Nevin Manimala

Am J Biol Anthropol. 2022 Aug;178 Suppl 74:54-114. doi: 10.1002/ajpa.24494. Epub 2022 Mar 22.

ABSTRACT

This article presents outcomes from a Workshop entitled “Bioarchaeology: Taking Stock and Moving Forward,” which was held at Arizona State University (ASU) on March 6-8, 2020. Funded by the National Science Foundation (NSF), the School of Human Evolution and Social Change (ASU), and the Center for Bioarchaeological Research (CBR, ASU), the Workshop’s overall goal was to explore reasons why research proposals submitted by bioarchaeologists, both graduate students and established scholars, fared disproportionately poorly within recent NSF Anthropology Program competitions and to offer advice for increasing success. Therefore, this Workshop comprised 43 international scholars and four advanced graduate students with a history of successful grant acquisition, primarily from the United States. Ultimately, we focused on two related aims: (1) best practices for improving research designs and training and (2) evaluating topics of contemporary significance that reverberate through history and beyond as promising trajectories for bioarchaeological research. Among the former were contextual grounding, research question/hypothesis generation, statistical procedures appropriate for small samples and mixed qualitative/quantitative data, the salience of Bayesian methods, and training program content. Topical foci included ethics, social inequality, identity (including intersectionality), climate change, migration, violence, epidemic disease, adaptability/plasticity, the osteological paradox, and the developmental origins of health and disease. Given the profound changes required globally to address decolonization in the 21st century, this concern also entered many formal and informal discussions.

PMID:36790761 | DOI:10.1002/ajpa.24494

J Phys Chem A. 2023 Feb 15. doi: 10.1021/acs.jpca.2c07476. Online ahead of print.

ABSTRACT

Recent low-temperature infrared-based experimental studies provided information about the effects of aqueous microsolvation on the intramolecular hydrogen bond of protonated glycine and β-alanine [J. Phys. Chem. A 2019, 123, 3355]. Here we address the temperature-dependent entropic effects on the aqueous microsolvation patterns of these protonated amino acids using the AAH⁺(H₂O)_n (n = 1-8) cluster model at 50 K and room temperature with Born-Oppenheimer molecular dynamics using a calibrated hybrid density functional. The C_COOH-O_w, N-O_w, and center-of-mass-O_w radial distribution functions provide accurate structural data and temperature-dependent water coordination numbers vs. solvation degree. The solvation patterns for protonated glycine at 50 K show structural features in agreement with previous static optimizations. However, entropic effects at room temperature play a crucial role in the evolution of the intramolecular HB strength vs. solvation degree for both protonated amino acids. With increasing hydration entropic effects favor the making of solvent hydrogen bond networks over full solvation of protonated glycine. At room temperature four water molecules are needed to build the first solvation shell for protonated glycine while five are required for protonated β-alanine. A new statistical Cumulative Percentage of Structures (CPS) scheme is proposed; when the CPS data are analyzed in light of the empirical formula of Rozenberg et al. [Phys. Chem. Chem. Phys. 2000, 2, 2699] and the hydrogen bond relative strength (HBRS) criteria of Jeffrey [An Introduction to Hydrogen Bonding; Oxford University: 1997] we can provide a detailed molecular mechanism for the weakening of the intramolecular hydrogen bond based on the average dynamical structures, which clearly reveals the temperature dependence of this process. The new CPS-HBRS scheme proposed here can be utilized using any type of molecular dynamics trajectory (classical, BOMD, CPMD, etc.).

PMID:36790739 | DOI:10.1021/acs.jpca.2c07476

Am J Biol Anthropol. 2023 Feb 7. doi: 10.1002/ajpa.24695. Online ahead of print.

ABSTRACT

OBJECTIVES: Recent studies have associated subarticular trabecular bone distribution in the extant hominid first metacarpal (Mc1) with observed thumb use, to infer fossil hominin thumb use. Here, we analyze the entire Mc1 to test for interspecific differences in: (1) the absolute volume of trabecular volume fraction, (2) the distribution of the deeper trabecular network, and (3) the distribution of trabeculae in the medullary cavity, especially beneath the Mc1 disto-radial flange.

