Nevin Manimala

Neuroradiol J. 2023 Aug 18:19714009231196471. doi: 10.1177/19714009231196471. Online ahead of print.

ABSTRACT

PURPOSE: Secondary language areas, including the pre-supplementary motor area (pre-SMA), dorsolateral prefrontal cortex (DLPFC), and the visual word form area (VWFA) play important roles in speech, but have been under-evaluated in the realm of resting-state (rs)-fMRI. The purpose of this study is to determine the incidence that secondary language areas and contralateral language areas can be localized using seed-based correlation (SBC) rs-fMRI.

METHODS: We retrospectively reviewed 40 rs-fMRIs for functional connectivity (FC) to secondary language areas in cases where FC to Broca’s or Wernicke’s area near tumor in the left hemisphere were successfully generated using SBC analysis. Logistical regression was used for statistical analysis.

RESULTS: SBC rs-fMRI with a seed in the left Broca’s or Wernicke’s area ipsilateral to the tumor was performed in the 40 patients. 72.5% of cases showed FC to the left DLPFC, 67.5% to left pre-SMA, and 52.5% of cases had FC to right Broca’s area. In addition to other correlations, we found older patients have a lower incidence of FC to the right Wernicke’s area when seeded from both left Broca’s and left Wernicke’s area (p-value = .016, odds ratio = 0.94).

CONCLUSION: SBC rs-fMRI can detect left hemispheric secondary language areas as well as right hemispheric primary and secondary language areas. The left DLPFC showed the highest incidence of FC, followed by the left pre-SMA when seeded from both left Broca’s and Wernicke’s area. Logistics regression also showed in some instances, differences in the incidence of FC to language areas was dependent on age, seed location, and gender.

PMID:37596790 | DOI:10.1177/19714009231196471

Int Wound J. 2023 Aug 18. doi: 10.1111/iwj.14322. Online ahead of print.

ABSTRACT

Because of the difficult surgical procedures, patients with lung cancer who have received thoracic surgery tend to have postoperative complications. It may lead to postoperative complications like wound infection, wound haematoma and pneumothorax. A lot of research has assessed the effect of various surgery methods on postoperative complications in pulmonary cancer. The purpose of this meta-analysis is to establish if thoracoscopic is superior to that of thoracotomy in the rate of post-operative complications. From the beginning to the end of June 2023, we performed an exhaustive search on four main databases for key words. The Hazard of Bias in Non-Randomized Interventional Studies (ROBINS-I) was evaluated in the literature. In the end, 13 trials that fulfilled the eligibility criteria underwent further statistical analyses. The results showed that thoracoscopic intervention decreased the risk of post operative wound infection (dominant ratio [OR], 3.00; 95% confidence margin [CI], 1.98, 4.55; p < 0.00001) and air-leakage after operation (OR, 1.30; 95% CI, 1.04, 1.63; p = 0.02). There was no statistically significant difference between the two groups in terms of the rate of haemorrhage after operation (OR, 0.10; 95% CI, 0.73, 1.66; p = 0.63). Our findings indicate that thoracoscopic is less likely to cause post operative infection and gas leakage than thoracotomy, and it does not decrease the risk of postoperative haemorrhage. As some of the chosen trials are too small to conduct meta-analyses, care must be taken when handling the data. In the future, a large number of randomized, controlled trials will be required to provide additional evidence for this research.

PMID:37596788 | DOI:10.1111/iwj.14322

Pigment Cell Melanoma Res. 2023 Aug 18. doi: 10.1111/pcmr.13119. Online ahead of print.

ABSTRACT

A PTEN deficiency leads to the activation of phospho-Akt at serine 473 (p-Akt) and promotes the tumorigenesis of melanomas by coupling with NUAK2 amplification. We tested the prognostic impact of p-Akt and/or NUAK2 expression on the relapse-free survival (RFS) and overall survival (OS) of melanoma patients. Primary tumors from patients with acral melanomas (112), Low-cumulative sun damage (CSD) melanomas (38), and High-CSD melanomas (18) were examined using immunohistochemistry and their prognostic significance was analyzed statistically. The expression of p-Akt was found in 32.1%, 68.4%, and 55.6% of acral, Low-CSD, and High-CSD melanomas, while NUAK2 expression was found in 46.4%, 76.3%, and 50.0%, respectively. Either p-Akt or NUAK2 expression was inversely correlated with the RFS of primary melanoma patients and acral melanoma patients (p-Akt: p < .0001, p < .0001; NUAK2; p = .0005, p < .0001, respectively). Strikingly, multivariate analyses revealed that p-Akt had a significant impact on RFS (Hazard ratio = 4.454; p < .0001), while NUAK2 did not. Further subset analyses revealed that p-Akt expression had an inferior RFS of patients with acral melanomas (Hazard ratio = 4.036; p = .0005). We conclude that the expression of p-Akt has a significant impact on RFS of patients with primary melanomas and can predict the relapse of patients with acral melanomas.

