Nevin Manimala

Med Oral Patol Oral Cir Bucal. 2023 Jun 18:25707. doi: 10.4317/medoral.25707. Online ahead of print.

ABSTRACT

BACKGROUND: To evaluate the prevalence and clinicopathological features of a large series of gingival neoplasms in Brazil.

MATERIAL AND METHODS: All gingival benign and malignant neoplasms were retrieved from the records of six Oral Pathology Services in Brazil, during a 41-year period. Clinical and demographic data, clinical diagnosis, and histopathological data were collected from the patients’ clinical charts. For statistical analysis, the chi-square, median test of independent samples and the U Mann-Whitney tests were used, considering a significance of 5%.

RESULTS: From 100,026 oral lesions, 888 (0.9%) were gingival neoplasms. There were 496 (55.9%) males, with a mean age of 54.2 years. Most cases (70.3%) were malignant neoplasms. Nodules (46.2%) and ulcers (38.9%) were the most common clinical appearance for benign and malignant neoplasms, respectively. Squamous cell carcinoma (55.6%) was the most common gingival neoplasm, followed by squamous cell papilloma (19.6%). In 69 (11.1%) malignant neoplasms, the lesions were clinically considered to be inflammatory or of infectious origin. Malignant neoplasms were more common in older men, appeared with larger size, and with a time of complaint shorter than benign neoplasms (p<0.001).

CONCLUSIONS: Benign and malignant tumors may appear as nodules in gingival tissue. In addition, malignant neoplasms, especially squamous cell carcinoma, should be considered in the differential diagnosis of persistent single gingival ulcers.

PMID:37330954 | DOI:10.4317/medoral.25707

Med Oral Patol Oral Cir Bucal. 2023 Jun 18:26015. doi: 10.4317/medoral.26015. Online ahead of print.

ABSTRACT

BACKGROUND: There are different surgical techniques to remove Oral mucoceles, including conventional surgery with scalpel, removal of the lesion with CO2 laser, and micro marsupialization. The present systematic review was conducted with the aim of comparing the recurrence rate of different surgical techniques for treatment of the oral mucoceles.

MATERIAL AND METHODS: An electronic search for randomized controlled trials published in English until September 2022 related to different surgical methods for the treatment of oral mucocele was performed in Medline/PubMed, Web of Science, Scopus, Embase and Cochrane databases. A random-effects meta-analysis was conducted to compare the recurrence rate of different techniques.

RESULTS: Among 1204 papers initially identified, after the removal of duplicate articles and screening of the titles and abstracts, fourteen full-text articles were reviewed. Seven articles comparing the recurrence rate of oral mucocele in different surgical techniques were found. Seven studies were included in qualitative studies, and five articles were included in the meta-analysis. The risk of mucocele recurrence in the micro-marsupialization technique was 1.30 times that of the surgical excision with scalpel technique, which was not statistically significant. The risk of mucocele recurrence in the CO2 Laser Vaporization technique was 0.60 times that of the Surgical Excision with Scalpel technique, which was not statistically significant.

CONCLUSIONS: The results of this systematic review showed that there is no significant difference between the recurrence rate of surgical excision, CO2 laser and marsupialization techniques for the treatment of oral mucoceles. Although more randomized clinical trials are needed for definitive results.

PMID:37330953 | DOI:10.4317/medoral.26015

Med Oral Patol Oral Cir Bucal. 2023 Jun 18:25859. doi: 10.4317/medoral.25859. Online ahead of print.

ABSTRACT

BACKGROUND: The purpose of this study is to explore whether decreasing the number of sutures can improve the quality of life after inferior third molar extraction.

MATERIAL AND METHODS: This study used a three-arm randomized design that included 90 individuals. Patients were randomized and divided into three groups-the airtight suture group (traditional), the buccal drainage group, and the no-suture group. Postoperative measurements, including treatment time, visual analog scale, questionnaire on postoperative patient quality of life, and details about trismus, swelling, dry socket, and other postoperative complications were obtained twice and the mean values were recorded. To verify the normal distribution of the data, the Shapiro-Wilk test was performed. The statistical differences were evaluated using the one-way ANOVA and the Kruskal-Wallis test with Bonferroni post-hoc correction.

