Nevin Manimala

J Electr Bioimpedance. 2024 Feb 26;15(1):4-9. doi: 10.2478/joeb-2024-0002. eCollection 2024 Jan.

ABSTRACT

Moisturizers are cosmetic compounds designed to increase the moisture content of the skin. There are many types of these products in the market making it difficult for consumers to select the most effective moisturizer according to their age and gender. Hence, the aim of this study was to evaluate the effects of different moisturizers on skin hydration as well as to figure out any dependencies of the effects of these products on age or gender-related differences. We investigated the short-term moisturizing effects of five different skin moisturizers on 60 participants by using a low frequency electrical instrument. Skin surface susceptance was recorded and compared before and after the application of moisturizers. Statistically significant differences were observed in the moisturizing effect among different types of products. However, with respect to gender and age differences, there were insignificant differences in the effects of the moisturizers. Results of this study suggest that some types of moisturizers that exist in the markets are not as effective as required, which calls for a further evaluation of the moisturizers before entering markets and offering them for sale. In addition, findings suggest that gender or age differences are perhaps not important to consider in the application of moisturizers.

PMID:38410783 | PMC:PMC10896182 | DOI:10.2478/joeb-2024-0002

Patient Prefer Adherence. 2024 Feb 22;18:475-486. doi: 10.2147/PPA.S450215. eCollection 2024.

ABSTRACT

BACKGROUND: Toenail onychomycosis affects approximately 6.7% of Canadians. Symptoms include nail discolouration/disfiguration and pain; psychosocial impacts contribute to reduced health-related quality-of-life. Comorbid diabetes increases the risk of complications and exacerbates burden. Treatment may include topical therapy and/or oral agents.

PURPOSE: To understand toenail onychomycosis treatment preferences, and to quantify the impact of toenail onychomycosis, with or without diabetes, on patient well-being.

METHODS: Adults living in Canada with self-reported, physician-diagnosed, toenail onychomycosis were recruited online. A discrete choice experiment was used to quantify treatment preferences. Scenarios were randomized; data were analyzed using conditional logit regression. Health state utilities were estimated using the Health Utilities Index Mark 3^®. Results were stratified by diabetes status and toenail onychomycosis severity; the Wilcoxon Rank Sum test was used to assess between-group utility differences.

RESULTS: Three-hundred thirteen participants with toenail onychomycosis were included (161 had comorbid diabetes; 61.3%, severe onychomycosis). The mean age was 57.7 years; 55.9% were male. Treatment attributes with statistically significant impacts on patient preferences were efficacy (odds ratio [OR],1.04; 95% confidence interval [CI], 1.02-1.05 per 1% increased treatment success), administration method (one pill versus topical nail lacquer reference, 1.14; 1.04-1.26; topical solution applicator versus reference: 1.15; 1.03-1.29), severe adverse events (0.85; 0.80-0.90 per 1% increased risk), and risk of potential pharmacodynamic (0.80; 0.76-0.85) and alcohol (0.93; 0.88-0.98) interactions; preferences were more pronounced for efficacy and avoiding severe adverse events among toenail onychomycosis patients with comorbid diabetes. The mean (95% CI) utility value was 0.73 (0.70-0.75) overall, and statistically significantly lower (p=0.02) for toenail onychomycosis patients with diabetes (0.70; CI, 0.66-0.73) than those without (0.76; CI, 0.72-0.79).

CONCLUSION: Among patients with toenail onychomycosis, the presence of diabetes was associated with differing treatment-related preferences. Utility values for patients with toenail onychomycosis represent a significant decline from full health that is exacerbated by comorbid diabetes.

PMID:38410773 | PMC:PMC10896105 | DOI:10.2147/PPA.S450215

Med Int (Lond). 2024 Feb 8;4(2):12. doi: 10.3892/mi.2024.136. eCollection 2024 Mar-Apr.

