Nevin Manimala

Niger J Clin Pract. 2024 Feb 1;27(2):268-271. doi: 10.4103/njcp.njcp_452_23. Epub 2024 Feb 26.

ABSTRACT

AIM: Volvulus is a disease characterized by the abnormal twisting of a gaseous distension of the loop of the intestine around itself. Colonic volvulus is the third common cause of colonic obstruction. The study aimed to determine whether the percentage of immature granulocytes is a marker of early necrosis in the volvulus.

METHODS: Demographic characteristics of the cases were collected in the study. In addition, age, gender, white blood cell count, immature granulocyte count, immature granulocyte percentage, platelet lymphocyte ratio, and neutrophil-lymphocyte ratio were compared between groups with and without necrosis in terms of treatment.

RESULTS: The effectiveness of immature granulocyte percentage (IG%) and IG markers were statistically significant in predicting necrosis. The AUC was the highest for IG (0.820, 95% CI: 0.586-1), followed by IG% (0.820, 95% CI: 0.617-1). The optimal cut-off value for the IG was 0.65, with a sensitivity of 76.2% and specificity of 85.7% (P = 0.013). The optimal cut-off value for the IG% was 0.065, with a sensitivity of 85.7% and specificity of 71.4% (0.018).

CONCLUSION: IG% and IG count were found to be useful for predicting necrosis in patients with volvulus.

PMID:38409157 | DOI:10.4103/njcp.njcp_452_23

Niger J Clin Pract. 2024 Feb 1;27(2):260-267. doi: 10.4103/njcp.njcp_346_23. Epub 2024 Feb 26.

ABSTRACT

BACKGROUND: Recognizing the oral needs of people living with rheumatic heart disease (RHD), particularly in relation to their jaws, is of paramount importance.

AIMS: This study aimed to evaluate potential jaw bone changes in children and adolescents diagnosed with RHD and compare them with a group of healthy children and adolescents.

METHODS AND MATERIAL: The dental panoramic radiographs (DPRs) of 32 children and adolescents diagnosed with RHD comprised the case group. In contrast, the control group consisted of DPRs from 32 children and adolescents without any known diseases. Two regions of interest (ROI1 and ROI2) of trabecular bone and a separate region of interest (ROI3) of cortical bone were selected for fractal analysis. The mandibular cortical index (MCI) was evaluated.

RESULTS: The ROI1 fractal dimension (FD) value of the individuals in the case group was statistically higher in the right jaw than in the left jaw (P < 0.01). Significant differences were determined between the case and control groups regarding the left ROI1, and the left and the right ROI2 (P < 0.05). No significant difference was found between the patient and control groups regarding the MCI value (P > 0.05).

CONCLUSIONS: The results of this study showed that bone metabolism was affected unilaterally in the condyle region and bilaterally in the gonial region of patients with RHD. It also revealed that the cortical layer was not affected.

PMID:38409156 | DOI:10.4103/njcp.njcp_346_23

Niger J Clin Pract. 2024 Feb 1;27(2):228-235. doi: 10.4103/njcp.njcp_634_23. Epub 2024 Feb 26.

ABSTRACT

BACKGROUND: In the past five years, observational evidence suggests that the rates and determinants of preterm birth may have changed due to the effect of the coronavirus disease 2019 (COVID-19) pandemic and other humanitarian crises in our environment.

AIM: This study aimed to determine the incidence, associated factors, and outcomes of preterm birth in tertiary hospitals in Enugu, southeastern Nigeria.

METHODS: This cross-sectional study included 238 pregnant women from the University of Nigeria Teaching Hospital (UNTH), Enugu State University of Science and Technology Teaching Hospital (ESUT-TH) Parklane, and Mother of Christ Specialist Hospital (MOCSH), Enugu, from April 2022 to March 2023. Eligible and consenting participants were recruited from 28-36 weeks +6 days of gestational age and followed up until delivery. Relevant outcome variables, such as sociodemographic characteristics, gestational age at delivery, and pregnancy outcomes, were recorded in a pro forma. These data were analyzed using IBM Statistical Package for the Social Sciences (SPSS) statistics for Windows, version 22.0, Armonk, NY: IBM Corp.

