Nevin Manimala

Bone Marrow Transplant. 2023 Aug 25. doi: 10.1038/s41409-023-02039-8. Online ahead of print.

ABSTRACT

Hematopoietic cell transplant (HCT) recipients are at risk for thromboembolic and bleeding complications. There is limited evidence regarding the optimal approach to managing venous thromboembolism (VTE) prophylaxis in hospitalized patients undergoing HCT. In this retrospective cohort study, we evaluated the incidence of bleeding and VTE events in hospitalized HCT patients who received VTE prophylaxis per our institution’s VTE Prophylaxis Protocol (VPP), with either enoxaparin 40 mg subcutaneously daily or heparin 5 000 units subcutaneously twice daily, compared to historical controls who did not receive VTE prophylaxis. The primary outcome was a composite of major bleeding events, clinically relevant non-major bleeding (CRNMB), and minor bleeding. The secondary outcome was a composite of VTE events. A total of 614 patients were evaluated, including 278 prior to and 336 after implementation of VPP. VTE prophylaxis resulted in no difference in bleeding events (15.1% in the pre-VPP group vs. 14.6% in the post-VPP group, p = 0.86) or composite of major and CRNMB events (0.72% vs. 0.30%, p = 0.59). There was a trend toward lower incidence of VTE events in the post-VPP group which did not reach statistical significance (8.6% vs. 6.0%, p = 0.20). We conclude that VTE prophylaxis does not pose additional bleeding risk in HCT patients.

PMID:37626267 | DOI:10.1038/s41409-023-02039-8

Obes Surg. 2023 Aug 26. doi: 10.1007/s11695-023-06789-8. Online ahead of print.

ABSTRACT

PURPOSE: For children and adolescents with severe obesity, metabolic and bariatric surgery including laparoscopic sleeve gastrectomy (LSG) is increasingly used to facilitate weight loss and reduce associated medical problems. Outcomes of LSG are understudied among patients under age 15 years. We sought to examine surgical complications and weight loss outcomes among children and adolescents who underwent LSG.

MATERIALS AND METHODS: This is a single-center retrospective cohort analysis at a high-volume metropolitan children’s hospital in the northeast USA between 2011 and 2021. Weight loss was assessed at routine follow-up appointments for up to 36 months postoperatively.

RESULTS: There were 12 patients under 13 years of age (< 13), 45 from 13 up to 15 years of age (13-14), and 57 patients aged 15 years or over (≥ 15). Among all patients, 70% were female, 41% were Hispanic, and 18% were non-Hispanic Black. There were no operative mortalities. Two patients had surgical complications requiring reoperation. Follow-up beyond 6 months occurred for 62% of patients. Weight loss was evident for each group at all time points, and there was no statistically significant difference among groups at any time point. BMI Z-score reduction at 6 months was 1.53 for the < 13 group, 0.89 for the 13-14 group, and 0.86 for the ≥ 15 group and at 36 months was 1.79, 1.50, and 1.16, respectively.

CONCLUSION: These results support that LSG is a safe and effective method of achieving weight loss for young adolescents with severe obesity. Strategies to promote postoperative follow-up are needed.

PMID:37626262 | DOI:10.1007/s11695-023-06789-8

Heart Vessels. 2023 Aug 26. doi: 10.1007/s00380-023-02301-5. Online ahead of print.

ABSTRACT

Recently, instantaneous wave-free ratio (iFR) has emerged as an alternative to the fractional flow reserve (FFR) for intracoronary physiological assessment. Although all diastolic resting indices are reportedly identical to the iFR, limited data exist on diastolic pressure ratio (dPR) measured using a microcatheter (dPR_micro). This study aimed to evaluate the diagnostic accuracy of dPR_micro compared to FFR measured using a microcatheter (FFR_micro) in real-world practice for intracoronary physiological assessment. This was a single-center, retrospective, observational study. We identified 103 consecutive suspected angina pectoris patients (107 lesions) who underwent dPR_micro and FFR_micro measurement using the Navvus® catheter at Takasaki Heart Hospital from March 2019 to June 2019. A total of 103 lesions in 103 patients were finally included in the study. The mean FFR_micro and dPR_micro values were 0.80 and 0.88, respectively. With an FFR_micro ≤ 0.80, the dPR_micro showed a diagnostic accuracy of 79.6%, sensitivity of 74.6%, specificity of 87.5%, positive predictive value of 90.4%, and negative predictive value of 68.6%. The area under the receiver operating characteristic (ROC) curve was 0.894 (95% confidence interval, 0.833-0.956), and the optimal cut-off value for dPR_micro derived from the ROC analysis was 0.90. dPR_micro and FFR_micro values were discordant in 21/103 cases (20.4%). As a multivariable logistic regression analysis was performed, the male sex (vs. female) had a statistically significant association with a dPR_micro-FFR_micro discordance (OR 4.91; 95% CI, 1.04-23.0; P = 0.044). No other factors were found to be significantly associated with the discordance. In conclusion, dPR_micro measured using a microcatheter had good diagnostic accuracy and correlation with FFR_micro, hence, it can be useful for making revascularization decisions. However, re-studies in larger populations will be needed to better understand the properties of diastolic resting index measured using a microcatheter in clinical settings.

