Nevin Manimala

BMC Med Educ. 2026 Feb 27. doi: 10.1186/s12909-026-08875-8. Online ahead of print.

ABSTRACT

BACKGROUND AND AIM: Academic resilience is a critical determinant of progress. Nursing students face significant stress due to both theoretical and clinical challenges. This study aimed to identify the level of academic resilience and its statistically associated factors among nursing students using self-report measures.

METHODS: In this correlational study, 375 undergraduate nursing students from three major medical universities in Tehran were selected via stratified random sampling (proportional to strata size) during April-May 2025. Data collection utilized the Academic Resilience Scale (ARS) and a researcher-developed questionnaire (validated via content and face validity). Data were analyzed using descriptive statistics, non-parametric tests, and multiple linear regression, with careful monitoring of residual diagnostics and multicollinearity (VIF).

RESULTS: The students’ mean academic resilience score was 89.89 ± 12.49, indicating a moderate-to-high level. Regression analysis identified seven significant statistical predictors: gender, health status, living situation, satisfaction with major, support resources, nutrition, and non-smoking. These factors collectively explained 19.6% (Adjusted R²) of the variance in resilience.

CONCLUSION: While several individual and social factors are associated with resilience, the cross-sectional nature of the study limits causal inferences. Interventions focusing on lifestyle and support systems may enhance resilience.

PMID:41749219 | DOI:10.1186/s12909-026-08875-8

Popul Health Metr. 2026 Feb 26. doi: 10.1186/s12963-026-00461-w. Online ahead of print.

ABSTRACT

While Poverty-Free Life Expectancy captures the average number of years individuals are expected to live above the poverty threshold, it fails to account for disparities in the distribution of these years across the population. Inspired by recent developments in the measurement of Healthy Lifespan Inequality, we propose a new indicator: Poverty-Free Lifespan Inequality. This paper introduces the formal definition of Poverty-Free Lifespan Inequality, elaborates its mathematical foundations, and discusses its policy relevance. Using Sullivan-type methods and age-specific poverty prevalence data, we derive the distribution of exit from poverty-free life and compute inequality using the Gini index. We demonstrate that Poverty-Free Lifespan Inequality provides critical insights into the heterogeneity of economic well-being over the life course.

PMID:41749198 | DOI:10.1186/s12963-026-00461-w

BMC Health Serv Res. 2026 Feb 26. doi: 10.1186/s12913-026-14059-3. Online ahead of print.

NO ABSTRACT

PMID:41749191 | DOI:10.1186/s12913-026-14059-3

BMC Med Educ. 2026 Feb 27. doi: 10.1186/s12909-026-08870-z. Online ahead of print.

NO ABSTRACT

PMID:41749190 | DOI:10.1186/s12909-026-08870-z

BMC Oral Health. 2026 Feb 26. doi: 10.1186/s12903-026-07977-5. Online ahead of print.

NO ABSTRACT

PMID:41749184 | DOI:10.1186/s12903-026-07977-5

J Cosmet Dermatol. 2026 Mar;25(3):e70755. doi: 10.1111/jocd.70755. Epub 2026 Feb 24.

ABSTRACT

BACKGROUND: Numerous retinoid‐based skincare products are available over‐the‐counter for photodamaged and photoaged skin, but are associated with objective (e.g., erythema, dryness, flaking, edema) and subjective (e.g., itching, tingling, stinging, burning) tolerability issues. A novel retinal formulation was developed using an engineered biomimetic vegan exosome as a delivery system. The formulation also contains proprietary and potent hyaluronic acid, as well as plant‐based actives commonly used in traditional herbal medicines for their anti‐inflammatory and antioxidant properties.

AIMS: Evaluate the efficacy and tolerability of this biomimetic exosome‐encapsulated retinal product for treatment of mild‐to‐moderate facial photodamage.

PATIENTS/METHODS: Twenty females aged 35 to 65 years, with Fitzpatrick skin types I‐VI, mild‐to‐moderate facial fine lines and wrinkles, and mild‐to‐moderate facial photodamage, were assessed at screening/baseline and weeks 2, 4, 8, and 12. Investigator‐ and participant‐assessed evaluations were performed at each visit. The primary objective was to demonstrate a decrease in the appearance of fine lines and wrinkles, erythema, as well as a reduction of overall facial photodamage after a 12‐week topical regimen. The secondary objective was to measure the frequency of adverse events throughout the study.

