Nevin Manimala

Urol Pract. 2023 Oct 30:101097UPJ0000000000000468. doi: 10.1097/UPJ.0000000000000468. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to investigate the association between social vulnerability, as measured by the Centers for Disease Control and Prevention’s Social Vulnerability Index (SVI), and the quality of life (QoL) of kidney stone patients using the validated Wisconsin Stone Quality of Life Questionnaire (WISQOL).

MATERIALS AND METHODS: A retrospective analysis was conducted on medical records of new urolithiasis patients who completed the WISQOL at the University of Rochester Medical Center kidney stone clinic. The primary outcome was WISQOL score, which was measured across multiple domains. SVI was used to assess social vulnerability. Neighborhoods with high SVI were defined by a threshold greater than or equal to the 75^th percentile nationally. Demographic and clinical data were collected. Statistical analyses, including univariate tests and multivariate linear regression, were performed to evaluate the relationships between social vulnerability and disease specific QoL.

RESULTS: A total of 1718 patients were included in the study. 105 subjects (6.1%) were from neighborhoods of high social vulnerability. Patients residing in neighborhoods with high social vulnerability (SVI quartile) reported significantly lower QoL scores (69.1 vs 77.2; P = .001) and this persisted across all domains, including social impact (32.6 vs 35.1; P = .002), emotional impact (25.2 vs 27.5; P = .006), disease impact (28.5 vs 31.4; P = .001), and vitality (10.3 vs 11.2; P = .015). Younger age, female sex, and higher number of comorbidities were identified as independent predictors of lower QoL scores. However, non-white race and Latinx ethnicity did not exhibit a significant association with QoL scores.

CONCLUSIONS: These findings highlight the negative impact of high social vulnerability on QoL, emphasizing the importance of considering socioeconomic factors in patient care. These results emphasize the need for targeted interventions to support vulnerable populations. While this study offers initial insights, further research is essential to corroborate these outcomes across larger and more diverse populations.

PMID:37902693 | DOI:10.1097/UPJ.0000000000000468

Psychol Methods. 2023 Oct 30. doi: 10.1037/met0000600. Online ahead of print.

ABSTRACT

How to model cross-lagged relations in panel data continues to be a source of disagreement in psychological research. While the cross-lagged panel model (CLPM) was the modeling approach of choice for many years, it has also been criticized repeatedly for its inability to separate within-person dynamics from stable between-person differences. Hence, various alternative models that disentangle these forms of variability have been proposed, and these are now rapidly gaining popularity. But not everyone agrees this is the right way forward. CLPM advocates point out that many psychological theories are concerned with longer-lasting differences between individuals, while these differences are not allowed to contribute to the estimation of cross-lagged effects in the novel within-between approaches. Reasoning this way, it is argued that the CLPM is superior when studying such processes, precisely because it includes the chronic between-person differences when estimating prospective effects. The goal of the current paper is to consider this within-between dispute in its broader context and to examine various directions in which this discussion needs expansion. To this end, three different perspectives are adopted: that of the study design, patterns in empirical data, and the nature of our research questions. It will be argued that to move forward, we need to look beyond the narrow focus on how to model our correlational panel data. Progress will involve theorizing more deliberately about the timescale that a process operates on, being more explicit about our research questions, considering alternative designs and models, and familiarizing ourselves with relevant discussions in other disciplines. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37902677 | DOI:10.1037/met0000600

Psychol Assess. 2023 Nov;35(11):1054-1067. doi: 10.1037/pas0001211.

ABSTRACT

To assess the public health impact of the COVID-19 pandemic on mental health, investigators from the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) research program developed the Pandemic-Related Traumatic Stress Scale (PTSS). Based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) acute stress disorder symptom criteria, the PTSS is designed for adolescent (13-21 years) and adult self-report and caregiver-report on 3-12-year-olds. To evaluate psychometric properties, we used PTSS data collected between April 2020 and August 2021 from non-pregnant adult caregivers (n = 11,483), pregnant/postpartum individuals (n = 1,656), adolescents (n = 1,795), and caregivers reporting on 3-12-year-olds (n = 2,896). We used Mokken scale analysis to examine unidimensionality and reliability, Pearson correlations to evaluate relationships with other relevant variables, and analyses of variance to identify regional, age, and sex differences. Mokken analysis resulted in a moderately strong, unidimensional scale that retained nine of the original 10 items. We detected small to moderate positive associations with depression, anxiety, and general stress, and negative associations with life satisfaction. Adult caregivers had the highest PTSS scores, followed by adolescents, pregnant/postpartum individuals, and children. Caregivers of younger children, females, and older youth had higher PTSS scores compared to caregivers of older children, males, and younger youth, respectively. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37902671 | DOI:10.1037/pas0001211