ABSTRACT

Epilepsy is an enduring predisposition of the brain to generate epileptic seizures and has a worldwide incidence of 21-24 per 100,000 cases among children. Epilepsy is a multifactorial disease; however, certain risk factors are predicted to increase its incidence. Abnormal brain development during prenatal life, particularly during the last trimester, is considered to play a crucial role in the development of certain neurological disorders. The present study evaluated a total of 453 children between the ages of 1 to 18 years, with or without epilepsy. The association between gestational age, birth weight, maternal age and sex, and the risk of developing epilepsy was examined in the children. It was found that children born preterm had a 2.3-fold higher risk of having epilepsy [odds ratio (OR), 2.3; 95% confidence interval (CI), 1.4-3.7], and those whose birth weight was <2,500 g had a 2-fold greater risk of developing epilepsy (OR, 2; 95% CI, 1.1-3.6). The male sex appeared to be associated with a lower risk of developing epilepsy and there was a statistically significant association between the female sex and the risk of developing epilepsy only in preterm children (OR, 3.2; 95% CI, 1.2-8.8). Maternal age was not found to be associated with the risk of developing epilepsy. On the whole, the present study demonstrates that a short gestational age, a low birth weight and the female sex are associated with an increased risk of developing epilepsy.

PMID:38410757 | PMC:PMC10895459 | DOI:10.3892/mi.2024.136

Sci Rep. 2024 Feb 26;14(1):4652. doi: 10.1038/s41598-024-55370-5.

ABSTRACT

In the past, quadratus lumborum block (QLB) was mostly used for postoperative analgesia in patients, and few anesthesiologists applied it during surgery with opioid-free anesthesia (OFA). Consequently, it is still unclear whether QLB in the supine position can provide perfect analgesia and inhibit anesthetic stress during surgery under the OFA strategy. To observe the clinical efficacy of ultrasound-guided quadratus lumborum block (US-QLB) in the supine position with OFA for lower abdominal and pelvic surgery. A total of 122 patients who underwent lower abdominal or pelvic surgery in People’s Hospital of Wanning between March 2021 and July 2022 were selected and divided into a quadratus lumborum block group (Q) (n = 62) and control group (C) (n = 60) according to the random number table method. Both groups underwent general anesthesia combined with QLB in the supine position. After sedation, unilateral or bilateral QLB was performed via the ultrasound guided anterior approach based on images resembling a “human eye” and “baby in a cradle” under local anesthesia according to the needs of the operative field. In group Q, 20 ml of 0.50% lidocaine and 0.20% ropivacaine diluted in normal saline (NS) were injected into each side. In group C, 20 ml of NS was injected into each side. The values of BP, HR, S_PO₂, SE, RE, SPI, NRS, Steward score, dosage of propofol, dexmedetomidine, and rocuronium, the number of patients who needed remifentanil, propofol, or diltiazem, puncture point, block plane, duration of anesthesia, catheter extraction, and wakefulness during the operation were monitored. There were no significant differences in the general data, number of cases requiring additional remifentanil, propofol, or diltiazem treatment, as well as puncture point and puncture plane between the two groups (P > 0.05). HR, SBP, and DBP values were higher in group Q than in group C at T1; HR, SPI, and SE, while RE values were lower in group Q than in group C at T3, SE, and RE; the Steward score was higher in group Q than in group C at T4 and T5, and the difference was statistically significant (P < 0.05). The extubation and awake times were lower in group Q than in group C, and the difference was statistically significant (P < 0.05). The SE, RE, and SPI values were lower at T1, T2, T3, and T4 than at T0. The Steward scores at T4 and T5 were higher in group Q than in group C, and were lower than at T0, with a statistically significant difference (P < 0.05). There were significant differences in the effectiveness of postoperative analgesia between the two groups at t1, t3 and t4 (P < 0.05). US-QLB in the supine position with OFA is effective in patients undergoing lower abdominal or pelvic surgery with stable intraoperative vital signs, complete recovery and better postoperative analgesia.

PMID:38409359 | DOI:10.1038/s41598-024-55370-5

Sci Rep. 2024 Feb 27;14(1):4712. doi: 10.1038/s41598-024-55509-4.

