Nevin Manimala

J Pediatr Nurs. 2023 Oct 18:S0882-5963(23)00286-5. doi: 10.1016/j.pedn.2023.10.009. Online ahead of print.

ABSTRACT

AIM: This study was performed with the aim of investigating the correlation and the effective factors between internet addiction, obesity risk and sleep disorders in children.

MATERIAL AND METHOD: The sample for this descriptive and relational search type study comprised the parents of 458 children aged 7-10 years attending a primary school in Turkey. Data were collected the Parent and Child Descriptive Information Form, Family Child Internet Addiction Scale (FCIAS), Family Nutrition and Physical Activity Tool (FNPAT) and Sleep Disturbance Scale for Children (SDSC).

RESULTS: There was a statistically significant, positive and weak correlation between the Body Mass Index (BMI) and FCIAS scores of children (p < 0.001). There was a statistically significant, negative and very weak correlation between FNPAT total score with FCIAS total score (p = 0.007). There was a statistically significant, positive and moderate correlation between SDSC total score and FCIAS total score (p < 0.001). According to regression analysis, FCIAS was a determinant at significant levels for FNPAT and SDSC (p < 0.05).

CONCLUSION: There was a relationship between internet addiction and obesity and sleep quality. As a result of the study, the increase in internet use was determined to negatively impact physical activity and health nutrition behavior, and to increase sleep disturbance.

IMPLICATIONS FOR PRACTICE: Pediatric nurses are recommended to give counseling to children and families about preventing obesity and the risk of sleep disorders by identifying children at risk in terms of internet addiction in the early period.

PMID:37863788 | DOI:10.1016/j.pedn.2023.10.009

Int Immunopharmacol. 2023 Oct 18;124(Pt B):111060. doi: 10.1016/j.intimp.2023.111060. Online ahead of print.

ABSTRACT

Tuberculosis poses a significant threat to human health due to the lack of an effective vaccine. Although promising progress has been made in the development of tuberculosis vaccines, new vaccines that broaden the antigenic repertoire need to be developed to eradicate this illness. In this study, we used Mycobacterium tuberculosis ferritin BfrB and heat-shock protein GrpE to construct a novel multi-antigenic fusion protein, BfrB-GrpE (BG). BG protein was stably overexpressed in the soluble form in Escherichia coli at a high yield and purified via sequential salt fractionation and hydrophobic chromatography. Purified BG was emulsified in an adjuvant containing N, N’-dimethyl-N, N’-dioctadecylammonium bromide, polyinosinic-polycytidylic acid, and cholesterol (DPC) to construct the BG/DPC vaccine, which stimulated strong cellular and humoral immune responses in mice. Moreover, combination of BG with our previously developed vaccine, Mtb10.4-HspX (MH), containing antigens from both the proliferating and dormant stages, significantly reduced the bacterial counts in the lungs and spleens of M. tuberculosis-infected mice. Importantly, mice that received BG + MH/DPC after M. tuberculosis H37Rv infection survived slightly better (100% survival) than those that received the BCG vaccine (80% survival), although the difference was not statistically significant. Our findings can aid in the selection of antigens and optimization of vaccination regimens to improve the efficacy of tuberculosis vaccines.

PMID:37862738 | DOI:10.1016/j.intimp.2023.111060

J Neurosurg Spine. 2023 Oct 20:1-8. doi: 10.3171/2023.8.SPINE23450. Online ahead of print.

ABSTRACT

OBJECTIVE: The purpose of this study was to compare and contrast lumbar bone quality and osteoporosis/osteopenia screening results via dual-energy x-ray absorptiometry (DEXA), CT, and MRI.

METHODS: A consecutive series of 426 candidates screened for lumbar disc replacement over a 5-year period beginning in 2018 was reviewed. Patients with a preoperative lumbar spine DEXA scan and a CT and/or MRI scan were included. The primary outcome measures included the bone mineral density (BMD) and osteoporosis or osteopenia classification from DEXA scans, Hounsfield units (HUs) for CT, and vertebral bone quality (VBQ) assessment for MRI. Patients were included if they had a DEXA scan within 1 year of an MRI or CT scan. DEXA BMD scores from composite or level-by-level reports were recorded. Asynchronous MRI and CT measurements were conducted using PACS. Interrater and intrarater reliability scores were generated for both CT and MRI measurements and ranged from 1.000 for MRI L1-4 scans to 0.683 for MRI VBQ.

