Nevin Manimala

J Orthop. 2025 Aug 8;69:265-270. doi: 10.1016/j.jor.2025.08.006. eCollection 2025 Nov.

ABSTRACT

INTRODUCTION: In total knee arthroplasty (TKA), positioning implants closer to the patient’s constitutional alignment improves joint line obliquity (JLO), replicating normal biomechanics and gait patterns. As a result, the joint line convergence angle (JLCA) has gained recognition as a key parameter for assessing intra-articular deformity and lateral soft tissue laxity. This study aimed to evaluate JLCA changes following robotic-assisted TKA (RA-TKA) using two alignment strategies. We hypothesized that a patient-specific alignment (PSA) strategy would result in greater JLCA correction and improved outcomes.

METHODS: A retrospective review of 98 patients (100 knees) undergoing RA-TKA was performed. Group I (50 knees) underwent mechanical alignment (MA), while Group II (50 knees) underwent PSA. JLCA was measured preoperatively and postoperatively by two independent observers. Demographic and functional data, including KOOS JR scores were collected, and statistical analyses were performed using STATA v.18.5.

RESULTS: Both groups showed significant postoperative improvement in JLCA: from 2.34° to 0.35° in the MA group, and from 2.43° to 0.29° in the PSA group. However, the degree of JLCA correction did not differ significantly between groups (p = 0.285). KOOS JR scores improved similarly in both groups, with no significant differences at 1-year follow-up.

CONCLUSIONS: Robotic-assisted TKA significantly improved JLCA regardless of alignment strategy. Patient-specific and mechanical alignment approaches yielded comparable radiographic and functional outcomes.

LEVEL OF EVIDENCE: Level IV.

PMID:40832623 | PMC:PMC12358653 | DOI:10.1016/j.jor.2025.08.006

J Orthop. 2025 Aug 9;69:283-287. doi: 10.1016/j.jor.2025.08.003. eCollection 2025 Nov.

ABSTRACT

BACKGROUND: Osteochondral defects of the knee are a frequent cause of pain that often require surgical intervention. Restorative procedures such as osteochondral autograft transplantation (OAT) and osteochondral allograft transplantation (OCA) aim to replace cartilage lesions with healthy autologous tissue or cadaveric tissue from the distal femur, respectively. Osteochondral graft donor sites are selected to optimize donor-recipient site congruity by assessing factors such as surface topography, cartilage thickness, and contact pressures. However, few studies have evaluated subchondral bone mineral density (BMD) when selecting an osteochondral graft donor site.

PURPOSE: To examine bone morphology and characterize variation in subchondral BMD of the human distal femur.

STUDY DESIGN: Descriptive Laboratory Study.

METHODS: 18 human cadaveric distal femurs were utilized in the current study. All soft tissue and ligaments of the distal femur were removed. Dual-energy X-ray absorptiometry (DEXA) scans were performed on each femur to determine BMD of five regions of interest (ROI). ROIs included the entire distal femur, medial condyle, lateral condyle, posterior condyles, and trochlea. Subsequently, 90 osteochondral bone plugs (10 mm diameter, 10 mm depth) were harvested collectively from the medial and lateral trochlea of included specimens. DEXA scans of each osteochondral graft were then performed. Statistical analysis was performed via Welch Two-Sample t-test. Significance was defined as p < 0.05.

RESULTS: All specimens were included for analysis. There were no significant differences in the dimensional characteristics or BMDs of corresponding ROIs across distal femurs. There was no significant difference in the BMD of the medial condyle compared to the lateral condyle, and the posterior condyle compared to the trochlea. Also, there was no significant difference in BMD of grafts extracted from the medial and lateral trochlea (all p > 0.05).

CONCLUSION: No significant difference was found in BMD between the medial and lateral condyles, trochlea and posterior condyles, or osteochondral grafts harvested from the medial and lateral trochlear ridges of the distal femur.

CLINICAL RELEVANCE: Similar BMD between common osteochondral donor and recipient sites may provide surgeons with added confidence that fewer adjustments must be made to optimize congruity with respect to bone density.

