Nevin Manimala

BMC Public Health. 2024 Dec 23;24(1):3563. doi: 10.1186/s12889-024-20992-x.

ABSTRACT

BACKGROUND: Digital leadership might be an innovative approach to decreasing the elevated rates of anxiety and depression symptoms among medical professionals, while also enhancing their psychological well-being. This emerging pathway may offer promising strategies to support the mental health of medical professionals. This study seeks to investigate the association among digital leadership, organizational identity, family-work conflict, and anxiety and depression symptoms, and further to uncover the underlying moderating mechanisms interplay.

METHODS: A cross-sectional online survey with 657 valid data were collected from four tertiary hospitals in Harbin, Heilongjiang Province, China, with a response rate of 69.3%. The statistical analysis was conducted employing IBM SPSS Statistics 22.0. Hierarchical regression analysis was performed to scrutinize the pertinent factors associated with anxiety and depression symptoms among medical professionals, while also evaluating the moderating influence of organizational identity and family-work conflict on the nexus among those.

RESULTS: The prevalence of anxiety and depression symptoms among medical professionals was 50.1%. Anxiety and depression symptoms were negatively correlated with digital leadership (r= -0.278, p < 0.01) and organizational identity (r = – 0.318, p < 0.01), and positively correlated with family-work conflict (r = 0.445, p < 0.01). Organizational identity (β = – 0.938, p < 0.05) and family-work conflict (β = 0.698, p < 0.05) moderate the relationship between digital leadership and anxiety and depression symptoms; The results of the simple slope analysis indicated that high organizational identity and low family-work conflict strengthened the effect of digital leadership on anxiety and depression symptoms among Chinese medical professionals.

CONCLUSIONS: The prevalence of anxiety and depression symptoms among medical professionals was noted to be high. This study posits that strengthening digital leadership could apparently improve anxiety and depression symptoms among medical professionals. Moreover, it highlights the moderating role of organizational identity and family-work conflict in the relationship between digital leadership and anxiety and depression symptoms. These discoveries underscore the significance of implementing support and interventions to enhance the mental well-being of medical professionals, encompassing the cultivation of organizational identity, reduction of family-work conflict, and acknowledgment of the potential role of digital leadership in addressing mental health challenges.

PMID:39716125 | DOI:10.1186/s12889-024-20992-x

BMC Pediatr. 2024 Dec 23;24(1):833. doi: 10.1186/s12887-024-05320-x.

ABSTRACT

BACKGROUND AND OBJECTIVE: Microsurgical resection of tumor is an important treatment for children with fourth ventricular tumors. There is a lack of data describing risk factors for postoperative extubation failure (EF) in these children. We aimed to identify risk factors for EF in children with fourth ventricular tumors and to determine the association between EF and clinical outcomes.

METHODS: A retrospective study review of children after fourth ventricular tumors surgery who had an extubation attempt between January 2020 to December 2023. Extubation failure was defined as re-intubation within 7 days of extubation. Multivariate logistic regression analysis was performed to explore the risk factors for EF. Bivariate statistical analysis was performed to determine associations between EF and clinical outcomes. Only the first extubation attempt was included in the analysis.

RESULTS: We included 103 children, of whom 10 (9.7%) experienced EF. In the logistic regression analysis, a weak/absent cough reflex was independently associated with EF (p < 0.001). Compared to those with a fair/ strong cough, patients with a weak/absent cough had a odds ratio (OR) of 41.25 for EF (95% CI,8.01-212.37; p < 0.001).Glasgow Coma Score(GCS), the obvious adhesion between the tumor and the fourth ventricle floor, and pulmonary variables were not associated with EF. Children who failed extubation had longer durations of mechanical ventilation [13 days (IQR 6.8-22.8) vs. 1 days (IQR 0.5-3), p < 0.001]; longer PICU lengths of stay [16.5 days (IQR 9.4-27.5) vs. 2 days (IQR1.5-4.3), p < 0.001] and longer hospital lengths of stay [27 days (IQR 21-31.8) vs. 20 days (IQR16-29), p = 0.05] than successfully extubated children.

