Nevin Manimala

Foot Ankle Surg. 2025 Jan 3:S1268-7731(25)00005-0. doi: 10.1016/j.fas.2025.01.004. Online ahead of print.

ABSTRACT

BACKGROUND: The optimal treatment of Osteochondral lesion of the talus (OLT) for subchondral bone cysts (SBCs) has not been finalized. The purpose of this systematic review and meta-analysis was to define whether OLT with small SBCs will affect the clinical outcomes of OLTs after arthroscopic microfracture.

METHODS: We searched the Embase, Cochrane Library and PubMed databases up to May 13, 2024 for eligible comparative studies. The methodological index for non-randomized studies (MINORS) were used for assessing the methodological quality. The Review Manager 5.4 software was applied to perform the statistical analysis.

RESULTS: A total of 4 studies involving 257 patients were included in this meta-analysis. No significant difference was noted in American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale, the improvement of Foot and Ankle Ability Measure- Activities of Daily Life (FAAM-ADL) and Foot and Ankle Ability Measure (FAAM-SP), Tegner Score and Visual Analogue Scale (VAS) between the cyst and noncyst group. The noncyst group was statistically significant in term of FAAM-ADL and FAAM-SP. Radiological outcomes in the cyst group had improved after arthroscopic microfracture.

CONCLUSIONS: Based on the results of the present study, there are no clinical differences with the technique of bone marrow stimulation between simple and cystic ostechondral lesions of talus with depth smaller than 5-6 mm, with respect to the medial part of talus and referring to age younger than 40 years old.

LEVEL OF CLINICAL EVIDENCE: Level 3.

PMID:39765451 | DOI:10.1016/j.fas.2025.01.004

J Voice. 2025 Jan 6:S0892-1997(24)00467-3. doi: 10.1016/j.jvoice.2024.12.032. Online ahead of print.

ABSTRACT

OBJECTIVE: Current literature involving gender-affirming voice therapy (GAVT) for transgender and nonbinary (TGNB) individuals is limited. This study describes treatment duration and satisfaction at a single institution.

STUDY DESIGN: Retrospective cohort.

SETTING: Tertiary laryngology center.

METHODS: TGNB patients receiving gender-affirming treatment were identified.

DATA COLLECTED: age, sex assigned at birth, gender identity, race, ethnicity, number/frequency of GAVT, Voice Handicap Index-10 (VHI-10), Trans Women Voice Questionnaire (TWVQ) (as appropriate), Gender Congruence Scale (GCS), patient and speech language pathologist (SLP) assessment of treatment satisfaction, and surgical data. Descriptive statistics were reported.

RESULTS: 82 TGNB patients [trans female (n=65), trans male (n=5), nonbinary (n=12)] sought gender-affirming voice care. Mean age was 33.6±10.7years. Majority were assigned male at birth (n=71). Mean presentation VHI-10 was 15.7±8. In the first year of treatment, patients had mean 5.7±3.1 (range 1-16, median 5) GAVT sessions, biweekly (n=36, 44%) or monthly (n=12, 15%). 62% (n=51) of patients were satisfied/very satisfied, 23% (n=19) fairly satisfied, and 10% (n=8) unsatisfied with GAVT outcomes. SLP impression of GAVT outcome was more variable: 15% (n=12) completely met voice goals and 11% (n=9) had excellent GAVT response. Most patients (39%, n=32) were making good progress, with further treatment recommended. SLP referred 11% (n=9) to the laryngologist for surgery consideration; 9% (n=6) underwent Wendler glottoplasty.

CONCLUSIONS: Voice therapy is integral to gender-affirming voice care and often requires more sessions (mean 5.7) than the literature-reported average (∼4) for other voice diagnoses. Appropriate expectations should be set for patients, treating clinicians, and third-party payors about the increased anticipated duration of GAVT.

PMID:39765446 | DOI:10.1016/j.jvoice.2024.12.032

J Hand Ther. 2025 Jan 6:S0894-1130(24)00061-9. doi: 10.1016/j.jht.2024.08.004. Online ahead of print.

