Nevin Manimala

J Mater Chem B. 2025 Nov 26. doi: 10.1039/d5tb01945a. Online ahead of print.

ABSTRACT

In this work, we have developed hierarchically porous phosphate-based glasses (PPGs) as novel materials capable of promoting wound closure and simultaneously delivering antibacterial effects at the glass-biological tissue interface. PPGs are characterised by extended porosity, which enhances the controlled release of therapeutic ions, whilst facilitating cell infiltration and tissue growth. Two series of PPGs in the systems P₂O₅-CaO-Na₂O-CuO and P₂O₅-CaO-Na₂O-Ga₂O₃ with (CuO and Ga₂O₃ 0, 1, 5 and 10 mol%) were manufactured using a supramolecular sol-gel synthesis strategy. Significant wound healing promotion (up to 97%) was demonstrated using a human ex vivo wound model. A statistically significant reduction of the bacterial strains Staphylococcus aureus and Escherichia coli was observed in both series of PPGs, particularly those containing copper. All PPGs exhibited good cytocompatibility on keratinocytes (HaCaTs), and analysis of PPG dissolution products over a 7-day period demonstrated controlled release of phosphate anions and Ca, Na, Cu, and Ga cations. These findings indicate that Cu- and Ga-loaded PPGs are promising materials for applications in soft tissue regeneration given their antibacterial capabilities, in vitro biocompatibility with keratinocytes and ex vivo wound healing properties at the biomaterial-human tissue interface.

PMID:41293853 | DOI:10.1039/d5tb01945a

Respir Care. 2025 Nov 24. doi: 10.1177/19433654251391770. Online ahead of print.

ABSTRACT

Background: Breathing frequency is a sensitive indicator of a neonate patient’s condition and a crucial parameter in the neonatal ICU (NICU). However, conventional methods require sensors to be adhered to the newborn’s sensitive skin. This study assesses a noncontact respiratory monitor, using linear frequency modulation continuous wave radar, to determine the monitor’s accuracy when used in the NICU setting. Methods: An observational study was conducted on the noncontact respiration module produced by Mindray, connected to a BeneVisionN12 patient monitor. This unit collected data on breathing frequency; at the same time, the patient breathing frequency was also being measured using a CO₂ monitor (accepted standard). Statistical analyses were performed to assess the agreement between the 2 measurements and to assess whether this noncontact monitor is sufficiently accurate for clinical use. Results: 20 neonatal patients at 2 NICUs were enrolled in the study. The mean bias between the radar-derived and CO₂-derived breathing frequency was -0.29 bpm (95% CI: -0.53 to -0.04); root-mean-square error was 2.60 bpm; concordance correlation coefficient was 0.98; and Pearson correlation coefficient was 0.98. Subgroup analyses grouped by body weight show that the technology has particularly high accuracy and clinical utility for neonates with low body weight (<1.5 kg). Conclusions: The noncontact respiration monitoring technology and module developed by Mindray showed a high degree of agreement with the CO₂ reference standard and met the standard of accuracy required for clinical use.

PMID:41293852 | DOI:10.1177/19433654251391770

J Cosmet Dermatol. 2025 Dec;24(12):e70556. doi: 10.1111/jocd.70556.

ABSTRACT

BACKGROUND: Regenerating Skin Nectar with TriHex+ Technology (Nectar 2.0; Alastin Skincare Inc., Carlsbad, CA) is a next-generation anhydrous serum reformulated with Octapeptide-45 to improve skin healing and hydration. Clinical trials and case studies assessed the safety, effectiveness, and patient satisfaction of Nectar 2.0 across various aesthetic procedures, including nonablative and ablative laser treatments, as well as microcoring technology.

METHODS: A multimodal clinical approach was used, including a randomized, double-blind, split-face study for nonablative laser procedures, an in-use study assessing skin barrier function and hydration, and case studies for ablative laser and Ellacor microcoring treatments. Investigator and subject assessments, standardized photography, and bioinstrumentation measurements (TEWL and Corneometry) were utilized to evaluate outcomes.

RESULTS: Nectar 2.0 showed superior outcomes in reducing edema and enhancing tactile roughness and fine lines in nonablative laser procedures. In ablative and microcoring treatments, faster healing, less crusting, and decreased exudation were noted, along with higher patient satisfaction compared to the control. Bioinstrumentation confirmed statistically significant improvements in skin barrier recovery and hydration over 14 days. The product was well tolerated.

CONCLUSION: Regenerating Skin Nectar with TriHex+ Technology Serum (Alastin Skincare Inc., Carlsbad, CA) has proven to be a safe and effective periprocedural skincare solution that enhances healing, improves skin quality, and increases patient satisfaction across various aesthetic procedures. Its benefits are especially significant in deeper treatments, supporting its widespread use in clinical practice.

PMID:41293824 | DOI:10.1111/jocd.70556

Behav Med. 2025 Nov 26:1-14. doi: 10.1080/08964289.2025.2590430. Online ahead of print.