RESULTS: Statistically significant improvements in erythema, skin tone, skin texture, and lines/wrinkles were observed at all follow‐up visits, compared to baseline. At weeks 8 and 12, all participants (100%) displayed improvements in facial aesthetics. Most participants (19/20; 95.00%) were satisfied with the product and would recommend it to others. No product‐related adverse events were reported.

CONCLUSIONS: Daily use of this “hydrating retinal” improved signs of facial photodamage with none to mild signs of skin irritation.

PMID:41735774 | PMC:PMC12932260 | DOI:10.1111/jocd.70755

Sports Med Open. 2026 Feb 24;12:14. doi: 10.1186/s40798-026-00987-1. eCollection 2026 Dec.

ABSTRACT

BACKGROUND: Rugby union is a popular contact sport during which high impact collisions frequently occur. There is concern for the overall brain health of those playing the game, as concussion is a potential outcome of high impact collisions. Repeated sub-concussive collisions may compromise rugby players’ neurological integrity, but little is known about the effects on young brains. The brain is still developing during adolescence and may generally be more susceptible to injury, but minimal objective research data are available regarding head acceleration events experienced by junior players.

RESULTS: Forty-one adolescent male rugby players underwent pre- and post-season MRI scans and neuro-cognitive assessments. Participants were fitted with instrumented mouthguards to record head acceleration events experienced during the season. Post-season processing of MRI scans focused on within-subject analysis of pre- to post-season changes in white matter as measured by diffusion tensor imaging. Linear mixed models were used to investigate correlations between neurological changes and cumulative head impact loading recorded by the mouthguards. MRI results indicated a non-significant difference between pre- and post-season for data relating to brain structure and function, including white matter microstructure, in response to one season of contact training and match play for under-16 male rugby players, as measured by diffusion tensor imaging. These results held irrespective of level of exposure.

CONCLUSIONS: Our data suggest that exposure to one season of rugby does not appear to result in neurological compromise. The statistical non-significance reported for the main outcome measure also held when controlling for variables, such as training age and headgear use. Although pre- to post-season differences were statistically non-significant, the long-term effects of high exposure may be of clinical significance going forward. Further research, particularly using longitudinal designs, is needed to further elucidate the potential for microstructural neurological changes in adolescent rugby players.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40798-026-00987-1.

PMID:41733814 | PMC:PMC12932775 | DOI:10.1186/s40798-026-00987-1

Ann Noninvasive Electrocardiol. 2026 Feb 24;31(2):e70162. doi: 10.1111/anec.70162. eCollection 2026 Mar.

ABSTRACT

OBJECTIVE: This study compared the accuracy of three transthoracic echocardiographic (TTE) techniques—fractional shortening (FS), left ventricular outflow tract velocity‐time integral (LVOT/VTI), and Simpson’s method—for measuring cardiac output (CO) and stroke volume (SV) in hemodynamically unstable patients (systolic pressure < 90 mmHg), using pulse index continuous cardiac output (PiCCO) as the reference.

METHODS: A retrospective analysis was conducted involving 12 patients admitted to an Emergency Intensive Care Unit between October 2023 and October 2024, who underwent a total of 54 echocardiographic examinations. The median length of hospital stay is 14 days. CO and SV values obtained using the three TTE methods as part of routine assessment were compared with simultaneous PiCCO measurements. The median number of examinations for patients is 4. Statistical analysis was performed using correlation methods.

RESULTS: All three TTE methods demonstrated the capability to estimate CO and SV. The VTI method showed the highest overall accuracy (CO‐VTI vs. CO‐PiCCO: r = 0.950, p< 0.001). Under reduced CO conditions, correlations between echocardiographic and PiCCO‐derived measurements decreased for all methods; however, the VTI method maintained superior reliability (r = 0.606, p = 0.006). In contrast, the Simpson’s method did not accurately reflect CO in this setting (SV‐Simpson vs. SV‐PiCCO: r = 0.408, p = 0.083). Notably, the performance of the VTI method remained consistent regardless of SV or heart rate variations (SV‐VTI vs. SV‐PiCCO: overall r = 0.970; with heart rate > 100 bpm, r = 0.946; with heart rate ≤ 100 bpm, r = 0.988).