PMID:37626238 | DOI:10.1007/s00380-023-02301-5

Surg Endosc. 2023 Aug 25. doi: 10.1007/s00464-023-10347-9. Online ahead of print.

ABSTRACT

BACKGROUND: Cap-assisted endoscopic mucosal resection (EMR-c) has emerged as a potential alternative to standard piecemeal wide-field EMR (WF-EMR) for the resection of laterally spreading tumors (LSTs). However, clear indications for this technique are still lacking. Our objective was to investigate the performance of salvage EMR-c after WF-EMR failure in the resection of large colorectal LSTs.

METHODS: The data of consecutive patients undergoing WF-EMR for large colorectal LSTs (2015-2021) were analyzed in this single-center, retrospective, observational study. In the event of a WF-EMR failure, the procedure was switched to EMR-c in the same session. The efficacy of the two techniques was evaluated in terms of complete endoscopic resection, R0 resection, and recurrence rate. Safety was also assessed.

RESULTS: Overall, the data from 81 WF-EMRs were collected. Eighteen cases of WF-EMR failure were switched to EMR-c in the same session and complete endoscopic resection was achieved in 17/18 patients (94.4%). No statistically significant difference was observed between WF-EMR and salvage EMR-c in terms of macroscopic radicality (P = 0.40) and R0 resection (P = 0.12). However, recurrence was more common with EMR-c (44.4% vs. 23.5%; P = 0.05), as were adverse events, particularly intraprocedural bleeding (27.8% vs. 7.9%; P = 0.04).

CONCLUSION: EMR-c is an effective salvage technique for challenging colorectal LSTs following WF-EMR failure. Due to the elevated risk of adverse events associated with this procedure, careful patient selection, endoscopic expertise, and close follow-up are strongly recommended.

PMID:37626237 | DOI:10.1007/s00464-023-10347-9

Pediatr Neurol. 2023 Aug 3;148:1-7. doi: 10.1016/j.pediatrneurol.2023.07.023. Online ahead of print.

ABSTRACT

BACKGROUND: One of the most severe perinatal lesions of the central nervous system is intraventricular hemorrhage, which often, especially in prematurely born babies with low gestational age and body weight, is complicated by posthemorrhagic hydrocephalus, which requires good early diagnosis and timely treatment. The purpose of the article is to improve the methods of diagnosis and treatment of posthemorrhagic hydrocephalus in young children.

METHODS: The study was conducted between 2009 and 2018 in the neurosurgical department of the City Children’s Hospital No. 2 in Astana. Three groups of patients from birth to age six months were studied. During the investigation the following research methods were used: clinical and anamnestic, laboratory, instrumental, and methods of mathematical statistics. Statistical analysis was performed using the program Statistica for Windows 13.0 (StatSoft Inc. No. JPZ804I382130ARCN10-J). Patients of the main and control groups underwent various surgical interventions to relieve posthemorrhagic occlusive hydrocephalus.

RESULTS: It was found that the maximum number of complications develop in newborns with low gestational age and low body weight. Repeated lumbar or ventricular punctures in patients with posthemorrhagic hydrocephalus followed by external drainage are characterized by the greatest number of complications, among which infection and catheter occlusion prevail.

CONCLUSIONS: It has been established that the proposed algorithm for the diagnosis and treatment of patients with posthemorrhagic hydrocephalus can significantly reduce the number of complications, shorten the duration of hospital stay, reduce the percentage of long-term complications, and improve the quality of life.

