal bone thickness and root length of the maxillary incisors in deep bite patients.

MATERIAL AND METHODS: Cone beam computed tomography data of 124 patients were randomly selected in this cross-sectional study. In the study, patients were divided into two groups, normal bite and deep bite, and buccal bone thickness and root length of the maxillary incisors were measured. Buccal bone thickness was measured at 4 mm apical to the cemento-enamel junction and at the midpoint of the root.

RESULTS: By comparing these factors between the two groups of normal and deep bite, only the difference in the buccal bone thickness at the midpoint of the root of the central incisor between these two groups was statistically significant. Also, by comparing these factors between male and female patients, the root length of the central and lateral incisors and the buccal bone thickness in the mid root of the central incisor were significantly more in Men.

CONCLUSION: A significant disparity in the buccal bone thickness at the mid-root level of central incisors between normal bite and deep overbite patients was revealed.

PMID:40874805 | DOI:10.1002/cre2.70207

Acta Chir Orthop Traumatol Cech. 2025 Jul;92(3):174-178. doi: 10.55095/achot2025/009.

ABSTRACT

PURPOSE OF THE STUDY: The study aimed to compare the postoperative outcomes of patients with total hip arthroplasty performed through Watson-Jones anterolateral approach and Röttinger minimally invasive anterolateral approach (MIS-AL). The hypothesis was that the MIS-AL approach enables faster recovery and better clinical outcomes in terms of abductor muscle strength and Harris Hip Score (HHS).

MATERIAL AND METHODS: The prospective comparative study included 136 patients who underwent surgery between 2018 and 2021. In 88 patients the Watson-Jones procedure was performed and in 48 patients Röttinger minimally invasive procedure was opted for. The Harris Hip Score (HHS) was used to evaluate the outcomes at three time points (before surgery, at 3 and 6 months after surgery) and the abductor muscle strength was measured using the dynamometer at four time points (before surgery, at 17 days, 3 and 6 months after surgery). The statistical analyses were conducted using the independent samples t-test at the level of significance p < 0.05.

RESULTS: In the MIS-AL group, the HHS after 3 months was 86.32 ± 4.8 points, which was a higher score than that achieved in the Watson-Jones group (78.76 ± 5.6; p = 0.0015). After 6 months the difference remained in favour of MIS-AL (94.68 ± 4.7 vs. 90.28 ± 5.4; p = 0.0078). The maximum abductor muscle strength after 6 months improved from 125.52 ± 14.8 N to 170.91 ± 16.2 N in the Watson-Jones group and from 142.78 ± 15.3 N to168.11 ± 15.8 N in the MIS-AL group, with no statistically significant difference between the two groups (p > 0.05).

DISCUSSION: The results show that the differences in abductor muscle strength between the MIS-AL approach and the Watson-Jones anterolateral approach were statistically insignificant. However, better results of the Harris Hip Score in patients in whom the MIS-AL approach was used are supported by the trend of faster functional recovery and higher satisfaction rate of patients undergoing less invasive surgical procedures.

CONCLUSIONS: The Röttinger minimally invasive anterolateral approach provides faster improvement of the HHS during the first six months after surgery. The differences in abductor muscle strength between the groups were statistically insignificant.

PMID:40874799 | DOI:10.55095/achot2025/009

Acta Chir Orthop Traumatol Cech. 2025 Jul;92(3):147-152. doi: 10.55095/achot2024/058.

ABSTRACT

PURPOSE OF THE STUDY: The study evaluates the functional outcomes of the treatment of pediatric trigger digits in two centers and compares them with data from the available literature. The secondary objective is to verify the possibilities of collecting data on patients’ health status through questionnaire surveys using remote communication via a web interface.

MATERIAL AND METHODS: Patients operated on at the Hand and Plastic Surgery Institute in Vysoké nad Jizerou (ÚCHRaPCH) and the Motol University Hospital, Department of Orthopaedics (FNM) between 2018 and 2021 were evaluated. An analysis of demographic data, affected digits, and an assessment of functional outcomes using the Quick-DASH questionnaire were performed. The data were collected through Google Forms and then statistically analyzed. The subgroups were compared using the chi-square test and two-tailed unpaired t-test and logistic regression with Firth’s correction was used to compare the obtained Quick-DASH scores.