RESULTS: The buccal drainage group showed a significant decrease in postoperative pain and better speech ability than the no-suture group on the 3st day, with a mean of 1.3 and 0.7 (P < 0.05). The airtight suture group also showed similar eating and speech ability, which was better than the no-suture group, with a mean of 0.6 and 0.7 (P < 0.05). However, no significant improvements were noted on the 1st and 7th days. The surgical treatment time, postoperative social isolation, sleep impairment, physical appearance, trismus, and swelling showed no statistical difference between the three groups at all measured times (P > 0.05).

CONCLUSIONS: Based on the above findings, the triangular flap without a buccal suture may be superior to the traditional group and no-suture group in less pain, and better postoperative patient satisfaction in the first 3 days and may be a simple and viable option in clinical practice.

PMID:37330952 | DOI:10.4317/medoral.25859

Med Oral Patol Oral Cir Bucal. 2023 Jun 18:25804. doi: 10.4317/medoral.25804. Online ahead of print.

ABSTRACT

BACKGROUND: The insertion torque of dental implants will depend on a combination of different factors such as bone density, the design of the implant and the drilling protocol used. However, it is not clear how the interaction of these factors affects the final insertion torque and which drilling protocol should be used in each clinical situation. The aim of this work is to analyse the influence of bone density, implant diameter and implant length on the insertion torque using different drilling protocols.

MATERIAL AND METHODS: An experimental study was carried out in which the maximum insertion torque was measured, in standardised polyurethane blocks (Sawbones Europe AB) of four densities, for M12 Oxtein dental implants (Oxtein, Spain) with diameters of 3.5, 4.0, 4.5 and 5mm, and lengths of 8.5mm, 11.5mm and 14.5mm. All these measurements were carried out following four drilling protocols, a standard protocol, adding a bone tap, cortical drill or conical drill. In this way, a total of 576 samples were obtained. For the statistical analysis, the table of confidence intervals, mean, standard deviation and covariance was carried out, in total and grouped by the parameters used.

RESULTS: The insertion torque for D1 bone obtained very high levels, reaching 77 6.95 N/cm, these values improved with the use of conical drills. In D2 bone, the mean torque obtained was 37.89± 13.70N/cm, with values within the standard. In D3 and D4 bone significantly low torques were obtained with values of 14.97± 4.40N/cm and 9.88± 4.16N/cm (p>0.001) respectively.

CONCLUSIONS: In D1 bone, conical drills must be incorporated in drilling to avoid excessive torque, while in D3 and D4 bone, these would be contraindicated, as they drastically decrease the insertion torque, which may compromise the treatment.

PMID:37330951 | DOI:10.4317/medoral.25804

Eur Spine J. 2023 Jun 18. doi: 10.1007/s00586-023-07804-3. Online ahead of print.

ABSTRACT

PURPOSE: To test whether multiple-level unilateral thoracic spinal nerves (TSN) resection can induce the initial thoracic cage deformity to cause early onset thoracic scoliosis in an immature porcine model; and 2) to create an early onset thoracic scoliosis in a large animal model that can be used to evaluate growth-friendly surgical techniques and instruments in growing spine researches.

METHODS: Seventeen one-month-old pigs were assigned to 3 groups. In group 1 (n = 6), right TSN were resected from T7 to T14 with the contralateral (left) paraspinal muscle exposing and stripping. In group 2 (n = 5), the animals were treated in the same way except the contralateral (left) side was intact. In group 3 (n = 6), bilateral TSN were resected from T7 to T14. All animals were followed up for 17-weeks. Radiographs were measured and analyzed the correlation between the Cobb angle and thoracic cage deformity. A histological examination of the intercostal muscle (ICM) was performed.

RESULTS: In the groups 1 and 2, an average 62 ± 12° and 42 ± 15° right thoracic scoliosis with apical hypokyphosis of a mean – 5.2 ± 16° and – 1.8 ± 9° were created, respectively, during 17-weeks follow up. All curves were located at the operated levels with the convexity toward the TSN resection side. Statistical analysis demonstrated that the thoracic deformities were strongly correlated with the Cobb angle. In group 3, no scoliosis was created in any animal, but an average thoracic lordosis of – 32.3 ± 20.3° was seen. The histological examination showed the ICM denervation on the TSN resection side.

CONCLUSION: Unilateral TSN resection induced the initial thoracic deformity toward the TSN resection side resulting in thoracic hypokyphotic scoliosis in an immature pig model. This early onset thoracic scoliosis model could be used to evaluate the growth-friendly surgical techniques and instruments in future growing spine researches.