ABSTRACT

To explore the effect of a combination of Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS) with modularization teaching in the context of clinical instruction in trauma care. A total of 244 nursing students who participated in clinical practice in orthopaedic wards from March 2020 to April 2022 were divided into two groups that received the same trauma care teaching content. The control group (n = 119) used the traditional teaching approach, and the experimental group (n = 125) utilized a combination of TeamSTEPPS with a modularization teaching model. A questionnaire was used to assess students’ theoretical knowledge, practical skills, self-concepts and professional benefits after one month with the goal of determining their end-of-course performance. The theoretical knowledge scores obtained by the control group and the experimental group were 89.56 ± 4.06 and 91.62 ± 2.84, respectively, and these results were statistically significant (P < 0.05). Students preferred the combination of TeamSTEPPS with the modularization teaching model to the traditional instructional method in terms of practical skills, professional self-concepts and professional benefits (P < 0.05). The application of the combination of TeamSTEPPS with modularization teaching in the context of clinical instruction in trauma care made significant contributions to nursing students’ mastery of theoretical knowledge and practical skills, enhanced their sense level of professional identity, instilled a correct occupational ideology in such students, and enhanced the professional benefits they were able to obtain.

PMID:38409342 | DOI:10.1038/s41598-024-55509-4

Sci Rep. 2024 Feb 26;14(1):4687. doi: 10.1038/s41598-024-54794-3.

ABSTRACT

The present study investigated several properties such as friction, hardness, penetration work, and cutting forces in soaps formulated with apple and carrot pomace at varying concentrations of 5%, 10%, and 15%. To gain insights into the molecular-level alterations within the formulated soap samples, they were spectroscopically analyzed using Fourier-transform infrared spectroscopy. The sliding friction analyses revealed that the investigated extrudate additives had no significant impact on the frictional forces of the soaps. However, notable differences were observed in the cutting force, hardness, and penetration work between the control and pomace-added samples. Excluding the control samples, no statistically significant distinctions were found between the cutting force, hardness, and work of penetration of soaps containing apple pomace and carrot pomace. Moreover, the quantity of pomace incorporated did not induce any significant variations in the results. The obtained samples were characterised at the molecular level using FTIR Fourier transform infrared spectroscopy. On the other hand, alterations in band intensities suggested improved molecular packing of the compounds within the samples due to the presence of the additives.

PMID:38409341 | DOI:10.1038/s41598-024-54794-3

Sci Rep. 2024 Feb 26;14(1):4598. doi: 10.1038/s41598-024-54513-y.

ABSTRACT

Geo-polymer concrete has a significant influence on the environmental condition and thus its use in the civil industry leads to a decrease in carbon dioxide (CO₂) emission. However, problems lie with its mixed design and casting in the field. This study utilizes supervised artificial-based machine learning algorithms (MLAs) to anticipate the mechanical characteristic of fly ash/slag-based geopolymer concrete (FASBGPC) by utilizing AdaBoost and Bagging on MLPNN to make an ensemble model with 156 data points. The data consist of GGBS (kg/m³), Alkaline activator (kg/m³), Fly ash (kg/m³), SP dosage (kg/m³), NaOH Molarity, Aggregate (kg/m³), Temperature (°C) and compressive strength as output parameter. Python programming is utilized in Anaconda Navigator using Spyder version 5.0 to predict the mechanical response. Statistical measures and validation of data are done by splitting the dataset into 80/20 percent and K-Fold CV is employed to check the accurateness of the model by using MAE, RMSE, and R². Statistical analysis relies on errors, and tests against external indicators help determine how well models function in terms of robustness. The most important factor in compressive strength measurements is examined using permutation characteristics. The result reveals that ANN with AdaBoost is outclassed by giving maximum enhancement with R² = 0.914 and shows the least error with statistical and external validations. Shapley analysis shows that GGBS, NaOH Molarity, and temperature are the most influential parameter that has significant content in making FASBGPC. Thus, ensemble methods are suitable for constructing prediction models because of their strong and reliable performance. Furthermore, the graphical user interface (GUI) is generated through the process of training a model that forecasts the desired outcome values when the corresponding inputs are provided. It streamlines the process and provides a useful tool for applying the model’s abilities in the field of civil engineering.

PMID:38409333 | DOI:10.1038/s41598-024-54513-y

Bone Marrow Transplant. 2024 Feb 26. doi: 10.1038/s41409-024-02230-5. Online ahead of print.