RESULTS: A total of 124 trigger digits in 102 patients were evaluated, including 113 thumbs and 11 fingers; bilateral findings were observed in 20.6% of patients. The mean age at the time of surgery was 3.7 years. The questionnaire was completed by 57.8% of patients treated at ÚCHRaPCH and 57.9% at FNM. The median Quick-DASH score was 0.0, indicating no disability or hand function limitation. The average Quick-DASH score was 1.7. No significant differences were found between the centers in demographic parameters or achieved scores. The prevalence of a non-zero Quick-DASH score was 24%.

DISCUSSION: Our results, in line with global literature, confirm that surgical release of the A1 pulley is an effective method for treating pediatric trigger thumb or fingers with minimal complications. The online questionnaire survey proved beneficial for data collection. The limitation is the low response rate and the unavailability of suitable validated questionnaires for the given age group. The relatively high risk of a non-zero Quick-DASH score may be influenced by the inappropriate choice of questionnaire given the age of the subjects. An advantage of the data collection method used is the ability to require full completion of the questionnaire before submission, thereby eliminating the need to discard incomplete questionnaires.

CONCLUSIONS: Surgical treatment of pediatric trigger digits provides excellent outcomes, and the use of online questionnaires is suitable for health data collection. Further research is needed to validate questionnaires for pediatric age categories and subsequently to expand the concept of web-based data collection.

PMID:40874796 | DOI:10.55095/achot2024/058

J Clin Lab Anal. 2025 Aug 28:e70094. doi: 10.1002/jcla.70094. Online ahead of print.

ABSTRACT

Zhao F. Fan Z. Huang X. Role of Matrix Metalloproteinase-9 Gene Polymorphisms in Glaucoma: A Hospital-Based Study in Chinese Patients Journal of Clinical Laboratory Analysis 34 no. 3 (2020): e23105, https://doi.org/10.1002/jcla.23105 The above article, published online on 12 November 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Rong Fu; and Wiley Periodicals LLC. The retraction has been agreed due to scientific inconsistencies and major flaws in the statistical evaluation. The journal received a request to retract this manuscript initially. During investigation, the authors stated that original data is no longer available and did not provide documentation for the ethical approval process of this study. Nanchong Central Hospital could not be reached for comment. Subsequently, the authors stopped responding. The conclusions of this manuscript are considered unreliable.

PMID:40874790 | DOI:10.1002/jcla.70094

J Alzheimers Dis. 2025 Aug 28:13872877251371719. doi: 10.1177/13872877251371719. Online ahead of print.

ABSTRACT

BackgroundMild cognitive impairment represents a critical precursor stage for dementia, and the search for reliable blood biomarkers is essential for early detection and intervention.ObjectiveThis study aimed to explore the relationship between serum levels of amyloid-β (Aβ)_1-42 and p-tau181 proteins and mild cognitive impairment (MCI), providing a foundation for early detection of MCI.MethodsA total of 128 qualified subjects aged 60 years or above were enrolled according to the inclusion and exclusion criteria at Yangpu Hospital of Tongji University, Shanghai, China, between June 2021 and December 2022. Serum levels of Aβ_1-42 and p-tau181 were measured using enzyme-linked immunosorbent assay (ELISA). Participants were divided into MCI and non-MCI groups based on clinical diagnostic criteria. Statistical analyses were conducted using chi-square tests to evaluate demographic variables, while Mann-Whitney U tests were employed to compare protein levels between groups. Additionally, Spearman correlation analysis was utilized to examine the relationship between protein levels and MCI.ResultsThe MCI group exhibited significantly higher serum levels of Aβ_1-42 (U = 3959.0, p < 0.001) and p-tau181 (U = 3032.5, p < 0.001) compared to the non-MCI group. A strong positive correlation was found between Aβ_1-42 levels and MCI (r = 0.819, p < 0.001), while a moderate correlation was observed for p-tau181 (r = 0.426, p < 0.001). Aβ_1-42 demonstrated high diagnostic value (AUC = 0.975, 95%CI 0.954-0.997; p < 0.001) at its optimal cutoff 105.37 pg/mL, and p-tau181 exhibited moderate diagnostic efficacy (AUC = 0.747, 95%CI 0.658-0.836; p < 0.001) at its optimal cutoff 12.07 pg/mL.ConclusionsSerum levels of Aβ_1-42 and p-tau181 are associated with MCI and may serve as potential biomarkers for early detection.

PMID:40874783 | DOI:10.1177/13872877251371719

J Psychopharmacol. 2025 Aug 28:2698811251364389. doi: 10.1177/02698811251364389. Online ahead of print.

ABSTRACT

BACKGROUND: The optimal lumateperone dose for bipolar depression remains uncertain.

AIMS: To examine its dose-response relationship for efficacy and safety.