PMID:37330938 | DOI:10.1007/s00586-023-07804-3

Int Urol Nephrol. 2023 Jun 18. doi: 10.1007/s11255-023-03668-0. Online ahead of print.

ABSTRACT

OBJECTIVE: To compare sperm retrieval rates between unilateral and bilateral microdissection testicular sperm extraction (MD-TESE) procedures in patients with non-obstructive azoospermia and to contribute to the literature by comparing them with literature data.

METHODS: This prospective study included 84 males with primary infertility who had azoospermic NOA, who had been married for at least one year, and whose female partners did not have a history of infertility. The study was conducted between January 2019 and January 2020. MD-TESE was applied bilaterally to 48% (n:41) (Group 1) and unilaterally to 52% (n:43) (Group 2) of the patients, and sperm retrieval rates were compared.

RESULTS: There was no statistically significant difference between Group 1 patients and Group 2 patients in terms of sperm availability (61%, 56.5%, p=0.495, respectively). In addition, while no complications were observed in unilateral MD-TESEs, 3 complications were observed in bilateral MD-TESEs.

CONCLUSIONS: In our study, it was determined that there was no significant difference between the groups in terms of sperm availability in patients with NOA. Considering the operative time and complication rates of bilateral MD-TESE in patients diagnosed with NOA and the possible MD-TESE procedures that may be performed later, we believe that unilateral MD TESE is a more preferable procedure for the patient and surgeon in this patient group.

PMID:37330932 | DOI:10.1007/s11255-023-03668-0

J Neurosci Res. 2023 Jun 18. doi: 10.1002/jnr.25205. Online ahead of print.

ABSTRACT

Elevated arterial blood pressure (BP) is a common risk factor for cerebrovascular and cardiovascular diseases, but no causal relationship has been established between BP and cerebral white matter (WM) integrity. In this study, we performed a two-sample Mendelian randomization (MR) analysis with individual-level data by defining two nonoverlapping sets of European ancestry individuals (genetics-exposure set: N = 203,111; mean age = 56.71 years, genetics-outcome set: N = 16,156; mean age = 54.61 years) from UK Biobank to evaluate the causal effects of BP on regional WM integrity, measured by fractional anisotropy of diffusion tensor imaging. Two BP traits: systolic and diastolic blood pressure were used as exposures. Genetic variant was carefully selected as instrumental variable (IV) under the MR analysis assumptions. We existing large-scale genome-wide association study summary data for validation. The main method used was a generalized version of inverse-variance weight method while other MR methods were also applied for consistent findings. Two additional MR analyses were performed to exclude the possibility of reverse causality. We found significantly negative causal effects (FDR-adjusted p < .05; every 10 mmHg increase in BP leads to a decrease in FA value by .4% ~ 2%) of BP traits on a union set of 17 WM tracts, including brain regions related to cognitive function and memory. Our study extended the previous findings of association to causation for regional WM integrity, providing insights into the pathological processes of elevated BP that might chronically alter the brain microstructure in different regions.

PMID:37330925 | DOI:10.1002/jnr.25205

J Safety Res. 2023 Jun;85:95-100. doi: 10.1016/j.jsr.2023.01.009. Epub 2023 Feb 8.

ABSTRACT

INTRODUCTION: Many studies have found that daytime running lights (DRLS) are effective in reducing daytime multi-vehicle crashes. From an Australian perspective, while studies exist using data from other jurisdictions, there has been uncertainty about how effective DRLs would be under Australian environmental conditions, which can differ from other parts of the world. In addition, in recent years DRLs have become a standard feature of many new vehicles. The objective of this work was to utilize Australian crash data to estimate the impact of DRLs on casualty crash risk reflecting the Australian crash population and local conditions. It also aimed to broadly examine the real-world crash-based effectiveness of DRLs currently present in the light vehicle fleet.

METHOD: The study utilized police reported casualty crash data for crashes that occurred during 2010-2017. The analysis used induced exposure methods, which offers the potential to assess the relationship between crash risk and DRL fitment by intrinsically controlling for confounding factors.