PMID:37596787 | DOI:10.1111/pcmr.13119

Am J Ind Med. 2023 Aug 18. doi: 10.1002/ajim.23529. Online ahead of print.

ABSTRACT

BACKGROUND: Long shifts and short rest periods (SRP) between shifts are important factors that greatly affect shift workers’ health. However, reports on the psychological effects of shift work, such as depression, have been inconsistent. Therefore, this study aimed to investigate the combined effect of long shifts and SRP on depression in shift workers.

METHODS: This cross-sectional study included 3295 shift workers in the sixth Korean Working Conditions Survey. The relative excess risk due to interaction (RERI) was computed to estimate the combined effect of long shifts and SRP on depression.

RESULTS: Depression in shift workers was not significantly associated with long shifts or SRP after adjustment, but the risk was significantly increased when exposed to both factors simultaneously (odds ratio 1.36, 95% confidence interval 1.03-1.79). The RERI between the two factors was statistically significant (p = 0.020), indicating a synergistic interaction with depression. Sensitivity analysis by occupation showed a significant interaction in the combined group of office and service workers (p = 0.034).

CONCLUSIONS: Simultaneous exposure to SRP and long shifts should be avoided when planning shift work schedules or devising health policies for shift workers. Special consideration is needed for healthcare and service workers, who may be particularly vulnerable to negative health impacts due to shift work.

PMID:37596767 | DOI:10.1002/ajim.23529

Am J Health Behav. 2023 Jun 30;47(3):428-449. doi: 10.5993/AJHB.47.3.1.

ABSTRACT

Objectives: Actual use of nicotine pouch products is not well studied. The objectives of this study were to characterize on ® nicotine pouch (Test Products (TP)) use behavior, including association with cigarette and smokeless tobacco (ST) product use. Methods: Adults who smoke cigarettes (AS) and/or adults who use ST (ASTU) (N=1147) that were not planning to quit and had expressed interest in trying and using TP after a 5-day trial were offered ad libitum use of TPs (7 flavors at 5 nicotine levels) for 6 weeks. Results: Participants used a median of ~5-6 pouches/day of a variety of flavors and nicotine levels. In the final week of the study, 27% of AS and 71% of ASTU reported no use of cigarettes or ST respectively, while reporting continued use of TPs. Additionally, 39% of AS and 14% of ASTU reduced consumption of cigarettes or ST products respectively by 50%-99%, compared to reported use at screening. We found a statistically significant inverse relationship between TP flavor varieties and number of cigarettes/ST. Conclusions: These data suggest that TPs can be potential substitutes for cigarettes/ST products, and complete switching may offer harm reduction potential for AS and ASTU not interested in quitting.

PMID:37596760 | DOI:10.5993/AJHB.47.3.1

Am J Health Behav. 2023 Jun 30;47(3):628-641. doi: 10.5993/AJHB.47.3.20.

ABSTRACT

Objectives: The aim of this study was to investigate the effectiveness of narrative therapy in reducing work pressure and improving health behavior among clinical and anesthesia frontline nurses. Methods: We used convenience sampling to select clinical and anesthesiology department nurses from hospitals between May 2019 and May 2021. We used a nursing knowledge-attitude-behavior questionnaire to assess the status of nurses and assess the effectiveness of the narrative therapy intervention. We analyzed our data using SPSS and Smart PLS. Results: We found statistically significant differences in scores on the Competence Scale (NCS) and the Nursing Caring Characters Assessment Tool (NCCAT) (p<.05). The average scores of items in each dimension of clinical and anesthesiology department narrative nursing knowledge and behavior were: knowledge score (3.67±0.52), attitude score (5.48±0.62), and behavior score (4.74±0.77). Conclusion: The ADDIE-based narrative nursing training program improved nurses’ narrative nursing ability and humanistic care quality, reducing work pressure and promoting health behavior. These findings highlight the importance of narrative therapy in clinical practice for frontline nurses.

PMID:37596759 | DOI:10.5993/AJHB.47.3.20

Am J Health Behav. 2023 Jun 30;47(3):533-538. doi: 10.5993/AJHB.47.3.10.