METHODS: We systematically searched major databases to 1 July 2025. Efficacy outcomes included change in depression severity, global illness severity, quality of life, responder, and remitter rates. Safety outcomes included all-cause dropout, discontinuations due to adverse event (AE), treatment-emergent AE, mania, suicidality, extrapyramidal symptoms, body weight, lipid profile, and fasting glucose. A one-step dose-response meta-analysis generated effect sizes, reported as standardized mean differences (SMDs) and risk ratios (RRs) with 95% confidence intervals (CIs).

RESULTS: Three randomized controlled trials involving 1454 patients showed that a 42-mg daily dose of lumateperone significantly improved depressive symptoms (SMD = -0.26; 95% CI: -0.51, -0.02), Clinical Global Impression-Bipolar-Severity (CGI-BP-S) overall bipolar illness (SMD = -0.31; 95% CI: -0.45, -0.16), CGI-BP-S bipolar depression (SMD = -0.33; 95% CI: -0.48, -0.17), quality of life (SMD = 0.22; 95% CI: 0.07, 0.36), and responder rate (RR = 1.27; 95% CI: 1.05, 1.53), but not remitter rate (1.06; 95% CI: 0.81, 1.38). Compared with placebo, discontinuation due to AE significantly increased at the 42 mg dose (RR = 3.12; 95% CI: 1.68, 5.80), but not at 28 mg (1.58; 95% CI: 0.25, 9.89). Moreover, dropout rates (42 mg RR = 1.15; 95% CI: 0.76, 1.73) and other safety outcomes did not exhibit a dose-response trend.

CONCLUSIONS: Preliminary evidence suggests that 42 mg daily of lumateperone may provide clinical benefit in bipolar depression, yet the higher rate of AE-related discontinuation warrants caution in practice. However, current data remain limited, requiring further studies to establish the optimal dosing range balancing efficacy and safety.

PMID:40874771 | DOI:10.1177/02698811251364389

Br J Soc Psychol. 2025 Oct;64(4):e70010. doi: 10.1111/bjso.70010.

ABSTRACT

The alt-right increasingly claims that White men are becoming targets of discrimination, yet few studies examine how, and for whom, perceived (reverse) discrimination manifests among White men. We address this oversight by examining rates of change in perceptions of ethnic and gender discrimination across 10 annual waves of a nationwide sample of White men (2014 to 2023; N = 20,486). Latent class growth analysis revealed that most White men (82.75% of participants) reported low and stable perceptions of discrimination over time, alleviating concerns of widespread discontent. However, we identified a Disenfranchised class (8.49%) that perceived moderate discrimination and a Radicalized class (8.76%) whose initially low levels of perceived discrimination increased markedly over time. These classes differed across socio-demographic variables, socio-political attitudes and well-being measures. We thus identify how, and for whom, perceptions of discrimination change over time among White men and how these changes undermine health and progressive social change.

PMID:40874728 | DOI:10.1111/bjso.70010

Hum Vaccin Immunother. 2025 Dec;21(1):2550102. doi: 10.1080/21645515.2025.2550102. Epub 2025 Aug 28.

ABSTRACT

Vaccine-preventable herpes zoster (HZ) poses substantial burden among Australian adults ≥50 years of age (YOA) despite available vaccination. This study aimed to understand the HZ vaccine-related preferences of adults paying out-of-pocket for HZ vaccination, to facilitate targeted recommendations by physicians and ultimately reduce disease burden. A discrete choice experiment was conducted (March-May 2023) to quantify preferences for HZ vaccine attributes among adults 50-64 YOA: HZ-naïve with selected self-reported comorbidities (n = 525; each comorbidity: n = 75), HZ-naïve without comorbidities (n = 150), and current/former HZ patients (n = 150). Each choice task comprised a “no vaccine” option and three hypothetical HZ vaccine profiles characterized by five attributes with varying levels. Attributes and levels were identified through literature review/concept elicitation/cognitive interviews/expert opinion. The attributes that most influenced HZ vaccine choice (measured by relative importance [RI]) were recommendation by government guidelines/medical societies, then HZ lifetime risk reduction, and protection duration. HZ-naïve adults with comorbidities indicated lower RI of recommendation by government guidelines/medical societies and higher RI of HZ lifetime risk reduction than other respondents. Between HZ-naïve adults without comorbidities and HZ patients, there were no significant differences in RI of each attribute. Respondents with comorbidities, whether overall or grouped by comorbidity, shared identical top three attributes. Between HZ-naïve, HZ-vaccinated adults (n = 146) and those without vaccination (n = 529), each top three attribute (recommendation by government guidelines/medical societies, HZ lifetime risk reduction, and protection duration) showed significantly different RI (p <.001). Findings elucidate the motivations underlying HZ vaccine preferences among Australian adults 50-64 YOA, guiding physician-patient conversations about HZ vaccines.