RESULTS: It was found that DRL fitment can reduce the overall risk of being involved in a non-nighttime multi-vehicle crash where vehicle visibility may be a factor in crash causation by a statistically significant 8.8%. Estimated crash reductions were higher at dawn or dusk and in higher speed zones.

CONCLUSION: Results provide clear evidence that mandating DRLs on all new vehicles would likely lead to reductions in the overall crash risk of the fleet through accelerating fitment through the fleet.

PRACTICAL APPLICATION: DRL fitment can reduce the overall risk of being involved in a non-night-time multi-vehicle crash where vehicle visibility may be a factor in crash causation. Governments should consider a DRL mandate on all new vehicle models, including all variants to accelerate the process of fitment through the fleet. This would likely lead to reductions in the overall crash risk of the fleet.

PMID:37330905 | DOI:10.1016/j.jsr.2023.01.009

J Safety Res. 2023 Jun;85:66-85. doi: 10.1016/j.jsr.2023.01.007. Epub 2023 Jan 31.

ABSTRACT

INTRODUCTION: The construction industry employs about 7% of global manpower and contributes about 6% to the global economy. However, statistics have depicted that the construction industry contributes significantly to workplace fatalities and injuries despite multiple interventions (including technological applications) implemented by governments and construction companies. Recently, immersive technologies as part of a suite of industry 4.0 technologies, have also strongly emerged as a viable pathway to help address poor construction occupational safety and health (OSH) performance.

METHOD: With the aim of gaining a broad view of different construction OSH issues addressed using immersive technologies, a review on the application of immersive technologies for construction OSH management is conducted using the preferred reporting items for systematic reviews and meta-analysis (PRISMA) approach and bibliometric analysis of literature. This resulted in the evaluation of 117 relevant papers collected from three online databases (Scopus, Web of Science, and Engineering Village).

RESULTS: The review revealed that literature have focused on the application of various immersive technologies for hazard identification and visualization, safety training, design for safety, risk perception, and assessment in various construction works. The review identified several limitations regarding the use of immersive technologies, which include the low level of adoption of the developed immersive technologies for OSH management by the construction industry, very limited research on the application of immersive technologies for health hazards, and limited focus on the comparison of the effectiveness of various immersive technologies for construction OSH management.

CONCLUSIONS AND PRACTICAL APPLICATIONS: For future research, it is recommended to identify possible reasons for the low transition level from research to industry practice and proffer solutions to the identified issues. Another recommendation is the study of the effectiveness of the use of immersive technologies for addressing health hazards in comparison to the conventional methods.

PMID:37330902 | DOI:10.1016/j.jsr.2023.01.007

J Safety Res. 2023 Jun;85:492-506. doi: 10.1016/j.jsr.2023.05.003. Epub 2023 May 16.

ABSTRACT

INTRODUCTION: Falling from heights can be a serious and potentially life-threatening hazard. In Malaysia, falls from heights are one of the leading causes of workplace accidents and fatalities. The Malaysian Department of Occupational Safety and Health (DOSH) reported that the year 2021 recorded an alarmingly high number of fatalities, of which the majority of the injuries were due to falls from heights.

OBJECTIVE: The purpose of this study is to understand the relationship between the different variables associated with fatal falls from heights, which will help identify potential areas to work on to prevent these types of injuries.

METHODS: The study analyzed 3,321 fatal falls from height accidents from 2010 to 2020 DOSH data. Data were cleaned and normalized to extract relevant information for analysis, with agreement on variables and reliability achieved through independent sampling.

RESULTS: This study found that general workers were the most vulnerable category to fatal falls, with a 32% yearly average, whereas supervisors were the least vulnerable, with 4%. Roofers recorded a yearly fatal falls average of 15.5%, followed by electricians with 12%. Cramer’s V results ranged from negligible, weak, and strong correlations; strong to moderate correlation between the dates of injuries and the factors used in this study, whereas the direct and root causes recorded a weak to negligible correlation with the rest of the variables.

CONCLUSIONS: This study provided a better understanding of the working conditions of the Malaysian construction industry. By analyzing fall injury patterns and uncovering the factors, direct and root causes relationship with other variables, it was clear how severe the Malaysian workplace conditions were.

PRACTICAL APPLICATIONS: This study will help better understand fatal fall injuries in the Malaysian construction industry and help develop prevention measures based on the uncovered patterns and associations.

PMID:37330899 | DOI:10.1016/j.jsr.2023.05.003