Nevin Manimala

J Patient Rep Outcomes. 2025 Jan 21;9(1):10. doi: 10.1186/s41687-025-00837-w.

ABSTRACT

BACKGROUND: Patient Reported Outcomes Measurement Information System Fatigue Short-Form (PROMIS-F-SF) is a self-administered, patient reported outcome (PRO) designed to assess fatigue in healthy and clinical populations and for tracking progress during treatment for disorders complicated with fatigue.

METHODS: Patients in the Mental Health Service Outpatient Clinics and healthy volunteers were invited to complete a survey, which included the Danish translation of the PROMIS-F-SF, the Chalder Fatigue Scale (CFS-11), and measures of depression and anxiety. We conducted a confirmatory factor analysis of the previously suggested single-factor structure of the instrument. We furthermore evaluated the construct validity of the PROMIS-F-SF by means of its relationship with the CFS-11. Finally, we evaluated the utility of the PROMIS-F-SF to identify patient-status by conducting receiver operating characteristic curves.

RESULTS: 70 healthy volunteers and 62 patients completed the instruments. The PROMIS-F-SF had a average fit to the previously reported single-factor structure. Cronbach’s alpha and McDonald’s omega showed good internal reliability (α = 0.96, ωtotal = 0.97). PROMIS-F-SF score was positively correlated with the CFS-11 (r =.76) and it correlated highly with depression (r =.78) and anxiety (r =.74) score. The optimal cut-off point in the ROC-analyses was 15, which yielded a sensitivity of 89% and a specificity of 67% in the prediction of patient status.

CONCLUSIONS: Level of fatigue among psychiatric outpatients is high in patients with psychiatric illness, compared to levels measured in healthy volunteers. The Danish PROMIS-F-SF shows good psychometric properties in this combined sample of healthy adults and psychiatric patients with non-psychotic disorders and it is recommended as PRO measure for psychiatric populations. Examination of psychometric properties in patient populations with somatic disorder could be a natural next step.

PMID:39836326 | DOI:10.1186/s41687-025-00837-w

Ophthalmol Ther. 2025 Jan 21. doi: 10.1007/s40123-024-01091-x. Online ahead of print.

ABSTRACT

INTRODUCTION: This study aimed to compare changes in retinal oxygen saturation 1 month after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) in Chinese adults with myopia using retinal oximetry.

METHODS: In this prospective, observational, single-center cohort study, Chinese adults aged 18-45 years with myopia were categorized into four groups according to spherical equivalent (SE), with 66 eyes characterized as low myopia (LM -3.00D < SE ≤ -0.50D), 68 eyes as moderate myopia (MM -6.00D < SE ≤ -3.00D), 68 eyes as high myopia (HM -9.00D < SE ≤ -6.00D), and 65 eyes as super-high myopia (SHM: SE ≤ -9.00D). The following were measured before and 1 month after FS-LASIK: SE, intraocular pressure (IOP), average keratometry (Km), and axial length (AL). Other ocular biological parameters included retinal arterial oxygen saturation (SaO₂) and retinal venous oxygen saturation (SvO₂); parameter difference values are expressed as ∆.

RESULTS: Of the 267 participants, 63.30% were female and 36.70% were male. The mean SE, AL, SaO₂, and SvO₂ were -5.93 ± 3.24 D, 26.01 ± 1.35 mm, 93.49% ± 1.67%, and 62.97% ± 4.52%, respectively. Before FS-LASIK, SaO₂ was significantly correlated with AL and SE (r_s = -0.305, P < 0.001; r_s = 0.385, P < 0.001). Significant differences were found in SaO₂ across myopia categories (P < 0.001). The changes in the retinal arterial oxygen saturation decreased significantly after FS-LASIK (F = 24.948, P < 0.001). After surgery, SaO₂ demonstrated a statistically significant but weak negative relationship with refractive correction (ΔSE) (r_s = -0.380, P < 0.001) and axial length (r_s = -0.404, P < 0.001), a significant but weak positive correlation with average keratometry cutting value (ΔKm) (r_s = 0.354, P < 0.001), and no correlation with the change in IOP (ΔIOP) (P > 0.05).

CONCLUSION: Ruling out the influence of refractive error, SaO₂ was significantly decreased 1 month after FS-LASIK, while there was no significant change in SvO₂. We conjecture that retinal amplification may affect differences in retinal oxygen saturation.