MATERIALS AND METHODS: Trabecular bone was imaged using micro-computed tomography in a sample of Homo sapiens (n = 11), Pan paniscus (n = 10), Pan troglodytes (n = 11), Gorilla gorilla (n = 10) and Pongo sp., (n = 7). Using Canonical Holistic Morphometric Analysis (cHMA), we tested for interspecific differences in the trabecular bone volume fraction (BV/TV) and its relative distribution (rBV/TV) throughout the Mc1, including within the head, medullary cavity, and base.

RESULTS: P. paniscus had the highest, and H. sapiens the lowest, BV/TV relative to other species. rBV/TV distribution statistically distinguished the radial concentrations and lack of medullary trabecular bone in the H. sapiens Mc1 from all other hominids. H. sapiens and, to a lesser extent, G. gorilla also had a significantly higher trabecular volume beneath the disto-radial flange relative to other hominids.

DISCUSSION: These results are consistent with differences in observed thumb use in these species and may also reflect systemic differences in bone volume fraction. The trabecular bone extension into the medullary cavity and concentrations beneath the disto-radial flange may represent crucial biomechanical signals that will aid in the inference of fossil hominin thumb use.

PMID:36790736 | DOI:10.1002/ajpa.24695

Eur Arch Otorhinolaryngol. 2023 Feb 15. doi: 10.1007/s00405-023-07870-9. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the relationship between cell content and histopathological features of parathyroid lesions and 18F-FCH uptake intensity on PET/CT images.

METHODS: Patients with primary hyperparathyroidism (age > 18) who were referred to 18F-FCH PET/CT were involved. All patients underwent parathyroidectomy. Correlation of SUVmax with following factors were statistically analysed: serum PTH, Ca, P levels and histopathological parameters, total absolute amounts of chief cell, oxyphyllic cell and clear cell components calculated by the multiplication of the volume of the parathyroid lesion and the percentage of each type of cell content (called as Absolute_chief, Absolute_oxyphyllic and Absolute_clear reflecting the total amount of each cell group).

RESULTS: A total of 34 samples from 34 patients (6M, 28F, mean age: 53.32 ± 15.15, min: 14, max: 84) who had a positive 18F-FCH PET/CT localizing at least one parathyroid lesion were involved. In the whole study group, SUVmax was found to be correlated with the greatest diameter and volume of the lesion and Absolute_chief (p = 0.004, p = 0.002 and p = 0.035, respectively). In the subgroup analysis of 28 samples with longest diameter > 1 cm, the correlation between SUVmax and Absolute_chief remained significant (p = 0.036) and correlation between SUVmax and volume and longest diameter became stronger (p = 0.011 and p > 0.001, respectively). No correlation was found between SUVmax and Absolute_oxyphyllic or Absolute_clear.

CONCLUSIONS: There might be a relationship between 18F-FCH uptake intensity and chief cell content in patients with parathyroid adenoma. Further studies with larger patient groups would be beneficial to support the data.

PMID:36790722 | DOI:10.1007/s00405-023-07870-9

Environ Sci Pollut Res Int. 2023 Feb 15. doi: 10.1007/s11356-023-25808-w. Online ahead of print.

ABSTRACT

Recycling agents provide better additions of reclaimed asphalt pavement (RAP) in the production of new asphalt mixtures. Alternative and residual materials that have the potential as asphalt binder viscosity reducers have gained visibility in the field of paving due to the perspective of circular economy in recycled mixtures. Soybean oil sludge fatty acid is a material produced from soybean oil sludge, a waste generated in the soybean oil refining step. Thus, this paper investigated the physical, chemical, and rheological effects of the asphalt binder PG 64-XX modified by the fatty acid of soybean oil sludge in the contents of 6% and 7% by weight of the binder. The modified binder samples were submitted to penetration tests, softening point, rotational viscosity, performance grade (PG), before and after short-term aging (RTFO), and multiple stress creep and recovery (MSCR). A control asphalt mixture and recycled asphalt mixtures produced with 40% RAP and fatty acid-modified binders were subjected to tensile strength, induced moisture damage, resilient modulus, and fatigue life. A Student’s t statistical test verified the significance of the data, as well as the estimation of production costs of these asphalt mixtures. The use of the fatty acid significantly reduced the stiffness and viscosity of the control asphalt binder, decreasing the mixing temperatures at 14 °C and 17 °C to 6% and 7%, respectively. Using higher fatty acid contents from soybean oil sludge significantly improved the performance of recycled mixtures in tensile strength, moisture damage, and fatigue life. The production cost of recycled asphalt mixtures was lower than that of the control mixture.