RESULTS: The incidence of preterm birth was 16.6% (37/223), with spontaneous preterm birth constituting 24 of 37 (64.5%) cases. The mean age of participants was 30.3 ± 4.8 years. Advanced maternal age (>35 years) (P = 0.01, adjusted odds ratio (AOR) =0.01, confidence interval (CI): 0.00-0.144), low socioeconomic status (P = 0.04, AOR = 0.40, CI: 0.11-1.46), and history of miscarriage (P = 0.02, AOR = 0.06, CI: 0.01-0.59) were the factors associated with spontaneous preterm birth. Neonatal death occurred in 21.6% (8/37) of cases within the first 24 hours. Rates of cesarean section and low birth weight were 73% (27/37) each.

CONCLUSIONS: The incidence of preterm birth is high in Enugu, and associated factors were advanced maternal age, low socioeconomic status, and a history of miscarriage.

PMID:38409152 | DOI:10.4103/njcp.njcp_634_23

Injury. 2024 Feb 15;55(4):111422. doi: 10.1016/j.injury.2024.111422. Online ahead of print.

ABSTRACT

INTRODUCTION: Whether displaced lateral clavicle fractures should be treated surgically remains controversial. This study aims to compare outcomes after surgical versus non-surgical treatment of such fractures.

PATIENTS AND METHODS: 113 patients with lateral clavicle fractures registered in the Swedish Fracture Register (SFR) during 2018 and with complete displacement on radiography were included in this cohort study. Linkage with the National Patient Register provided information on baseline medical comorbidities and further interventions. Patient-reported outcome measures (PROM) were assessed using the European Quality of Life Scale (EQ-5D-3L), the Short Musculoskeletal Function Assessment (SMFA), and the Quick Disabilities of the Arm, Shoulder and Hand (QDASH). The primary outcome was the total number of initial and delayed surgical procedures. The secondary outcome was difference in PROM between surgically and non-surgically treated patient groups.

RESULTS: At a mean follow-up of 4.4 (range 3.9-4.9) years, 35 (67 %) of the 52 patients initially treated surgically had undergone a secondary procedure, mostly for implant removal. Of the 61 initially non-surgically treated patients, 3 (5 %) underwent delayed surgical treatment due to non- or malunion. 45 (40 %) patients responded to follow-up questionnaires, but no statistically significant differences were found in any PROM between groups.

CONCLUSIONS: Two thirds of surgically treated patients with displaced lateral clavicle fractures underwent two procedures. The need for delayed surgical treatment in non-surgically treated patients was low and PROM was similar in both treatment groups. Nonsurgical treatment should be considered as an option to surgery for fully displaced lateral fractures of the clavicle more often.

PMID:38408424 | DOI:10.1016/j.injury.2024.111422

Health Place. 2024 Feb 25;86:103209. doi: 10.1016/j.healthplace.2024.103209. Online ahead of print.

ABSTRACT

INTRODUCTION: Neighborhoods are complex and multi-faceted. Analytic strategies used to model neighborhoods should reflect this complexity, with the potential to better understand how neighborhood characteristics together impact health. We used latent profile analysis (LPA) to derive a residential neighborhood typology applicable for census tracts across the US.

METHODS: From tract-level 2015-2019 American Community Survey (ACS) five-year estimates, we selected five indicators that represent four neighborhood domains: demographic composition, commuting, socioeconomic composition, and built environment. We compared model fit statistics for up to eight profiles to identify the optimal number of latent profiles of the selected neighborhood indicators for the entire US. We then examined differences in national tract-level 2019 prevalence estimates of physical and mental health derived from CDC’s PLACES dataset between derived profiles using one-way analysis of variance (ANOVA).

RESULTS: The 6-profile LPA model was the optimal categorization of neighborhood profiles based on model fit statistics and interpretability. Neighborhood types were distinguished most by demographic composition, followed by commuting and built environment domains. Neighborhood profiles were associated with meaningful differences in the prevalence of health outcomes. Specifically, tracts characterized as “Less educated non-immigrant racial and ethnic minority active transiters” (n = 3,132, 4%) had the highest poor health prevalence (Mean poor physical health: 18.6 %, SD: 4.30; Mean poor mental health: 19.6 %, SD: 3.85), whereas tracts characterized as “More educated metro/micropolitans” (n = 15, 250, 21%) had the lowest prevalence of poor mental and physical health (Mean poor physical health: 10.6 %, SD: 2.41; Mean poor mental health: 12.4 %, SD: 2.67; p < 0.001).