PMID:39836318 | DOI:10.1007/s40123-024-01091-x

Eur J Health Econ. 2025 Jan 21. doi: 10.1007/s10198-024-01749-0. Online ahead of print.

ABSTRACT

INTRODUCTION: Cesarean deliveries account for approximately one-third of all births in Germany, prompting ongoing discussions on cesarean section rates and their connection to medical staffing and birth volume. In Germany, the majority of departments integrate obstetric and gynecological care within a single department.

METHODS: The analysis utilized quality reports from German hospitals spanning 2015 to 2019. The outcome variable was the annual risk-adjusted cesarean section ratio-a metric comparing expected to observed cesarean sections. Explanatory variables included annual counts of physicians, midwives, and births. To account for case number-related staffing variations, full-time equivalent midwife and physician staff positions were normalized by the number of deliveries. Uni- and multivariate panel models were applied, complemented by multiple instrument variable analyses, including two-stage least square and generalized method of moments models.

RESULTS: Incorporating data from 509 integrated obstetric departments and 2089 observations, representing 2,335,839 deliveries with 720,795 cesarean sections (over 60% of all inpatient births in Germany), multivariate model with fixed effects revealed a statistically significant positive association between the number of physicians per birth and the risk-adjusted cesarean section ratio (0.004, p = 0.004). Two-stage least square instrument variable analysis (0.020, p < 0.001) and a system GMM estimator models (0.004, p < 0.001) validated these results, providing compelling evidence for a causal relationship.

CONCLUSION: The study established a robust connection between the number of physicians per birth and the risk-adjusted cesarean section ratio in integrated obstetric and gynecological departments in Germany. While the cause of the effect remains unclear, one possible explanation is a lack of specialization within these departments due to the combined provision of both obstetric and gynecological care.

PMID:39836312 | DOI:10.1007/s10198-024-01749-0

Odontology. 2025 Jan 21. doi: 10.1007/s10266-024-01052-7. Online ahead of print.

ABSTRACT

We aimed to investigate the wound-healing, antioxidant, and anti-inflammatory effects of pterostilbene (PTS) on human gingival fibroblasts (GF). Different concentrations of PTS were applied to GFs and cell viability was evaluated by MTT assay. GFs were stimulated by lipopolysaccharide (LPS) and the study groups were determined as LPS, LPS + 1 μM PTS, LPS + 10 μM PTS, and control. The most effective PTS concentrations were applied in a wound-healing model, with cell counts in the wound area assessed at 0, 24, 48, and 72 h. The effect of PTS on the release of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), basic fibroblast growth factor (bFGF), and collagen type I (COL I) was assessed at 24 and 48 h by ELISA. The data was statistically analyzed. Our results showed that PTS had a dose-dependently negative effect on wound healing and cell proliferation at 10 μM concentration, but not at low concentration (1 μM). PTS exhibited a potent anti-inflammatory effect by reducing IL-6 and TNF-α levels, while also enhancing antioxidant activity, as evidenced by increased GSH-Px levels in the LPS + 1 μM PTS group (P < 0.05). According to our results, PTS could be a potential and promising substance with anti-inflammatory and antioxidant effects on LPS-stimulated GF. Therefore our results have merit in terms of providing pioneering data for future studies.

PMID:39836293 | DOI:10.1007/s10266-024-01052-7

Eur J Clin Microbiol Infect Dis. 2025 Jan 21. doi: 10.1007/s10096-025-05041-8. Online ahead of print.

ABSTRACT

PURPOSE: Infective endocarditis (IE) can be complicated by vertebral osteomyelitis (VO). This study investigates risk factors associated with VO in patients with infective endocarditis, and 6-month mortality and relapse rates in patients with IE and concomitant VO.

METHODS: We performed a observational study in two hospitals between September 2016 and October 2022. Patients with possible or definite IE according European Society of Cardiology (2015) modified criteria were retrieved from the local endocarditis team registries. The VO diagnosis was based on radiological signs, irrespective of clinical symptoms. Multivariable logistic regression analysis was performed to identify risk factors for vertebral osteomyelitis.

