Nevin Manimala

Gac Med Mex. 2022;158(6):343-348. doi: 10.24875/GMM.M22000711.

ABSTRACT

INTRODUCTION: In older adults, the association of frailty and sarcopenia with vitamin D deficiency is well known, but the association of the components of frailty syndrome has been poorly studied.

OBJECTIVE: To determine the association of the components of frailty and sarcopenia with vitamin D insufficiency in older adults.

METHODS: Adults were studied, in whom age, education, marital status, history of fractures, hospitalizations, anthropometric indicators, sarcopenia, Charlson index, polypharmacy, Fried’s frailty phenotype, and plasma vitamin D were recorded; figures < 30 ng/mL were considered indicative of vitamin D insufficiency. Descriptive and inferential statistics were used for statistical analysis. The association was determined by binary logistic regression.

RESULTS: One-hundred and seventy-five adults with a mean age of 71.7 ± 6.7 years (95% CI = 60-90 years) were studied. Binary logistic regression showed that the variables associated with vitamin D deficiency were exhaustion (OR = 2.6, 95% CI = 1.0-6.5, p = 0.03), frailty (OR = 9.2, 95% CI = 2.5-34.1, p = 0.001) and pre-frailty (OR = 4.6, 95% CI = 2.1-10.0, p < 0.001).

CONCLUSION: The frail and pre-frail phenotypes, as well as exhaustion, are associated with vitamin D insufficiency.

PMID:36657111 | DOI:10.24875/GMM.M22000711

Health Care Women Int. 2023 Jan 19:1-19. doi: 10.1080/07399332.2022.2164582. Online ahead of print.

ABSTRACT

In this study, we aimed to determine the effects of the PRECEDE-PROCEED model-based educational program on women’s genital hygiene behaviors. A randomized controlled trial was conducted with 120 women diagnosed with genital infections and assigned to the experimental (n = 60) and control (n = 60) groups. Educational intervention was designed based on the PRECEDE-PROCEED model and implemented in the experimental group. Data were collected three times before (pretest), right after (posttest) and 1 month after the intervention using the personal information form, Data Form for Knowledge, Attitudes, and Beliefs about Genital Hygiene and Genital Hygiene Behaviors Inventory (GHBI). After the educational intervention, the participants’ hygiene-related knowledge, attitudes and behaviors improved in the experimental group at the posttest and follow-up test from the baseline. A statistically significant difference was found between the groups. We concluded that PRECEDE-PROCEED model-based educational program positively affected the women’s genital hygiene-related knowledge, attitudes, and behaviors.

PMID:36657105 | DOI:10.1080/07399332.2022.2164582

JCO Oncol Pract. 2023 Jan 19:OP2200551. doi: 10.1200/OP.22.00551. Online ahead of print.

ABSTRACT

PURPOSE: The Accelerated Diagnostic Assessment Program (ADAP) manages patients with imaging abnormalities, with or without concomitant symptoms, where cancer is suspected. The ADAP is offered to primary care practitioners and emergency departments with cases triaged by a medical oncologist.

METHODS: We performed a retrospective patient chart review of electronic medical records from January 2019 until June 2021 to validate the program. We collected information on the referral pathways, patient demographics, wait-times, and diagnostic results. The control group consisted of outpatients who were referred for biopsy over a 1-year period outside the ADAP stream. Statistical analyses were performed using IBM SPSS software.

RESULTS: Of the 97 patients included, 54% were female, with ages ranging from 18 to 96 years. Twenty-nine percent (n = 20) of the malignant cases were incidental findings. Most patients referred to the ADAP were diagnosed with a malignancy (71%; n = 69), comprising hematologic (45%; n = 31), GI (26%; n = 18), or other cancers (29%; n = 20). The ADAP had decreased wait-times from referral to biopsy collection (17.6 days ± 10.7 [standard deviation (SD)]; n = 43) when compared with the control group (41.2 days ± 40.0 [SD]; n = 67; P < .001). ADAP patients with malignancies saw a treating specialist 7.6 ± 7.6 days [SD] after their follow-up appointment at the ADAP.

CONCLUSION: The ADAP accelerated time to biopsy in a statistically significant manner when compared with age-, referring physician-, and biopsy site-matched controls. It also outperformed national and provincial standards, suggesting that its model addresses a gap in care by providing an underserved population timely access to diagnosis and treatment.

PMID:36657095 | DOI:10.1200/OP.22.00551

Rom J Intern Med. 2023 Jan 19. doi: 10.2478/rjim-2023-0002. Online ahead of print.

ABSTRACT

Introduction: Coronavirus disease-2019 (COVID-19) is still a global health problem nowadays. A particular COVID-19 patients develop severe symptoms. Some biomarkers can be used to determine disease severity and improve outcome. Homocysteine is one of the novel biomarkers. The objective of this study is to determine the role of serum homocysteine level in stratifying severity of COVID-19. Methods: A cross-sectional study was conducted in Medan, Indonesia from May to December 2021. Subjects were obtained using consecutive sampling method. Inclusion criteria was COVID-19 patients aged 18 years or older and willing to participate in the study. Patients with malignancy, chronic kidney disease, thyroid disease, coronary heart disease, and who consume several medications including cholestyramine, metformin, methotrexate, fibrate, and contraceptive pill, were excluded. Data regarding demographic, laboratory, and biomarker were gathered from each subject. Statistical analyses were conducted at 95% confidence interval. Results: A total of 100 patients were enrolled. Most subjects were males (59%) and from Batak ethnicity (64%). Twenty percent subjects had severe COVID-19. The levels of serum high-sensitivity C-reactive protein (hs-CRP), D dimer, homocysteine, and procalcitonin were significantly higher in severe COVID-19 subjects. D dimer had the highest sensitivity (91.7%) and specificity (94.7%) in stratifying severe COVID-19, followed by hs-CRP (91.7% and 85.5%, respectively), homocysteine (87.5% and 78.9%, respectively), and procalcitonin (58.3% and 74.0%, respectively). Conclusion: Homocysteine can be used as a biomarker to determine COVID-19 severity.