ABSTRACT

Young adults attending vocational education and training schools often engage in various health risk factors, including poor dietary habits. School canteens are key settings that can promote students’ healthy food choices. This study aims to enhance the skills of vocational school canteen staff in preparing healthy food, student-centered communication, and meal presentation. A mixed-methods approach incorporated participatory action research and grounded theory (GT) analysis. The participants included 17 staff members, aged 21 to 60 years, working at three canteens that serve 557 students. Over eight months, four workshops were conducted, with staff engaging in exploratory actions between sessions to enhance student interaction and create healthy meals accommodating student preferences. Data collected from observations, field notes, and interviews were analyzed using GT, while survey data on student meal preferences were described statistically. A one-week choice architecture intervention was implemented in one canteen, and receipt data were collected to assess the impact of the new meal presentations and assessed using binomial logistic regression. The GT analysis identified the core category: “A dialogical hospitality approach facilitates reassurance.” The workshops enhanced the staff’s skills in healthy food preparation, incorporating student preferences and boosting their confidence in employing a hospitality-based dialogical approach, reassuring students to make healthy food choices. The choice architecture intervention led to a significant increase in the sales of healthy meals. This study highlights the importance of involving staff in targeted training through participatory methods to promote students’ healthier food options in vocational school settings.

PMID:41293805 | DOI:10.1080/08964289.2025.2590430

Community Dent Health. 2025 Nov 26:265539X251400580. doi: 10.1177/0265539X251400580. Online ahead of print.

ABSTRACT

Background: Oral pathology (e.g. caries, periodontal disease, edentulism) contributes to poor overall health and negatively impacts quality of life. Ageing increases susceptibility to oral diseases and poor oral health is common among older adults. In contrast, dental attendance is low among this group. This descriptive study aims to examine dental utilisation patterns among older adults in Flanders, Belgium. Methods: The study included all members from the two largest Belgian healthcare insurance funds aged 65 and older, residing in Flanders (Belgium). Descriptive and bivariate analyses were performed with dental utilisation patterns as main outcome and socio-demographic data, care dependency and oral status as covariates. Statistical analysis was performed using chi-square tests, with effect sizes calculated using Cramér’s V. Results: Data from 911,159 older adults were analysed. Between 2020 and 2022, preventive care was regularly received by 36.8% of the participants, 37.0% had no contact with an oral health professional and 21.9% only received curative care. Lower utilisation of preventive care was observed in the following groups: the oldest-old (Cramér’s V = 0.136), individuals having an increased reimbursement (Cramér’s V = 0.171), residents of long-term care facilities (Cramér’s V = 0.090), recipients of domiciliary nursing care (Cramér’s V = 0.121), and edentulous older adults (Cramér’s V = 0.362). Conclusion: A significant proportion of older adults did not attend a dentist or only received curative care. Further research is needed to investigate whether health promotion campaigns and enhanced collaboration among health professionals can motivate these older adults to engage in preventive oral care.

PMID:41293800 | DOI:10.1177/0265539X251400580

OTJR (Thorofare N J). 2025 Nov 26:15394492251391678. doi: 10.1177/15394492251391678. Online ahead of print.

ABSTRACT

Chronic pain may impede occupational participation in older adults, but links among mobility, social networks, cognitive function, and pain-related factors remain unclear. To examine the relationships among these factors in relation to occupational participation in community-dwelling older Japanese adults. In this cross-sectional study, 130 adults more than 60 answered questions about occupational participation, mobility, social networks, cognitive function, and pain. Exploratory factor analysis was used to extract latent variables representing key constructs. These were incorporated into structural equation modeling to examine their associations with occupational participation. Latent factors combining mobility and social networks (standardized coefficient: 0.75), and cognitive functions (0.35), were directly and positively associated with occupational participation, while pain-related factors were strongly negatively correlated with mobility/social networks (-0.79, -0.73) but showed no direct association with participation. Interventions addressing both physical and social function and pain-related barriers may support occupational participation in older adults.

PMID:41293790 | DOI:10.1177/15394492251391678

OTJR (Thorofare N J). 2025 Nov 26:15394492251391664. doi: 10.1177/15394492251391664. Online ahead of print.

ABSTRACT

Many parents live with enduring health conditions; however, the impact of enduring health conditions on parenting roles is poorly understood. The aim of this study was to explore the experiences, support needs and preferences of parents in Ireland living with enduring health conditions. Data were collected using a custom e-survey, developed and refined using cognitive interviewing (n = 6). Quantitative data were analysed using descriptive statistics and group comparisons, while open-ended responses were analysed using interpretative content analysis. In total, 281 eligible parents completed the survey. Participants reported considerable difficulties with parenting tasks, particularly physically demanding tasks. Participants had limited access to formal services and many reported unmet needs and dissatisfaction with current services. Enduring health conditions have a significant impact on parenting capacity. There is a need for integrated support systems to ensure parents with enduring health conditions are supported to engage in parenting occupations and roles.

PMID:41293779 | DOI:10.1177/15394492251391664

ERJ Open Res. 2025 Nov 24;11(6):00044-2025. doi: 10.1183/23120541.00044-2025. eCollection 2025 Nov.

