Nevin Manimala

J Speech Lang Hear Res. 2023 Jan 18:1-28. doi: 10.1044/2022_JSLHR-22-00387. Online ahead of print.

ABSTRACT

PURPOSE: This study conducted a transcription-based and spectral moments’ analysis of alveolar and alveopalatal fricatives in monolingual and bilingual French-speaking children, aged 2;6-6;10 (years;months). We measured the percent accuracy of fricatives and investigated whether young children could distinguish alveolar and alveopalatal fricatives on the basis of spectral moments. In addition, we examined which child- (i.e., age, gender, bilingualism, and alveopalatal fricative inventory size) and word/sound-related (i.e., place-of-articulation [PoA], voicing, vowel quality, and word position) factors influenced spectral moments and fricative duration.

METHOD: Children (N = 89) participated in a picture-naming task in which they produced words containing alveolar /s, z/ and alveopalatal /ʃ, ʒ/ fricatives in word-initial, -medial, and -final positions. The words were transcribed and analyzed acoustically, and the first and third spectral moments (i.e., centroid and skewness) and the duration of fricatives were calculated. The data were subject to mixed-effects linear regression.

RESULTS: Percent accuracy results indicated effects of age on alveopalatal fricatives and effects of word position on voiced fricatives. Statistical models indicated that age, gender, and alveopalatal fricative inventory size influenced spectral moments. Age and inventory size interacted significantly with PoA. Children as young as age 2;6 distinguished alveopalatal and alveolar fricatives on the basis of centroid but not skewness values. The distinction between the two sets of fricatives increased with age. Bilingual children who spoke languages with greater numbers of alveopalatal fricatives distinguished alveopalatal and alveolar fricatives less well than monolinguals and bilinguals who spoke languages with fewer numbers of alveopalatal fricatives. Girls had higher centroid and lower skewness values than boys. Models also revealed a significant influence of word/sound-related factors (voicing, vowel quality, and word position) on spectral moments and fricative duration.

CONCLUSIONS: Findings indicated that multiple factors influence the spectral moments and duration measures of children’s alveolar and alveopalatal fricatives. In particular, we found that spectral moments were sensitive to gender and bilingualism effects.

PMID:36652703 | DOI:10.1044/2022_JSLHR-22-00387

J Clin Psychiatry. 2023 Jan 16;84(1):22m14430. doi: 10.4088/JCP.22m14430.

ABSTRACT

Objective: Most research on safety of attention-deficit/hyperactivity disorder (ADHD) medications during pregnancy concerns central nervous system stimulants, while little is known about the safety of atomoxetine, a primary treatment alternative. We assessed the prevalence of major congenital malformations overall, and cardiac malformations and limb malformations specifically, after first-trimester exposure.

Methods: In this cohort study, we included all approximately 2.4 million pregnancies ending in live births recorded in the population-based nationwide health registers of Denmark, Iceland, Norway, and Sweden (2003-2017) and approximately 1.8 million publicly insured pregnancies ending in live births recorded in the US Medicaid Analytic eXtract (MAX, 2001-2013) health care claims database. We compared the prevalence of major congenital malformations in the newborn among pregnancies exposed and unexposed to atomoxetine. For each country, we calculated prevalence ratios (PRs), crude and stratified by propensity scores (PSs). We pooled the country-specific PS strata to obtain a PR adjusted for potential confounding factors.

Results: We identified 368 pregnancies exposed to atomoxetine during the first trimester in the 4 Nordic countries and 622 in the US. The pooled crude PR for any major congenital malformation was 1.18 (95% CI, 0.88-1.60), and the adjusted PR was 0.99 (95% CI, 0.74-1.34). For cardiac malformations, the adjusted PR was 1.34 (95% CI, 0.86-2.09). For limb malformations, the adjusted PR was 0.90 (95% CI, 0.38-2.16).

Conclusions: After atomoxetine exposure in early pregnancy, we observed no increase in major congenital malformations overall and, although with some uncertainty due to sample size, no statistically increased risk estimates for cardiac malformations and limb malformations.

PMID:36652686 | DOI:10.4088/JCP.22m14430

JCO Precis Oncol. 2023 Jan;7:e2200113. doi: 10.1200/PO.22.00113.

ABSTRACT

PURPOSE: Total cell-free DNA (cfDNA) and tumor-derived cfDNA (ctDNA) can be used to study tumor-derived genetic aberrations. We analyzed the diagnostic and prognostic potential of cfDNA and ctDNA, obtained from pediatric patients with rhabdomyosarcoma.

