Nevin Manimala

J Perinatol. 2022 Dec 31. doi: 10.1038/s41372-022-01588-y. Online ahead of print.

ABSTRACT

OBJECTIVE: The gold standard for diagnosing metabolic bone disease in pediatrics is dual-energy x-ray absorptiometry (DXA). Bone quantitative ultrasound (QUS) has increasing applications. This study compared the relationship of DXA to QUS in preterm infants.

DESIGN: Prospective observational study of preterm infants ≤32 weeks gestation or ≤1800 grams at birth. DXA scans measuring bone mineral content (BMC) and tibial QUS scans measuring bone speed of sound (SOS) were obtained near term gestation.

RESULTS: 41 infants had bone scans at mean corrected gestation 37.7 ± 2.1 weeks. BMC and SOS showed weak inverse correlation (R² 0.163, p < 0.01). BMC and SOS correlated with parameters at corrected gestational age at the time of the bone scans (p < 0.05-0.001). SOS correlated with birth gestational age (p < 0.001), not BMC.

CONCLUSIONS: A statistically significant weak inverse correlation between DXA and QUS was observed. QUS may have advantages over DXA.

PMID:36587053 | DOI:10.1038/s41372-022-01588-y

Am J Crit Care. 2023 Jan 1;32(1):43-50. doi: 10.4037/ajcc2023213.

ABSTRACT

BACKGROUND: Delirium is a severe complication in critical care patients. Accurate prediction could facilitate determination of which patients are at risk. In the past decade, several delirium prediction models have been developed.

OBJECTIVES: To compare the prognostic accuracy of the PRE-DELIRIC, E-PRE-DELIRIC, and Lanzhou models, and to investigate the difference in prognostic accuracy of the PRE-DELIRIC model between patients receiving and patients not receiving mechanical ventilation.

METHODS: This retrospective study involved adult patients admitted to the intensive care unit during a 2-year period. Delirium was assessed by using the Confusion Assessment Method for the Intensive Care Unit or any administered dose of haloperidol or quetiapine. Model discrimination was assessed by calculating the area under the receiver operating characteristic curve (AUC); values were compared using the DeLong test.

RESULTS: The study enrolled 1353 patients. The AUC values were calculated as 0.716 (95% CI, 0.688-0.745), 0.681 (95% CI, 0.650-0.712), and 0.660 (95% CI, 0.629-0.691) for the PRE-DELIRIC, E-PRE-DELIRIC, and Lanzhou models, respectively. The difference in model discrimination was statistically significant for comparison of the PRE-DELIRIC with the E-PRE-DELIRIC (AUC difference, 0.035; P = .02) and Lanzhou models (AUC difference, 0.056; P < .001). In the PRE-DELIRIC model, the AUC was 0.711 (95% CI, 0.680-0.743) for patients receiving mechanical ventilation and 0.664 (95% CI, 0.586-0.742) for those not receiving it (difference, 0.047; P = .27).

CONCLUSION: Statistically significant differences in prognostic accuracy were found between delirium prediction models. The PRE-DELIRIC model was the best-performing model and can be used in patients receiving or not receiving mechanical ventilation.

PMID:36587002 | DOI:10.4037/ajcc2023213

J Chem Phys. 2022 Dec 28;157(24):244106. doi: 10.1063/5.0130945.

ABSTRACT

Quantum mechanics has a deterministic Schrödinger equation for the wave function. The Göttingen-Copenhagen statistical interpretation is based on the Born Rule that interprets the wave function as a “probability amplitude.” A precept of this interpretation is the lack of determinism in quantum mechanics. The Bohm interpretation is that the wave function is a source of a field experienced by the electrons, thereby attributing determinism to quantum theory. In this paper, we present a new perspective on such determinism. The ideas are based on the equations of motion or “Quantal Newtonian” Laws obeyed by each electron. These Laws, derived from the temporal and stationary-state Schrödinger equation, are interpreted in terms of “classical” fields whose sources are quantal expectations of Hermitian operators taken with respect to the wave function. According to the Second Law, each electron experiences an external field-the quantal Coulomb-Lorentz law. It also experiences an internal field representative of properties of the system: correlations due to Coulomb repulsion and Pauli principle; the density; kinetic effects; and an internal magnetic field component. There is a response field. The First Law states that the sum of the external and internal fields experienced by each electron vanishes. These fields are akin to those of classical physics: They pervade all space; their structure is descriptive of the quantum system; the energy of the system is stored in these fields. It is in the classical behavior of these fields, which arise from quantal sources that one may then speak of determinism in quantum mechanics.

PMID:36586987 | DOI:10.1063/5.0130945

J Acoust Soc Am. 2022 Dec;152(6):3323. doi: 10.1121/10.0016442.

