Nevin Manimala

J Surg Educ. 2024 Aug 22;81(10):1374-1382. doi: 10.1016/j.jsurg.2024.07.009. Online ahead of print.

ABSTRACT

OBJECTIVE: The transition of Step 1 to pass/fail has generated concerns over selecting promising candidates. Holistic reviews integrate other proficiencies, including extracurriculars such as sports. Grit – defined as perseverance and passion for long-term goals – has been positively associated with competitive activities and is predictive of academic success. The prevalence and impact of sports participation and its relationship to grit in the general surgery resident population has not been described and was investigated in this study.

DESIGN: Surveys measuring sports participation and grit were distributed after the 2021 ABSITE. Grit was assessed through the short grit scale. Inferential statistics were performed.

SETTING/PARTICIPANTS: General surgery residents in all US training programs who completed the 2021 ABSITE.

RESULTS: Of 5468 respondents (response rate 59.6%), 2,548 (46.7%) were female, 917 (17.4%) URiM, 2171 (39.8%) married, and 1,069 (19.6%) parents. About 4284 (83.8%) residents reported being involved in competitive sports. Grit was higher in residents with a competitive sports history (3.67 ± 0.58 versus 3.60 ± 0.61, p = 0.0022). Greater time commitment and being part of a team was positively correlated to grit (both p < 0.0001). Individuals that self-identified as underrepresented in medicine (URiM) had higher grit (3.71 ± 0.59 versus 3.65 ± 0.58 for non-URiM, p < 0.0001) as did female (p = 0.0016), married residents (p < 0.0001), and parents (p < 0.0001). Being an athlete was associated with significantly higher grit for nearly all demographic subgroups, including URiM (p = 0.0068), married (p = 0.0175), and parents (p = 0.0487).

CONCLUSIONS: Higher grit was found in athletes and marginalized groups including females, URiM, and residents that were married or parents. Our data suggests that recruiting applicants of diverse backgrounds and experiences will result in a grittier cohort; a group potentially equipped to weather the arduous surgical residency training path. Recruiting residents with characteristics associated with higher grit can potentially impact diversity of the surgical workforce.

PMID:39178487 | DOI:10.1016/j.jsurg.2024.07.009

J Neurosurg Pediatr. 2024 Aug 23:1-11. doi: 10.3171/2024.6.PEDS24198. Online ahead of print.

ABSTRACT

OBJECTIVE: The authors assessed the safety and accuracy of stereoelectroencephalography (SEEG) electrode implantation in pediatric patients who had previously undergone craniotomy compared to those without prior cranial surgery.

METHODS: The authors performed a retrospective analysis of patients under 25 years of age with medically refractory epilepsy at a single institution who underwent SEEG electrode placement between March 2016 and July 2023. Surgical history and demographic characteristics were collected from the electronic medical records. The coordinates of the anchor bolts and their respective SEEG electrode contacts were manually annotated using postoperative head CT scans. Bolt coordinates were used to calculate the initiated electrode trajectory set by the bolt by using the least-squares method to define a line along the bolt, projected along the length of the electrode. The shortest distance from each electrode contact to this line was calculated to obtain the error measurement. Statistical analysis was conducted using the Kolmogorov-Smirnov test to compare the distribution of errors between groups, the Student t-test was used for continuous variables, and the chi-square/Fisher’s exact test was used for categorical variables.

RESULTS: Fifty-eight patients underwent a total of 60 SEEG placements and met the inclusion criteria. Eighteen had a history of prior craniotomy and 40 without prior surgery, indicating entirely native cranial bone. Mean age, sex, and mean number of electrodes implanted per surgery were similar between groups. For the electrode contact furthest from the bolt, a mean (IQR) deviation of 1.32 (0.73-2.53) mm was noted for the prior craniotomy group and 1.08 (0.65-1.55) mm for the native bone group (p < 0.0001). A greater number of outliers for the contact furthest from the bolt, defined as > 6 mm from the initiated electrode trajectory, was seen in the prior craniotomy group (p < 0.0001). The complication rate was low and not statistically different between groups.

CONCLUSIONS: The authors’ analysis draws attention to the effect of the intracranial biomechanical environment along the path of the electrode after traversing past the anchor bolt and found that prior craniotomy was associated with a higher number of contacts with a significant deviation from the initiated trajectory. Despite these deviations, we did not find a difference in the overall low complication rate in both groups. Therefore, the authors conclude that SEEG electrode placement is a safe option in pediatric patients even after prior craniotomy.

PMID:39178469 | DOI:10.3171/2024.6.PEDS24198

Phys Rev Lett. 2024 Aug 9;133(6):060601. doi: 10.1103/PhysRevLett.133.060601.