CONCLUSIONS: Children with weak/absent cough reflex after surgery are at increased risk for extubation failure. Extubation failure is associated with significant adverse outcomes in our setting.

PMID:39716124 | DOI:10.1186/s12887-024-05320-x

BMC Oral Health. 2024 Dec 23;24(1):1542. doi: 10.1186/s12903-024-05347-7.

ABSTRACT

BACKGROUND: Lithium disilicate occlusal veneers are popular for minimally invasive posterior teeth restoration. The aim of this study was to compare the fatigue resistance and crack pattern of lithium disilicate occlusal veneers fabricated using pressing and milling techniques with varying thicknesses.

METHODS: Sixty lithium disilicate discs, representing occlusal veneers, were divided into four groups (n = 15) based on processing technique (IPS e.max Press or IPS e.max CAD) and thickness (0.5 or 0.8 mm). A step-stress fatigue test was applied with axial loading, consisting of 10,000 cycles/step with a step size of 50 N until failure. Fractographic analysis was performed using SEM. Statistical analysis was performed using the Kaplan-Meier test, Mantel-Cox test, and Weibull analysis.

RESULTS: Both processing techniques resulted in similar fatigue resistances at 0.5 mm and 0.8 mm thicknesses. However, the 0.8 mm lithium disilicate restorations showed a significantly higher survival rate than the 0.5 mm lithium disilicate restorations (log-rank tests, χ² = 58.6; df = 3; P < 0.001). Fractographic analysis revealed radial cracks originating from defects on the ceramic surface at the cementing interface, extending towards the occlusal surface.

CONCLUSIONS: At 0.5 mm or 0.8 mm material thickness, the processing technique did not affect the fatigue resistance or crack patterns of the lithium disilicate occlusal veneers. However, the lithium disilicate with a thickness of 0.8 mm exhibited a superior survival probability compared to that with a thickness of 0.5 mm.

PMID:39716117 | DOI:10.1186/s12903-024-05347-7

BMC Pregnancy Childbirth. 2024 Dec 23;24(1):848. doi: 10.1186/s12884-024-07077-8.

ABSTRACT

BACKGROUND: Hyperemesis gravidarum (HG), excessive vomiting in pregnancy, occurs in 0.3-10.8% of pregnancies and is associated with maternal and fetal morbidity. Despite the existence of several off-label treatment options that have shown clinical effectiveness in managing HG symptoms, the variability in treatment response highlights the need for more effective therapies. Our study aims to identify novel therapeutic targets that could lead to the development of additional, more effective treatment options.

METHODS: A two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of blood-druggable genes on HG. Summary statistics for HG were obtained from the FinnGen study and UK Biobank. Cis-expression quantitative trait loci (cis-eQTL) for blood druggable genes were obtained from the eQTLGen Consortium and used as genetic instrumental variables. Another MR method, summary level mendelian randomization (SMR), was used to further confirm our results. We also used eQTL data of other vomiting-related tissues, brain regions, and esophagus, to validate our MR results. Finally, the potential side effects of the druggable genes for HG treatment were assessed using a phenome-wide MR.

RESULTS: Overall, 2499 unique druggable genes were gathered. Two blood drug targets (OVGP1 and LGALS1) showed significant MR results in two independent datasets. No significant heterogeneity of instrumental variables or pleiotropy was detected. In addition, SMR analysis further confirmed the significance of these two prior druggable genes in the brain and esophagus tissues. Further phenome-wide MR analysis revealed no association between genetic proxies of OVGP1, and LGALS1 has been detected in increasing the risk of adverse pregnancy outcomes and other common diseases.

