Nevin Manimala

Psychol Assess. 2023 Nov;35(11):1054-1067. doi: 10.1037/pas0001211.

ABSTRACT

To assess the public health impact of the COVID-19 pandemic on mental health, investigators from the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) research program developed the Pandemic-Related Traumatic Stress Scale (PTSS). Based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) acute stress disorder symptom criteria, the PTSS is designed for adolescent (13-21 years) and adult self-report and caregiver-report on 3-12-year-olds. To evaluate psychometric properties, we used PTSS data collected between April 2020 and August 2021 from non-pregnant adult caregivers (n = 11,483), pregnant/postpartum individuals (n = 1,656), adolescents (n = 1,795), and caregivers reporting on 3-12-year-olds (n = 2,896). We used Mokken scale analysis to examine unidimensionality and reliability, Pearson correlations to evaluate relationships with other relevant variables, and analyses of variance to identify regional, age, and sex differences. Mokken analysis resulted in a moderately strong, unidimensional scale that retained nine of the original 10 items. We detected small to moderate positive associations with depression, anxiety, and general stress, and negative associations with life satisfaction. Adult caregivers had the highest PTSS scores, followed by adolescents, pregnant/postpartum individuals, and children. Caregivers of younger children, females, and older youth had higher PTSS scores compared to caregivers of older children, males, and younger youth, respectively. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37902671 | DOI:10.1037/pas0001211

Psychol Assess. 2023 Nov;35(11):925-937. doi: 10.1037/pas0001258.

ABSTRACT

Psychological assessment underwent substantive challenges and changes when the COVID-19 pandemic began, and these changes are likely to endure given the rapid growth of telehealth clinical practice and assessment research using virtual procedures. COVID-19-related changes to assessment practices have impacted accordingly how we study overreporting scale functioning, including the modality through which we administer measures. No available research provides direct comparisons of overreporting scale effectiveness within simulation research across in-person and telehealth modalities, despite early support for novel instruments relying on remote procedures within the historic context of the pandemic. We used simulated feigning conditions collected using best telehealth practices to examine if, and how, overreporting scales differed in effectiveness by evaluating mean scores, elevation rates, and classification accuracy statistics, relative to parallel in-person conditions. Results indicate no meaningful differences in scale effectiveness, particularly when exclusion procedures included a posttest questionnaire. Our findings support telehealth assessment practice and the integration of research collected virtually into the traditional, in-person feigning literature. Limitations and future directions are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37902662 | DOI:10.1037/pas0001258

Acta Otolaryngol. 2023 Oct 30:1-7. doi: 10.1080/00016489.2023.2269255. Online ahead of print.

ABSTRACT

BACKGROUND: To determine the anatomical proximity of the vestibular nuclei to the respiratory nuclei and the effect of susceptibility of the posterior labyrinth to a hypoxic state on the vestibular system.

OBJECTIVE: It was aimed to evaluate the possible effects of periodic hypoxia on vestibular reflexes and proprioceptive perception in patients with obstructive sleep apnea syndrome (OSAS).

MATERIAL AND METHODS: The study was conducted with 40 patients diagnosed with moderate and severe OSAS and 21 healthy individuals. All individuals were evaluated with Dizziness Handicap Inventory, ocular vestibular evoked myogenic potential (oVEMP), cervical vestibular evoked myogenic potential (cVEMP), video head impulse test (vHIT), videonystagmography (VNG) and sportKAT 3000.

RESULTS: In the vHIT, a statistically significant difference was found between the groups in terms of anterior and posterior semicircular canal vestibulo-ocular reflex gains (p < .05). A negative correlation was found between the lateral gain asymmetry and RALP gain asymmetry and the awake blood oxygen level in the OSAS groups. There was a statistically significant difference between the groups in terms of wave response rates cVEMP 100 dB nHL and oVEMP 100-110 dB nHL (p < .05).

CONCLUSION AND SIGNIFICANCE: It was concluded that vestibular reflexes and proprioceptive perception were affected due to periodic/chronic hypoxia in patients with moderate and severe OSAS.

PMID:37902611 | DOI:10.1080/00016489.2023.2269255

J Physiol. 2023 Oct 30. doi: 10.1113/JP284958. Online ahead of print.