PMID:36790704 | DOI:10.1007/s11356-023-25808-w

Environ Sci Pollut Res Int. 2023 Feb 15. doi: 10.1007/s11356-023-25790-3. Online ahead of print.

ABSTRACT

The application of spatiotemporal functional analysis techniques in environmental pollution research remains limited. As a result, this paper suggests spatiotemporal functional data clustering and visualization tools for identifying temporal dynamic patterns and spatial dependence of multiple air pollutants. The study uses concentrations of four major pollutants, named particulate matter (PM2.5), ground-level ozone (O₃), carbon monoxide (CO), and sulfur oxides (SO₂), measured over 37 cities in Yemen from 1980 to 2022. The proposed tools include Fourier transformation, B-spline functions, and generalized-cross validation for data smoothing, as well as static and dynamic visualization methods. Innovatively, a functional mixture model was used to capture/identify the underlying/hidden dynamic patterns of spatiotemporal air pollutants concentration. According to the results, CO levels increased 25% from 1990 to 1996, peaking in the cities of Taiz, Sana’a, and Ibb before decreasing. Also, PM2.5 pollution reached a peak in 2018, increasing 30% with severe concentrations in Hodeidah, Marib, and Mocha. Moreover, O₃ pollution fluctuated with peaks in 2014-2015, 2% increase and pollution rate of 265 Dobson. Besides, SO₂ pollution rose from 1997 to 2010, reaching a peak before stabilizing. Thus, these findings provide insights into the structure of the spatiotemporal air pollutants cycle and can assist policymakers in identifying sources and suggesting measures to reduce them. As a result, the study’s findings are promising and may guide future research on predicting multivariate air pollution statistics over the analyzed area.

PMID:36790700 | DOI:10.1007/s11356-023-25790-3

Am J Biol Anthropol. 2023 Jan;180(1):207-215. doi: 10.1002/ajpa.24660. Epub 2022 Nov 20.

ABSTRACT

OBJECTIVES: Height is a complex, highly heritable polygenic trait subject to both genetic composition and environmental influences. Recent studies suggest that a large proportion of height heritability is determined by the cumulative effect of many low allele frequency variants across the genome. Previous research has also identified an inverse relationship between height and runs of homozygosity (ROH); however, this has yet to be examined within African populations. We aim to identify this association within the Himba, an endogamous Namibian population who are recently bottlenecked, resulting in elevated haplotype sharing and increased homozygosity.

MATERIALS AND METHODS: Here, we calculate the fraction of the genome composed of long runs of homozygosity (F_ROH) in a sample of 245 adults and use mixed effects models to assess its effect on height.

RESULTS: We find that Himba adults exhibit increased homozygosity. However, in contrast to previous studies in other populations, we do not find a significant effect of F_ROH on height within the Himba. We further estimated heritability of height, noting both an enrichment of distant relatives and greater developmental homogeneity across households; we find that $h_g^2=0.59$ (SE ± 0.146), comparable to estimates reported in Europeans.

DISCUSSION: Our results may be due to other environmental variables we were not able to include, measurement error, or low statistical power, but may also imply that phenotypic expression resulting from increased homozygosity may vary from population to population.

PMID:36790690 | DOI:10.1002/ajpa.24660

Am J Biol Anthropol. 2022 Oct;179(2):184-210. doi: 10.1002/ajpa.24605. Epub 2022 Aug 15.

ABSTRACT

OBJECTIVES: This study examines dental morphology trait prevalence among three southern Naga groups and compares them to 10 ethnic groups from other regions of South Asia to accomplish two objectives: assess the biological relationship of these Tibeto-Burman-speakers to speakers of non-Tibeto-Burman languages in other South Asian regions, and determine which traits distinguish northeast Indians from other South Asians.

METHODS: Dental morphology traits were scored with the Arizona State University Dental Anthropology System. Tooth-trait combinations were evaluated for significant inter-trait correlation and intra-trait correspondence within dental fields. Comparisons were based on simple trait prevalence and with Smith’s MMD. Affinities based on the former were accomplished with correspondence analysis and principal components analysis. Affinities based on the latter were undertaken with neighbor-joining cluster analysis and multidimensional scaling.

