Nevin Manimala

Heliyon. 2023 Jul 28;9(8):e18807. doi: 10.1016/j.heliyon.2023.e18807. eCollection 2023 Aug.

ABSTRACT

The aluminium alloy (AA1100) was familiar with automotive flexible shaft coupling applications due to its high strength, good machinability, and superior thermal and resistance to corrosion characteristics. Machining tool life drives the prominent role for deciding the product quality (machining) act aims to productivity target with zero interruptions. The novelty of this present investigation is the focus on increasing tool life during the complexity of CNC turning operation for AA1100 alloy by using CBN coated insert tool with varied input parameters of spindle speed (SS), feed rate (f), and depth of cut (DOC). Design of experiment (L16), analysis of variance (ANOVA) statistical system adopted with response surface methodology (RSM) is implemented for experimental analysis. The turning input parameters of SS, f and DOC are considered as factors and its SS (900, 1100, 1300, and 1500 rpm), f (0.1, 0.15, 0.2, and 0.25), and DOC (0.1, 0.2, 0.3, and 0.4 mm) values are treated as levels. The investigational analysis was made with the ANOVA technique and the desirability of high tool life with input turning parameters was optimized by RSM, and sample no 11/16 was predicted as high tool life and performed with extended working hours compared to other samples. The RSM optimized best turning parameter combinations are 0.1 mm DOC, 0.2mm/rev to 0.25mm/rev f, and 1300 rpm-1500 rpm SS, facilitating a higher tool life of more than 20min.

PMID:37560707 | PMC:PMC10407727 | DOI:10.1016/j.heliyon.2023.e18807

Heliyon. 2023 Jul 27;9(8):e18631. doi: 10.1016/j.heliyon.2023.e18631. eCollection 2023 Aug.

ABSTRACT

Road traffic accidents (RTAs) are a major cause of morbidity in Somaliland. This study aimed to determine the prevalence and factors associated with traffic-related incidents in Hargeisa city. A cross-sectional study was conducted between January and March 2022, utilizing a mixed approach involving quantitative and qualitative research approaches. Key informant interviews were conducted with 15 government officials, and structured questionnaires were administered to 387 drivers. Cluster sampling and purposive sampling were employed to select drivers and government officials, respectively. Data collection was performed using the Kobo Collect application, followed by cleaning and analysis using IBM SPSS version 25. Descriptive statistics, binary logistic regression, and chi-square tests were utilized for data analysis. The findings revealed an increasing trend of RTAs in Somaliland over the past 11 years (2011-2021). Moreover, the prevalence of RTAs in the past two years alone was determined to be 28.17% (CI: 23.67, 32.63). Factors significantly associated with RTAs in the research area included the type of vehicle, particularly Minibus (AOR = 3.249, CI: 1.022, 10.322) and Vitz (AOR = 2.325, CI: 1.092, 5.494), encountering aggressive behavior from other drivers (AOR = 1.790, CI: 1.013, 3.162), vehicles less than 4 years (AOR = 0.446, CI: 0.258, 0.771), traffic law violations (AOR = 2.726, CI: 1.296, 5.735), and the presence of traffic campaigns (AOR = 0.465, CI: 0.236, 0.917). The study recommends increasing awareness of RTAs among drivers and pedestrians, regular vehicle maintenance checks, enforcement of traffic laws, and increased police presence in road management to reduce fatalities associated with RTAs.

PMID:37560702 | PMC:PMC10407217 | DOI:10.1016/j.heliyon.2023.e18631

Heliyon. 2023 Jul 29;9(8):e18646. doi: 10.1016/j.heliyon.2023.e18646. eCollection 2023 Aug.

ABSTRACT

Different studies have suggested that fluoride can induce apoptosis in non-skeletal tissues, however, evidence from these experimental studies is still controversial. This meta-analysis aims to clarify the mechanism of fluoride-induced apoptosis in non-skeletal tissues of experimental animals. Primary studies which measured apoptosis were identified through exhaustive database searching in PubMed, Embase, Web of Science Core Collection, Scopus, and references of included studies. A random effects model with standardized mean difference (SMD) was used for meta-analyses. The heterogeneity of the studies was evaluated using Higgin’s I² statistics. The risk of bias and publication bias were assessed using the SYRCLE’s risk of bias tool and Egger’s test, respectively. There was an increase in total apoptotic cells, and the expression of Bax, Bax/Bcl-2 ratio, caspase-3, caspase-8, caspase-9, Cyt c, and p53, and a decrease in the expression of Bcl-2 in the fluoride-treated groups as compared to the control groups. However, there was no evidence of a difference in the expression of APAF-1 in the two groups. The subgroup analysis highlighted the role of the intervention period in modification of the apoptotic effect of fluoride and that the susceptibility and tolerance of different animal species and tissues vary. Meta-regression analysis indicated that the studies’ effect size for total apoptotic cells was influenced by animal species and that of Bax by the sample source. The results of this meta-analysis revealed that fluoride causes apoptosis by up-regulating caspase-3, -8, and -9, Cyt c, p53, Bax, and down-regulating Bcl-2 with a concomitant up-regulation of the Bax/Bcl-2 ratio.