PMID:37625173 | DOI:10.1016/j.pediatrneurol.2023.07.023

J Orthop Sports Phys Ther. 2023 Sep;0(9):1-3. doi: 10.2519/jospt.2023.12209.

ABSTRACT

SYNOPSIS: The Journal of Orthopaedic & Sports Physical Therapy was first published in the summer of 1979 by the Orthopaedic and Sports Sections of the American Physical Therapy Association. The journal’s mission was to publish scientifically rigorous content and promote its application to movement-related health. In 1979, we were focused solely on 1 journal, and the publishing organization shared the journal’s name. In the decades since, our organization has grown such that it now publishes 3 peer-reviewed journals and provides plenty of additional resources to help the musculoskeletal rehabilitation community translate quality research to quality practice. We are pleased to reintroduce ourselves as Movement Science Media. We aspire to deliver your one-stop shop for trustworthy content-helping you stay informed about the latest in musculoskeletal rehabilitation. J Orthop Sports Phys Ther 2023;53(9):1-3. doi:10.2519/jospt.2023.12209.

PMID:37625167 | DOI:10.2519/jospt.2023.12209

Trans R Soc Trop Med Hyg. 2023 Aug 25:trad058. doi: 10.1093/trstmh/trad058. Online ahead of print.

ABSTRACT

BACKGROUND: The study aimed to identify predictors of severe dengue during the 2017 epidemic and to develop and validate a simple predictive score for severity.

METHODS: A retrospective analytical study was conducted using clinical and laboratory data from adult dengue patients with a confirmed microbiological diagnosis. The study included patients who presented to a tertiary care centre in Kerala, India, during the febrile phase (≤4 d) between June 2017 and February 2019. Using appropriate statistical tests, we derived predictors of severe disease and computed a risk score model.

RESULTS: Of the 153 patients (mean age 50±17 y; 64% males), 31 (20%) had severe dengue and 4 (3%) died. Petechial lesions, hypoalbuminemia (<3.5 g/dl), elevated alanine aminotransferase (>40 IU/l) and urea >40 IU/l were significant predictors. Our scoring system (cut-off: 2) showed excellent performance, with an area under the receiver operating characteristics curve of 0.9741, sensitivity of 100%, specificity of 96% and accuracy of 98%. The risk score was secondarily validated on 48 patients hospitalized from March 2019 to June 2019.

CONCLUSION: Our scoring system is easy to implement and will help primary healthcare practitioners in promptly identifying severe dengue cases upon hospital presentation.

PMID:37625166 | DOI:10.1093/trstmh/trad058

J Clin Oncol. 2023 Aug 25:JCO2300641. doi: 10.1200/JCO.23.00641. Online ahead of print.

ABSTRACT

PURPOSE: Adolescents and young adults (AYAs) with cancer receive high rates of medically intensive measures at the end of life. This study aimed to characterize the prevalence and timing of conversations about goals of care and advance care planning among AYAs at the end of life as one potential influence on care received.

METHODS: This was a review of electronic health data and medical records for 1,929 AYAs age 12-39 years who died after receiving care at one of three sites between 2003 and 2019, including documented conversations about goals of care and advance care planning, and care received.

RESULTS: A majority of AYAs were female (54%) and White (61%); 12% were Asian, 8% Black, and 27% Hispanic. Most patients had documented discussions about prognosis (86%), goals of care (83%), palliative care (79%), hospice (79%), and preferred location of death (64%). When last documented goals of care were evaluated, 69% of patients wanted care focused on palliation; however, 29% of those with palliative goals spent time in the intensive care unit (ICU) in the last month of life, and 32% had multiple emergency room (ER) visits. When goals-of-care discussions happened earlier, >30 days before death, AYAs were less likely to receive chemotherapy in the last 14 days of life (P = .001), ICU care (P < .001), ER visits (P < .001), and hospitalizations in the last month (P < .001).

CONCLUSION: High rates of medically intensive measures among AYAs near the end of life do not appear to be the result of a lack of discussions about goals of care and advance care planning. Although some interventions may be used to support palliative goals, earlier discussions have potential to reduce late-life intensive measures.