RESULTS: After elimination due to inter-trait correlations and uniform prevalence, biodistances based on the remaining 17 tooth-trait combinations identify significant differences between northeast Indians and other South Asian ethnic groups due to high frequencies of shoveling on the maxillary incisors and Cusp 6 on the mandibular molars coupled with low frequencies of Carabelli’s trait and Cusp 5 on UM1 and UM2, respectively.

CONCLUSIONS: Patterns of biodistances obtained from dental morphology are consilient with those obtained from DNA indicating statistically significant differences between northeast Indians from members of ethnic groups of other regions of South Asia. Researchers should explore the sex-specific patterns. Biodistances should not be limited to “key” teeth within dental fields, for in almost every case traits present on mesial and distal teeth yield non-redundant information.

PMID:36790681 | DOI:10.1002/ajpa.24605

Qual Life Res. 2023 Feb 15. doi: 10.1007/s11136-023-03365-6. Online ahead of print.

ABSTRACT

PURPOSE: In this study, it was aimed to compare the administration of chemotherapy drugs via venous port catheter and peripheral vein in metastatic colon cancer patients in terms of quality of life and treatment costs.

METHODS: The research was carried out in a university hospital in Turkey. The population of the study consists of 130 patients with metastatic colon cancer who were treated with chemotherapy. The sample of the study consists of 103 participants. During the data collection phase of the study, three data collection tools were used: demographic information form, EOTC QLQ-30 quality of life scale and invoices for treatments. Data were analyzed using Microsoft Office Excel and IBM SPSS 20 package programs.

RESULTS: In the study, 71.8% of the participants received chemotherapy with a venous port catheter, 65% for more than 3 months, 56.3% in the day unit. As a result of the study, it was found that there were no significant differences in the quality of life (except social function) according to the chemotherapy method. In addition, when the research results are examined in terms of cost, statistically significant differences were found in the treatment cost (except total costs excluding drugs) according to the chemotherapy application method.

CONCLUSION: In line with these results, it is thought that when choosing the chemotherapy application method, factors such as the treatment duration of the patients, the ease of opening the vascular access, and the patient’s psychological state should be taken into consideration.

PMID:36790666 | DOI:10.1007/s11136-023-03365-6

Hemodial Int. 2023 Feb 14. doi: 10.1111/hdi.13069. Online ahead of print.

ABSTRACT

INTRODUCTION: We evaluated the effects of pre-analytical care on total carbon dioxide (tCO₂ ) in hemodialysis patients, as calculated by blood gas analysis (ctCO₂ ) or measured by an enzymatic assay (mtCO₂ ).

METHODS: Blood samples were collected via vascular access before dialysis sessions. For blood gas analysis, eight aliquots were collected, refrigerated or non-refrigerated, and analyzed at 0, 4, 8, and 24 h after collection. A blood sample was then collected for the enzymatic method and distributed into 14 aliquots. Half of the aliquots were refrigerated. The samples analyzed at time point 0 were centrifuged immediately. The remaining aliquots of both the refrigerated and non-refrigerated clusters were centrifuged before storage. Samples were analyzed at 4, 8, and 24 h post-collection.

FINDINGS: By blood gas analysis, no significant change was found in bicarbonate values over time, either in the non-refrigerated or refrigerated samples. ctCO₂ values during the experiment showed a minor but statistically significant increase of questionable clinical relevance in both non-refrigerated and refrigerated aliquots. In the enzymatic assay, the reduction in mtCO₂ levels during the experiment was negligible. The median absolute reductions at the end of the experiment were 1.77, 1.21, 1.04, and 1.12 mmol/L for the non-centrifuged/non-refrigerated, centrifuged/non-refrigerated, non-centrifuged/refrigerated, and centrifuged/refrigerated aliquots, respectively.

DISCUSSION: Our results suggest that measured or calculated tCO₂ levels of capped and cooled samples are adequate for analyzing the acid-base status of hemodialysis patients, even when such determination is not performed immediately after collection.

PMID:36788419 | DOI:10.1111/hdi.13069