Nevin Manimala

J Patient Rep Outcomes. 2022 Sep 23;6(1):100. doi: 10.1186/s41687-022-00508-0.

ABSTRACT

BACKGROUND: The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale has demonstrated good internal consistency and responsiveness to changes in clinical status among patients with ankylosing spondylitis (AS). We aimed to further evaluate the psychometric properties of the FACIT-F scale in adult patients with AS.

METHODS: Measurement properties of the FACIT-F scale were evaluated using data from tofacitinib phase 2/3 (NCT01786668/NCT03502616) studies in adult patients with active AS.

RESULTS: Second-order confirmatory factor modeling supported the measurement structure of the FACIT-F scale (Bentler’s comparative fit index ≥ 0.91), and FACIT-F demonstrated excellent internal consistency (Cronbach’s coefficient α ≥ 0.88) and test-retest reliability (Intraclass Correlation Coefficient ≥ 0.75). Correlation coefficients between FACIT-F and other patient-reported outcomes generally exceeded 0.40, supporting convergent validity. Meaningful within-patient change was estimated as 3.1-6.3 for FACIT-F total score, and 1.4-2.8 and 1.7-3.6 for FACIT-F Experience and Impact domain scores, respectively. Large (effect size ≥ 1.17 standard deviation units), statistically significant differences in FACIT-F domain/total scores between ‘no disease activity’ (Patient Global Assessment of Disease Activity [PtGA] = 0) and ‘very active disease’ (PtGA = 10) patient groups supported known-groups validity. Ability to detect change was evidenced by an approximately linear relationship between changes in FACIT-F and PtGA scores.

CONCLUSIONS: FACIT-F is a reliable and valid measure for evaluating fatigue in adult patients with active AS.

TRIAL REGISTRATION: ClinicalTrials.gov; NCT01786668 (registered 6 February 2013, https://clinicaltrials.gov/ct2/show/NCT01786668 ) and NCT03502616 (registered 11 April 2018, https://clinicaltrials.gov/ct2/show/NCT03502616 ).

PMID:36138330 | DOI:10.1186/s41687-022-00508-0

Vet Med Sci. 2022 Sep 22. doi: 10.1002/vms3.945. Online ahead of print.

ABSTRACT

To investigate the potential intraocular pressure (IOP)-lowering effects of nitric oxide (NO)-donating compounds in healthy canine eyes METHODS: A total of 79 dogs were divided into 3 groups in a masked, controlled and randomised study. Group N (n = 26) was administered 0.03% nitroglycerin in one eye and vehicle-control in the other, Group H (n = 26) was administered 0.1% hydralazine in one eye and vehicle-control in the other, while Group C (n = 27) received vehicle-control in both eyes (control group). Following eye drop administration, IOP was measured in both eyes at selected times (10-250 min), along with monitoring of heart rate and signs of ocular discomfort. Data was analysed with repeated measures mixed model and one-way ANOVA RESULTS: IOP was significantly reduced over the 4-h period with 0.03% nitroglycerin (p < 0.0001) but not 0.1% hydralazine (p = 0.520) when compared to contralateral vehicle-controlled eyes. IOP was reduced by up to 12% with 0.03% nitroglycerin from 10 to 70 min post-treatment; however, differences in IOP at individual time points were not statistically significant for either drug (p ≥ 0.133) as compared to contralateral vehicle-control eyes. No treatment group significantly affected heart rate (compared to Group C), and both treatment groups appeared well tolerated CONCLUSIONS: Both compounds were well-tolerated in healthy dogs. Nitroglycerin mildly reduced IOP in canine eyes, and further investigations are warranted in healthy and diseased states (e.g. glaucoma, ocular hypertension).

PMID:36137290 | DOI:10.1002/vms3.945

PLoS One. 2022 Sep 22;17(9):e0274694. doi: 10.1371/journal.pone.0274694. eCollection 2022.

ABSTRACT

The two studies presented in this paper concern the Italian epistemic marker mi sa [lit. to me it knows], which seems to have no equivalent in other European languages and has received very little attention in the literature. No analysis of the occurrences of mi sa in contemporary spoken corpora can be found (first gap) as well as no investigation on the epistemic relationship between mi sa and (1) the other modal expressions that use the verb sapere [to know] in the first person singular of the simple present, i.e., so [I know], non so [I do not know], non so se [I do not know whether] as well as (2) its supposed synonyms credo [I believe] and penso [I think] (second gap). The two studies are closely intertwined, the first being an exploratory, qualitative pilot study for the second. Study 1 aims to fill the first gap through the analysis of the contemporary Italian spoken corpus KIParla. The quantitative and qualitative analyses revealed five types of occurrences (theoretically reducible to two main ones), the most numerous of which are ‘mi sa che + proposition’. Study 2 aims to fill the second gap through a questionnaire administered online. The quantitative and statistical results showed the epistemic relationships between the six markers: for the majority of the participants, in the epistemic continuum that goes from unknowledge to uncertainty and then to knowledge, (1) non so refers to unknowledge; non so se, mi sa, credo and penso refer to uncertainty; so refers to knowledge; (2) mi sa, credo, penso confirm to be synonyms; (3) non so se is evaluated as much more uncertain than mi sa, credo, penso. These four epistemic markers seem to occupy a different position along the uncertainty continuum ranging between two poles: doubt (high uncertainty) and belief (low uncertainty).