Psychol Assess. 2023 Nov;35(11):925-937. doi: 10.1037/pas0001258.

ABSTRACT

Psychological assessment underwent substantive challenges and changes when the COVID-19 pandemic began, and these changes are likely to endure given the rapid growth of telehealth clinical practice and assessment research using virtual procedures. COVID-19-related changes to assessment practices have impacted accordingly how we study overreporting scale functioning, including the modality through which we administer measures. No available research provides direct comparisons of overreporting scale effectiveness within simulation research across in-person and telehealth modalities, despite early support for novel instruments relying on remote procedures within the historic context of the pandemic. We used simulated feigning conditions collected using best telehealth practices to examine if, and how, overreporting scales differed in effectiveness by evaluating mean scores, elevation rates, and classification accuracy statistics, relative to parallel in-person conditions. Results indicate no meaningful differences in scale effectiveness, particularly when exclusion procedures included a posttest questionnaire. Our findings support telehealth assessment practice and the integration of research collected virtually into the traditional, in-person feigning literature. Limitations and future directions are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

PMID:37902662 | DOI:10.1037/pas0001258

Acta Otolaryngol. 2023 Oct 30:1-7. doi: 10.1080/00016489.2023.2269255. Online ahead of print.

ABSTRACT

BACKGROUND: To determine the anatomical proximity of the vestibular nuclei to the respiratory nuclei and the effect of susceptibility of the posterior labyrinth to a hypoxic state on the vestibular system.

OBJECTIVE: It was aimed to evaluate the possible effects of periodic hypoxia on vestibular reflexes and proprioceptive perception in patients with obstructive sleep apnea syndrome (OSAS).

MATERIAL AND METHODS: The study was conducted with 40 patients diagnosed with moderate and severe OSAS and 21 healthy individuals. All individuals were evaluated with Dizziness Handicap Inventory, ocular vestibular evoked myogenic potential (oVEMP), cervical vestibular evoked myogenic potential (cVEMP), video head impulse test (vHIT), videonystagmography (VNG) and sportKAT 3000.

RESULTS: In the vHIT, a statistically significant difference was found between the groups in terms of anterior and posterior semicircular canal vestibulo-ocular reflex gains (p < .05). A negative correlation was found between the lateral gain asymmetry and RALP gain asymmetry and the awake blood oxygen level in the OSAS groups. There was a statistically significant difference between the groups in terms of wave response rates cVEMP 100 dB nHL and oVEMP 100-110 dB nHL (p < .05).

CONCLUSION AND SIGNIFICANCE: It was concluded that vestibular reflexes and proprioceptive perception were affected due to periodic/chronic hypoxia in patients with moderate and severe OSAS.

PMID:37902611 | DOI:10.1080/00016489.2023.2269255

J Physiol. 2023 Oct 30. doi: 10.1113/JP284958. Online ahead of print.

