Nevin Manimala

Addict Behav. 2021 Nov 26;126:107193. doi: 10.1016/j.addbeh.2021.107193. Online ahead of print.

ABSTRACT

Two systematic reviews have been conducted to summarize the literature on Internet Gaming Disorder (IGD) and personality. However, the data was not synthesized statistically, imposing a limit to their conclusions. The current study aimed to extend on the two reviews by conducting a series of five meta-analyses, one for each of the Big Five personality factors, to examine their relationships with IGD. A comprehensive search was conducted on the databases PsycArticles, PsycInfo, and Web of Science from inception to 29 July 2021. The data was analyzed using Meta-Essentials and the random effects model was used to obtain the pooled estimate of the effect size. A total of 12 articles were included (n = 145 to 3389). IGD was not significantly correlated with openness to experience (r = -0.05). However, IGD was negatively correlated with conscientiousness (r = -0.29), extraversion (r = -0.15), and agreeableness (r = -0.17), and positively correlated with neuroticism (r = 0.20). Age moderated the relationships between IGD and openness to experience and conscientiousness. The results were broadly consistent with the DSM-5 IGD criteria and the Big Five personality framework. Future research directions might include examining age as moderator variables, and using appropriate instruments based on the DSM-5 IGD criteria.

PMID:34844064 | DOI:10.1016/j.addbeh.2021.107193

J Surg Res. 2021 Nov 26;271:67-72. doi: 10.1016/j.jss.2021.10.004. Online ahead of print.

ABSTRACT

PURPOSE: Surgical management of pediatric ovarian torsion includes total oophorectomy (TO) or ovarian preservation surgery (OPS). This study sought to identify factors contributing to surgical management and readmission outcomes for ovarian torsion.

METHODS: The Nationwide Readmission Database from 2010-2014 was used to identify patients < 18 years admitted with ovarian torsion. Patient factors, hospital characteristics, and readmission outcomes were compared by TO and OPS. Standard statistical analysis was performed and results were weighted for national estimates.

RESULTS: There were 6028 patients (age 13 ± 4 years) identified with ovarian torsion who underwent either TO (50%) or OPS (50%). Patients had secondary pathology of ovarian cyst (41%), benign mass (19%), and malignant mass (0.4%). OPS was more common in teaching hospitals (84% vs. 74% TO, P<0.001), patients < 13 years of age (41% vs. 37% TO, P = 0.001), and those from high-income households (51% vs. 41% TO, P<0.001). The overall readmission rate was 4%, with no difference between surgical approach (4.3% OPS vs. 4.4% TO, P = 0.882). Of those readmitted (n = 265), readmission diagnoses were cyst (10%), malignant mass (9%), benign mass (7%), and torsion (5%). The overall rate of recurrent torsion was 0.2%, with no difference between OPS and TO (< 0.3% vs. < 0.2%, P = 0.282).

CONCLUSION: Half of pediatric patients are undergoing TO for ovarian torsion in the U.S. and disparities exist with the utilization of OPS. There is no difference in rate of readmission or recurrent torsion between surgical approaches, and the overall rate of retorsion is lower than previously reported.

PMID:34844056 | DOI:10.1016/j.jss.2021.10.004

Thromb Res. 2021 Nov 25;209:16-22. doi: 10.1016/j.thromres.2021.11.015. Online ahead of print.

ABSTRACT

BACKGROUND: This study aims to validate the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria in Chinese patients with atrial fibrillation (AF) and acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) who received both oral anticoagulants (OAC) and antiplatelet therapy (APT).

METHODS: 930 consecutive patients with AF and ACS or undergoing PCI receiving both OAC and APT were recruited and followed up for 1 year. The primary endpoint was BARC type 3 or 5 bleeding. The secondary endpoints included BARC type 2, 3, or 5 bleeding, TIMI major bleeding, TIMI major or minor bleeding, and major adverse cardiovascular events (a composite of all-cause death, stroke, non-central nervous system embolism, myocardial infarction, definite or probable stent thrombosis, and target vessel revascularization). Cox regressions were performed to evaluate the association between the ARC-HBR score and outcomes. Discrimination was evaluated through analysis of the receiver operating characteristic (ROC) curves, net reclassification improvement (NRI), and integrated discrimination improvement (IDI).

RESULTS: Compared to patients with no HBR other than OAC, patients with HBR besides OAC tended to have more comorbidities and worse outcomes. The ARC-HBR score was significantly associated with the primary and secondary endpoints, both as a continuous variable and as a categorical variable. The ARC-HBR score performed better than the HAS-BLED score (c-statistic: 0.692 vs. 0.575, NRI = 0.313, IDI = 0.061) and the PRECISE-DAPT score (c-statistic: 0.692 vs. 0.616, NRI = 0.393, IDI = 0.049).