ABSTRACT

Transport measurements are fundamental for understanding condensed matter phenomena, from superconductivity to the fractional quantum Hall effect. Analogously, they can be powerful tools for probing synthetic quantum matter in quantum simulators. Here we demonstrate the measurement of in situ particle current in a superconducting circuit lattice and apply it to study transport in both coherent and bath-coupled lattices. Our method utilizes controlled tunneling in a double-well potential to map current to on-site density, revealing site-resolved current and current statistics. We prepare a strongly interacting Bose-Hubbard lattice at different lattice fillings, and observe the change in current statistics as the many-body states transition from superfluid to Mott insulator. Furthermore, we explore nonequilibrium current dynamics by coupling the lattice to engineered driven-dissipative baths that serve as tunable particle source and drain. We observe steady-state current in discrete conduction channels and interaction-assisted transport. These results establish a versatile platform to investigate microscopic quantum transport in superconducting circuits.

PMID:39178460 | DOI:10.1103/PhysRevLett.133.060601

Phys Rev Lett. 2024 Aug 9;133(6):060401. doi: 10.1103/PhysRevLett.133.060401.

ABSTRACT

With the control of increasingly complex quantum systems, the relevant degrees of freedom we are interested in may not be those traditionally addressed by statistical quantum mechanics. Here, we employ quantum channels to define generalized subsystems, capturing the pertinent degrees of freedom, and obtain their associated canonical state. We show that the generalized subsystem description from almost any microscopic pure state of the whole system will behave similarly to its corresponding canonical state. Such canonical typicality behavior depends on the entropy of the channel used to define the generalized subsystem.

PMID:39178447 | DOI:10.1103/PhysRevLett.133.060401

Phys Rev Lett. 2024 Aug 9;133(6):060202. doi: 10.1103/PhysRevLett.133.060202.

ABSTRACT

A black hole evaporates by Hawking radiation. Each mode of that radiation is thermal. If the total state is nevertheless to be pure, modes must be entangled. Estimating the minimum size of this entanglement has been an important outstanding issue. We develop a new theory of constrained random symplectic transformations, based on the assumptions that the total state is pure and Gaussian with given marginals. In the random constrained symplectic model we then compute the distribution of mode-mode correlations, from which we bound mode-mode entanglement. Modes of frequency much larger than [k_{B}T_{H}(t)/ℏ] are not populated at time t and drop out of the analysis. Among other relatively thinly populated modes (early-time high-frequency modes and/or late modes of any frequency), we find correlations and hence entanglement to be strongly suppressed. Relatively highly populated modes (early-time low-frequency modes) can, on the other hand, be strongly correlated, but a detailed analysis reveals that they are nevertheless very unlikely to be entangled. Our analysis hence establishes that restoring unitarity after a complete evaporation of a black hole does not require any significant quantum entanglement between any pair of Hawking modes. Our analysis further gives exact general expressions for the distribution of mode-mode correlations in random, pure, Gaussian states with given marginals, which may have applications beyond black hole physics.

PMID:39178446 | DOI:10.1103/PhysRevLett.133.060202

Phys Rev Lett. 2024 Aug 9;133(6):063401. doi: 10.1103/PhysRevLett.133.063401.

ABSTRACT

Quantum gas microscopes have revolutionized quantum simulations with ultracold atoms, allowing one to measure local observables and snapshots of quantum states. However, measurements so far were mostly carried out in the occupation basis. Here, we demonstrate how all kinetic operators, such as kinetic energy or current operators, can be measured and manipulated with single-bond resolution. Beyond simple expectation values of these observables, the single-shot measurements allow one to access full counting statistics and complex correlation functions. Our work paves the way for the implementation of efficient quantum state tomography and hybrid quantum computing protocols for itinerant particles on a lattice. In addition, we demonstrate how site-resolved programmable potentials enable a spatially selective, parallel readout in different bases as well as the engineering of arbitrary initial states.

PMID:39178442 | DOI:10.1103/PhysRevLett.133.063401

Phys Rev Lett. 2024 Aug 9;133(6):066101. doi: 10.1103/PhysRevLett.133.066101.

ABSTRACT

We study Anderson localization in disordered tight-binding models on hyperbolic lattices. Such lattices are geometries intermediate between ordinary two-dimensional crystalline lattices, which localize at infinitesimal disorder, and Bethe lattices, which localize at strong disorder. Using state-of-the-art computational group theory methods to create large systems, we approximate the thermodynamic limit through appropriate periodic boundary conditions and numerically demonstrate the existence of an Anderson localization transition on the {8,3} and {8,8} lattices. We find unusually large critical disorder strengths, determine critical exponents, and observe a strong finite-size effect in the level statistics.

PMID:39178435 | DOI:10.1103/PhysRevLett.133.066101

Phys Rev Lett. 2024 Aug 9;133(6):063601. doi: 10.1103/PhysRevLett.133.063601.

ABSTRACT

Homo- and heterodyne detection are fundamental techniques for measuring propagating electromagnetic fields. However, applying these techniques to stationary fields confined in cavities poses a challenge. As a way to overcome this challenge, we propose to use repeated indirect measurements of a two-level system interacting with the cavity. We demonstrate numerically that the proposed measurement scheme faithfully reproduces measurement statistics of homo- or heterodyne detection. The scheme can be implemented in various physical architectures, including circuit quantum electrodynamics. Our results pave the way for implementation of quantum algorithms requiring linear detection of stationary modes, including quantum verification protocols.