PMID:40832622 | PMC:PMC12359186 | DOI:10.1016/j.jor.2025.08.003

Demogr Res. 2023 Jul-Dec;49(33):865-904. doi: 10.4054/demres.2023.49.33. Epub 2023 Nov 16.

ABSTRACT

BACKGROUND: The distribution of job tenure plays an important role in demography, economics, and sociology. Job tenure in a labor market is analogous to age in a population. Demographers have used indirect methods based on variable-r methods to estimate parameters for life table models. The variable-r method can also be employed to estimate the parameters of a job tenure table model that yields the expected length of job tenure and related measures.

METHODS AND DATA: Only two retrospective surveys of current employee tenure lengths and a count of between-survey hires are required to estimate the parameters of a period tenure table using the variable-r method. Tenure-specific sources of decrement allow an analyst to estimate the parameters of multiple-decrement tenure tables and associated single-decrement tenure tables that isolate the proximate contribution of a specific decrement to the job separation process. I illustrate and evaluate the method using publicly available US data.

RESULTS: Variable-r methods generated reasonable parameter estimates: The expected job tenure was 2.48 years at 2002-2004 decrement rates. Multiple-decrement methods can estimate the fraction of employment relationships that end via job displacement. Cause-deleted tenure tables can capture the static effect of eliminating a particular risk to the population of employment relationships.

CONTRIBUTION: Arthur and Vaupel (1984) provide a framework for studying nonstable populations that subsume the variable-r relations that I utilize in this work. Vaupel had an interest in formal demography throughout his life but started his academic career in business statistics. This paper combines those interests.

PMID:40832619 | PMC:PMC12360750 | DOI:10.4054/demres.2023.49.33

Prev Med Rep. 2025 Aug 7;57:103196. doi: 10.1016/j.pmedr.2025.103196. eCollection 2025 Sep.

ABSTRACT

OBJECTIVES: Veterinarians are observed to be vulnerable to various occupational hazards due to the nature of their work. Veterinary students face an even greater risk, as their academic and professional training in animal handling is still incomplete. Therefore, this study aimed to investigate the prevalence of and factors associated with occupational hazard exposure among undergraduate veterinary students in Bangladesh.

METHODS: A cross-sectional study was conducted from August 25, 2024 to September 10, 2024 among 330 veterinary students from two conveniently selected institutions in Bangladesh. Third- to fifth-year students were invited to participate through a self-administered questionnaire. Statistical analyses were performed with the chi-square test and logistic regression to investigate the associated factors.

RESULTS: Overall, 62.4 % students reported exposure to occupational hazards. Physical hazards were the most frequently reported (44.2 %), followed by chemical (19.4 %), psychosocial (17.6 %), biological (13.6 %), and ergonomic hazards (9.1 %). Senior-level students reported a higher exposure to hazards than 3rd year students (4th year: adjusted odds ratio [AOR] = 2.45, 95 % confidence interval [CI] = 1.04, 5.74; 5th year: AOR = 2.43, 95 % CI = 1.30, 4.55). Those who received formal training outside the curriculum were more likely to report exposure (AOR = 2.49, 95 % CI = 1.16, 5.36). Moreover, a higher knowledge level was a protective factor for occupational hazards (AOR = 0.56, 95 % CI = 0.31, 0.99).

CONCLUSION: Our findings emphasize the need for training programs both within and beyond the curriculum to improve students’ practical skills, particularly among senior-level students involved in clinical duties.

PMID:40832616 | PMC:PMC12359168 | DOI:10.1016/j.pmedr.2025.103196

Ther Innov Regul Sci. 2025 Aug 19. doi: 10.1007/s43441-025-00845-4. Online ahead of print.

ABSTRACT

BACKGROUND: Tazemetostat, an EZH2 inhibitor approved for select sarcomas and lymphomas, has limited post-marketing safety data despite growing clinical use. This study aimed to evaluate the real-world safety profile of tazemetostat using data from the FDA Adverse Event Reporting System (FAERS) between Q1 2020 and Q4 2024.

METHODS: Reports listing tazemetostat as the primary suspect drug were extracted, deduplicated, and analyzed using four disproportionality methods. Preferred Terms (PTs) were standardized via MedDRA 26.1 and mapped to System Organ Classes (SOCs). Subgroup analyses and time-to-onset assessments were performed across age, sex, and reporter types.