CONCLUSIONS: In patients with AF and ACS or undergoing PCI receiving both OAC and APT, the ARC-HBR score was a significant predictor of 1-year bleeding and ischemic endpoints. The ARC-HBR score performed better than the HAS-BLED score and the PRECISE-DAPT score in BARC type 3 or 5 bleeding prediction.

PMID:34844044 | DOI:10.1016/j.thromres.2021.11.015

Oral Oncol. 2021 Nov 26;124:105634. doi: 10.1016/j.oraloncology.2021.105634. Online ahead of print.

ABSTRACT

BACKGROUND: Taxane-based checkpoint inhibitor combination therapy might improve the outcome in recurrent/metastatic (R/M) head and neck cancer (HNSCC) patients. Thus, we investigated the efficacy and safety of docetaxel (DTX) plus pembrolizumab (P) in a prospective phase I/II trial.

METHODS: Platinum-resistant R/M HNSCC patients received DTX 75 mg/m^² plus P 200 mg for up to six cycles followed by P maintenance therapy. The primary endpoint was overall response rate (ORR) and safety. Secondary endpoints comprised disease control rate (DCR), overall survival (OS) and progression free survival (PFS).

RESULTS: Twenty-two patients were enrolled. Nine patients (40.9%) had a primary tumor in the oropharynx, 8 (36.4%) in the oral cavity, 3 (13.6%) in the hypopharynx and 2 (9.1%) in the larynx. The ORR was 22.7% (95% CI 10.1%-43.4%) and one (4.5%) complete response was achieved. The DCR was 54.6% (95% 34.7%-73.1%). The median PFS was 5.8 months (95% CI 2.7-11.6) and the median OS 21.3 months (95% CI 6.3-31.1). The 1-year PFS and OS rates were 27.3% and 68.2%, respectively. While the most frequent adverse event (AE) was myelosuppression, which was reported in all 22 patients, 3 (13.6%) patients experienced grade 3 febrile neutropenia. The most common immune-related AEs were grade skin rash (40.9%) and hypothyroidism (40.9%). One patient (4.5%) experienced grade 5 immune thrombocytopenia.

CONCLUSION: DXT in combination with P shows promising activity accompanied with a manageable side effect profile in pre-treated R/M HNSCC patients.

PMID:34844042 | DOI:10.1016/j.oraloncology.2021.105634

J Gynecol Obstet Hum Reprod. 2021 Nov 26:102274. doi: 10.1016/j.jogoh.2021.102274. Online ahead of print.

ABSTRACT

INTRODUCTION: Previous international studies showed that endometriosis could have a link with obstetrical complications, as an increased risk of preterm birth, gestational diabetes mellitus, and cesarean section. However, the results are difficult to interpret because biases are common, such as heterogeneity in the severity of the endometriosis cases included. That’s why some complications as risk of miscarriage and post-partum hemorrhage are still debated. Our objective was to study pregnancy outcome after In Vitro Fertilization (IVF) in women suffering from rAFS stage III and IV endometriosis.

METHODS: We conducted a case-control study between 2009 and 2019. We compared pregnancy outcomes after IVF in two groups of women matched by age, body mass index and smoking in two hospital centers. Group A was constituted by singleton pregnancies following ART for moderate and severe endometriosis (rAFS stage III and IV endometriosis). Group B was composed of singleton pregnancies in women with no endometriosis following ART for another reproductive disease. All women achieved pregnancy after 22 weeks.

RESULTS: A total of 240 pregnant women were included: 80 singleton IVF pregnancies (group A) were compared with 160 singleton IVF pregnancies (group B). We observed an increased risk of placenta previa (12.5% Vs 1.9%; p = 0,001), and cesarean section (49.4 % (n = 39) Vs 29.6% (n = 47) p=0,004). Rate of postpartum hemorrhage was not significantly different in endometriosis group (11.2% Vs 7.5% p=0.47).

CONCLUSION: Despite conflicting results in literature due to a lot of confounding variables, the impact of endometriosis on pregnancy is still debated in women suffering from rAFS III and IV endometriosis. In our study, we observed statistically higher rates of placenta previa and cesarean section but not an increased risk of postpartum hemorrhage. Further larger series are needed to confirm our findings and a possible link with other obstetrical complications. However, we think that an ART pregnancy in a context of severe endometriosis should be considered at risk of adverse obstetrical outcomes.