ABSTRACT

Objectives: Since the outbreak of COVID-19, Internet use has become more frequent as the reaction to quarantine and social distancing have continued, which has had a significant impact on mental health. The aim of this study was to examine the relationship between Internet use and mental health during the COVID-19 pandemic. Methods: We obtained data from the 2020 China Family Panel Study (CFPS), a nationwide typical longitudinal follow-up social survey that began in 2010 and is implemented every 2 years. We assessed Internet use by whether or not people used a mobile device or a computer to access the Internet. We measured the mental health of individuals using values for the depression variable, which was collected through the Center for Epidemiologic Studies Depression Scale (CES-D). Statistical analysis involved independent sample t-tests and multiple linear regression analysis. Results: Internet use was significantly associated with a decrease in depression scores; the length of Internet use was significantly associated with an increase in depression scores. The relationship between various Internet functions and depression scores differed significantly, with gaming and social functions being significantly associated with a decrease in depression scores; shopping and learning functions were not significantly associated with depression scores. For youth, play functioning was significantly associated with a decrease in depression scores, while shopping functioning was significantly associated with an increase in depression scores; for the middle-aged group, social functioning was significantly associated with a decrease in depression scores; and for the elderly, social and shopping functioning were significantly associated with a decrease in depression scores.Conclusion: Public mental health can be promoted through the use of the Internet during the COVID-19 pandemic. Different groups should make reasonable use of Internet functions but control the length of time spent using them.

PMID:37596757 | DOI:10.5993/AJHB.47.3.10

Am J Health Behav. 2023 Jun 30;47(3):510-519. doi: 10.5993/AJHB.47.3.8.

ABSTRACT

Objectives: In this study, we investigate the relationships among personal well-being, self-esteem, supervisor support, life satisfaction, and happiness in a sample of nurses. In this study, we also investigate the mediating role of life satisfaction. Methods: Present research was quantitative in nature and the research design was cross-sectional. Data were collected from a convenience sample of nurses working in hospitals by using a self-administered survey. We used partial least square-structural equation modeling (PLS-SEM) for the assessment of statistical significance of the proposed model. Results: We found a statistically significant and positive relationship between personal well-being, life satisfaction, and happiness. Similarly, self-esteem and supervisor support positively affected life satisfaction. Conclusion: Our research adds to the present literature on the factors that affect happiness among nurses. The study also adds to the current literature on PLS-SEM in terms of the assessment of mediation and direct relationships. Our findings are helpful for decision-makers in the health sector in developing happiness and life satisfaction among nurses. These results are also valuable for academicians for their future studies.

PMID:37596749 | DOI:10.5993/AJHB.47.3.8

Am J Health Behav. 2023 Jun 30;47(3):498-509. doi: 10.5993/AJHB.47.3.7.

ABSTRACT

Objectives: In this paper, we examined the impact of abusive leadership (AB) on psychological well-being (PWB) and presenteeism (PR) by considering the moderating effect of mental health (MH) of employees in Saudi small and medium enterprises (SME’s). Methods: We used non-probability sampling to collect data from employees in the Saudi SME’s. We used 152 complete questionnaires for statistical analysis, including descriptive statistics, validity and reliability tests, confirmatory factor analysis, and structural equation modeling. Results: AB significantly and negatively impacted the PWB of employees in the Saudi SME’s (p<.05). Furthermore, we found a statistically significant association (p<.05) between AB and PR, where increased AB increased presenteeism. Regarding the moderation effect, findings revealed that MH significantly suppressed the negative association between AB and PWB and significantly dampened the positive relationship between AB and PR. Conclusion: Leadership plays a ctitical role in employees’ well-being and presenteeism; therefore, our study has important implications for managers, workers, and policymakers to promote healthy leadership for improved employee well-being and productivity.

PMID:37596746 | DOI:10.5993/AJHB.47.3.7

Am J Health Behav. 2023 Jun 30;47(3):579-587. doi: 10.5993/AJHB.47.3.15.

ABSTRACT

Objective: This research was conducted to analyze the relationship between maternal body mass index (BMI) before pregnancy and weight gain in childbirth. This research is also an approach to understand women health behavior for BMI. Methods: In this descriptive analysis of 588 singleton pregnancies, their pre-pregnancy BMI was measured and gestational weight growth in the third trimester, all reserved pregnant women were tracked, and the method of delivery was recorded in Maternity Teaching Hospital from February to December 2020. The data collected throughout the investigation were analyzed using the SPSS 25 package application. Results: According to the study’s findings, the average age of women was 24.4 years old, with a standard deviation of 5.04. About 66% of women had standard BMI, 17.56% were underweight, 10.13% were overweight, and 6.08% were obese. Conclusion: A statistically significant association was discovered between maternal weight during pregnancy and mode of delivery in this study. The study highlighted that women health behavior is significant factor to improve their BMI during pregnancy and delivery.

PMID:37596743 | DOI:10.5993/AJHB.47.3.15