RESULTS: A total of 1,179 adverse event reports associated with tazemetostat were retrieved from FAERS. Disproportionality analysis revealed significant signals across gastrointestinal, hematologic, and general systemic domains. Fatigue, nausea, decreased appetite, and anemia were the most commonly reported events. Significantly, taste disorder and somnolence were identified as new signals that were not present in FDA labeling. Most events occurred within the first 60 days of treatment, with similar onset patterns across demographic subgroups.

CONCLUSION: This FAERS-based analysis confirmed known toxicities and identified novel signals associated with tazemetostat in routine clinical use. These findings underscore the importance of continued pharmacovigilance to detect emerging adverse events and inform real-world monitoring strategies.

CLINICAL TRIAL NUMBER: Not applicable.

PMID:40830697 | DOI:10.1007/s43441-025-00845-4

Cult Med Psychiatry. 2025 Aug 19. doi: 10.1007/s11013-025-09940-5. Online ahead of print.

ABSTRACT

Prolonged grief disorder (PGD) was added to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) in 2022. It proposed that after persisting in an acute manner for more than a year, grief becomes pathological. This article explores cultural challenges to the application of the DSM-5-TR in diagnosing PGD and discusses culturally sensitive approaches to addressing grief pathology. We have identified three key dimensions that present cultural challenges to the PGD diagnosis: duration of mourning, intensity of emotions, and anomalous cognitions. While the DSM-5-TR clarifies that PGD symptoms must exceed contextual norms (Criterion E), here we critically assess the relevance and limitations of PGD from a cultural perspective and discuss the role rituals and traditional healing might play in grief interventions.

PMID:40830691 | DOI:10.1007/s11013-025-09940-5

J Appl Genet. 2025 Aug 20. doi: 10.1007/s13353-025-01001-2. Online ahead of print.

ABSTRACT

Senataxin, an RNA/DNA helicase, is a key protein providing genome stability and one of the best characterized R-loop-binding factors playing an important role in transcription and DNA repair processes. Pathogenic SETX gene variants cause autosomal recessive spinocerebellar ataxia with axonal neuropathy (AOA2, MIM #606002) and autosomal dominant juvenile amyotrophic lateral sclerosis (ALS4, MIM #602433), rare neurodegenerative disorders characterized by juvenile onset of progressive cerebellar ataxia, axonal sensorimotor peripheral neuropathy, combined upper and lower motor neuron symptoms, and increased serum alpha-fetoprotein (AFP; specific for AOA2). We report two cases of adult patients presenting with cerebellar syndrome, scanned speech, and exercise intolerance which started in the second/third decade of life and were followed by muscle weakness and impaired gait coordination. Whole exome sequencing (WES) was performed to analyze single nucleotide and copy number variants. A decreased coverage of a genomic region of around 16 kb on chromosome 9 (chr9:132,295,852-132,311,876), suggesting a deletion encompassing 5 exons of the SETX gene (exons 11-15, NM_015046.7) was observed. This homozygous SETX (9q34.13) deletion leads to a frame shift and consequently truncation of the helicase domain in the protein. Loss-of-function variants in the SETX gene are known to be pathogenic. Statistical analysis of NGS data from the Polish population identified a few heterozygous carriers, suggesting its region-specific origin.

PMID:40830689 | DOI:10.1007/s13353-025-01001-2

Discov Ment Health. 2025 Aug 19;5(1):127. doi: 10.1007/s44192-025-00269-4.