CONCLUSIONS: This study provides genetic evidence that targeting two druggable genes for HG has potential therapeutic advantages. This information is of considerable value in guiding and prioritizing the development of more effective therapies for HG.

PMID:39716115 | DOI:10.1186/s12884-024-07077-8

BMC Nephrol. 2024 Dec 23;25(1):471. doi: 10.1186/s12882-024-03872-9.

ABSTRACT

BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is a known complication after coronary angiography (CAG) or percutaneous coronary intervention (PCI). Clinical evidence suggests that trimetazidine (TMZ), an anti-ischemic drug, may prevent CI-AKI. We aimed to evaluate the role of trimetazidine in preventing CI-AKI in patients with pre-existing renal dysfunction undergoing CAG or PCI.

METHODS: We searched PubMed, Cochrane Library, EBSCOhost, Web of Science, and Google Scholar databases from January 2004 to January 2024. We reviewed RCTs involving participants aged ≥ 18 years with pre-existing renal insufficiency who underwent CAG or PCI. Outcomes should include the incidence of CI-AKI, adverse events, and changes in serum creatinine (Scr) levels at different time intervals. Two reviewers independently extracted the data, evaluated the quality and relevance of the studies, and graded the strength of evidence for each study through consensus.

RESULTS: Nine RCTs met the inclusion criteria and assessed the role of TMZ in patients with renal dysfunction who underwent CAG or PCI. All RCTs showed a significant decrease in the incidence of CI-AKI in the TMZ group compared to the control group (RR 0.36, 95% CI, [0.25, 0.52] P < 0.001). Changes in Scr at 24 h (SMD -0.33, 95% CI, [-0.56, -0.10], P = 0.01), at 48 h (SMD -0.27, 95% CI, [-0.46, -0.09], P = 0.01), and 72 h (SMD -0.32, 95% CI, [-0.56, -0.07], P = 0.01) were statistically significant in the TMZ group compared to the control group. However, the changes in Scr beyond 72 h following CAG or PCI were statistically insignificant in the TMZ group when compared to the control group (SMD -0.22, 95% CI, [-0.52, 0.09], P = 0.16). The incidence of adverse effects was lower in the TMZ group than in the control group, and the difference was statistically significant (RR 0.51, 95% CI, [0.29, 0.90]; P = 0.02).

CONCLUSION: The addition of TMZ to standard hydration protocols may offer a promising strategy for lowering the incidence of CI-AKI, adverse events, and postoperative SCr levels in patients with renal insufficiency within 72 h after CAG or PCI. However, large-scale RCTs are necessary to definitively establish the efficacy and safety of TMZ in patients with renal insufficiency after CAG or PCI.

PMID:39716106 | DOI:10.1186/s12882-024-03872-9

BMC Cancer. 2024 Dec 24;24(1):1573. doi: 10.1186/s12885-024-13302-6.

ABSTRACT

BACKGROUND: Evidence of the association between sleep duration, depressive symptoms, and mortality in cancer survivors is limited.

METHODS: 2,111 participants from the National Health and Nutrition Examination Surveys were involved and linked to a mortality database up to 31 December 2019. Sleep duration was self-reported at baseline. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ-9) and a total score of ≥ 10 is considered clinically relevant depressive symptoms. Cox proportional hazards regression model was the main statistical models.

RESULTS: A 2% increase in all-cause mortality was found for each 1-point increase in depressive symptoms score (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00-1.03). Compared with those patients who slept 7 h, positive associations of < 6 h (HR, 1.79; 95% CI, 1.29-2.50), 8 h (HR, 1.46; 95% CI, 1.15-1.85), and > 8 h (HR, 1.49; 95% CI, 1.09-2.05) durations with all-cause mortality were observed. In the joint analysis, cancer survivors with depressive symptoms had a higher risk of all-cause mortality when sleeping < 6 h (HR, 1.69; 95% CI, 1.09-2.62) or ≥ 8 h (HR, 1.55; 95% CI, 1.02-2.35).