PMID:36137275 | DOI:10.1371/journal.pone.0274694

J Homosex. 2022 Sep 22:1-24. doi: 10.1080/00918369.2022.2122361. Online ahead of print.

ABSTRACT

This study aims to analyze cultural competence through the knowledge and attitudes regarding LGBT people held by the students of social work at two universities in southern Spain (N = 512). An ex post facto correlational study has been conducted. The Sex Education and Knowledge about Homosexuality Questionnaire, the Modern Homonegativity Scale and the Negative Attitudes toward Transgender People Scale have been applied to gather information. Data analysis was carried out using frequencies, descriptive statistics, correlations and inferential statistics. The findings show that men, religious, and politically conservative people reported higher levels of homonegative and transphobic attitudes than women, non-religious and politically more liberal people. There is also a lack of specific knowledge on the reality of and specific legislation regarding LGBT people. There is a need to continue to examine and to progress in the training of future social workers in cultural competence, incorporating the contributions of feminist theory.

PMID:36137263 | DOI:10.1080/00918369.2022.2122361

Mol Biol Cell. 2022 Oct 1;33(12):pe6. doi: 10.1091/mbc.E22-04-0140.

ABSTRACT

Although the process of publishing a scientific paper has gotten simpler, it is increasingly difficult to publish a paper in high profile journals. We have analyzed the publishing data in the cell biology field and found several alarming trends developing over the last two decades. There is an emerging divide between scientist-run journals and professional-run high profile journals. How did this happen? What should we do? The core issue is whether the current standard for high profile journals hurts rather than helps the scientific discovery process. In this regard, we suggest that the editors and scientists should direct their focus on the potential impact and rigor of the work instead of the “perfection” or “completeness” of the study.

PMID:36137240 | DOI:10.1091/mbc.E22-04-0140

Int J Clin Exp Hypn. 2022 Sep 22:1-9. doi: 10.1080/00207144.2022.2124377. Online ahead of print.

ABSTRACT

This article presents French norms for the online version of the Sussex-Waterloo Scale of Hypnotizability. This scale is an online adaptation of the well-established Waterloo-Stanford Group C Scale of Hypnotic Susceptibility: with both behavioral and subjective scores. Insofar as hypnotizability (the ability to respond to suggestions in a hypnotic context) varies substantially in the general population and remains generally stable throughout life, it is important to measure it in experiments using hypnotic suggestion. However, these scales are time consuming, as they often require multiple sessions to achieve a suitable sample size for subsequent participant screening. One promising route for overcoming this inconvenience is to perform hypnotizability assessment online. The Sussex-Waterloo Scale of Hypnotizability is the first to have demonstrated the viability of online measurement. The authors demonstrate that their translation of this scale yields similar statistics.

PMID:36137222 | DOI:10.1080/00207144.2022.2124377

J Phys Chem A. 2022 Sep 22. doi: 10.1021/acs.jpca.2c04038. Online ahead of print.

ABSTRACT

The prediction of comonomer incorporation statistics in polyolefin catalysis necessitates an accurate calculation of free energies corresponding to monomer binding and insertion, often requiring sub-kcal/mol resolution to resolve experimental free energies. Batch reactor experiments are used to probe incorporation statistics of ethene and larger α-olefins for three constrained geometry complexes which are employed as model systems. Herein, over 6 ns of quantum mechanics/molecular mechanics (QM/MM) molecular dynamics is performed in combination with the zero-temperature string method to characterize the solution-phase insertion barrier and to analyze the contributions from conformational and vibrational anharmonicity arising both in vacuum and in solution. Conformational sampling in the solution-phase results in 0-2 kcal/mol corrections to the insertion barrier which are on the same scale necessary to resolve experimental free energies. Anharmonic contributions from conformational sampling in the solution phase are crucial energy contributions missing from static density functional theory calculations and implicit solvation models, and the accurate calculation of these contributions is a key step toward the quantitative prediction of comonomer incorporation statistics.

PMID:36137217 | DOI:10.1021/acs.jpca.2c04038

Scand J Pain. 2022 Sep 26. doi: 10.1515/sjpain-2022-0030. Online ahead of print.

ABSTRACT

OBJECTIVES: We aimed to investigate whether coexistent self-reported neck pain influences cephalic and extracephalic pain sensitivity in individuals with migraine and tension-type headache (TTH) in relation to diagnosis and headache frequency.