ABSTRACT

Mesenchymal stromal cells (MSC) have immunomodulatory and tissue-regenerative properties and have shown promising results in acute respiratory distress syndrome (ARDS) of multiple causes, including COVID-19. We conducted a randomised (1:1), placebo-controlled, double-blind clinical trial to assess the efficacy and safety of one bone marrow-derived MSC infusion in twenty patients with moderate to severe ARDS caused by COVID-19. The primary endpoint (increase in PaO2/FiO2 ratio from baseline to day 7, MSC 83.3 versus placebo 57.6) was not statistically significant, although a clinical improvement at day 7 in the WHO scale was observed in MSC patients (5, 50% vs 0, 0%, p = 0.033). Median time to discontinuation of supplemental oxygen was also shorter in the experimental arm (14 versus 23 days, p = 0.007), resulting in a shorter hospital stay (17.5 versus 28 days, p = 0.042). No significant differences were observed for other efficacy or safety secondary endpoints. No infusion or treatment-related serious adverse events occurred during the one-year follow-up. This study did not meet the primary endpoint of PaO2/FiO2 increase by day 7, although it suggests that MSC are safe in COVID-19 ARDS and may accelerate patients’ clinical recovery and hospital discharge. Larger studies are warranted to elucidate their role in ARDS and other inflammatory lung disorders.Trial Registration: EudraCT Number: 2020-002193-27, registered on July 14th, 2020, https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002193-27/ES . NCT number: NCT04615429, registered on November 4th, 2020, https://clinicaltrials.gov/ct2/show/NCT04615429 .

PMID:38409332 | DOI:10.1038/s41409-024-02230-5

Sci Rep. 2024 Feb 27;14(1):4706. doi: 10.1038/s41598-024-54929-6.

ABSTRACT

The development opportunities and high-performance capacity of offshore wind energy project depends on the selection of the suitable offshore wind power station (OWPS) location. The present study aims to introduce a decision-making model for assessing the locations for OWPS from multiple criteria and uncertainty perspectives. In this regard, the concept of interval-valued intuitionistic fuzzy set (IVIFS) is utilized to express uncertain information. To quantify the degree of difference between IVIFSs, an improved distance measure is proposed and further utilized for deriving the objective weights of criteria. Numerical examples are discussed to illustrate the usefulness of introduced IVIF-distance measure. The RANking COMparison (RANCOM) based on interval-valued intuitionistic fuzzy information is presented to determine the subjective weights of criteria. With the combination of objective and subjective weights of criteria, an integrated weighting tool is presented to find the numeric weights of criteria under IVIFS environment. Further, a hybrid interval-valued intuitionistic fuzzy Weighted integrated Sum Product (WISP) approach is developed to prioritize the OWPS locations from multiple criteria and uncertainty perspectives. This approach combines the benefits of two normalization tools and four utility measures, which approves the effect of beneficial and non-beneficial criteria by means of weighted sum and weighted product measures. Further, the developed approach is applied to the OWPS location selection problem of Gujarat, India. Sensitivity and comparative analyses are presented to confirm the robustness and stability of the present WISP approach. This study provides an innovative decision analysis framework, which makes a significant contribution to the OWPS locations assessment problem under uncertain environment.

PMID:38409321 | DOI:10.1038/s41598-024-54929-6

Sci Rep. 2024 Feb 26;14(1):4639. doi: 10.1038/s41598-024-55116-3.

ABSTRACT

Knowledge regarding the ligament footprints in the canine stifle is essential for biomechanical modeling of the joint and patient-specific surgical planning for anatomical ligament reconstruction. The present study aimed to establish and evaluate deformable shape templates (DSTs) of the femur and tibia with footprints of the cruciate and collateral ligaments embedded for the noninvasive estimation of ligament footprint positions. To this end, a data set of computed tomography (CT)-derived surface models of the femur and tibia were established and used to build statistical shape models (SSMs). The contours of the stifle ligaments were obtained from CT scans of 27 hindlimb specimens with radio-opaque markings on the ligament footprints. The DST, constructed by embedding averaged footprint contours into the SSM, was used to estimate subject-specific ligament footprints in a leave-one-out cross-validation framework. The DST predictions were compared with those derived from radio-opaque-marked footprints. The results showed that the averaged Euclidean distances between the estimated and reference footprint centroids were less than 1.2 mm for the cruciate ligaments and 2.0 mm for the collateral ligaments. The DST appeared to provide a feasible alternative approach for noninvasively estimating the footprints of the stifle ligaments in vivo.

PMID:38409316 | DOI:10.1038/s41598-024-55116-3