METHODS: cfDNA was isolated from diagnostic plasma samples from 57 patients enrolled in the EpSSG RMS2005 study. To study the diagnostic potential, shallow whole genome sequencing (shWGS) and cell-free reduced representation bisulphite sequencing (cfRRBS) were performed in a subset of samples and all samples were tested using droplet digital polymerase chain reaction to detect methylated RASSF1A (RASSF1A-M). Correlation with outcome was studied by combining cfDNA RASSF1A-M detection with analysis of our rhabdomyosarcoma-specific RNA panel in paired cellular blood and bone marrow fractions and survival analysis in 56 patients.

RESULTS: At diagnosis, ctDNA was detected in 16 of 30 and 24 of 26 patients using shallow whole genome sequencing and cfRRBS, respectively. Furthermore, 21 of 25 samples were correctly classified as embryonal by cfRRBS. RASSF1A-M was detected in 21 of 57 patients. The presence of RASSF1A-M was significantly correlated with poor outcome (the 5-year event-free survival [EFS] rate was 46.2% for 21 RASSF1A-M‒positive patients, compared with 84.9% for 36 RASSF1A-M‒negative patients [P < .001]). RASSF1A-M positivity had the highest prognostic effect among patients with metastatic disease. Patients both negative for RASSF1A-M and the rhabdomyosarcoma-specific RNA panel (28 of 56 patients) had excellent outcome (5-year EFS 92.9%), while double-positive patients (11/56) had poor outcome (5-year EFS 13.6%, P < .001).

CONCLUSION: Analyzing ctDNA at diagnosis using various techniques is feasible in pediatric rhabdomyosarcoma and has potential for clinical use. Measuring RASSF1A-M in plasma at initial diagnosis correlated significantly with outcome, particularly when combined with paired analysis of blood and bone marrow using a rhabdomyosarcoma-specific RNA panel.

PMID:36652664 | DOI:10.1200/PO.22.00113

J Patient Saf. 2023 Jan 19. doi: 10.1097/PTS.0000000000001104. Online ahead of print.

ABSTRACT

OBJECTIVES: Improving patient safety by investigating sentinel events (SEs) is hampered by the focus on isolated events within hospitals and a narrow scope of traditional root cause analysis methods. We aimed to examine if performing cross-hospital aggregate analysis of SEs applying a novel generic analysis method (GAM) bearing a human factor perspective can enhance learning from SEs.

METHODS: A retrospective cross-sectional review of SE reports from 28 Dutch general hospitals using the GAM to reanalyze events was performed. A qualitative approach was used to identify contributing factors and system issues. Findings were discussed with a patient safety expert panel. Descriptive statistics and measures of associations between domains were calculated.

RESULTS: Sixty-nine SE reports were reviewed. Applying the GAM provided a more holistic SE analysis than a traditional method. Of the 405 identified contributing factors in all SEs, the majority was related to the persons involved (patients and professionals, n = 146 [36.2%]) and the organization (n = 121 [30%]). The most frequently recurring pattern was the combination of factors related to the persons involved, the technology used, the tasks of professionals, and organizational factors influencing the event. Cross-hospital aggregate GAM analysis of SEs helped to identify system issues and propose more system-oriented overarching recommendations.

CONCLUSIONS: This study found that applying the GAM to analyze SEs across hospitals can help to improve learning from SEs and may result in proposing stronger recommendations. The method can support hospitals, working together in a network of hospitals, to jointly learn from SEs.

PMID:36652656 | DOI:10.1097/PTS.0000000000001104

ACS Appl Mater Interfaces. 2023 Jan 18. doi: 10.1021/acsami.2c17198. Online ahead of print.

ABSTRACT

Water management in the catalyst layers (CLs) of proton-exchange membrane fuel cells is crucial for its commercialization and popularization. However, the high experimental or computational cost in obtaining water distribution and diffusion remains a bottleneck in the existing experimental methods and simulation algorithms, and further mechanistic exploration at the nanoscale is necessary. Herein, we integrate, for the first time, molecular dynamics simulation with our customized analysis framework based on a multiattribute point cloud dataset and an advanced deep learning network. This was achieved through our workflow that generates simulated transport data of water molecules in the CLs as the training and test dataset. Deep learning framework models the multibody solid-liquid system of CLs on a molecular scale and completes the mapping from the Pt/C substrate structure and Nafion aggregates to the density distribution and diffusion coefficient of water molecules. The prediction results are comprehensively analyzed and error evaluated, which reveals the highly anisotropic interaction landscape between 50,000 pairs of interacting nanoparticles and explains the structure and water transport property relationship in the hydrated Nafion film on the molecular scale. Compared to the conventional methods, the proposed deep learning framework shows computational cost efficiency, accuracy, and good visual display. Further, it has a generality potential to model macro- and microscopic mass transport in different components of fuel cells. Our framework is expected to make real-time predictions of the distribution and diffusion of water molecules in CLs as well as establish statistical significance in the structural optimization and design of CLs and other components of fuel cells.