CONCLUSION: LPA can be used to derive meaningful and standardized profiles of tracts sensitive to the spatial patterning of social and built conditions, with observed differences in mental and physical health by neighborhood type in the US.

PMID:38408408 | DOI:10.1016/j.healthplace.2024.103209

Pregnancy Hypertens. 2024 Feb 25;36:101116. doi: 10.1016/j.preghy.2024.101116. Online ahead of print.

ABSTRACT

BACKGROUND: The early and accurate diagnosis of preeclampsia is crucial to avoid serious complications for both the mother and baby. However, the current diagnostic methods are limited, and there is a need for new diagnostic biomarkers. Previous studies have shown that cathepsin D (CTD) participates in the pathophysiology of preeclampsia and is present in urine samples, making it a potential biomarker for the disease. This study aimed to compare urinary and serum levels of CTD in preeclamptic and normotensive women and analyze its potential role as a diagnostic biomarker in preeclampsia.

METHODS: The study included thirty-nine patients with preeclampsia and twelve normotensive pregnant women as controls. Biomarkers were determined using Multiplex Assay kit, and serum prolactin (Prl) and urinary TNF-α levels were also evaluated. Statistical analysis was conducted using the Mann-Whitney U test.

RESULTS: We found that urinary and serum CTD levels were significantly higher in the preeclampsia group than in the normotensive group, suggesting that CTD could be a diagnostic biomarker for preeclampsia. No significant differences were found in the levels of serum prolactin or urinary TNF-α between the two groups.

CONCLUSIONS: The study provides evidence that non-invasive biological samples such as urine can be used to improve new therapeutic strategies for the early management of preeclampsia.

PMID:38408407 | DOI:10.1016/j.preghy.2024.101116

J Occup Environ Hyg. 2024 Feb 26:1-13. doi: 10.1080/15459624.2024.2302470. Online ahead of print.

ABSTRACT

Work-related deaths are a persistent occupational health issue that can be prevented. However, prevention opportunities can be hampered by a lack of adequate public health resources. The Western States Occupational Network (WestON) is a network of federal, state, and local occupational health professionals that includes a 19-state region of the United States. To encourage public health collaboration, WestON partners examined work-related fatalities within the region. Fatality counts (numerators) were obtained from the U.S. Bureau of Labor Statistics (BLS) Census of Fatal Occupational Injuries restricted-access research files for all workers ages ≥15 years and fatally injured in WestON states from 2011 through 2017. Estimates of full-time equivalent hours worked (FTE) (denominators) were retrieved from the BLS Current Population Survey. Annual average fatality rates were calculated as number of fatalities per 100,000 FTE over the study period. Rates were stratified by state, select demographics, industry sector, and event/exposure types. Pearson chi-squared tests and rate ratios with 95% confidence probability limits were used to assess rate differences. All analyses were conducted using SAS v.9.4. From 2011 through 2017, the annual average overall occupational fatality rate for the WestON region was 3.5 fatalities per 100,000 FTE, comparable to the overall U.S. fatality rate. Male workers had a fatality rate almost 10 times higher than female workers in the region. Fatality rates increased with successive age groups. Alaska and New Mexico had significantly higher fatality rates for all racial/ethnic groups compared to respective regional rates. Wyoming, North Dakota, and Montana had the three highest occupational fatality rates among foreign-born workers. Agriculture/forestry/fishing, mining/oil/gas extraction, and transportation/warehousing/utilities were industry sector groups with the three highest fatality rates regionally. Transportation-related incidents were the most frequent event type associated with occupational fatalities for all 19 states. Work-related fatalities are a crosscutting occupational public health priority. This analysis can be an impetus for collaborative multistate initiatives among a dynamic and varied occupational public health network to better meet the needs of a rapidly changing workforce.

PMID:38408355 | DOI:10.1080/15459624.2024.2302470

J Neurosurg Case Lessons. 2024 Feb 26;7(9):CASE23702. doi: 10.3171/CASE23702. Print 2024 Feb 26.