METHODS: A population of 496 individuals completed a headache interview based on ICHD criteria, providing data collected by self-administered questionnaires, assessments of pericranial total tenderness score (TTS) and pressure pain thresholds (PPT). Stimulus-response (SR) functions for pressure vs. pain were recorded. Presence of neck pain in the past year was assessed by the self-administered questionnaire. We categorized participants by primary headache type. We also categorized participants into 3 groups by headache frequency: chronic (≥15) or episodic (<15 headache days/month) headache and controls. TTS, PPTs and the area under the SR curve were compared between subgroups using Generalized Linear Models with pairwise comparisons controlling for age and sex.

RESULTS: Individuals with chronic followed by episodic headache had higher TTS than controls (overall p≤0.001). The difference between chronic and episodic headache subgroups was significant in the group with neck pain (p≤0.001) but not in the group without neck pain. In individuals with neck pain, mean TTS was higher in coexistent headache (migraine and TTH), 23.2 ± 10.7, and pure TTH, 17.8 ± 10.3, compared to pure migraine, 15.9 ± 10.9 and no headache 11.0 ± 8.3 (overall p<0.001). Temporal and finger PPTs did not statistically differ among the chronic headache, the episodic headache and controls in individuals with and without neck pain. Temporalis and trapezius SR-functions showed that tenderness was increased in individuals with chronic headache to higher degree than in those with episodic headache, and more so in those with neck pain.

CONCLUSIONS: Coexistent neck pain is associated with greater pericranial tenderness in individuals with chronic headache and to a lesser degree in those with episodic headache. Sensitization may be a substrate or consequence of neck pain and primary headache, but a longitudinal study would be needed for further clarification.

PMID:36137215 | DOI:10.1515/sjpain-2022-0030

PLoS One. 2022 Sep 22;17(9):e0274964. doi: 10.1371/journal.pone.0274964. eCollection 2022.

ABSTRACT

The aim of the present study was to explore the impact of TARGET-based teaching strategies on students’ motivation in a Dutch secondary school PE context. We examined to what extent mastery climate teaching strategies perceived by students (independently or interactively) explain variability in students’ motivation towards PE. In total 3,150 students (48.2% girls; 51.8% boys) with a mean age of 13.91 years (SD = 1.40) completed the Behavioural Regulations in Physical Education Questionnaire (BRPEQ), measuring students’ autonomous motivation, controlled motivation and amotivation, and the Mastery Teaching Perception Questionnaire (MTP-Q), measuring student-perceived application of mastery TARGET teaching strategies. Hierarchical regression analyses indicated that after controlling for gender, age, and educational type, the predictive effects of the perceived mastery climate teaching strategies differed by motivational outcome. Overall, students who reported higher levels of perceived application of mastery TARGET teaching strategies showed more autonomous motivation and less amotivation. Specifically, the teaching strategies within the task structure were the strongest predictors for students’ autonomous motivation and amotivation. No meaningful statistically significant two-way interaction effects between any of the TARGET variables were found, supporting the proposition of an additive relationship between the TARGET teaching strategies.

PMID:36137168 | DOI:10.1371/journal.pone.0274964

PLoS One. 2022 Sep 22;17(9):e0274104. doi: 10.1371/journal.pone.0274104. eCollection 2022.

ABSTRACT

OBJECTIVES: This study aimed to assess the clinical characteristics, treatment and outcomes of the multisystem inflammatory syndrome in children (MIS-C) following COVID-19 in five different geographical regions of Iran.

METHODS: In this multicenter observational study, patients <21 years were included between March 2020 and October 2021. By Disease Control and Prevention (CDC) checklist, demographic characteristics, comorbidities, clinical signs and symptoms, laboratory and radiology findings, and treatment were collected. Statistical analysis was using Chi-square and t-test in STATA14.

RESULTS: In total 225 patients with median age of 55 (26-96) months were included that 59.56% boys. 57.33% were admitted to the PICU with a median of 7 days (4-10). 95.56% of patients were discharged with recovery and the rest died. All of the patients in our study were included based on the MIS-C criteria. However, some patients had Kawasaki symptoms, so we compared the clinical and epidemiological characteristics of the two groups. Conjunctival injection, cervical lymphadenopathy>1.5 cm diameter, and strawberry tongue in Kawasaki-like MIS-C patients were higher than of MIS-C patients, and this difference was significant(p<0.001). The most common comorbidity was obesity (24.86%). Most patients tested for COVID-19 and about 60% of the patients had a positive test by serology or reverse transcription-polymerase chain reaction (RT-PCR). Gastrointestinal (88.89%) and hematologic signs (84.44%) were most common. Most drugs used in patients were IVIG and steroids. 88.07% and 61.29% of the patients had at least one problem in echocardiography and lung CT, respectively.

CONCLUSIONS: The best outcome was seen in patients who were treated with both IVIG and steroids on the first days of admission. Myocarditis was common in two groups of patients. According to most patients had echocardiography abnormal, screening of heart function is recommended for patients.

PMID:36137147 | DOI:10.1371/journal.pone.0274104