PMID:36652634 | DOI:10.1021/acsami.2c17198

Stress Health. 2023 Jan 18. doi: 10.1002/smi.3225. Online ahead of print.

ABSTRACT

Being a family carer is associated with increased risk of experiencing depressive symptoms. Despite many decades of research investigating the association between coping strategies and depressive symptoms in carers results across studies remain contradictory. The objective of this study was to systematically review evidence on the association between depressive symptoms and coping strategies in carers of dependent people aged 18 and over and investigate potential sources of heterogeneity of findings. The study design was a systematic review and meta-analysis. We searched Pubmed, CINAHL, PsycINFO and LILACS up to April 2021. We performed meta-analyses following the PRISMA statement and several subgroup analyses to investigate whether cause of caring dependency, study design, and controlling for several biases influenced results. Fifty-nine studies met our inclusion criteria. We found a robust and statistically significant association between greater use of dysfunctional coping and higher depressive symptoms. Greater use of emotion-focused coping was associated with fewer depressive symptoms only in studies controlling for confounding bias. Use of problem-focused coping was related to fewer depressive symptoms in carers of frail older people. The combined use of both problem-focused and emotion-focused coping was associated with lower symptoms of depression. Our review concludes that the broad domain of dysfunctional coping is consistently associated with higher levels of depressive symptoms in carers. After controlling for confounders, emotion-focused coping and several of its individual strategies were consistently associated with fewer depressive symptoms. Whilst problem-focused coping and some of its individual strategies are also associated with lower depressive symptoms, these strategies may not be as helpful in all caregiving groups.Clinical Impact Statement: fcBoth broad dimensions of coping and individual coping strategies are important correlates of depressive symptoms in family carers, and should be utilized in informing and improving the effectiveness of future caregiving interventions. This article is protected by copyright. All rights reserved.

PMID:36652619 | DOI:10.1002/smi.3225

JMIR Form Res. 2022 Dec 20. doi: 10.2196/34074. Online ahead of print.

ABSTRACT

BACKGROUND: Due to the COVID-19 pandemic, telehealth has become a safer way to access healthcare. The telehealth industry has rapidly expanded over the last decade as a modality to provide patient-centered care. However, the prevalence of its use and patient acceptability remains unclear in the Middle East and North Africa (MENA) region.

OBJECTIVE: The primary aim was to assess the prevalence of telehealth use before and during the pandemic by utilizing social media (Instagram) as an online platform for survey administration across different countries simultaneously. Our secondary aim was to assess the perceptions regarding telehealth usage amongst those utilizing it.

METHODS: An online social media platform (Instagram) that reaches 130,000 subjects daily was used to administer a questionnaire that assessed the current prevalence of telehealth use and public attitudes and acceptability towards this modality of healthcare delivery during the COVID-19 pandemic.

RESULTS: 1524 respondents participated in the survey (females 89.0%; median age 31 years), of whom 97.6% lived in the Gulf Cooperation Council (GCC). Prior to COVID-19, 1350 (88.6%) had no exposure to telehealth. Following the COVID-19 pandemic, telehealth usage increased by 251% to a total of 611 users (40% of all users). About 89% of telehealth users used virtual visits for specialist visits. Of the 642 participants who reported using telehealth, 236 (36.8%) reported their willingness to continue using telehealth, 241 (37.5%) were unsure, and 164 (25.5%) did not wish to continue to use telehealth after the COVID-19 pandemic. An inverse trend, although not statistically significant, was seen between willingness to continue telehealth usage and the number of medical comorbidities (OR= 0.81, p= 0.094). Compared to the respondents who chose only messaging as their used modality for telehealth, respondents who chose both messaging and phone calls were significantly less likely to recommend telehealth (OR= 0.42, p= 0.009). Overall, there was general satisfaction with telehealth usage and respondents reported that telehealth consultations made them feel safer and saved both time and money.

CONCLUSIONS: Telehealth usage increased dramatically after the COVID-19 pandemic and usage was found to be acceptable among some young adult groups on Instagram. However, further innovation is warranted to increase acceptability and willingness to continue telehealth use for the delivery of healthcare.

PMID:36652596 | DOI:10.2196/34074

J Nurs Educ. 2023 Jan;62(1):47-50. doi: 10.3928/01484834-20221109-08. Epub 2023 Jan 1.