ABSTRACT

Critical torque (CT) represents the highest oxidative steady state for intermittent knee extensor exercise, but the extent to which it is influenced by skeletal muscle mitochondria and sex is unclear. Vastus lateralis muscle biopsy samples were collected from 12 females and 12 males -matched for relative maximal oxygen uptake normalized to fat-free mass (FFM) (F: 57.3 (7.5) ml (kg FFM)^-1 min^-1 ; M: 56.8 (7.6) ml (kg FFM)^-1 min^-1 ; P = 0.856) – prior to CT determination and performance fatiguability trials. Males had a lower proportion of myosin heavy chain (MHC) I isoform (40.6 (18.4)%) compared to females (59.5 (18.9)%; P = 0.021), but MHC IIa and IIx isoform distributions and protein markers of mitochondrial content were not different between sexes (P > 0.05). When normalized to maximum voluntary contraction (MVC), the relative CT (F: 42.9 (8.3)%; M: 37.9 (9.0)%; P = 0.172) and curvature constant, W’ (F: 26.6 (11.0) N m s (N m)^-1 ; M: 26.4 (6.5) N m s (N m)^-1 ; P = 0.962) were not significantly different between sexes. All protein biomarkers of skeletal muscle mitochondrial content, as well as the proportion of MHC I isoform, positively correlated with relative CT (0.48 < r < 0.70; P < 0.05), and the proportion of MHC IIx isoform correlated positively with relative W’ (r = 0.57; P = 0.007). Indices of performance fatiguability were not different between males and females for MVC- and CT-controlled trials (P > 0.05). Greater mitochondrial protein abundance was associated with attenuated declines in potentiated twitch torque for exercise at 60% MVC (P < 0.05); however, the influence of mitochondrial protein abundance on performance fatiguability was reduced when exercise was prescribed relative to CT. Whether these findings translate to whole-body exercise requires additional research. KEY POINTS: The quadriceps critical torque represents the highest intensity of intermittent knee extensor exercise for which an oxidative steady state is attainable, but its relationship with skeletal muscle mitochondrial protein abundance is unknown. Matching males and females for maximal oxygen uptake relative to fat-free mass facilitates investigations of sex differences in exercise physiology, but studies that have compared critical torque and performance fatiguability during intermittent knee extensor exercise have not ensured equal aerobic fitness between sexes. Skeletal muscle mitochondrial protein abundance was correlated with critical torque and fatigue resistance for exercise prescribed relative to maximum voluntary contraction but not for exercise performed relative to the critical torque. Differences between sexes in critical torque, skeletal muscle mitochondrial protein abundance and performance fatiguability were not statistically significant. Our results suggest that skeletal muscle mitochondrial protein abundance may contribute to fatigue resistance by influencing the critical intensity of exercise.

PMID:37902588 | DOI:10.1113/JP284958

J Cogn Neurosci. 2023 Oct 30:1-24. doi: 10.1162/jocn_a_02080. Online ahead of print.

ABSTRACT

Web-based experiments are gaining momentum in motor learning research because of the desire to increase statistical power, decrease overhead for human participant experiments, and utilize a more demographically inclusive sample population. However, there is a vital need to understand the general feasibility and considerations necessary to shift tightly controlled human participant experiments to an online setting. We developed and deployed an online experimental platform modeled after established in-laboratory visuomotor rotation experiments to serve as a case study examining remotely collected data quality for an 80-min experiment. Current online motor learning experiments have thus far not exceeded 60 min, and current online crowdsourced studies have a median duration of approximately 10 min. Thus, the impact of a longer-duration, web-based experiment is unknown. We used our online platform to evaluate perturbation-driven motor adaptation behavior under three rotation sizes (±10°, ±35°, and ±65°) and two sensory uncertainty conditions. We hypothesized that our results would follow predictions by the relevance estimation hypothesis. Remote execution allowed us to double (n = 49) the typical participant population size from similar studies. Subsequently, we performed an in-depth examination of data quality by analyzing single-trial data quality, participant variability, and potential temporal effects across trials. Results replicated in-laboratory findings and provided insight on the effect of induced sensory uncertainty on the relevance estimation hypothesis. Our experiment also highlighted several specific challenges associated with online data collection including potentially smaller effect sizes, higher data variability, and lower recommended experiment duration thresholds. Overall, online paradigms present both opportunities and challenges for future motor learning research.

PMID:37902584 | DOI:10.1162/jocn_a_02080

Trauma Violence Abuse. 2023 Oct 30:15248380231204887. doi: 10.1177/15248380231204887. Online ahead of print.