PMID:37560699 | PMC:PMC10407679 | DOI:10.1016/j.heliyon.2023.e18646

Heliyon. 2023 Jul 22;9(8):e18382. doi: 10.1016/j.heliyon.2023.e18382. eCollection 2023 Aug.

ABSTRACT

The annual incidence of suicide among Chinese doctoral students remains high. We reviewed the statistics for doctoral student suicides over the past 12 years and administered a questionnaire survey and interviews to relatives and friends of doctoral students who committed suicide. The results indicated that suicide among doctoral students is closely related to academic pressure, the teacher-student relationship, and the academic environment, reflecting the current condition of China’s doctoral tutorial system. This study provides a theoretical basis for society to understand Chinese doctoral student suicide and the Chinese doctoral tutorial system as well as the relationship between the two. Our results may serve as a warning to the academic community to prevent the worsening of the suicide contagion.

PMID:37560672 | PMC:PMC10407023 | DOI:10.1016/j.heliyon.2023.e18382

Heliyon. 2023 Jul 28;9(8):e18784. doi: 10.1016/j.heliyon.2023.e18784. eCollection 2023 Aug.

ABSTRACT

This article presents a study on the tensile properties of knitted fabrics commonly employed in polymeric matrix textile composites. The key mechanical parameters investigated include stress (Pa), strain, Young’s modulus (Pa), and work of rupture (J). The knitted fabrics were developed using the Cixing Knitting System software and subsequently manufactured using a double jersey (electronic) flat knitting machine. The primary objective of this research was to explore the impact of various factors on the mechanical behavior of these knitted fabrics. The factors studied were wale and course directions, float stitch density, loop length (cm), and the type of synthetic knitting yarns used (100% polyester and 100% polyamide) along with different combinations of knitting yarns (100% cotton and 67% polyester/33% cotton hybrid). The adopted ASTM D 5034 standard, Response Surface Methodology (RSM), and Analysis of Variance (ANOVA) were employed to evaluate the mechanical performance of these fabric structures. The findings of the study revealed that the statistical adjustment of the data set for stress, strain, Young’s modulus, and work of rupture in knitted fabric structures significantly reduced the standard deviations for mechanical responses. This information holds particular significance as it pertains to the frequent use of these knitted fabric structures as reinforcement in textile-reinforced composite materials. Overall, this study sheds light on the mechanical behavior in structures of knitted fabrics used in polymeric matrix composites, providing valuable insights for the design and optimization of advanced textile-based materials.

PMID:37560668 | PMC:PMC10407213 | DOI:10.1016/j.heliyon.2023.e18784

Heliyon. 2023 Jul 22;9(8):e18126. doi: 10.1016/j.heliyon.2023.e18126. eCollection 2023 Aug.

ABSTRACT

BACKGROUND: Obstetric fistula among women of reproductive age is a significant public health issue in developing countries, including Sub-Saharan Africa. However, the pooled awareness of obstetric fistula among women of reproductive age in Sub-Saharan Africa and its variation between countries have not yet been studied. Hence, the review aims to assess variability and awareness of obstetric fistula among women of reproductive age in Sub-Saharan African Countries.

METHOD: Articles were searched using different electronic databases, such as PubMed, Web of science, science direct (Scopus), Google scholar, and HINARI and manual search without regard to publication date. A random-effects model was used to ascertain the pooled prevalence of obstetric fistula awareness among women of reproductive age in Sub-Saharan Africa. Publication bias was checked by using funnel plot and Egger’s test at a 5% level of significance. I² test statistics was performed to evaluate heterogeneity among included studies. In addition, to identify the possible reason for the potential heterogeneity between the studies, sub-group and meta-regression analyses were conducted. A sensitivity analysis was performed to determine the impact of individual research on the overall results. The data were extracted by using Microsoft excel and analyzed using statistical software STATA/SE version 17.