ABSTRACT

BACKGROUND: Traditional clinical education does not prepare future nurses well for practice. Clinical immersion models are recommended to enhance critical thinking, clinical judgment, and confidence with nursing roles and skills. This study explored the effects of implementing an innovative clinical immersion model on readiness for nursing practice for accelerated Bachelor of Science in nursing students.

METHOD: The Casey-Fink readiness for practice survey was used to determine graduate students’ confidence and comfort with nursing roles and skills based on descriptive statistics for each survey question.

RESULTS: Study results indicated students who experienced the clinical immersion model had high levels of confidence with nursing roles and felt prepared for practice.

CONCLUSION: Nursing programs should consider implementing clinical immersion models in undergraduate nursing education programs. [J Nurs Educ. 2023;62(1):47-50.].

PMID:36652578 | DOI:10.3928/01484834-20221109-08

J Chin Med Assoc. 2023 Feb 1;86(2):246-253. doi: 10.1097/JCMA.0000000000000854. Epub 2023 Jan 18.

ABSTRACT

BACKGROUND: The Greulich-Pyle (GP) and Tanner-Whitehouse 3 (TW3) methods are two common methods for assessing bone age (BA). The applicability of these methods for populations other than those in the United States and Europe has been questioned. Thus, this study tested the applicability of these methods for Taiwanese children.

METHODS: In total, 1476 radiographs (654 boys, 822 girls) were analyzed. A subset of 200 radiographs was evaluated to determine intrarater and interrater reliability and the time required to yield a BA assessment. BA was determined by two reviewers using the GP method and two of the TW3 methods (the Radial-Ulnar-Short bones [RUS] method and the carpals method [Carpal]). The GP and TW3 methods were directly compared using statistical techniques. A subgroup analysis by age was performed to compare BA and chronological age using a paired t test for each age group.

RESULTS: The average times required to yield an assessment using the GP and TW3-RUS methods were 0.79 ± 0.14 and 3.01 ± 0.84 min (p < 0.001), respectively. Both the intrarater and interrater correlation coefficients were higher for the GP method (0.993, 0.992) than the TW3-RUS (0.985, 0.984) and TW3-Carpal (0.981, 0.973) methods. The correlation coefficient for the GP and TW3-RUS methods was highest in the pubertal stage (0.898 for boys and 0.909 for girls). The mean absolute deviations for the GP and TW3-RUS methods in the pubertal stage were 0.468 years (boys) and 0.496 years (girls). Both the GP and TW3-Carpal methods underestimated BA for boys in the prepubertal stage. Both the GP and TW3-RUS methods overestimated BA for girls in the pubertal and postpubertal stages.

CONCLUSION: The GP and TW3-RUS methods exhibit strong agreement in the pubertal and postpubertal stages for both sexes. With appropriate adjustments based on Taiwanese data, both methods are applicable to our children.

PMID:36652571 | DOI:10.1097/JCMA.0000000000000854

J Chin Med Assoc. 2023 Feb 1;86(2):155-165. doi: 10.1097/JCMA.0000000000000840. Epub 2022 Nov 4.

ABSTRACT

BACKGROUND: It is unclear whether hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy decreases the risk of mortality and cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD).

METHODS: We performed a literature search of PubMed, Cochrane Library, Embase, and other databases for research publications up to June 2022. The outcomes of interest were fatal and nonfatal CVDs, all-cause mortality, and changes in the biochemical profiles. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled and synthesized using a random-effects model. The certainty of the evidence was determined using Grading of Recommendations, Assessment, Development, and Evaluation.

RESULTS: Nine studies, including 2,933 patients undergoing PD, were included. Among them, three studies, including 2,099 patients, reported all-cause mortality, and three, including 1,571 patients, reported CVDs. In these patients, pooling results of two observational studies (very low-certainty evidence) showed that statin therapy significantly reduced CVDs (HR = 0.67; 95% CI = 0.54-0.84; p = 0.0004). Moreover, statin therapy was associated with significantly reduced low-density lipoprotein cholesterol, total cholesterol, and C-reactive protein levels (very low certainty of evidence). However, the effects of statin therapy on triglyceride, high-density lipoprotein, and albumin levels were not statistically significant.

CONCLUSION: Although statin therapy was associated with significantly reduced low-density lipoprotein cholesterol, total cholesterol, and C-reactive protein levels, the probable beneficial effect of statins on CVD risk in patients undergoing PD could not be concluded firmly. Additional high-quality studies are required to assess the potential beneficial effects of statin therapy in PD patients.

PMID:36652565 | DOI:10.1097/JCMA.0000000000000840