RESULTS: We included 633 consecutive patients with IE. A total of 229 (36.2%) patients had prosthetic valves and 127 (20.1%) had cardiac implantable electronic devices. The most frequent causative micro-organism was Streptococcus species (217, 34.3%), followed by Staphylococcus aureus (167, 26.4%). VO was diagnosed in 73 patients (11.5%, 95% CI 9.0%-14.0%). Enterococcus spp.(OR 2.48, 95% CI 1.31-4.52) and age (OR 1.04 per year, 95% CI 1.02-1.06) were independently associated with concomitant VO. The 6-month mortality risk did not differ between patients with (16/73, 21.9%) or without (110/560, 19.6%) VO (HR 1.13, 95% CI 0.67-1.91). Relapse rate was higher in patients with VO but the difference was not statistically significant (16.1 vs. 7.5%, OR 3.62, 95% CI 0.94-13.34).

CONCLUSIONS: Twelve percent of patients with IE also had VO. Among older patients and patients with IE caused by enterococci, there should be a higher index of suspicion for vertebral infection.

PMID:39836291 | DOI:10.1007/s10096-025-05041-8

Int J Pediatr Otorhinolaryngol. 2025 Jan 9;189:112228. doi: 10.1016/j.ijporl.2025.112228. Online ahead of print.

ABSTRACT

OBJECTIVE: The primary aim of this study was to examine the relationship between parental attitudes and language development in preschool children with cochlear implants. In addition, the study aimed to examine parental attitudes in relation to socio-demographic and cochlear implant related variables.

METHODS: This study is based on the relational survey model. A total of 47 children aged 2-5 years, 23 girls and 24 boys, and one of their parents were included in the study. Test of Early Language Development Test-3-Turkish Adaptation was applied to measure the language development levels of the children. In order to determine parental attitudes, 5-point Likert-type Parental Attitude Scale consisting of 46 items was completed by the parents.

RESULTS: Democratic attitudes were found to be the most common type of parental attitude (4.33 ± 0.45). Significance was found for overprotective parental attitudes according to cochlear implant age and economic income level. Statistically significant, moderate negative correlation was found between overprotective parental attitude scores and receptive language, expressive language, and composite verbal language scores (r: 0.401; r: 0.337; r: 0.390; p < 0.05, respectively).

CONCLUSION: It was concluded that there was a relationship between overprotective parental attitude and language skills of preschool children with cochlear implants. Overprotective parental attitudes were significantly associated with cochlear implant age and economic income level, with earlier cochlear implant age and higher income correlating with less overprotection.

PMID:39832397 | DOI:10.1016/j.ijporl.2025.112228

J Med Internet Res. 2025 Jan 20;27:e65372. doi: 10.2196/65372.

ABSTRACT

BACKGROUND: With the rapid expansion of social media platforms, the demand for health information has increased substantially, leading to innovative approaches and new opportunities in health education.

OBJECTIVE: This study aims to analyze the characteristics of articles published on the “Dr Ding Xiang” WeChat official account (WOA), one of the most popular institutional accounts on the WeChat platform, to identify factors influencing readership engagement and to propose strategies for enhancing the effectiveness of health information dissemination.

METHODS: A total of 5286 articles published on the “Dr Ding Xiang” WOA from January 2021 to December 2021 were collected and analyzed. Additionally, a random sample of 324 articles was selected for detailed text analysis. Univariate analysis was conducted using the chi-square test, and multivariate analysis was performed using multivariable logistic regression.

RESULTS: In 2021, the total number of reads for “Dr Ding Xiang” articles reached 323,479,841, with an average of 61,196 reads per article. Articles exceeding 100,000 reads accounted for 33.90% of the total. Most articles were published during the time slots of 8:00-10:00 AM, 11:30 AM to 1:30 PM, and 8:30-10:30 PM. Analysis indicated that the order of publication, style of the title sentence, number of likes, number of in-views, total likes on comments, and number of replies to comments were significantly associated with an article’s number of reads. Text analysis further revealed that the article’s reasoning approaches and concluding methods also had a significant impact on readership.

CONCLUSIONS: To enhance readership and the effectiveness of health communication, health-focused WOAs should consider key factors such as optimal publication timing, engaging title design, and effective content structuring. Attention to these elements can improve user engagement and support the broader dissemination of health information.

PMID:39832357 | DOI:10.2196/65372

Clin Exp Optom. 2025 Jan 20:1-6. doi: 10.1080/08164622.2024.2447469. Online ahead of print.

ABSTRACT

CLINICAL RELEVANCE: When selecting an intervention for myopia management, parental inquiries centre around the comparative efficacy of orthokeratology versus myopic defocus spectacle lenses. This prompts an intriguing investigation into the nuanced differences between these two treatment methods.