LIMITATIONS: Dynamics of sleep and depression data were not available.

CONCLUSIONS: Long (≥ 8 h) and short (< 6 h) sleep duration was both associated with increased risks of all-cause deaths after adjusting for depressive symptoms scores. We also observed a joint effect of sleep duration and depressive symptoms. The findings may provide evidence to guide optimal sleep duration for prolonged cancer survival.

PMID:39716102 | DOI:10.1186/s12885-024-13302-6

JAMA Surg. 2024 Dec 23. doi: 10.1001/jamasurg.2024.5788. Online ahead of print.

ABSTRACT

IMPORTANCE: Paraesophageal hernias can cause severe limitations in quality of life and life-threatening complications. Even though minimally invasive paraesophageal hernia repair (MIS-PEHR) is safe and effective, anatomic recurrence rates remain notoriously high. Retrospective data suggest that suturing the stomach to the anterior abdominal wall after repair-an anterior gastropexy-may reduce recurrence, but this adjunct is currently not the standard of care.

OBJECTIVE: To determine whether anterior gastropexy reduces 1-year recurrence after MIS-PEHR.

DESIGN, SETTING, AND PARTICIPANTS: This registry-based randomized clinical trial was conducted by 10 surgeons at 3 academic hospitals within the Cleveland Clinic Enterprise. Between June 26, 2019, and July 24, 2023, 348 patients were assessed for eligibility, and 240 patients were enrolled and randomized. Statistical analysis was performed from January to March 2024.

INTERVENTION: Enrolled patients were randomized to and received either an anterior gastropexy (n = 119) or no anterior gastropexy (n = 121).

MAIN OUTCOME: The primary outcome was recurrence as determined by reherniation of the stomach greater than 2 cm above the diaphragm on routine imaging at 1 year or reoperation. Secondary outcomes included quality of life as measured by the Gastroesophageal Reflux Health-Related Quality of Life survey, additional foregut symptom questionnaire, and patient satisfaction at 30 days and 1 year.

RESULTS: A total of 240 patients were randomized to either anterior gastropexy (n = 119; 104 [97%] women; median [IQR] age, 70 [64-75] years) or no anterior gastropexy (n = 121; 97 [80%] women; median [IQR] age, 68 [62-73] years) at the end of their MIS-PEHR. At 1 year, 188 patients (78%) had completed follow-up. By intention-to-treat analysis, 1-year recurrence was significantly lower in patients who received an anterior gastropexy (15% vs 36%; risk difference, 0.21 [95% CI, 0.09-0.33]), which remained significant after risk-adjusted regression analysis (hazard ratio, 0.38 [95% CI, 0.23-0.60]). Of 13 reoperations (5.4%) for recurrence in the first year, 3 (2.5%) were in the anterior gastropexy group and 10 (8.2%) were in the no-gastropexy group (P = .052). Two patients (1.7%) had their anterior gastropexy sutures removed for pain. There were no significant differences in quality-of-life outcomes at 30 days and 1 year between treatment groups.

CONCLUSIONS AND RELEVANCE: This randomized clinical trial found that the addition of an anterior gastropexy to MIS-PEHR is superior to no gastropexy in regard to reducing 1-year paraesophageal hernia recurrence. These results suggest that an anterior gastropexy should be routinely used in the context of minimally invasive paraesophageal hernia repair.

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04007952.

PMID:39714889 | DOI:10.1001/jamasurg.2024.5788

JAMA Netw Open. 2024 Dec 2;7(12):e2451605. doi: 10.1001/jamanetworkopen.2024.51605.

ABSTRACT

IMPORTANCE: Access to appropriate postpartum care is essential for improving maternal health outcomes and promoting maternal health equity.

OBJECTIVE: To analyze the impact of the Nurse-Family Partnership (NFP) home visiting program on use of routine and emergency postpartum care.