CONCLUSION: The LVOT/VTI method exhibits the highest accuracy and consistency for measuring SV and CO, making it the preferred non‐invasive technique for hemodynamic evaluation in critically ill patients.

PMID:41735802 | PMC:PMC12932115 | DOI:10.1111/anec.70162

Australas J Dermatol. 2026 Feb 24. doi: 10.1111/ajd.70076. Online ahead of print.

ABSTRACT

BACKGROUND/OBJECTIVES: The Royal Brisbane & Women’s Hospital (RBWH) in Queensland, Australia provides definitive care for all diagnosed adult patients with SJS/TEN within its catchment. In this retrospective cohort study, we identified all SJS/TEN cases at RBWH over a 10-year period. We assessed disease incidence and the relationship of 3 variables (disease severity, time taken to admission to the definitive tertiary centre and systemic immunosuppressive treatment) to the outcome of mortality.

METHODS: Patients were identified via ICU MetaVision dermatology entries, discharge coding and manual admission recording. Age, gender, culprit drug, time to definitive tertiary centre admission, total body surface area (TBSA), SCORTEN, complications, systemic therapy utilisation and mortality were recorded. Relationships between variables were analysed using Spearman’s Rank correlations and logistic regression.

RESULTS: Fifty-two cases over 10 years met inclusion criteria (37 TEN, 8 SJS/TEN and 7 SJS). Mortality (9.6%; 5 deaths) was low compared to published rates. Multivariate regression analysis revealed a significant relationship between increased SCORTEN and mortality as expected. There was no significant relationship between systemic treatment and mortality or between ‘days to definitive care’ and mortality. Modelling accounted for 44% of variance in mortality.

CONCLUSIONS: SJS/TEN incidence matched published rates. Severity of SJS/TEN and mortality were correlated. Neither systemic immune suppression nor time taken to be admitted to the definitive tertiary centre correlated with mortality. Expert multidisciplinary care in the RBWH ICU and Burns Unit is likely to contribute to the excellent mortality outcomes found. Limitations of the study included its retrospective cohort design, that it was performed in a single centre, and the relatively small sample size leading to statistically insignificant findings. Our results should bolster growing data to improve understanding of this rare but serious condition.

PMID:41736175 | DOI:10.1111/ajd.70076

Diabetol Metab Syndr. 2026 Feb 24. doi: 10.1186/s13098-026-02107-1. Online ahead of print.

ABSTRACT

OBJECTIVE: This study evaluated the effects of intensive lifestyle modification (ILM) incorporating calorie-carbohydrate restriction (CCR) with or without time-restricted feeding (IFCCR) on psychological health in adults with type 2 diabetes (T2D).

RESEARCH DESIGN AND METHODS: In a 24-week randomized controlled trial, 120 adults with T2D were allocated to CCR (n = 40), IFCCR (n = 40), or a control group (n = 40). Both intervention arms followed an energy-restricted diet (1000-1200 kcal/day), received behavioral support, and performed ≥ 150 min/week of physical activity. The IFCCR group additionally restricted eating to an 8-hour daily window. Primary and secondary outcomes were eating disorder psychopathology (EDE-Q scale) and diabetes-related distress (PAID scale), respectively.

RESULTS: Both CCR and IFCCR significantly reduced diabetes-related distress compared to the control (CCR: β = -1.80, p = 0.007; IFCCR: β = -1.78, p = 0.01). EDE-Q scores also improved significantly. Improvements were observed across EDE-Q subscales, particularly in weight and shape concern. After adjustment for changes in weight and HbA1c, reductions in PAID became non-significant, while improvements in several EDE-Q domains, particularly in the IFCCR group, remained significant. IFCCR showed numerically greater reductions than CCR, though differences were not statistically significant. The control group demonstrated minimal changes.

CONCLUSIONS: Intensive lifestyle modification incorporating CCR or IFCCR improved eating disorder psychopathology, whereas reductions in diabetes-related distress appear largely related to metabolic changes. These findings support the integration of structured dietary and behavioral interventions into diabetes care.

TRIAL REGISTRATION: This trial was registered in Iranian Registry of Clinical Trials (IRCT), IRCT20230917059447N1 (https//irct.behdasht.gov.ir/trial/72666).

PMID:41736129 | DOI:10.1186/s13098-026-02107-1