ABSTRACT

Critical torque (CT) represents the highest oxidative steady state for intermittent knee extensor exercise, but the extent to which it is influenced by skeletal muscle mitochondria and sex is unclear. Vastus lateralis muscle biopsy samples were collected from 12 females and 12 males -matched for relative maximal oxygen uptake normalized to fat-free mass (FFM) (F: 57.3 (7.5) ml (kg FFM)^-1 min^-1 ; M: 56.8 (7.6) ml (kg FFM)^-1 min^-1 ; P = 0.856) – prior to CT determination and performance fatiguability trials. Males had a lower proportion of myosin heavy chain (MHC) I isoform (40.6 (18.4)%) compared to females (59.5 (18.9)%; P = 0.021), but MHC IIa and IIx isoform distributions and protein markers of mitochondrial content were not different between sexes (P > 0.05). When normalized to maximum voluntary contraction (MVC), the relative CT (F: 42.9 (8.3)%; M: 37.9 (9.0)%; P = 0.172) and curvature constant, W’ (F: 26.6 (11.0) N m s (N m)^-1 ; M: 26.4 (6.5) N m s (N m)^-1 ; P = 0.962) were not significantly different between sexes. All protein biomarkers of skeletal muscle mitochondrial content, as well as the proportion of MHC I isoform, positively correlated with relative CT (0.48 < r < 0.70; P < 0.05), and the proportion of MHC IIx isoform correlated positively with relative W’ (r = 0.57; P = 0.007). Indices of performance fatiguability were not different between males and females for MVC- and CT-controlled trials (P > 0.05). Greater mitochondrial protein abundance was associated with attenuated declines in potentiated twitch torque for exercise at 60% MVC (P < 0.05); however, the influence of mitochondrial protein abundance on performance fatiguability was reduced when exercise was prescribed relative to CT. Whether these findings translate to whole-body exercise requires additional research. KEY POINTS: The quadriceps critical torque represents the highest intensity of intermittent knee extensor exercise for which an oxidative steady state is attainable, but its relationship with skeletal muscle mitochondrial protein abundance is unknown. Matching males and females for maximal oxygen uptake relative to fat-free mass facilitates investigations of sex differences in exercise physiology, but studies that have compared critical torque and performance fatiguability during intermittent knee extensor exercise have not ensured equal aerobic fitness between sexes. Skeletal muscle mitochondrial protein abundance was correlated with critical torque and fatigue resistance for exercise prescribed relative to maximum voluntary contraction but not for exercise performed relative to the critical torque. Differences between sexes in critical torque, skeletal muscle mitochondrial protein abundance and performance fatiguability were not statistically significant. Our results suggest that skeletal muscle mitochondrial protein abundance may contribute to fatigue resistance by influencing the critical intensity of exercise.

PMID:37902588 | DOI:10.1113/JP284958

J Cogn Neurosci. 2023 Oct 30:1-24. doi: 10.1162/jocn_a_02080. Online ahead of print.

ABSTRACT

Web-based experiments are gaining momentum in motor learning research because of the desire to increase statistical power, decrease overhead for human participant experiments, and utilize a more demographically inclusive sample population. However, there is a vital need to understand the general feasibility and considerations necessary to shift tightly controlled human participant experiments to an online setting. We developed and deployed an online experimental platform modeled after established in-laboratory visuomotor rotation experiments to serve as a case study examining remotely collected data quality for an 80-min experiment. Current online motor learning experiments have thus far not exceeded 60 min, and current online crowdsourced studies have a median duration of approximately 10 min. Thus, the impact of a longer-duration, web-based experiment is unknown. We used our online platform to evaluate perturbation-driven motor adaptation behavior under three rotation sizes (±10°, ±35°, and ±65°) and two sensory uncertainty conditions. We hypothesized that our results would follow predictions by the relevance estimation hypothesis. Remote execution allowed us to double (n = 49) the typical participant population size from similar studies. Subsequently, we performed an in-depth examination of data quality by analyzing single-trial data quality, participant variability, and potential temporal effects across trials. Results replicated in-laboratory findings and provided insight on the effect of induced sensory uncertainty on the relevance estimation hypothesis. Our experiment also highlighted several specific challenges associated with online data collection including potentially smaller effect sizes, higher data variability, and lower recommended experiment duration thresholds. Overall, online paradigms present both opportunities and challenges for future motor learning research.

PMID:37902584 | DOI:10.1162/jocn_a_02080

Trauma Violence Abuse. 2023 Oct 30:15248380231204887. doi: 10.1177/15248380231204887. Online ahead of print.