ABSTRACT

INTRODUCTION: Nontuberculous mycobacteria (NTM) are opportunistic pathogens primarily found in soil and water. Previous studies have linked higher population density and tropical/subtropical climates with increased NTM pulmonary disease (NTM-PD). However, the effects of meteorological parameters and population density on NTM incidence in European countries remain unclear. This study aimed to assess whether climate conditions (temperature, humidity, wind speed, precipitation) and urbanisation influence the occurrence of NTM-PD.

METHODS: We conducted a case-control study evaluating meteorological conditions (in the 12 months before the first NTM isolate) and urbanisation in the municipalities of residence of 1061 adults with NTM-PD enrolled in an Italian multicentre observational study (2017-2023), compared with a random sample of 10 000 adults from the Italian population.

RESULTS: The mean age of patients was 63.1 years, and 67.2% were female. Less densely populated areas were at lower risk for NTM-PD, even after adjusting for age, sex and meteorological parameters in a multivariable mixed-effects logistic regression model (OR 0.66 (95% CI: 0.56-0.78) and 0.68 (95% CI: 0.52-0.89) for semi-urban and rural areas, respectively, versus urban areas). Hotter climates were found to be at higher risk for NTM infection (OR 1.21 (95% CI: 1.10-1.33) for each °C increase in mean annual temperature). More ventilated climates with higher precipitation were at lower risk for NTM infection (OR 0.90 (95% CI: 0.86-0.95) for each km·h^-1 increase in mean annual wind speed; OR 0.99 (95% CI: 0.99-0.99) for each 10 mm increase in mean annual precipitation).

CONCLUSIONS: Climate change, particularly global warming and urbanisation, may increase NTM infections in regions with Mediterranean and continental climates.

PMID:41293774 | PMC:PMC12643029 | DOI:10.1183/23120541.00044-2025

Int J Womens Health. 2025 Nov 20;17:4705-4715. doi: 10.2147/IJWH.S537210. eCollection 2025.

ABSTRACT

This study aimed to analyze the changes in quality of life (QOL) and emotional well-being of patients undergoing diathermy ablation for cervical intraepithelial neoplasia 2/3 (CIN). A total of 40 patients were recruited for a prospective clinical trial, and the European Organization of Research and Treatment for Cancer (EORTC)-QLQ-C30 and EORTC-QLQ-CX24 questionnaires were used to assess QOL before surgery and at 3 and 6 months postoperatively. Friedman and Wilcoxon tests were employed for statistical analysis. The results showed significant improvements in emotional functioning, body image, symptom experience, and physical functioning after surgery. Vaginal discharge and abnormal bleeding decreased over time, indicating improved symptom control. Sexual activity was temporarily affected but eventually returned to preoperative levels at 6 months after surgery. This study highlights the positive impact of diathermy ablation on psychological well-being and QOL, and emphasizes the importance of patient-centered care in CIN treatment. These survey questionnaires will eventually enable us to compare global QOL assessments between patients undergoing various cervical cancer treatments, such as trachelectomy, and those with precancerous lesions.

PMID:41293763 | PMC:PMC12642790 | DOI:10.2147/IJWH.S537210

Risk Manag Healthc Policy. 2025 Nov 19;18:3689-3712. doi: 10.2147/RMHP.S553410. eCollection 2025.

ABSTRACT

INTRODUCTION: Stroke is the second leading cause of death worldwide and ranks third as a cause of disability. The American Heart Association/American Stroke Association (AHA/ASA) recommends that treatment begin within three hours of onset with intravenous thrombolysis therapy. This scoping review aimed to identify the factors that influence the delay in intravenous thrombolysis (IVT) management in patients with ischemic stroke.

METHODS: We searched relevant studies in PubMed, ScienceDirect, and EBSCO and this review includes studies on ischemic stroke patients that analyze the factors contributing to delays in intravenous thrombolysis therapy, and it demonstrates that such delays are present in the management of IVT.

RESULTS: A total of 48 studies were included in this study. Among pre-hospital factors, the most frequently reported contributors to delays in IVT for acute ischemic stroke (AIS) patients were the use of Emergency Medical Services (EMS) (12 studies), mode of hospital presentation (12 studies), comorbidities (6 studies), symptom recognition (5 studies), and timing of event (5 studies), with several studies reporting statistically significant associations (p<0.05). Emergency department use shortened hospital admission time by an average of 30 minutes, p<0.05Regarding in-hospital delay factors, the main contributors to delays included long scan times (5 studies), low NIHSS scores (5 studies), and limited implementation of stroke programs (5 studies). Other in-hospital delay variables included delayed activation of stroke codes (3 studies), inefficiency of human resources (3 studies), suboptimal triage processes (2 studies), diagnostic process (1 study), and logistics (1 study).

CONCLUSION: Delayed thrombolysis in ischemic stroke patients is caused by various factors, both pre-hospital and in-hospital. Community education and telemedicine can reduce delays by 30%. Collaboration between the community, stroke units, medical personnel, and the government through comprehensive programs is key in accelerating stroke treatment and improving patient clinical outcomes.

PMID:41293747 | PMC:PMC12640776 | DOI:10.2147/RMHP.S553410