ABSTRACT

Mental health in childhood brings up the state of a child’s emotional and psychological well-being, encompassing their ability to navigate challenges, form relationships, and get by stressors, laying the foundation for their future mental and emotional resilience. This cross-sectional study, conducted between December 1, 2023, and February 1, 2024, intended to identify the substantial risk factors of children’s mental health (CMH) development in Bangladesh. The data were collected using two-phase sampling through a questionnaire filled out by trained interviewers. To test the normality of the dependent variable, Kolmogorov-Smirnov and Shapiro-Wilk tests were applied, and the tests confirmed the non-normality assumption (P < 0.05) of the study variables. Mann-Whitney U and Kruskal-Wallis H tests were applied as bivariate analyses, and generalized gamma regression was performed to determine the significant risk factors of mental development. The odds ratio (OR) and 95% confidence interval (CI) were the measuring parameters of the risk factors of CMH. The results revealed that early childhood disease (OR 0.9537, CI 0.93-0.97, p = 0.000769), monthly family income (OR 0.9247, CI 0.87-0.98, p = 0.015046), and providing supplementary food sometimes (OR 1.0583, CI 1.02-1.09, p = 0.001819) were significant socio-economic factors influencing CMH. Among demographic factors, gender (OR 0.9693, CI 0.94-0.99, p = 0.025684) and division (OR 1.0496, CI 1.007-1.09, p = 0.021429) showed significant associations. Additionally, child opportunities to play outside (OR 0.9451, CI 0.91-0.98, p = 0.007235), which may be shaped by cultural attitudes toward child supervision, gender roles, and norms around outdoor activity, was also found to be significantly associated with children’s mental health. The results of this study would assist policymakers to take initiatives in mental health development including the funding of interventions so that children in Bangladesh can achieve their developmental potential.

PMID:40830687 | DOI:10.1007/s44192-025-00269-4

Sci Rep. 2025 Aug 20;15(1):30486. doi: 10.1038/s41598-025-15256-6.

ABSTRACT

In the recent years, there has been a notable shift in the landscape of statistical and data science research, with increasing attention directed toward the development of advanced probability distributions aimed at addressing the challenges posed by medical and health-related data. In response to this need, the present study introduces a novel probability distribution model termed as the Exponentiated Odd Lomax Power Lindley distribution constructed by embedding the Power Lindley distribution within the Lomax family framework through the T-X transformation technique. This article delves into the application of probability distributions in medical data analysis, with a special focus on their role in understanding and managing the COVID-19 data. A comprehensive theoretical investigation is conducted, deriving key statistical properties including the probability and cumulative distribution functions, reliability functions, moments, moment generating function, order statistics, and entropy measures. To ensure accurate parameter estimation, several estimation methods are employed and rigorously compared through simulation studies. The real-world applicability of the developed distribution is illustrated through the modelling of COVID-19 datasets, where its performance is evaluated against a range of well-established probability distribution models. Empirical findings demonstrate the superior adaptability and modelling accuracy of the distribution while analysing real-world datasets.

PMID:40830631 | DOI:10.1038/s41598-025-15256-6

Sci Rep. 2025 Aug 19;15(1):30423. doi: 10.1038/s41598-025-15428-4.

ABSTRACT

High-sensitivity C-reactive protein (hs-CRP) has been associated with prognosis in acute myocardial infarction (AMI) patients, but data on its role in elderly individuals remains limited. This single-center, retrospective study included 590 elderly AMI patients, who were stratified into three groups based on hs-CRP tertiles. The incidence of adverse in-hospital events increased progressively across higher hs-CRP tertiles (17.2%, 25.5%, and 48%, P<0.001). Notably, patients who experienced these events had significantly higher hs-CRP levels compared to those without adverse outcomes (7.04 [2.38, 20.00] vs. 2.59 [1.06, 6.07], P<0.001). Multivariate logistic regression identified hs-CRP as an independent predictor of in-hospital outcomes in elderly AMI patients (Q3: OR 2.21, 95% CI 1.23-3.97, P=0.008). The area under the curve (AUC) for hs-CRP’s predictive accuracy was 0.712 (95% CI 0.664-0.755, P<0.001). Furthermore, integrating hs-CRP into an established risk factor model significantly improved both reclassification and discrimination (Continuous NRI: 0.461, 95% CI 0.292-0.631, P<0.001; IDI: 0.046, 95% CI 0.025-0.067, P<0.001), although it did not substantially enhance the C-statistic (0.867 (95% CI 0.831-0.895, P<0.001) vs. 0.876 (95% CI 0.841-0.905, P<0.001) , P=0.183). These findings suggest that hs-CRP is a reliable and practical biomarker for predicting poor prognosis in elderly patients with AMI.

PMID:40830625 | DOI:10.1038/s41598-025-15428-4