RESULTS: All 3 types of scans were statistically significantly correlated with one another; however, CT was more strongly correlated with the lumbar DEXA value (r = 0.439, p < 0.001). The correlation between MRI VBQ and DEXA was -0.103, (p < 0.045). The CT level-by-level measurements correlate with the corresponding level-by-level DEXA BMD values (correlation ranging from 0.531 to 0.289, p < 0.001 to p = 0.007). CT HU values were more strongly related to osteoporosis/osteopenia classification based on DEXA T-scores than were MRI VBQ values. Receiver operating characteristic analyses found that the area under the curve was 0.817 for CT and 0.539 for MRI.

CONCLUSIONS: These results demonstrate that CT HUs more closely correlate to DEXA scores than MRI VBQ in this population of patients undergoing surgery for symptomatic disc degeneration. Thus, CT may be an alternative to DEXA for assessing VBQ in this population.

PMID:37862719 | DOI:10.3171/2023.8.SPINE23450

J Neurosurg Spine. 2023 Oct 20:1-10. doi: 10.3171/2023.8.SPINE23427. Online ahead of print.

ABSTRACT

OBJECTIVE: Malignant melanotic nerve sheath tumors are rare tumors characterized by neoplastic melanin-producing Schwann cells. In this study, the authors report their institution’s experience in treating spinal and peripheral malignant melanotic nerve sheath tumors and compare their results with the literature.

METHODS: Data were collected from 8 patients who underwent surgical treatment for malignant melanotic nerve sheath tumors between 1996 and 2023 at Mayo Clinic and 63 patients from the literature. Time-to-event analyses were performed for the combined group of 71 cases to evaluate the risk of recurrence, metastasis, and death based on tumor location and type of treatment received. Unpaired 2-sample t-tests and Fisher’s exact tests were used to determine statistical significance between groups.

RESULTS: Between 1996 and 2023, 8 patients with malignant melanotic nerve sheath tumors underwent surgery at the authors’ institution, while 63 patients were identified in the literature. The authors’ patients and those in the literature had the same mean age at diagnosis (43 years). At the authors’ institution, 5 patients (63%) experienced metastasis, 6 patients (75%) experienced long-term recurrence, and 5 patients (62.5%) died. In the literature, most patients (60.3%) were males, with a peak incidence between the 4th and 5th decades of life. Nineteen patients (31.1%) were diagnosed with Carney complex. Nerve root tumors accounted for most presentations (n = 39, 61.9%). Moreover, 24 patients (38.1%) had intradural lesions, with 54.2% (n = 13) being intramedullary and 45.8% (n = 11) extramedullary. Most patients underwent gross-total resection (GTR) (n = 41, 66.1%), followed by subtotal resection (STR) (n = 12, 19.4%), STR with radiation therapy (9.7%), and GTR with radiation therapy (4.8%). Sixteen patients (27.6%) experienced metastasis, 23 (39.7%) experienced recurrence, and 13 (22%) died. Kaplan-Meier analyses showed no significant differences among treatment approaches in terms of recurrence-free, metastasis-free, and overall survival (p > 0.05). Similar results were obtained when looking at the differences with respect to intradural versus nerve root location of the tumor (p > 0.05).

CONCLUSIONS: Malignant melanotic nerve sheath tumors are rare tumors with a high potential for malignancy. They carry a dismal prognosis, with a pooled local recurrence rate of 42%, distant metastasis rate of 27%, and mortality rate of 26%. The findings from this study suggest a trend favoring the use of GTR alone or STR with radiation therapy over STR alone. Mortality was similar regardless, which highlights the need for the development of effective treatment options to improve survival in patients with melanotic schwannomas.

PMID:37862711 | DOI:10.3171/2023.8.SPINE23427

Inorg Chem. 2023 Oct 20. doi: 10.1021/acs.inorgchem.3c02205. Online ahead of print.