ABSTRACT

Sonic boom propagation over urban areas is studied using numerical simulations based on the Euler equations. Two boom waves are examined: a classical N-wave and a low-boom wave. Ten urban geometries, generated from the local climate zone classification [Stewart and Oke (2012), Bull. Am. Meteorol. Soc. 93(12), 1879-1900], are considered representative of urban forms. They are sorted into two classes, according to the aspect ratio of urban canyons. For compact geometries with a large aspect ratio, the noise levels and the peak pressure, especially for the N-wave, are highly variable between canyons. For open geometries with a small aspect ratio, these parameters present the same evolution in each urban canyon, corresponding to that obtained for isolated buildings. A statistical analysis of the noise levels in urban canyons is then performed. For both boom waves, the median of the perceived noise levels mostly differs by less than 1 dB from the value obtained for flat ground. The range of variation is greater for open geometries than for compact ones. Finally, low-frequency oscillations, associated with resonant modes of the canyons, are present for both compact and open geometries. Their amplitude, frequency and decay rate vary greatly from one canyon to another.

PMID:36586837 | DOI:10.1121/10.0016442

Vet Ital. 2022 Dec 30;58(2). doi: 10.12834/VetIt.1866.9913.1.

ABSTRACT

The present study was designed to investigate Mycobacterium avium subsp. paratuberculosis (MAP) in dairy buffalo herds from six different geographical areas in Nineveh, Iraq. A total of 87 individual faecal samples from river buffaloes, representing 12 dairy herds, were investigated for detection of MAP using cultural, Ziehl‑Neelsen and MAP‑specific PCR‑based methods. Overall, MAP was detected at a high frequency at herd‑level (4/12; 33 %) compared to the total individual faecal samples (14/87; 16%) with a cell density ranging from 101 to 103 CFU g‑1. Not statistically significant difference (≥ 0.05) was observed in the frequency of MAP occurrence between clinical (9; 65%) and apparently healthy (5; 35%) cases. This report, which is the first MAP study based on data from Iraqi dairy buffalo herds suggests that MAP transmission is a significant health risk for grazing livestock. In conclusion, this study would help farm owners and regulatory authorities to realise the importance of developingand applying best farm management practices in order to prevent transmission of MAP to healthy animals and the environment. In addition, effective diagnostic tests should be taken into account when carrying out the screening tests.

PMID:36586121 | DOI:10.12834/VetIt.1866.9913.1

J Relig Health. 2022 Dec 31. doi: 10.1007/s10943-022-01729-9. Online ahead of print.

ABSTRACT

The purpose of the article was to analyze the collected empirical material in the form of in-depth interviews, observations, statistical data, and numerous accounts of the assistance of the Catholic Church in Poland in the first 8 months of Russia’s invasion of Ukraine. The results of the survey revealed that the Catholic Church’s activities and support to Ukrainians were carried out on many levels: charitable-mainly material, financial and social housing assistance, psychological, educational, and medical. All Catholic parishes and almost all women’s and men’s convents and monasteries in Poland, Caritas Poland, as well as dozens of church institutions, joined in helping refugees from Ukraine.

PMID:36586089 | DOI:10.1007/s10943-022-01729-9

Inflammopharmacology. 2022 Dec 31. doi: 10.1007/s10787-022-01123-7. Online ahead of print.

ABSTRACT

OBJECTIVE AND DESIGN: Prostatic inflammation is the driving force in benign prostatic hyperplasia (BPH). This work investigated the potential modulatory effect of COX-2 inhibition on ADAM-17/EGFR/ERK1/2 axis.

MATERIALS OR SUBJECTS: Adult male Wistar rats were used.

TREATMENT: Celecoxib (10 and 20 mg/kg; i.p.) was injected i.p. daily for three weeks. Testosterone (TST) (3 mg/kg; s.c.) was used to induce BPH.

METHODS: Prostatic inflammation and hyperplasia were assessed by organ weight and histopathology. Inflammatory mediators were measured using ELISA technique. Protein analysis was performed using western blotting and immunohistochemistry. Gene expression analysis was performed using qRT-PCR. Statistical analyses included one-way ANOVA and Tukey’s multiple comparison test.

RESULTS: Testosterone-treated rats had a marked increase in COX-2, prostate weight, and index. Moreover, TST-induced COX-2 was inferred from cytoskeletal changes and was attributable to the overexpression of PGE2, NF-κB (p65), and IL-6. COX-2-derived PGE2 increased the activity of ADAM-17, TGF-α, and TNF-α. Consequently, EGFR-ERK1/2 pathway was over-activated, disrupting anti-apoptotic Bcl-2, cyclin D1, and pro-apoptotic Bax. Celecoxib reversed these effects.

CONCLUSION: COX-2 stimulates the ERK1/2 pathway via PGE2-ADAM-17-catalyzed shedding of TGF-α in testosterone-induced BPH. The results indicate a functional correlation between inflammation and hyperplasia in BPH.

PMID:36586043 | DOI:10.1007/s10787-022-01123-7

Eur Phys J E Soft Matter. 2022 Dec 31;45(12):102. doi: 10.1140/epje/s10189-022-00258-3.