PMID:36657014 | DOI:10.2478/rjim-2023-0002

Int J Nurs Educ Scholarsh. 2023 Jan 20;20(1). doi: 10.1515/ijnes-2022-0016. eCollection 2023 Jan 1.

ABSTRACT

OBJECTIVES: Evaluate effectiveness of a multisite program promoting the successful transition of baccalaureate and graduate entry (with a prior degree) students into pre-licensure curricula. Faculty concern around nursing students’ successful completion of nursing programs and passage of the nursing licensure exam stems from challenges students encounter in core courses, study habits, and civility.

METHODS: One hundred eighty-five students participated in a quasi-experimental pre-post-test mixed-methods study. Students completed content modules and open-ended surveys.

RESULTS: Most students found the program helpful. Statistically significant improvements were shown in medication calculation, reading comprehension, and medical terminology. No statistically significant improvement was shown in anatomy and physiology.

CONCLUSIONS: Our Transition to Nursing program shows promise and adds to proactive strategies in preparing students for a successful transition into nursing programs. Our innovative approach may serve as a model to nursing schools and colleges around the world to promote student success.

PMID:36656999 | DOI:10.1515/ijnes-2022-0016

Clin Chem Lab Med. 2023 Jan 19. doi: 10.1515/cclm-2022-1256. Online ahead of print.

ABSTRACT

This tutorial shows how to perform a meta-analysis of diagnostic test accuracy studies (DTA) based on a 2 × 2 table available for each included primary study. First, univariate methods for meta-analysis of sensitivity and specificity are presented. Then the use of univariate logistic regression models with and without random effects for e.g. sensitivity is described. Diagnostic odds ratios (DOR) are then introduced to combine sensitivity and specificity into one single measure and to assess publication bias. Finally, bivariate random effects models using the exact binomial likelihood to describe within-study variability and a normal distribution to describe between-study variability are presented as the method of choice. Based on this model summary receiver operating characteristic (sROC) curves are constructed using a regression model logit-true positive rate (TPR) over logit-false positive rate (FPR). Also it is demonstrated how to perform the necessary calculations with the freely available software R. As an example a meta-analysis of DTA studies using Procalcitonin as a diagnostic marker for sepsis is presented.

PMID:36656998 | DOI:10.1515/cclm-2022-1256

Science. 2023 Jan 20;379(6629):228-233. doi: 10.1126/science.adg6746. Epub 2023 Jan 19.

ABSTRACT

Richard Gill is fighting the shoddy statistics that put nurses in prison for serial murder.

PMID:36656931 | DOI:10.1126/science.adg6746

Science. 2023 Jan 20;379(6629):232. doi: 10.1126/science.adg6747. Epub 2023 Jan 19.

NO ABSTRACT

PMID:36656930 | DOI:10.1126/science.adg6747

Science. 2023 Jan 20;379(6629):278-283. doi: 10.1126/science.ade7651. Epub 2023 Jan 19.

ABSTRACT

Synthesizing many-body quantum systems with various ranges of interactions facilitates the study of quantum chaotic dynamics. Such extended interaction range can be enabled by using nonlocal degrees of freedom such as photonic modes in an otherwise locally connected structure. Here, we present a superconducting quantum simulator in which qubits are connected through an extensible photonic-bandgap metamaterial, thus realizing a one-dimensional Bose-Hubbard model with tunable hopping range and on-site interaction. Using individual site control and readout, we characterize the statistics of measurement outcomes from many-body quench dynamics, which enables in situ Hamiltonian learning. Further, the outcome statistics reveal the effect of increased hopping range, showing the predicted crossover from integrability to ergodicity. Our work enables the study of emergent randomness from chaotic many-body evolution and, more broadly, expands the accessible Hamiltonians for quantum simulation using superconducting circuits.

PMID:36656924 | DOI:10.1126/science.ade7651

PLoS Genet. 2023 Jan 19;19(1):e1010054. doi: 10.1371/journal.pgen.1010054. Online ahead of print.

ABSTRACT

We introduce a fast, new algorithm for inferring from allele count data the FST parameters describing genetic distances among a set of populations and/or unrelated diploid individuals, and a tree with branch lengths corresponding to FST values. The tree can reflect historical processes of splitting and divergence, but seeks to represent the actual genetic variance as accurately as possible with a tree structure. We generalise two major approaches to defining FST, via correlations and mismatch probabilities of sampled allele pairs, which measure shared and non-shared components of genetic variance. A diploid individual can be treated as a population of two gametes, which allows inference of coancestry coefficients for individuals as well as for populations, or a combination of the two. A simulation study illustrates that our fast method-of-moments estimation of FST values, simultaneously for multiple populations/individuals, gains statistical efficiency over pairwise approaches when the population structure is close to tree-like. We apply our approach to genome-wide genotypes from the 26 worldwide human populations of the 1000 Genomes Project. We first analyse at the population level, then a subset of individuals and in a final analysis we pool individuals from the more homogeneous populations. This flexible analysis approach gives advantages over traditional approaches to population structure/coancestry, including visual and quantitative assessments of long-standing questions about the relative magnitudes of within- and between-population genetic differences.

PMID:36656906 | DOI:10.1371/journal.pgen.1010054