ABSTRACT

Gender-based violence (GBV) is a pervasive public health issue that harms victims. Bystanders’ interventions are crucial in preventing the risks of GBV; however, numerous barriers impede their willingness and behaviors to intervene. As a part of efforts to thwart these barriers, this study used a systematic review and meta-analysis to identify such barriers and assess their impact on bystanders’ engagement to intervene. The researchers explored academic databases and included 38 studies in the analysis; we extracted and coded the identified barriers (e.g., lack of responsibility, rape myth) and allocated them to six domains: failure to notice, failure to perceive risk, failure to take responsibility for engaging, lack of bystander efficacy/competency, failure to take an action, and failure of previous intervention attempts. We calculated the overall and domain-specific effect sizes (ES) and performed moderator analysis. The overall ES of the barriers identified in the review were small but statistically significant. The most potent bystander intervention barrier domain was failed previous intervention attempts; the greatest specific barriers therein were negative emotions and feelings of uncertainty after engaging in bystander behaviors. University/college populations were more vulnerable to barriers to intervention than community members. Moreover, the barriers were more prohibitive in incidents of violence against women and sexual assaults than in intimate partner violence. Bystander-focused programs that address negative emotions and feelings arising from prior intervention experiences are needed to foster continued bystander engagement and assistance in GBV; moreover, tailored program content should also be provided for groups most vulnerable to intervention barriers.

PMID:37902582 | DOI:10.1177/15248380231204887

J Cardiovasc Imaging. 2023 Oct;31(4):200-206. doi: 10.4250/jcvi.2023.0055.

ABSTRACT

BACKGROUND: Right ventricular (RV) dysfunction is a significant risk of major adverse cardiac events in patients with acute heart failure (AHF). In this study, we evaluated RV-pulmonary artery (PA) coupling, assessed by tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) and assessed its prognostic significance, in AHF patients.

METHODS: We measured the TAPSE/PASP ratio and analyzed its correlations with other echocardiographic parameters. Additionally, we assessed its prognostic role in AHF patients.

RESULTS: A total of 1147 patients were included in the analysis (575 men, aged 70.81 ± 13.56 years). TAPSE/PASP ratio exhibited significant correlations with left ventricular (LV) ejection fraction(r = 0.243, p < 0.001), left atrial (LA) diameter(r = -0.320, p < 0.001), left atrial global longitudinal strain (LAGLS, r = 0.496, p < 0.001), mitral E/E’ ratio(r = -0.337, p < 0.001), and right ventricular fractional area change (RVFAC, r = 0.496, p < 0.001). During the median follow-up duration of 29.0 months, a total of 387 patients (33.7%) died. In the univariate analysis, PASP, TAPSE, and TAPSE/PASP ratio were significant predictors of mortality. After the multivariate analysis, TAPSE/PASP ratio remained a statistically significant parameter for all-cause mortality (hazard ratio [HR], 0.453; p = 0.037) after adjusting for other parameters. In the receiver operating curve analysis, the optimal cut-off level of TAPSE/PASP ratio for predicting mortality was 0.33 (area under the curve = 0.576, p < 0.001), with a sensitivity of 65% and a specificity of 47%. TAPSE/PASP ratio < 0.33 was associated with an increased risk of mortality after adjusting for other variables (HR, 1.306; p = 0.025).

CONCLUSIONS: In AHF patients, TAPSE/PASP ratio demonstrated significant associations with RVFAC, LA diameter and LAGLS. Moreover, a decreased TAPSE/PASP ratio < 0.33 was identified as a poor prognostic factor for mortality.

PMID:37901999 | DOI:10.4250/jcvi.2023.0055

ACS Nano. 2023 Oct 30. doi: 10.1021/acsnano.3c08377. Online ahead of print.

ABSTRACT

An electron-hole pair in a cube-shaped CdSe/CdS core/shell nanocrystal exists in the form of dynamic excitons across the strongly and weakly confined regimes under ambient temperatures. Photochemical doping is applied to distinguish the band-edge electron and hole levels, confirming an effective mass model with universal constants. Reduction of the optical bandgap upon epitaxy of the CdS shells is caused by lowering the band-edge electron level and barely affecting the band-edge hole level. Similar shifts of the electron levels, yet retaining the hole levels, can switch the order in energy of the three lowest-energy transitions. Thermal distribution of 1-4 electrons among the two thermally accessible electron levels follows number-counting statistics, instead of Fermi-Dirac distribution.

PMID:37901990 | DOI:10.1021/acsnano.3c08377