ABSTRACT

The problem of classifying turbulent environments from partial observation is key for some theoretical and applied fields, from engineering to earth observation and astrophysics, e.g., to precondition searching of optimal control policies in different turbulent backgrounds, to predict the probability of rare events and/or to infer physical parameters labeling different turbulent setups. To achieve such goal one can use different tools depending on the system’s knowledge and on the quality and quantity of the accessible data. In this context, we assume to work in a model-free setup completely blind to all dynamical laws, but with a large quantity of (good quality) data for training. As a prototype of complex flows with different attractors, and different multi-scale statistical properties we selected 10 turbulent ‘ensembles’ by changing the rotation frequency of the frame of reference of the 3d domain and we suppose to have access to a set of partial observations limited to the instantaneous kinetic energy distribution in a 2d plane, as it is often the case in geophysics and astrophysics. We compare results obtained by a machine learning (ML) approach consisting of a state-of-the-art deep convolutional neural network (DCNN) against Bayesian inference which exploits the information on velocity and entropy moments. First, we discuss the supremacy of the ML approach, presenting also results at changing the number of training data and of the hyper-parameters. Second, we present an ablation study on the input data aimed to perform a ranking on the importance of the flow features used by the DCNN, helping to identify the main physical contents used by the classifier. Finally, we discuss the main limitations of such data-driven methods and potential interesting applications.

PMID:36586035 | DOI:10.1140/epje/s10189-022-00258-3

Ann Nucl Med. 2022 Dec 31. doi: 10.1007/s12149-022-01815-8. Online ahead of print.

ABSTRACT

OBJECTIVE: To evaluate the efficiency of a novel lymph node radiotracer ^99mTc-rituximab in sentinel lymph node (SLN) lymphoscintigraphy and SLN biopsy (SLNB), and the influence of SLNB results on the prognosis of cutaneous malignant melanoma (CMM) patients.

METHODS: A retrospective study was performed on 533 patients with CMM who underwent lymphoscintigraphy and SLNB. All patients received a preoperative peritumoral injection of 11.1-18.5 MBq of ^99mTc-rituximab 0.5 to 1 h before lymphoscintigraphy and SLNB.

RESULTS: The detection rate of lymphoscintigraphy and SLNB was both 99.81% (532/533), and the average number of detected SLNs was 2.1 (range 1 to 8) and 2.7 (range 1 to 11) per patient, respectively. 12.1% SLNs and 22.2% patients were found metastatic, with an average of 1.5 (range 1 to 5) metastatic SLNs per patient. The SLN metastatic rates were different in patients with different Breslow thickness, Clark levels, ulceration, mitotic counts, and HMB45 expression (p < 0.05). Ninety patients were proceeded with the regional lymph node dissection (RLND) after SLNB, and the sensitivity, specificity and accuracy of SLNB in metastatic diagnosis is 97.4, 100 and 96.7%, respectively. And SLNs with metastases was an independent prognostic factor for OS and PFS by multivariate prognostic analyses (HR was 5.9 and 4.3, p < 0.001). For patients with metastatic SLNs, the non-SLNs with metastasis and non-SLNs without metastasis in RLND, and observation groups showed different mean PFS as 14.9, 24.8 and 25.5 months (p = 0.018), but no statistically significant difference existed in the OS.

CONCLUSION: The novel radiotracer ^99mTc-rituximab could identify SLNs specifically in SLN lymphoscintigraphy and SLNB in CMM patients, and the pathology obtained from SLNB rather than from RLND better indicated the staging and long-term prognosis.

PMID:36586034 | DOI:10.1007/s12149-022-01815-8

Environ Sci Pollut Res Int. 2022 Dec 31. doi: 10.1007/s11356-022-24958-7. Online ahead of print.

ABSTRACT

Telomere length (TL) is considered a marker of biological aging and lifetime health, and some epidemiological studies report that the environmental exposures may influence TL at birth. We aimed to investigate the associations between prenatal rare earth elements (REE) exposure and newborn TL. A total of 587 mother-newborn pairs were recruited during 2013 to 2015 in Wuhan, China. Maternal urinary concentrations of REE collected during three trimesters were measured by inductively coupled plasma mass spectrometry. Quantitative real-time polymerase chain reaction was used to measure relative cord blood TL. The trimester-specific associations between prenatal REE exposure and cord blood TL were evaluated using multiple informant models. Weighted quantile sum regression was used to estimate the mixture effect of urinary REE on cord blood TL. After adjustment for potential confounders, per doubling of urinary REE (Dy, Yb, Pr, Nd, and Tm) concentrations (μg/g creatinine) during the second trimester was respectively associated with 1.94% (95% CI 0.19%, 3.72%), 2.10% (95% CI 0.31%, 3.92%), 2.11% (95% CI 0.35%, 3.89%), 2.08% (95% CI 0.01%, 4.20%), and 1.38% (95% CI 0.09%, 2.70%) increase in cord blood TL. Furthermore, exposure to the mixture of REE during the second trimester was also significantly associated with increased cord blood TL (percent change 1.20%, 95% CI 0.30%, 2.11%). However, these associations were not statistically significant in the first and third trimesters. This study provides new evidence on the potential effect of prenatal REE exposure on the initial (newborn) setting of offspring’s telomere biology. Further epidemiological studies are warranted to confirm our findings.

PMID:36586020 | DOI:10.1007/s11356-022-24958-7