ABSTRACT

Eutectic mixtures of choline chloride, urea, and water in deep eutectic solvent (DES)/water molar hydration ratios (w) of 2, 5, and 10, with dissolved cerium salt, were measured using neutron diffraction with isotopic substitution. Structures were modeled using empirical potential structure refinement (EPSR). Ce³⁺ was found to form highly charged complexes with a mean coordination number between 7 and 8, with the shell containing mostly chloride, followed by water. The shell composition is strongly affected by the molar ratio of dilution, as opposed to the mass or volume fraction, due to the high affinity of Cl^– and H₂O ligands that displace less favorable interactions with ligands such as urea and choline. The presence of Ce³⁺ salt disrupted the bulk DES structure slightly, making it more electrolyte-like. The measured coordination shell of choline showed significant discrepancies from the statistical noninteracting distribution, highlighting the nonideality of the blend. Cluster analysis revealed the trace presence of percolating water clusters (25 ≥ n ≥ 2) in solvent compositions of 5 and 10w for the first time.

PMID:37862703 | DOI:10.1021/acs.inorgchem.3c02205

Pediatr Infect Dis J. 2023 Nov 1;42(11):e411-e415. doi: 10.1097/INF.0000000000004067. Epub 2023 Oct 11.

ABSTRACT

INTRODUCTION: Childhood immune thrombocytopenic purpura (ITP) is a heterogeneous immune-mediated process triggered by infections, vaccines, allergies and parasites. Currently, there is little evidence in the literature beyond case reports of an association with Toxoplasma gondii (T. gondii).

METHODS: The authors describe the unusual case of an earlier healthy 2.5-year-old Greek boy who developed acute ITP with a life-threatening platelet count a few days after a T. gondii infection. Evidence for the infection onset was found incidentally 3 months after the initial admission to the hospital and only after any other plausible cause of thrombocytopenia was excluded, according to diagnosis guidelines.

RESULTS: The boy underwent 3 intravenous immunoglobulin treatments within a trimester, a period during which his alarming platelets count levels led to housebound activities. A quite slow recovery was only ignited after the third treatment, which was administered in conjunction with a mild antibiotic medication for the T. gondii infection. Full recovery was obtained 9 months after the initial admission, although the boy’s potential scored high in clinical prediction models for developing transient ITP.

CONCLUSION: There is a need for more research on ITPs with no obvious cause to investigate a causal association with toxoplasmosis. Currently, testing for diseases of greater rarity and of higher diagnostic cost than T. gondii is included in the ITP guidelines. Hence, routinely testing for toxoplasmosis when considering potential childhood ITP triggers and infection treatment complementary to treating the ITP might be the key to accelerating the healing process and improving the quality of life of otherwise confined children.

PMID:37862699 | DOI:10.1097/INF.0000000000004067

Phys Rev Lett. 2023 Oct 6;131(14):141802. doi: 10.1103/PhysRevLett.131.141802.

ABSTRACT

Using 7.33 fb^{-1} of e^{+}e^{-} collision data taken with the BESIII detector at the BEPCII collider, we report the first experimental study of the purely leptonic decay D_{s}^{*+}→e^{+}ν_{e}. Our data contain a signal of this decay with a statistical significance of 2.9σ. The branching fraction of D_{s}^{*+}→e^{+}ν_{e} is measured to be (2.1_{-0.9_{stat}}^{+1.2}±0.2_{syst})×10^{-5}, corresponding to an upper limit of 4.0×10^{-5} at the 90% confidence level. Taking the total width of the D_{s}^{*+} [(0.070±0.028) keV] predicted with the radiative D_{s}^{*+} decay from the lattice QCD calculation as input, the decay constant of the D_{s}^{*+} is determined to be f_{D_{s}^{*+}}=(214_{-46_{stat}}^{+61}±44_{syst}) MeV, corresponding to an upper limit of 354 MeV at the 90% confidence level.

PMID:37862669 | DOI:10.1103/PhysRevLett.131.141802

Phys Rev Lett. 2023 Oct 6;131(14):140401. doi: 10.1103/PhysRevLett.131.140401.