ABSTRACT

BACKGROUND: Shoulder pain is a major musculoskeletal problem after wrist-hand immobilization. There is limited evidence regarding the relationship of kinesiophobia or pain catastrophizing with shoulder pain and disability after wrist-hand injury.

PURPOSE: To explore associations between kinesiophobia and pain catastrophizing with ipsilateral persistent shoulder disability in patients with wrist-hand injury after 6 months.

STUDY DESIGN: Prospective study.

METHODS: Participants aged ≥18 years referred to hand therapy after wrist-hand injury requiring wrist-hand immobilization were recruited and completed the Numeric Pain Scale, Shoulder Pain and Disability Index, Pain Catastrophizing Scale (PCS), and Tampa scale for kinesiophobia (TSK) at baseline, after an immobilization period, and after 6 months.

RESULTS: A total of 107 patients were included in the study. Scaphoid fractures were found in 49 (45.8%) of patients, and 58 (54.2%) had distal radius fractures. For each week of increased time spent in immobilization, the Shoulder Pain and Disability Index score increased by 10.2 points, 95% confidence interval (CI) [6.76, 13.57], with higher levels of immobilization being associated with increased shoulder pain and disability. The baseline TSK score was 17.4 and 11.2 at follow-up. The PCS score was initially 14.8 and decreased to 9.3 at follow-up. The addition of TSK and PCS to the predictive model led to a statistically significant increase in R² of 0.163, F(2,100) = 47.471, p < 0.001.

CONCLUSIONS: The duration of wrist immobilization following an injury may play a crucial role in the level of shoulder disability experienced at the 6-month mark post-injury. This shoulder disability may be influenced by factors such as fear of movement.

PMID:39765429 | DOI:10.1016/j.jht.2024.08.004

J Hand Ther. 2025 Jan 6:S0894-1130(24)00168-6. doi: 10.1016/j.jht.2024.12.001. Online ahead of print.

ABSTRACT

BACKGROUND: The effect of conservative treatments on sleep quality in carpal tunnel syndrome is unclear.

PURPOSE: Comparing the effect of splinting and kinesiotaping in carpal tunnel syndrome on functional status, pain, grip strength, nerve cross-sectional area and sleep quality.

STUDY DESIGN: Randomized controlled study.

METHODS: The participants were divided into three groups. One group was given night splint and nerve tendon gliding exercises, one group was given kinesiotaping and nerve tendon gliding exercises and one group was given only nerve tendon gliding exercises. The participants was evaluated with Visual Analog Scale (VAS), Boston Carpal Tunnel Syndrome Questionnaire, Pittsburgh Sleep Quality Index (PSQI), Jamar hand dynamometer, ultrasonography by a blind investigator in the treatment group at baseline and at 3 months.

RESULTS: A total of 90 participants, 53 women and 37 men, with a mean age of 47.6±10.5, participated in the study. The decrease in Boston symptom severity and functional status scores was higher in the kinesiotaping group than in the splint group (Cohen’s d=-0.78). A statistically significant decrease was found in PSQI scores in all groups (p<0.05). A statistically significant decrease was found in the PSQI total and sleep duration component score in the kinesiotaping group compared to the splint group and the exercise group (Cohen’s d=0.69).

CONCLUSIONS: Both splinting and kinesiotaping are effective on pain, functional status, hand grip strength and median nerve cross-sectional area. This effect is greater in kinesiotaping. Splinting, kinesiotaping and nerve tendon gliding exercises treatments are effective in improving sleep quality, but this effect is greater in kinesiotaping.

CLINICALTRIALS: gov ID: NCT06514625.

PMID:39765425 | DOI:10.1016/j.jht.2024.12.001

Br J Anaesth. 2025 Jan 6:S0007-0912(24)00724-4. doi: 10.1016/j.bja.2024.11.033. Online ahead of print.