PMID:40874719 | DOI:10.1080/21645515.2025.2550102

Int Nurs Rev. 2025 Sep;72(3):e70086. doi: 10.1111/inr.70086.

ABSTRACT

AIM: To develop an original scale to measure nurses’ attitudes toward incarcerated patients and assess its psychometric properties.

METHODS: This study employed a psychometric testing approach involving test-retest design. The sample size was determined based on the rule of selecting a sample 5 to 10 times the number of scale items. The study included 672 nurses. Data were collected using the Descriptive Information Form and the Nurses’ Attitudes Toward Incarcerated Patients Scale. Content validity was determined using the Lawshe technique. Construct validity was examined through exploratory (n1 = 336) and confirmatory factor analysis (n2 = 336). Internal consistency was assessed using Cronbach’s alpha coefficient. Temporal stability was evaluated through the test-retest method conducted four weeks later (n = 32).

RESULTS: The scale consists of 12 items and was categorized into three factors-discriminatory attitudes, emotional discomfort, and patient equality-accounting for 67.6% of the variance. Items with factor loadings between 0.69 and 0.85 supported the scale’s validity. The fit indices from confirmatory factor analysis indicated an acceptable model fit. Internal consistency was confirmed with a Cronbach’s alpha of 0.84. Test-retest reliability analysis showed moderate, significant correlations among subdimensions.

CONCLUSION: The scale is valid and reliable in assessing nurses’ attitudes toward incarcerated patients. Future research should test its applicability across diverse cultural and geographical contexts to enhance generalizability.

IMPLICATIONS FOR NURSING POLICY: This study underscores the need for policies addressing nurses’ attitudes toward incarcerated patients. The developed scale may support the identification of biases and emotional discomfort, guiding targeted education and institutional interventions to promote equitable, ethical, and nonjudgmental healthcare practices.

PMID:40874718 | DOI:10.1111/inr.70086

J Magn Reson Imaging. 2025 Aug 28. doi: 10.1002/jmri.70053. Online ahead of print.

ABSTRACT

BACKGROUND: Pericardial adipose tissue (PAT) is a cardiovascular disease risk factor in children, but normative data for PAT thickness, area, and volume are lacking.

PURPOSE: To establish the percentile reference values for MRI PAT parameters in healthy Chinese children aged 3-18.

STUDY TYPE: Prospective.

SUBJECTS: 218 healthy children divided into 3-10 years (n = 125, 62 males) and 10-18 years (n = 93, 53 males).

FIELD STRENGTH/SEQUENCE: Balanced steady-state free-precession cine sequence at 3.0 T.

ASSESSMENT: PAT thickness, area and volume.

STATISTICAL TESTS: Student’s t-test, Mann-Whitney U test, Pearson correlation, the generalized additive model for location scale and shape, and intraclass correlation coefficients (ICC). A p value < 0.05 was considered statistically significant.

RESULTS: PAT volume showed no significant sex difference in the overall (boys: 32.7 ± 16.2 mL, girls: 28.2 ± 10.0 mL, p = 0.179) or childhood group (boys: 22.9 ± 7.9 vs. girls: 22.9 ± 6.6 mL, p = 0.954), but adolescent boys had a higher volume than girls (44.1 ± 15.9 vs. 36.9 ± 8.4 mL). PAT thickness at the right ventricular free wall (RVFW) was greater in boys across both age groups. PAT volume correlated strongly with age (r = 0.672) and BSA (r = 0.741). Age-specific percentile curves showed a progressive PAT volume increase with no clear plateau, with the most rapid growth between ages 10 and 14. BSA-specific curves revealed gradual PAT parameter increases, with steeper trends in boys. Good to excellent inter- and intra-observer agreement was observed for almost all PAT parameter measurements (95% CI > 0.75).

CONCLUSION: This study proposes sex-, age-, and BSA-specific reference values for pericardial adipose tissue in healthy Chinese children and showed developmental patterns and sex differences that may have potential to inform future clinical and research applications.

EVIDENCE LEVEL: 2.

TECHNICAL EFFICACY: Stage 2.

PMID:40874717 | DOI:10.1002/jmri.70053