PMID:37625111 | DOI:10.1200/JCO.23.00641

J Clin Oncol. 2023 Aug 25:JCO2202834. doi: 10.1200/JCO.22.02834. Online ahead of print.

ABSTRACT

PURPOSE: Financial toxicity (FT) affects 20% of cancer survivors and is associated with poor clinical outcomes. No large-scale programs have been implemented to mitigate FT. We evaluated the effect of monthly FT screening as part of a larger patient-reported outcomes (PROs) digital monitoring intervention.

METHODS: PRO-TECT (AFT-39) is a cluster-randomized trial of patients undergoing systemic therapy for metastatic cancer. Practices were randomly assigned 1:1 to digital symptom monitoring (PRO practices) or usual care (control practices). Digital monitoring consisted of between-visit online or automated telephone patient surveys about symptoms, functioning, and FT (single-item screening question from Functional Assessment of Chronic Illness Therapy-COmprehensive Score for financial Toxicity) for up to 1 year, with automated alerts sent to practice nurses for concerning survey scores. Clinical team actions in response to alerts were not mandated. The primary outcome of this planned secondary analysis was development or worsening of financial difficulties, assessed via the European Organisation for Research and Treatment of Cancer QLQ-C30 financial difficulties measure, at any time compared with baseline. A randomly selected subset of patients and nurses were interviewed about their experiences with the intervention.

RESULTS: One thousand one hundred ninety-one patients were enrolled (593 PRO; 598 control) at 52 US community oncology practices. Overall, 30.2% of patients treated at practices that received the FT screening intervention developed, or experienced worsening of, financial difficulties, compared with 39.0% treated at control practices (P = .004). Patients and nurses interviewed stated that FT screening identified patients for financial counseling who otherwise would be reluctant to seek, or unaware of the availability of, assistance.

CONCLUSION: In this report of a secondary outcome from a randomized clinical trial, FT screening as part of routine digital patient monitoring with PROs reduced the development, or worsening, of financial difficulties among patients undergoing systemic cancer therapy.

PMID:37625107 | DOI:10.1200/JCO.22.02834

Mil Med. 2023 Aug 25:usad335. doi: 10.1093/milmed/usad335. Online ahead of print.

ABSTRACT

INTRODUCTION: There is a knowledge gap concerning the occurrence of physical complaints/injuries, i.e., musculoskeletal disorders (MSD), among Swedish women who undergo basic military training (BMT). The aims were to describe prevalence and factors related to MSD and explore physical exposure and performance in Swedish female recruits during BMT.

MATERIALS AND METHODS: A total of 144 females (mean age 22 years) who underwent BMT in 2016 participated in this cross-sectional study. Data regarding self-reported MSD, physical performance, physical activity and exercise, motivation and mental and physical preparation, and physical exposure during BMT and perceived health were collected at the end of BMT through the Musculoskeletal Screening Protocol questionnaire. Additional data on muscle strength were retrieved from IsoKai isokinetic lift tests. Descriptive and analytic (paired samples t-test and logistic binary regression) statistics were used.

RESULTS: The prevalence of MSD was high, with 33% (n = 48) reporting MSD before BMT, 78% (n = 113) during, and 50% (n = 72) at the end of BMT. Knee and upper back were the most frequently reported MSD locations. Forty-four (30%) participants felt insufficiently physically prepared for BMT. The physical exposure was high with loaded marches/runs and carrying heavy loads as the most demanding tasks. The longest walking distance was reportedly 55 km, and the reported maximum load was 50 kg. Forty-five participants (31%) had carried a load representing over 50% of their body weight. Most participants reported good to excellent health at the end of BMT. There was a small (8 N) but significant (P = 0.045) increase in mean force over time. Two variables, MSD before BMT (odds ratio 2.24, P = 0.03) and being physically unprepared (odds ratio 3.03, P < 0.01), were associated with MSD at the end of BMT.

CONCLUSION: This study showed that the prevalence of MSD in Swedish female recruits was high before, during, and at the end of BMT, with knee and upper back as the most frequent locations. Although the physical exposure during BMT was occasionally high, self-rated health was mainly perceived as good to excellent at the end of BMT. Previous MSD and being physically unprepared were related to MSD at the end of BMT. These important and relevant findings indicate the necessity for implementing interventions to increase physical fitness and treat MSD at the beginning of BMT.

PMID:37625078 | DOI:10.1093/milmed/usad335