DESIGN, SETTING, AND PARTICIPANTS: This study was a secondary analysis of a randomized clinical trial that enrolled eligible participants between 2016 and 2020 to receive NFP or usual care from a South Carolina Medicaid program. Participants were nulliparous pregnant individuals at less than 28 weeks’ gestation at enrollment who were enrolled in Medicaid during pregnancy or delivery. Analysis was performed February 2, 2023, to July 16, 2024.

INTERVENTION: Participants were enrolled in a 2:1 ratio to receive NFP, an established model of nurse home visiting, or usual care. NFP visits are conducted prenatally and for up to 2 years post partum.

MAIN OUTCOMES AND MEASURES: This study assessed one of the trial’s preregistered secondary outcomes: attendance at a routine postpartum health care visit before 12 weeks post partum. Other exploratory outcomes included outpatient care use, hospitalization, and emergent, nonemergent, and any use of emergency department (ED) health services at 12 weeks and 1 year post partum. Subgroup analyses examined individuals who underwent cesarean delivery, had chronic disease, experienced pregnancy complications, reported non-Hispanic Black race and ethnicity, were socially vulnerable, or were unaffected by COVID-19.

RESULTS: Among 5670 participants enrolled, 4877 were analyzed (median [IQR] age, 21 [19-25] years), including 3261 who received NFP and 1616 who received usual care. By race and ethnicity, the sample included 259 Hispanic individuals (5.7%); 56 non-Hispanic Asian, Indigenous, or Native Hawaiian and Pacific Islander individuals (1.2%); 2535 non-Hispanic Black individuals (55.4%); 1587 non-Hispanic White individuals (34.7%); and 141 individuals (3.1%) with more than 1 race reported (and non-Hispanic ethnicity). There was no significant difference in attendance of routine postpartum visit at 12 weeks between NFP and usual care groups (63.8% vs 64.2%; adjusted difference [AD] -0.3 [95% CI, -3.2 to 2.5] percentage points). In exploratory analyses, the NFP group was less likely to have a visit to the ED without admission (AD, -2.5 [95% CI, -4.8 to -0.1] percentage points) in the first 12 weeks post partum. Other outcomes, including hospitalizations, outpatient visits, and emergent and nonemergent ED visits, were not different between intervention and control groups. There were also no statistically significant differences within subgroups.

CONCLUSIONS AND RELEVANCE: In this secondary analysis of a randomized clinical trial of nulliparous pregnant individuals with low income, nurse home visiting did not increase use of routine postpartum care in the immediate or extended postpartum periods, even among those with greater health challenges. Nurse home visiting was associated with reduced ED use. More research is needed on how to improve continuity of perinatal care for low-income populations.

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03360539.

PMID:39714843 | DOI:10.1001/jamanetworkopen.2024.51605

JAMA Netw Open. 2024 Dec 2;7(12):e2451625. doi: 10.1001/jamanetworkopen.2024.51625.

ABSTRACT

IMPORTANCE: Little is known about the spatial accessibility to dental clinics across the US.

OBJECTIVE: To map the spatial accessibility of dental clinics nationally and to examine the characteristics of counties and US Census block groups with dental care shortage areas.

DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional study of US dental clinics in 2023 using data from the IQVIA national practitioners’ database, which includes 205 762 active dentists. Data were analyzed from November 2023 to April 2024.

EXPOSURES: Socioeconomic characteristics of block groups and counties including rurality, area deprivation, racial and ethnic segregation, and uninsured population.

MAIN OUTCOMES AND MEASURES: Enhanced 2-step floating catchment area method with a 30-minute drive time impedance was used to calculate the accessibility score to dental clinics at the block group level. The outcomes were dental clinic shortage areas and inequality in access to dental clinics.