PMID:39178427 | DOI:10.1103/PhysRevLett.133.063601

J Craniofac Surg. 2024 Aug 26. doi: 10.1097/SCS.0000000000010544. Online ahead of print.

ABSTRACT

OBJECTIVE: Facial paralysis (FP), which resulted from head and neck cancer resection, significantly impacts patients’ quality of life. Traditional assessments rely on subjective evaluations and electromyography, whereas functional magnetic resonance imaging offers a noninvasive alternative for enhanced rehabilitation. Acupuncture has shown promise in promoting cerebral cortex reorganization, yet the precise relationship between acupuncture-induced structural and functional changes remains unclear, necessitating further investigation into therapeutic mechanisms.

METHODS: Fifty-five patients afflicted with FP underwent evaluations using voxel-mirrored homotopic connectivity (VMHC) and tract-based spatial statistics and were divided into the acupuncture intervention group (n = 35) and pseudo intervention group (n = 20). Comparative analyses of metrics pre and postintervention were conducted to delineate therapy-induced modifications in acupuncture intervention. The postacupuncture effect between groups to verify the necessity of accurate positioning for the rehabilitation of FP.

RESULTS: Patients with FP showed deficits in VMHC in regions of the postcentral, precentral, and parietal areas. Corpus callosum and internal capsule showed significantly increased fractional anisotropy of the white matter skeleton in tract-based spatial statistics after treatment. Comparison postintervention results between groups exhibited deficits in VMHC and increased fractional anisotropy in regions of the corpus callosum in the acupuncture intervention group.

CONCLUSIONS: Early acupuncture intervention may suppress cortical hyperactivation and restore interhemispheric inhibition across the corpus callosum to inhibit maladaptive structural plasticity. Precise acupoint localization is crucial for effective therapy, highlighting the potential of postacupuncture cortical space data for refining therapeutic strategies.

PMID:39178417 | DOI:10.1097/SCS.0000000000010544

ACS Appl Mater Interfaces. 2024 Aug 23. doi: 10.1021/acsami.4c07960. Online ahead of print.

ABSTRACT

Purpose/Aim: Acrylamides are hydrolytically stable at pH lower than 2, and were shown to preserve bonded interface integrity with two-step, total etch adhesives. The objective of this study was to leverage those two characteristics in self-etching primers containing the acidic monomer 10-MDP and test the microtensile bond strength before and after incubation with S. mutans incubation. Materials and Methods: Acidic primers (10 wt % 10-methacryloyloxydecyl dihydrogen phosphate─10-MDP; 45 wt % N,N-diethyl-1,3-bis(acrylamido)propane─DEBAAP, or 2-hydroxyethyl methacrylate─HEMA; 45 wt %, glycerol-dimethacrylate─GDMA) and adhesives (DEBAAP or HEMA/10-MDP/UDMA 45/10/45 wt %) were made polymerizable by the addition of 0.2 wt % camphorquinone, 0.8 wt % ethyl-4-dimethylaminobenzoate, 0.4 wt % diphenyliodonium hexafluorophosphate, and 0.1 wt % butylhydroxytoluene. Nonsolvated materials were characterized for flexural strength (FS), modulus (E), toughness, water sorption/solubility (WS/SL), contact angle, and vinyl conversion (DC). Viscosity was evaluated after adding 20 and 40 vol % ethanol to the primer and adhesive, respectively. The experimental materials or Clearfil SE Bond (CC─commercial control) were used to bond a commercial composite (Filtek Supreme) to the flat surface of human dentin. Microtensile bond strength (MTBS) was tested in 1 mm² sticks for the 5 primer/bond combinations: CC (Clearfil Bond Primer and Bond), HH (HEMA/HEMA), DD (DEBAAP/DEBAAP), HD (HEMA/DEBAAP), and DH (DEBAAP/HEMA). Prior to testing, sticks were stored in water or biofilm-inducing culture medium with S. mutans for 1 week. Confocal images and FTIR-ATR evaluation evaluated the hybrid layer of the adhesives. Results were analyzed using Student’s t-test (WS, SL, DC, contact angle, FS, E, toughness), one-way ANOVA/Tukey’s test for viscosity, and two-way ANOVA/Tukey’s test for MTBS (95%). Results: HEMA-based materials had lower contact angle (p = 0.004), higher WS (p < 0.001), and similar SL values compared to DEBAAP (p = 0.126). FS (p = 0.171) and E (p = 0.065) dry values were similar, but after one week of water storage, FS/E dropped more significantly for HEMA materials. Dry and wet toughness was greater for DEBAAP (p < 0.001), but it also had the greatest drop (46%). Clearfil bonds had the highest viscosity, followed by DEBAAP and HEMA, respectively (p = 0.002). For the primers, HEMA had the lowest viscosity (p = 0.003). As far as MTBS, all groups tested in water were statistically different when compared with HH (p < 0.001). After storage in biofilm, DH had the highest MTBS value, being statistically different from HH (p = 0.002), CC (p = 0.015), and DD (p = 0.027). Conclusions: The addition of a diacrylamide and its association with HEMA in self-etching adhesive systems provided greater bonding stability after bacterial challenge.

PMID:39178414 | DOI:10.1021/acsami.4c07960