BACKGROUND: This study aimed to compare the efficacy of spectacle lenses with highly aspherical lenslets (HAL) versus orthokeratology (Ortho-k) in controlling axial length elongation.

METHODS: Electronic medical records of children aged 8 to 14 years who were prescribed either spectacle lenses with HAL or one of the four Ortho-k brands were reviewed. The standardised axial length changes within one year were compared between HAL lenses and Ortho-k lenses with analysis of variance and multivariable regression analysis, adjusting for age, gender, and baseline spherical equivalent.

RESULTS: A total of 308 subjects were included in the analyses. The mean (standard error) of the standardised one-year changes in axial length was 0.12 ± 0.02 mm for HAL, 0.17 ± 0.02 mm for Dreamlite, 0.22 ± 0.02 mm for Alpha, 0.21 ± 0.02 mm for Lucid, and 0.18 ± 0.02 mm for Euclid user cohorts. After adjusting for covariates, the mean differences in axial length growth between HAL and both Alpha and Lucid cohorts were estimated at 0.11 mm (95% CI, 0.03 to 0.19 mm and 95% CI, 0.03 to 0.20 mm). The differences between HAL and Dreamlite or Euclid lenses were not statistically significant. Baseline spherical equivalent demonstrated a significant positive association with axial length growth in Lucid and Euclid lens users.

CONCLUSIONS: Spectacle lenses with HAL design exhibited comparable or superior efficacy in mitigating axial length growth compared to conventional Ortho-k lenses. Furthermore, orthokeratology showed greater efficacy in controlling axial length elongation among individuals with greater baseline myopia.

PMID:39832350 | DOI:10.1080/08164622.2024.2447469

Gac Med Mex. 2024;160(4):420-428. doi: 10.24875/GMM.M24000919.

ABSTRACT

BACKGROUND: The underreporting of vital statistics poses a problem for the quality of information. To address underreporting, Mexico implemented the “Intentional Search for Children Deaths” in 2002.

OBJECTIVE: To analyze trends in the underreporting of deaths in neonates and children under 5 years of age (U5) from 1992 to 2022 at the national level and by state.

MATERIAL AND METHODS: A comparative analysis was conducted between the records of the National Institute of Statistics and Geography (INEGI) and the Institute for Health Metrics and Evaluation (IHME) chosen as the gold standard after comparison with five other independent data sources. The analysis considers marginalization to describe the magnitude of underreporting.

RESULTS: From 2001 to 2022, at the national level, the underreporting gap decreased from 38.2% to 9.0% among children U5 and from 30.7% to 5.5% in the neonatal age, with heterogeneous results across states.

CONCLUSIONS: The registration of deaths has improved; however, it is crucial to identify states needing further investigation and intervention to reduce the underreporting gap in infant mortality.

PMID:39832330 | DOI:10.24875/GMM.M24000919

Gac Med Mex. 2024;160(4):399-403. doi: 10.24875/GMM.24000149.

ABSTRACT

BACKGROUND: In developed countries, most of the neurologists use pericranial nerve blocks to treat headache patients, nevertheless, the knowledge and use patterns of this technique in developing countries are unknown.

OBJECTIVE: Evaluate the knowledge and use patterns of pericranial nerve blocks in headache treatment by Mexican neurologists.

MATERIAL AND METHODS: We did a cross-sectional study, 90 Mexican neurologists completed a 26-question survey including data about sociodemographics, knowledge and patterns of use of pericranial nerve blocks. All statistical analyses were performed with R (version 4.2.0).

RESULTS: The mean age was 43.2 + 9.9 years, 55(61.1%) were men. In terms of knowledge, migraine was correctly identified by 74 participants (82.2%), while cluster headache by 65 participants (72.2%) as indications for pericranial nerve blocks. Regarding the use patterns of pericranial nerve blocks, 87(96.7%) of the neurologists had heard about the technique, but only 12(13.3%) use it in their clinical practice. In terms of education, 19(21.1%) received training during the residency and 27(30%) during the post-residency period.

CONCLUSIONS: The knowledge and use of pericranial nerve blocks for the treatment of headaches in Mexico is low. Stakeholders should develop strategies to improve the field of headache disorders in Mexico.

PMID:39832328 | DOI:10.24875/GMM.24000149