RESULTS: Nearly 1.7 million people in the US (0.5%) lacked access to dental clinics within a 30-minute drive. This included 0.9 million male (52.2%), 1.2 million White (71.0%), 52 636 Black (3.0%), and 176 885 Hispanic (10.2%) individuals. Approximately 24.7 million people (7.5%) lived in dental care shortage areas (defined as <1 dentist per 5000 population). There was a significant difference in spatial accessibility scores between rural and urban areas, with 1 dentist for every 3850 people in rural areas and 1 dentist for every 1470 people in urban areas. Additionally, there were 387 counties with significant disparities in access to dental clinics. Rural block groups (23.9 percentage points [pp]; 95% CI, 23.6-24.3), block groups with higher levels of Black (1.5 pp; 95% CI, 1.3-1.7) and Hispanic (4.5 pp; 95% CI, 4.3-4.8) segregation, and block groups with the highest levels of area deprivation (5.5 pp; 95% CI, 5.1-5.9) were more likely to experience dental care shortages compared with urban block groups and those with lower levels of segregation and area deprivation. Moreover, rural counties (11.3 pp; 95% CI, 8.9-13.7), counties with a high uninsured population (3.0 pp; 95% CI, 1.5-4.4), and counties with high levels of deprivation (5.8 pp; 95% CI, 2.1-9.5) were more likely to have inequality in access to dental clinics.

CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US dental clinics, there was geographic shortage and maldistribution of the dental workforce. These findings can support dental workforce planning efforts at the federal and state levels to encourage dentists to practice in underserved areas to reduce disparities in access to dental care.

PMID:39714842 | DOI:10.1001/jamanetworkopen.2024.51625

JAMA Netw Open. 2024 Dec 2;7(12):e2451844. doi: 10.1001/jamanetworkopen.2024.51844.

ABSTRACT

IMPORTANCE: Although cumulative evidence suggests that higher blood pressure (BP) and a greater burden of social determinants of health (SDOH) are associated with an increased risk of stroke, few studies have examined whether SDOH burden modifies the association between BP and stroke risk.

OBJECTIVE: To evaluate whether the association between BP classification and stroke risk differs by SDOH burden among Chinese adults.

DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, analyses were conducted among 90 850 participants in the prospective subcohort of the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project, with recruitment from January 1, 2016, to December 31, 2020. Participants without cardiovascular diseases and with complete data were included and followed up for stroke events until June 30, 2023.

EXPOSURES: Social determinants of health burden was defined using 5 components: educational attainment, economic stability, health care access, social support, and urban vs rural residence. Blood pressure was categorized according to the 2017 American College of Cardiology/American Heart Association BP guideline.

MAIN OUTCOMES AND MEASURES: Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs for associations of BP classification with incident stroke stratified by SDOH burden groups.

RESULTS: The study included 90 850 participants (median age, 54.0 years [IQR, 46.0-62.0 years]; 55 390 women [61.0%]). During a median follow-up of 5.0 years (IQR, 4.1-5.8 years), 4408 incident stroke events were recorded. Compared with normal BP, elevated BP (HR, 1.33 [95% CI, 1.17-1.52]), stage 1 hypertension (HR, 1.60 [95% CI, 1.43-1.78]), and stage 2 hypertension (HR, 1.79 [95% CI, 1.61-2.00]) were associated with stroke among participants with high SDOH burden, while only stage 2 hypertension (HR, 1.52 [95% CI, 1.20-1.93]) was associated with stroke among those with low SDOH burden, with a significant multiplicative interaction of SDOH burden and BP classification (P = .03). Participants with high SDOH burden and stage 2 hypertension had the highest risk of stroke compared with participants with low SDOH burden and normal BP (HR, 2.13 [95% CI, 1.75-2.60]).

CONCLUSIONS AND RELEVANCE: This study suggests that higher BP levels, even at lower stages of hypertension, pose a greater stroke risk for individuals with high SDOH burden. Early surveillance and intervention for high BP should be emphasized in socioeconomically disadvantaged populations.

PMID:39714839 | DOI:10.1001/jamanetworkopen.2024.51844