ABSTRACT

BACKGROUND: Spontaneous intracranial hypotension (SIH) is a rare condition characterized by positional headache, for which contrast-enhanced magnetic resonance imaging (MRI) is the preferred diagnostic method. Although MRI reveals characteristic findings, head computed tomography (CT) is usually the first diagnostic step, but identifying features of SIH on CT is often difficult. This study was specifically designed to evaluate the utility of head CT in detecting upper cervical epidural venous engorgement as a sign of SIH.

OBSERVATIONS: Of 24 patients with SIH diagnosed between March 2011 and May 2023, 10 did not undergo upper cervical CT. In the remaining 14 patients, engorgement of the upper cervical epidural venous plexus was observed. CT detection rates were consistent with MRI for spinal fluid accumulation or dural thickening. After treatment, in 92.9% of patients, the thickness of the epidural venous plexus decreased statistically significantly from 4.8 ± 1.3 mm to 3.6 ± 1.2 mm.

LESSONS: This study suggests that upper cervical spine CT focused on epidural venous engorgement may be helpful in the initial diagnosis of SIH and may complement conventional MRI evaluation. Extending CT imaging to the upper cervical spine will improve the diagnostic accuracy of patients with positional headaches suspected to be SIH.

PMID:38408340 | DOI:10.3171/CASE23702

J Phys Chem A. 2024 Feb 26. doi: 10.1021/acs.jpca.3c08203. Online ahead of print.

ABSTRACT

Triply periodic minimal surfaces (TPMS) inspired by nature serve as a foundation for developing novel nanomaterials, such as templated silicas, graphene sponges, and schwarzites, with customizable optical, poroelastic, adsorptive, catalytic, and other properties. Computer simulations of reactions on TPMS using reactive intermolecular potentials hold great promise for constructing and screening potential TPMS with the desired properties. Here, we developed an off-lattice, surface-constrained Metropolis Monte Carlo (SC-MMC) algorithm that utilized a temperature quench process. The presented SC-MMC algorithm was used to investigate the process of graphitization reactions on the Schwarz primitive, Schwarz diamond, and Schoen gyroid TPMS, all with a cubic lattice parameter of 8 nm. We show that the optimized carbon TPMS exhibits a low energy, approximately -7.1 eV/atom, comparable to that of graphite and diamond crystals, along with a variety of topological defects. Furthermore, these structures showcase extensive and smooth surfaces characterized by a negative discrete Gaussian curvature, a distinctive feature indicative of an interconnected morphology. They possess specific surface areas of ∼2700 m²/g, comparable to graphene, and exhibit a significant porosity of around 90%. The theoretical X-ray correlation functions and nitrogen adsorption isotherms confirm that the constructed TPMS exhibit remarkably similar surface properties, although the pore space topology varies significantly.

PMID:38408339 | DOI:10.1021/acs.jpca.3c08203

J Craniofac Surg. 2024 Feb 26. doi: 10.1097/SCS.0000000000010017. Online ahead of print.

ABSTRACT

Anthropometric measurements are essential for diagnosing and treating various craniofacial disorders during nasal reconstruction and esthetic surgery. Different people have unique individual esthetic features that are a mixture of different races and backgrounds. This study aimed to compare 12 different anthropometric measurements in the Saudi Arabian population with those in other local and international studies. This cross-sectional study was conducted with 420 volunteers from December 2022 to August 2023 in Riyadh, Saudi Arabia. Study samples were drawn from the general population, and 12 nasal anthropometric variables were measured, including 7 linear and 5 angular variables, by taking digital photographs from frontal and lateral views. Anthropometric landmarks and measurements were obtained as previously described by Farkas et al. Photographs were analyzed using Adobe Photoshop CS4 software, and facial landmarks were identified. Data were analyzed using an independent sample t test to assess the mean and SD with differences (P<0.05 indicated a significant value). After statistical analysis, the results were compared with previously published standards for other races. Exactly 420 Saudi Arabian volunteers were examined to compare nasal anthropometric variables. All 12 nasal anthropometric variables differed significantly between male and female individuals. Anthropometry of the nose has an enormous miscellaneous relationship between sexes and populations of different geographic areas. It is important to create average anthropometric measurements for different groups for successful plastic surgery and rhinoplasty.

PMID:38408327 | DOI:10.1097/SCS.0000000000010017