NO ABSTRACT

PMID:39765404 | DOI:10.1016/j.bja.2024.11.033

Pancreatology. 2025 Jan 1:S1424-3903(24)00848-2. doi: 10.1016/j.pan.2024.12.020. Online ahead of print.

ABSTRACT

BACKGROUND/OBJECTIVES: Loss-of-function chymotrypsin C (CTRC) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5′ upstream region that includes the promoter might affect CTRC expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.

METHODS: We analyzed ∼1.4 kb of the 5′ region of the CTRC gene in 293 patients with chronic pancreatitis of alcoholic and non-alcoholic etiology and 402 controls from the Hungarian National Pancreas Registry by direct Sanger sequencing.

RESULTS: We identified 14 gene variants, which included 11 novel variants and 3 previously reported variants. When allele frequencies were considered, none of the variants were significantly overrepresented in CP cases or controls. Genotype distribution of the frequently occurring variant c.-913A>G showed a statistically significant enrichment of the homozygous GG genotype (versus the AA genotype) in CP cases versus controls (OR 1.67, 95 % CI 1.2-2.4, P 0.0053). However, the disease association was driven by the linkage disequilibrium with the known CTRC risk variant c.180C>T.

CONCLUSIONS: We found no significant association between variants in the 5′ region of the CTRC gene and CP risk.

PMID:39765393 | DOI:10.1016/j.pan.2024.12.020

Arab J Gastroenterol. 2025 Jan 6:S1687-1979(24)00127-8. doi: 10.1016/j.ajg.2024.11.003. Online ahead of print.

ABSTRACT

BACKGROUND AND STUDY AIMS: This study was aimed to validate the correlation of circular RNA HIPK3 (CircHIPK3) expression in serum and tissues with the progression of liver fibrosis (LF) and liver cirrhosis (LC).

PATIENTS AND METHODS: Serum CircHIPK3 expressions were detected in 120 patients with LF/LC and 120 healthy controls (HCs). CircHIPK3 expression in tissues was detected in 120 fibrotic liver tissues and compared to 57 healthy liver tissues from patients with hepatic hemangioma. The expressions of CircHIPK3, TGF-β1, and CollA1 mRNAs were assessed by qRT-PCR. The Child-Pugh (CP) classification was used to evaluate disease severity. The Ishak score was applied to assess LF/LC in liver biopsy samples. The levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also investigated. Receiver operating characteristic (ROC) analysis was conducted to assess the diagnostic value of CircHIPK3 expressions in serum and tissues.

RESULTS: CircHIPK3 expressions in serum and tissues were upregulated in patients with LF/LC compared to HCs. The patient group comprised 39 with CP class A (CP-A), 45 with CP class B (CP-B), and 36 with CP class B (CP-C). Patients with CP-C had markedly increased serum and local CircHIPK3 levels compared to those with CP-B and CP-A. Patients with CP-B showed upregulated CircHIPK3 expressions in serum and tissues compared to CP-A with statistical significance. ROC curve analysis indicated that CircHIPK3 expressions in both serum and tissues may serve as potential diagnostic indicators for the progression of LF/LC. Moreover, serum CircHIPK3 expressions were positively associated with serum ALT and AST levels. Tissue CircHIPK3 expressions were positively correlated with tissue TGF-β1 and CollA1 mRNA expressions. In addition, both serum and tissue CircHIPK3 expressions were positively associated with the Ishak score.

CONCLUSIONS: For the first time, this study demonstrated the positive correlation of CircHIPK3 expressions in both serum and tissues with the progression of LF/LC, regardless of etiology. CircHIPK3 might play a significant role in the development of LF/LC and act as a potential therapeutic target for these conditions.

PMID:39765392 | DOI:10.1016/j.ajg.2024.11.003

Nutr Metab Cardiovasc Dis. 2024 Dec 25:103842. doi: 10.1016/j.numecd.2024.103842. Online ahead of print.