RESULT: A total of 22 studies with 79,693 women of reproductive age were included in this systematic review and meta-analyses. In Sub-Saharan Africa, the pooled prevalence of awareness towards obstetric fistula among women of reproductive age was 40.85% (95% CI: 33.48, 48.22%). Analysis of the subgroups by specific countries revealed significant variation. The highest awareness of obstetric fistula was found among Tanzanian women of reproductive age (61.10%, 95% CI: 55.87-66.33%), whereas the lowest awareness was found in research from the Gambia (12.80%, 95% CI: 12.20-13.40%).The likelihood of obstetric fistula awareness were lower by a factor of 0.424 among studies with sample sizes greater than 3542 (β = -0.424 (95% CI: -0.767 to 0.081), p -value <0.05).

CONCLUSION: According to the current review, there is a low level of awareness about obstetric fistula among women of reproductive age in sub-Saharan Africa, and the results of the sub-group analysis by country showed wide variations. Therefore, we emphasize the need for country-specific public health initiatives to raise awareness about obstetric fistula among women of reproductive age, which could reduce the risk of delayed treatment.

PMID:37560629 | PMC:PMC10407677 | DOI:10.1016/j.heliyon.2023.e18126

Orthop J Sports Med. 2023 Jul 20;11(7):23259671231183416. doi: 10.1177/23259671231183416. eCollection 2023 Jul.

ABSTRACT

BACKGROUND: Regular walking in different types of footwear may increase the mediolateral shear force, knee adduction moment, or vertical ground-reaction forces that could increase the risk of early development of knee osteoarthritis (OA).

PURPOSE: To compare kinematic and kinetic parameters that could affect the development of knee OA in 3 footwear conditions.

STUDY DESIGN: Controlled laboratory study.

METHODS: A total of 40 asymptomatic participants performed walking trials in the laboratory at self-selected walking speeds under barefoot (BF), minimalistic (MF), and neutral (NF) footwear conditions. Knee joint parameters were described using discrete point values, and continuous curves were evaluated using statistical parametric mapping. A 3 × 1 repeated-measures analysis of variance was used to determine the main effect of footwear for both discrete and continuous data. To compare differences between footwear conditions, a post hoc paired t test was used.

RESULTS: Discrete point analyses showed a significantly greater knee power in NF compared with MF and BF in the weight absorption phase (P < .001 for both). Statistical parametric mapping analysis indicated a significantly greater knee angle in the sagittal plane at the end of the propulsive phase in BF compared with NF and MF (P = .043). Knee joint moment was significantly greater in the propulsive phase for the sagittal (P = .038) and frontal planes (P = .035) in BF compared with NF and MF and in the absorption phase in the sagittal plane (P = .034) in BF compared with MF and NF. A significant main effect of footwear was found for anteroposterior (propulsion, ↑MF, NF, ↓BF [P = .008]; absorption, ↑BF, MF, ↓NF [P = .001]), mediolateral (propulsion, ↑MF, NF, ↓BF [P = .005]; absorption, ↑NF, MF, ↓BF [P = .044]), and vertical (propulsion, ↑NF, BF, ↓MF [P = .001]; absorption, ↑MF, BF, ↓NF [P < .001]) ground-reaction forces. Knee power showed a significant main effect of footwear (absorption, ↑NF, MF, ↓BF [P = .015]; propulsion, ↑MF, NF, ↓BF [P = .039]).

CONCLUSION: Walking in MF without sufficient accommodation affected kinetic and kinematic parameters and could increase the risk of early development of knee OA.

PMID:37560612 | PMC:PMC10406632 | DOI:10.1177/23259671231183416

Adv Med Educ Pract. 2023 Aug 3;14:837-844. doi: 10.2147/AMEP.S419333. eCollection 2023.

ABSTRACT

BACKGROUND AND AIMS: This study evaluates the use of virtual anatomy dissection (Anatomage Table) in teaching anatomy for Jordanian medical students. The study also highlights any gender differences in students’ perception on this method of teaching anatomy.

METHODS: This is a cross-sectional questionnaire-based study that was carried out on medical students enrolled in Al-Balqa Applied University, a Jordanian public university. A group of expert anatomists designed a questionnaire that investigates the students’ perceptions and attitudes toward using virtual anatomy dissection. The questionnaire also investigated student’s opinions and expectations on the impact of using this method on the academic achievement of students.