ABSTRACT

Gender-based violence (GBV) is a pervasive public health issue that harms victims. Bystanders’ interventions are crucial in preventing the risks of GBV; however, numerous barriers impede their willingness and behaviors to intervene. As a part of efforts to thwart these barriers, this study used a systematic review and meta-analysis to identify such barriers and assess their impact on bystanders’ engagement to intervene. The researchers explored academic databases and included 38 studies in the analysis; we extracted and coded the identified barriers (e.g., lack of responsibility, rape myth) and allocated them to six domains: failure to notice, failure to perceive risk, failure to take responsibility for engaging, lack of bystander efficacy/competency, failure to take an action, and failure of previous intervention attempts. We calculated the overall and domain-specific effect sizes (ES) and performed moderator analysis. The overall ES of the barriers identified in the review were small but statistically significant. The most potent bystander intervention barrier domain was failed previous intervention attempts; the greatest specific barriers therein were negative emotions and feelings of uncertainty after engaging in bystander behaviors. University/college populations were more vulnerable to barriers to intervention than community members. Moreover, the barriers were more prohibitive in incidents of violence against women and sexual assaults than in intimate partner violence. Bystander-focused programs that address negative emotions and feelings arising from prior intervention experiences are needed to foster continued bystander engagement and assistance in GBV; moreover, tailored program content should also be provided for groups most vulnerable to intervention barriers.

PMID:37902582 | DOI:10.1177/15248380231204887

J Cardiovasc Imaging. 2023 Oct;31(4):200-206. doi: 10.4250/jcvi.2023.0055.

ABSTRACT

BACKGROUND: Right ventricular (RV) dysfunction is a significant risk of major adverse cardiac events in patients with acute heart failure (AHF). In this study, we evaluated RV-pulmonary artery (PA) coupling, assessed by tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) and assessed its prognostic significance, in AHF patients.

METHODS: We measured the TAPSE/PASP ratio and analyzed its correlations with other echocardiographic parameters. Additionally, we assessed its prognostic role in AHF patients.

RESULTS: A total of 1147 patients were included in the analysis (575 men, aged 70.81 ± 13.56 years). TAPSE/PASP ratio exhibited significant correlations with left ventricular (LV) ejection fraction(r = 0.243, p < 0.001), left atrial (LA) diameter(r = -0.320, p < 0.001), left atrial global longitudinal strain (LAGLS, r = 0.496, p < 0.001), mitral E/E’ ratio(r = -0.337, p < 0.001), and right ventricular fractional area change (RVFAC, r = 0.496, p < 0.001). During the median follow-up duration of 29.0 months, a total of 387 patients (33.7%) died. In the univariate analysis, PASP, TAPSE, and TAPSE/PASP ratio were significant predictors of mortality. After the multivariate analysis, TAPSE/PASP ratio remained a statistically significant parameter for all-cause mortality (hazard ratio [HR], 0.453; p = 0.037) after adjusting for other parameters. In the receiver operating curve analysis, the optimal cut-off level of TAPSE/PASP ratio for predicting mortality was 0.33 (area under the curve = 0.576, p < 0.001), with a sensitivity of 65% and a specificity of 47%. TAPSE/PASP ratio < 0.33 was associated with an increased risk of mortality after adjusting for other variables (HR, 1.306; p = 0.025).

CONCLUSIONS: In AHF patients, TAPSE/PASP ratio demonstrated significant associations with RVFAC, LA diameter and LAGLS. Moreover, a decreased TAPSE/PASP ratio < 0.33 was identified as a poor prognostic factor for mortality.

PMID:37901999 | DOI:10.4250/jcvi.2023.0055

ACS Nano. 2023 Oct 30. doi: 10.1021/acsnano.3c08377. Online ahead of print.

ABSTRACT

An electron-hole pair in a cube-shaped CdSe/CdS core/shell nanocrystal exists in the form of dynamic excitons across the strongly and weakly confined regimes under ambient temperatures. Photochemical doping is applied to distinguish the band-edge electron and hole levels, confirming an effective mass model with universal constants. Reduction of the optical bandgap upon epitaxy of the CdS shells is caused by lowering the band-edge electron level and barely affecting the band-edge hole level. Similar shifts of the electron levels, yet retaining the hole levels, can switch the order in energy of the three lowest-energy transitions. Thermal distribution of 1-4 electrons among the two thermally accessible electron levels follows number-counting statistics, instead of Fermi-Dirac distribution.