PMID:34844027 | DOI:10.1016/j.jogoh.2021.102274

J Craniofac Surg. 2021 Jun 1;32(4):1409-1412. doi: 10.1097/SCS.0000000000007545.

ABSTRACT

Patients with equine-related injuries (ERI) have high rates of hospitalization and often require surgical treatment. This study aimed to clarify the injury profiles of patients sustaining ERI-related craniofacial fractures and their relationship with other severe head and neck injuries.This retrospective study included all patients with craniofacial fractures admitted to a tertiary trauma center during 2013 to 2018. Out of 3256 patients, a total of 39 patients were included in the study (1.2%). Demographic and clinically relevant variables were reported and statistically evaluated.Males represented only 7.7% of the study population. Isolated facial fractures were over-represented in this study population at 84.6% whereas only 7.7% of patients sustained isolated cranial fractures and 7.7% of patients sustained combined craniofacial fractures, respectively. Surgical intervention for craniofacial fractures was required in 48.7% of patients. In total, 17.9% of patients sustained severe head and neck injuries. Periods of unconsciousness and/or post-traumatic amnesia were seen in 41% of patients. Helmet use could only be confirmed in 17.9% of patients.As trauma mechanisms behind ERI are often multifactorial and patients are at a high risk of sustaining associated injuries, attentive examination, and exclusion of serious life-threatening injuries through a multi-disciplinary approach is imperative for this specific patient population.

PMID:34842402 | DOI:10.1097/SCS.0000000000007545

Trends Psychiatry Psychother. 2021 Nov 28. doi: 10.47626/2237-6089-2021-0348. Online ahead of print.

ABSTRACT

BACKGROUND: The aim of this study was to examine the effect of group cognitive-behavioural therapy (GCBT) on pathological internet use.

METHOD: The study applied a group randomized controlled trial design to assign participants to intervention and control groups. A total of 40 college students aged 18 to 30 who were pathological internet users participated in this study and were randomly assigned to treatment and control groups. Participants completed a self-report scale titled Problematic Internet Use Scale (PIUS) at three time points. The intervention lasted for 8 weeks. The data collected were statistically analyzed using repeated-measures ANOVA.

RESULTS: The result showed that GCBT has significant effect in decreasing the symptoms of pathological internet use among the participants in GCBT compared to those in control group and that the improvements were maintained at follow-up. We also found a significant interaction effect by time for pathological internet use.

CONCLUSION: From the finding of the study, we can conclude that GCBT has significant benefit in mitigating severity of pathological internet use among the college students. Therefore, mental health professionals are encouraged to explore the benefits of GCBT in treating symptoms associated with pathological internet use in school setting and beyond.

PMID:34842397 | DOI:10.47626/2237-6089-2021-0348

Pak J Biol Sci. 2021 Jan;24(11):1162-1168. doi: 10.3923/pjbs.2021.1162.1168.

ABSTRACT

&lt;b&gt;Background and Objective:&lt;/b&gt; &lt;i&gt;Justicia gendarussa &lt;/i&gt;(family &lt;i&gt;Acanthaceae&lt;/i&gt;) is regarded as a medicinal plant valued for its beneficial pharmacological activities. A polybag experiment has been conducted at Bogor (Indonesia) to determine the effects on growth, photosynthetic and yield of various NPK ratios and manure fertilizer application in &lt;i&gt;J. gendarussa&lt;/i&gt;. &lt;b&gt;Materials and Methods:&lt;/b&gt; Six treatments (control: 50 g/plant manure, NPK (1.1 g/plant N:0.7 g/plant P&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;5&lt;/sub&gt; and 0.6 g/plant K), 50+50%/plant (manure+NPK), 10+50%/plant (manure+NPK) and 50+10%/plant (manure+NPK) were performed in a randomized complete block design. Data of individual plants were extracted from various treatments: plant height, number of leaves, number of branches, chlorophyll content, photosynthetic parameters, yield and sugar content were collected. &lt;b&gt;Results:&lt;/b&gt; The plant treated with 10+50%/plant (manure+NPK) demonstrated a statistically significant increase in plant height, number of leaves and number of branches with the value of 59.00 cm, 85.00 per plant and 9.50 per plant, respectively. Chlorophyll a (0.538 mg g&lt;sup&gt;1&lt;/sup&gt; FW), chlorophyll b (0.192 mg g&lt;sup&gt;1&lt;/sup&gt; FW) and total chlorophyll (0.730 mg g&lt;sup&gt;1&lt;/sup&gt; FW) were significantly improved by the treatment of NPK fertilizer. The application of manure and NPK at (50+50%) and (50+10%) was significantly increased stomatal conductance and transpiration rate, respectively. Leaves yield (9 g/plant DW) was improved by the application of 10+50%/plant (manure+NPK) fertilizer. The highest sugar content was obtained from &lt;i&gt;J. gendarussa&lt;/i&gt; growth with 50+50%/plant (manure+NPK) followed by 10+50% plant (manure+NPK) fertilizer. &lt;b&gt;Conclusion:&lt;/b&gt; The &lt;i&gt;J. gendarussa&lt;/i&gt; plants could benefit from combined manure and NPK fertilizer application in growth, stomatal conductance, intercellular CO&lt;sub&gt;2&lt;/sub&gt; concentration, transpiration rate, leaves yield and sugar content.