RESULTS: The findings of the study showed that most students agreed that Anatomage Table helped them better understand (64.3%) and memorize (64%) anatomy lectures. In addition, most students were interested in using this learning method in lab groups (72.3%). However, the didactic approach that combined anatomical models and the Anatomage Table was preferred over the unilateral approach that included only the Anatomage Table (80.5% vs 30.2%, p<0.001, r=0.9). Of note, there was a statistically significant difference between males and females in their preference for Anatomage Table (p<0.001), and in their perceptions on the impact of Anatomage Table on understanding of lectures (p<0.001) and memorization of anatomical structures (p=0.004).

CONCLUSION: The Anatomage Table is a powerful teaching and learning method in undergraduate medical education. Its application to Al-Balqa Applied University has proven to be effective so far. It can be used to overcome the problems facing anatomical education in the college of medicine in Al-Balqa Applied University and perhaps other universities in Jordan, but this needs better cooperation between universities and stakeholders to provide adequate funding for this method.

PMID:37560611 | PMC:PMC10406572 | DOI:10.2147/AMEP.S419333

Adv Med Educ Pract. 2023 Aug 4;14:845-857. doi: 10.2147/AMEP.S417649. eCollection 2023.

ABSTRACT

OBJECTIVE: The purpose of this study was to examine the application of faculty to stimulate the critical thinking and deep analysis of their students through instructional practice including lecture design, assessment structure, and assignment instructions.

METHODS: Faculty from multiple different health colleges at Saudi Arabia were asked to respond to survey items about the activities they use in their classrooms with regards to designing lectures, assessment structures, and instructional assignments. A correlation analysis was performed to determine if the level of applied critical thinking and deep analysis that is stimulated by faculty members were statistically related between designing lectures, assessment structure, and instructional assignments. An analysis of variance (ANOVA) was also performed to determine if there were significant differences based on the demographic characteristics of the participants and level of applied critical thinking and deep analysis.

RESULTS: A correlational analysis revealed that the mean score for designing lectures was 67.276, following by a mean score of 65.233 for instructional assignment and 64.688 for assessment structure. The result of the ANOVA showed that there was a significant difference in the perceptions of the participants between designing lectures, assessment structure, and instructional assignment (p<0.05).

CONCLUSION: The participants applied critical thinking and deep analysis when they design their lectures more than assessments and instructional assignments. They had the flexibility to stimulate critical thinking during the lecture activities. In contrast, this flexibility was limited when they were structuring the assessment as they had instructions to consider and were required to provide a rubric with unified key answer which is a mandatory requirement from the assessment department. This is due to the nature of high level of critical thinking answers that lead to high subjectivity in student responses.

PMID:37560610 | PMC:PMC10408665 | DOI:10.2147/AMEP.S417649

Surg Neurol Int. 2023 Jul 7;14:235. doi: 10.25259/SNI_409_2023. eCollection 2023.

ABSTRACT

BACKGROUND: Continuous electroencephalograms (cEEGs) are often used in the neurosurgical intensive care unit (NSICU) to detect subclinical seizures (SCSs) in patients with altered mental status (AMS). This retrospective study evaluated the efficacy of this approach for improving patient outcomes.

METHODS: We reviewed the records of 100 patients admitted to the NSICU between 2015 and 2020 who underwent continous electroencephalograms (cEEG) during workup of unexplained AMS. Patient outcomes were classified as positive (discharged), neutral (transfer of care), or negative (dead). Incidence of SCSs on cEEG and association with patient outcomes was analyzed with Chi-square analysis and relative risk (RR).

RESULTS: For the 99 included patients, median age was 62 years and 43% were female. About 15.2% had a known or newly diagnosed brain tumor. Outcomes were positive in 22 patients, neutral in four, and negative in 73. SCSs were detected in 15 patients, of whom 12 died, two were discharged, and one whose care was transferred. Chi-square association between SCS and outcome (P = 0.59) and RR of death associated with SCS diagnosis (1.1) was not significant.

CONCLUSION: We found a lower incidence of SCSs (15.2%) than reported in the literature. In the absence of clinically evident seizures, continous cEEGs performed in the NSICU to determine the etiology of AMS did not yield an improvement in patient outcomes, and patients diagnosed and treated for SCS did not have statistically decreased risk of death. In summary, electroencephalogram monitoring for SCS is important but should not delay diagnosis and treatment of other, potentially life-threating etiologies of AMS.

PMID:37560585 | PMC:PMC10408650 | DOI:10.25259/SNI_409_2023