PMID:37901990 | DOI:10.1021/acsnano.3c08377

Circulation. 2023 Oct 30. doi: 10.1161/CIRCULATIONAHA.123.066017. Online ahead of print.

ABSTRACT

Background: Climate change is causing an increase in extreme heat. Individuals with cardiovascular disease are at high risk of heat-related adverse health effects. How the burden of extreme heat-associated cardiovascular deaths in the United States will change with the projected rise in extreme heat is unknown. Methods: We obtained data on cardiovascular deaths among adults and the number of extreme heat days (maximum heat index ≥90 °F [32.2 °C]) in each county in the contiguous United States from 2008 to 2019. Based on representative concentration pathway trajectories that model greenhouse gas emissions and shared socioeconomic pathways (SSP) that model future socioeconomic scenarios and demographic projections, we obtained county-level projected numbers of extreme heat days and populations under 2 scenarios for the midcentury period 2036 to 2065: SSP2-4.5 (representing demographic projections from a “middle-of-the-road” socioeconomic scenario and an intermediate increase in emissions) and SSP5-8.5 (demographic projections in an economy based on “fossil-fueled development” and a large increase in emissions). The association of cardiovascular mortality with extreme heat was estimated with a Poisson fixed-effects model. Using estimates from this model, the projected number of excess cardiovascular deaths associated with extreme heat was calculated. Results: Extreme heat was associated with 1651 (95% CI, 921-2381) excess cardiovascular deaths per year from 2008 to 2019. By midcentury, extreme heat is projected to be associated with 4320 (95% CI, 2369-6272) excess deaths annually, which is an increase of 162% (95% CI, 142-182) under SSP2-4.5, and 5491 (95% CI, 3011-7972) annual excess deaths, which is an increase of 233% (95% CI, 206-259) under SSP5-8.5. Elderly adults are projected to have a 3.5 (95% CI, 3.2- 3.8) times greater increase in deaths in the SSP2-4.5 scenario compared with nonelderly adults. Non-Hispanic Black adults are projected to have a 4.6 (95% CI, 2.8-6.4) times greater increase compared with non-Hispanic White adults. The projected change in deaths was not statistically significantly different for other race and ethnicity groups or between men and women. Conclusions: By midcentury, extreme heat is projected to be associated with a significantly greater burden of excess cardiovascular deaths in the contiguous United States.

PMID:37901952 | DOI:10.1161/CIRCULATIONAHA.123.066017

Nucl Med Commun. 2023 Oct 30. doi: 10.1097/MNM.0000000000001761. Online ahead of print.

ABSTRACT

OBJECTIVE: Human epidermal growth factor receptor 2 (HER2) is an important biomarker for targeted gastric cancer (GC) immunotherapy. However, heterogeneous HER2 overexpression in GC, loss of HER2 expression during therapy, and inability to non-invasively identify HER2 overexpressing tumors impede effective targeting therapies. Improved HER2-specific functional imaging can address these challenges. Trastuzumab is a HER2-directed mAb to treat HER2 overexpressing cancers. The 64Cu-DOTA-trastuzumab radiotracer is used to detect HER2+ metastatic breast cancer. We aimed to develop 64Cu-DOTA-trastuzumab PET-CT to detect and characterize tumor uptake in HER2+ or – GC patients.

METHODS: We conducted a single-arm phase II pilot study exploring the feasibility of 64Cu-DOTA-trastuzumab for PET imaging of HER2 overexpressing GC compared to HER2 non-expressing tumors. Eight patients with biopsy-confirmed gastric adenocarcinoma were included. Immunohistochemistry was used to evaluate primary tumor biopsies for HER2 overexpression. Patients were injected with 45 mg of cold trastuzumab followed by 5 mg of 64Cu-DOTA-trastuzumab. PET-CT scans were performed 24-48 h post radiotracer injection and compared to standard staging CT scans.

RESULTS: We observed limited toxicity following 64Cu-DOTA-trastuzumab injections. While there was uptake of the radiotracer in portions of HER2+ lesions, there was no statistically significant distinction between tumor and background by standardized uptake value analysis.

CONCLUSION: Despite the potential of 64Cu-DOTA-trastuzumab PET imaging of HER2+ metastatic breast cancer, a 5 mg dose of this radiotracer injected 24-48 h before imaging was insufficient to identify HER2+ GC. These results inform future GC imaging studies to optimize biomarker-targeted therapies based on dosage and timing for more clinically relevant imaging.

PMID:37901917 | DOI:10.1097/MNM.0000000000001761