PMID:34842388 | DOI:10.3923/pjbs.2021.1162.1168

Pak J Biol Sci. 2021 Jan;24(11):1144-1151. doi: 10.3923/pjbs.2021.1144.1151.

ABSTRACT

&lt;b&gt;Background and Objective:&lt;/b&gt; Angiogenesis is a mechanism by which new blood vessels are developed in healing and tumour tissues, where it is necessary for regeneration growth, tumour cells survival and metastasis. This study aimed to assess the angiogenesis mechanism among Sudanese females with breast cancer using anti-CD34 and anti-CD105 markers. &lt;b&gt;Materials and Methods:&lt;/b&gt; Three hundred female representative Formalin-Fixed Paraffin-Embedded (FFPE) breast tissue blocks were included in this study. Of the 300 representative tissue blocks, 200 were breast cancer patient’s tissues (confirmed cases) and 100 were normal breast tissues (controls). Their ages mean±SD, 47.3±12.9 years. &lt;b&gt;Results:&lt;/b&gt; The results showed the MVD of CD34 significantly increased in malignant lesions as compared to normal breast tissues. The mean of MVD CD34 and MVD CD105 showed statistical differences among different histologic types of breast cancer. Also, a strong positive correlation was detected between the manual and automated MVD counting methods. Also, the current study revealed no significant differences were observed in mean MVD counting for both markers and menopausal status or the age groups of the study population. &lt;b&gt;Conclusion:&lt;/b&gt; The MVD is a good tool for assessing prognostic markers. The CD105 marker has a high specificity to the new evolving tumour vessels and is a useful predictor for angiogenesis and breast cancer metastasis.

PMID:34842386 | DOI:10.3923/pjbs.2021.1144.1151

Pak J Biol Sci. 2021 Jan;24(10):1077-1083. doi: 10.3923/pjbs.2021.1077.1083.

ABSTRACT

&lt;b&gt;Background and Objective:&lt;/b&gt; Environment pollution and resistance of many pests to the most frequently used chemical insecticides gave the rationale of altering to replace them with natural herbal extracts for pests and vector control. This study investigated the effect of methanolic extract of &lt;i&gt;Annona reticulata&lt;/i&gt; on the mortality and development of larvae of &lt;i&gt;Culex quinquefasciatus&lt;/i&gt;. &lt;b&gt;Materials and Methods:&lt;/b&gt; Methanolic herbal extracts were analyzed using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) to identify the phytochemical compounds in them. Ten mosquito larvae were used as replicates and exposed to each of the five concentrations of the plant extract (30, 100, 150, 200 and 250 mg mL&lt;sup&gt;1&lt;/sup&gt;) and ten larvae were exposed to double distilled water and considered as control. &lt;b&gt;Results:&lt;/b&gt; Phytochemical analysis revealed the presence of phenols, steroids, quinones, tannins and saponins. Statistical analysis showed a significant strong correlation and regression between exposure to the different concentrations of the extract and mortality of &lt;i&gt;Culex quinquefasciatus&lt;/i&gt; larvae where R&lt;sup&gt;2&lt;/sup&gt; = 0.982, the Correlation value is 0.991099 (p<0.05). Results also showed that the extracts affect the development of larvae more than mortality. The effect of the extracts on the early larval stages was significantly high compared to the late stages of larvae. &lt;b&gt;Conclusion:&lt;/b&gt; According to our knowledge results of this study has been reported for the first time in Saudi Arabia where &lt;i&gt;Annona reticulata&lt;/i&gt; is neglected regionally and no study approved its efficacy as a botanical herbal extract against mosquitoes.

PMID:34842378 | DOI:10.3923/pjbs.2021.1077.1083