ABSTRACT

BACKGROUND AND AIM: The relationship between socio-economic inequalities (SEIs) and early life malnutrition with muscle health remains unclear. This study aims to examine the effects of SEIs and early life exposure to famine on relative hand grip strength (rHGS).

METHODS AND RESULTS: We analyzed data of 37,008 individuals from the China National Health Survey. SEI were assessed using the Population Attributable Fraction (PAF), the Relative Index of Inequality (RII), and the Slope Index of Inequality (SII). The propensity score matching and cohort size shrinkage index were used to examine the impact of famine on low rHGS. The RII for education- and income-based SEI was 1.17 (95 % CI: 1.09 to 1.27) and 1.20 (95 % CI: 1.11 to 1.29) in men, and 1.20 (95 % CI: 1.12 to 1.28) and 1.06 (95 % CI: 0.99 to 1.13) in women, respectively. The SII per 100,000 persons for education- and income-based SES was 609 (207-1011) and 912 (481-1343) in men, compared to 909 (580-1237) and 218 (-134 to 570) in women. The stimulation analysis showed that both RII and SII increased with a higher proportion of individuals at the highest income level, exhibiting a sex-differential pattern. Early-life exposure to famine was significantly associated with decreased rHGS. The PAFs of low rHGS attributed to famine ranged from 2.5 % to 4.6 % in men and 5.8 %-9.6 % in women.

CONCLUSIONS: SEI and early life malnutrition increased the risk of low rHGS. These findings are valuable for informing policymaking aimed at healthy aging.

PMID:39765377 | DOI:10.1016/j.numecd.2024.103842

J Pediatr Surg. 2024 Dec 31:162128. doi: 10.1016/j.jpedsurg.2024.162128. Online ahead of print.

NO ABSTRACT

PMID:39765367 | DOI:10.1016/j.jpedsurg.2024.162128

Dent Mater. 2025 Jan 7:S0109-5641(24)00366-X. doi: 10.1016/j.dental.2024.12.010. Online ahead of print.

ABSTRACT

OBJECTIVE: To analyze the impact of the translucency/opacity of two commercial brands of resin cements and different translucency of lithium disilicate on the masking ability of saturated substrates.

METHODS: 120 samples (n = 5) were prepared using 0.5 mm lithium disilicate (IPS e.max CAD) in three translucencies (HT, MT, LT). These were cemented onto A1 and A4 resin substrates using two brands of resin cements: Allcem Veneer (FGM) in Trans (T) and Opaque White (OW), and Variolink Esthetic LC (Ivoclar Vivadent) in Neutral (N) and Light+ (L+), with a thickness of 100 µm. Color analysis was performed using reflectance measurements with a CM-3700d spectrophotometer (Konica Minolta). The Relative Translucency Parameter (RTP) and the Color Difference (∆E00) were calculated using the CIEDE2000 formula, with Perceptibility Threshold (PT) of ∆E00 = 0.8 and Acceptability Threshold (AT) of ∆E00 = 1.8. Statistical analyses were conducted using three-way ANOVA followed by Tukey’s tests (α=0.05).

RESULTS: For ∆E00 between substrates saturation (A1 VS A4), the isolated fixed factors and their interaction were statistically significant (p < .001) and showed ∆E00 > 1.8 for all groups. ∆E00 between resin cements colors of the same brand reveals significant factors (p < .001) but a non-significant statistical interaction (p = 0.072). The RTP of the resin cement were N(47.64) > T(47.47) > Ow(42.02)>L+ (23.39). For restorative set RTP, a non-significant interaction (p > 0.05) and groups cemented with L+ reveal lower RTP values than those cemented with OW.

SIGNIFICANCE: The ceramic translucency, the resin cement brand and color were influential on ability to mask substrates of different saturations. The opaquest resin cement contributes to reduce the influence of the ceramic on restoration final color. Resin cement brand and color influences restoration esthetics.

PMID:39765364 | DOI:10.1016/j.dental.2024.12.010