ABSTRACT

Owing to its probabilistic nature, a measurement process in quantum mechanics produces a distribution of possible outcomes. This distribution-or its Fourier transform known as full counting statistics (FCS)-contains much more information than say the mean value of the measured observable, and accessing it is sometimes the only way to obtain relevant information about the system. In fact, the FCS is the limit of an even more general family of observables-the charged moments-that characterize how quantum entanglement is split in different symmetry sectors in the presence of a global symmetry. Here we consider the evolution of the FCS and of the charged moments of a U(1) charge truncated to a finite region after a global quantum quench. For large scales these quantities take a simple large-deviation form, showing two different regimes as functions of time: while for times much larger than the size of the region they approach a stationary value set by the local equilibrium state, for times shorter than region size they show a nontrivial dependence on time. We show that, whenever the initial state is also U(1) symmetric, the leading order in time of FCS and charged moments in the out-of-equilibrium regime can be determined by means of a space-time duality. Namely, it coincides with the stationary value in the system where the roles of time and space are exchanged. We use this observation to find some general properties of FCS and charged moments out of equilibrium, and to derive an exact expression for these quantities in interacting integrable models. We test this expression against exact results in the Rule 54 quantum cellular automaton and exact numerics in the XXZ spin-1/2 chain.

PMID:37862655 | DOI:10.1103/PhysRevLett.131.140401

J Urol. 2023 Oct 20:101097JU0000000000003765. doi: 10.1097/JU.0000000000003765. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the association between family history of RCC and RCC risk.

MATERIALS AND METHOD: RCC cases diagnosed in Sweden between 2005-2014 and 10 matched controls were identified using Renal Cell Cancer dataBase Sweden, with linkage to the Multigeneration Register and the Swedish Cancer Register. The association between a family history of RCC and RCC was investigated, overall and by sex and age groups.

RESULTS: Among 9416 RCC cases, 294 (3.1%) had 1 or more parent or sibling (first-degree relative, FDR) with RCC. Median age at diagnosis for cases with an affected FDR was 65 years (IQR 59-71) and 68 years (IQR 60-75) for all cases. The proportion of women was significantly higher among familial RCC compared to sporadic RCC (44.6% vs 38.5%, P = .035). RCC was twice as likely with 1 or more FDR with RCC (OR 1.9; CI 1.65-2.16). Stratified analysis showed an OR of 2.4 for women (CI 1.93-2.92) and 1.6 for men (CI 1.35-1.93). Two or more FDRs was associated with a 6-fold increased risk (95% CI 2.37-15.5). Familial RCC was strongly associated with bilateral- and multifocal tumours ([OR 5.5; CI 2.36-13.0], [OR 3.5; CI 1.89-6.49]).

CONCLUSIONS: In this Swedish dataset, 3.1% of RCC patients have 1 or more FDR diagnosed with RCC. There was no statistical difference in median age between sporadic RCC and familial RCC. Having 1 or more FDR with RCC approximately doubles the risk of RCC with a higher risk increase for women than for men. People with 2 FDRs with RCC constitute a small high-risk group that may benefit from screening.

PMID:37862613 | DOI:10.1097/JU.0000000000003765

J Acoust Soc Am. 2023 Oct 1;154(4):2489-2498. doi: 10.1121/10.0021871.

ABSTRACT

In the context of global warming leading to rapidly changing Arctic sea ice and the environment, it is necessary to understand the statistical characteristics of noise under existing Arctic ocean environmental conditions. The data recorded from August 1, 2018 to November 2, 2019, on the Arctic Chukchi Plateau, have been studied to analyze the relationship between the ice transient events and the non-Gaussian statistics of under-ice noise. The ice-generated transient noise largely contributes to the under-ice noise environment, and the total under-ice noise exhibits non-Gaussian statistics due to the occurrence of these ice transients. The number of ice transients has a strong negative correlation with the characteristic index α, meaning that the higher the occurrence of transient events, the stronger the non-Gaussian statistics of under-ice noise. Stronger non-Gaussian noise with full ice coverage is observed compared to partial ice coverage. The under-ice noise in 0.5-1 kHz exhibits the strongest non-Gaussian statistics, followed by 1-4 kHz, while it is weakest in 20-500 Hz. The statistics of ice transients and under-ice noise have been provided in this paper, which can be used in sonar detection algorithms and have important significance for the performance prediction and optimization of sonar processors.

PMID:37862571 | DOI:10.1121/10.0021871