Nevin Manimala

J Esthet Restor Dent. 2021 Nov 12. doi: 10.1111/jerd.12833. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aimed to evaluate the fracture strength and failure modes of different core techniques in teeth with simulated coronal destruction.

MATERIALS AND METHODS: Forty teeth were endodontically prepared and the specimens were divided into four experimental groups (n = 10) according to the core composition: Filtek One Bulk Fill-FOBF, Filtek Z350 XT-FZ350 (standard group), Filtek Bulk Fill Flow-FBFF, and LuxaCore Z-LCZ. CAD/CAM Monolithic zirconia crowns were obtained and cemented with RelyX U200. After storage in distilled water at 37°C for 48 h, the specimens were subjected to thermal cycling and to compressive strength mechanical tests. Statistical analyses (α = 0.05) were performed by non-parametric Kruskal-Wallis, Dunn post hoc, and Fisher’s exact tests.

RESULTS: No significant differences (p > 0.05) were observed among FOBF, FZ350, and FBFF (mean ranks = 20.30, 12.20, and 23.20, respectively). LCZ (mean rank = 26.30) produced results similar to those of FOBF and FBFF (p > 0.05) and higher than those of FZ350 (p = 0.042). The most frequent type of failure was irreparable, regardless of the experimental condition. The lowest percentages of reparable fractures were produced by FOBF group (10%).

CONCLUSIONS: The use of bulk fill materials, including the “core-and-post” LCZ dual-cure resin composite, did not impair the fracture strength of endodontically treated teeth with coronal destruction.

CLINICAL SIGNIFICANCE: Resin composite bulk fill materials that can be used as a core-and-post cementation in an only stage are interesting, since they enable clinicians to work with one only material, and avoid several materials interfaces, technical sensitivity, and longer chair-time due to multistep procedures.

PMID:34766704 | DOI:10.1111/jerd.12833

Obes Rev. 2021 Nov 12:e13383. doi: 10.1111/obr.13383. Online ahead of print.

ABSTRACT

We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], and polychlorinated biphenyls [PCBs]), perfluoroalkyl and polyfluoroalkyl substances (PFAS), and polybrominated diphenyl ethers (PBDEs) that are the POPs more widely studied in environmental birth cohorts so far. We search two databases (PubMed and Embase) through July/09/2021 and identified 33 studies reporting associations with prenatal organochlorine exposure, 21 studies reporting associations with prenatal PFAS, and five studies reporting associations with prenatal PBDEs. We conducted a qualitative review. Additionally, we performed random-effects meta-analyses of POP exposures, with data estimates from at least three prospective studies, and BMI-z. Prenatal DDE and HCB levels were associated with higher BMI z-score in childhood (beta: 0.12, 95% CI: 0.03, 0.21; I² : 28.1% per study-specific log increase of DDE and beta: 0.31, 95% CI: 0.09, 0.53; I² : 31.9% per study-specific log increase of HCB). No significant associations between PCB-153, PFOA, PFOS, or pentaPBDEs with childhood BMI were found in meta-analyses. In individual studies, there was inconclusive evidence that POP levels were positively associated with other obesity indicators (e.g., waist circumference).

PMID:34766696 | DOI:10.1111/obr.13383

J Nurs Scholarsh. 2021 Nov 12. doi: 10.1111/jnu.12730. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to investigate the predictors of self-care behavior among homebound older adults using the Health Empowerment theory as a framework.

DESIGN: This was a cross-sectional, predictive correlational study.

METHODS: Sixty-eight participants were randomly selected from five Hong Kong community centers from May 21, 2020 through July 20, 2020. Self-care behaviors were assessed using the Chinese version of Partners in Health. Self-efficacy, eHealth literacy, and perceived social support were assessed as potential predictors of self-care behaviors. A multiple linear regression analysis was adopted to examine the predictive effects.

RESULTS: The age of the sample ranged from 61 to 85 years (mean = 71.7, SD = 6.0). Participants who reported having sufficient or more than sufficient financial resources had better self-care behaviors than those who claimed to have insufficient financial resources (F = 5.08, p = 0.009). Statistically significant correlations were found between the participants’ eHealth literacy (r = 0.54, p < 0.001), perceived social support (r = 0.60, p < 0.001), and self-care behaviors. eHealth literacy (β = 0.13, p = 0.007) and perceived social support (β = 0.13, p < 0.001) were significant predictors of self-care behaviors. Collectively, the three variables accounted for 41% of the variances in self-care behaviors.

CONCLUSIONS: The findings in this study suggest that eHealth literacy and perceived social support are two key factors that predicted the self-care behaviors of this vulnerable population.

CLINICAL RELEVANCE: In this technological era, the use of eHealth, together with enhanced social support, can lead to better self-care among older adults, particularly those who are homebound.

PMID:34766694 | DOI:10.1111/jnu.12730

Microsc Res Tech. 2021 Nov 12. doi: 10.1002/jemt.23985. Online ahead of print.

ABSTRACT

The purpose of this study was to evaluate the surface roughness, microhardness, color change, and translucency of a newly marketed universal nanohybrid composite resin (CR) (G-aenial A’CHORD) comparing with four contemporary universal CRs including two nanofilled (Filtek and Estelite Asteria) and two nanohybrid CRs (Charisma Dimond and Neo Spectra ST HV in vitro). Sixty-five specimens (8.0 mm × 2.0 mm) were fabricated (n = 13, per group). After finishing and polishing, specimens were subjected to surface roughness and microhardness tests. Color and translucency of the specimens were evaluated at baseline and after darkening with coffee solution at day 1 and day 7. A representative specimen from each group was investigated under scanning electron microscopy (SEM). Data was analyzed statistically (p < .05). There were significant differences among the groups in terms of surface roughness, microhardness, color, and translucency. The surface roughness was recorded as: Charisma Diamond > Neo Spectra ST HV, Filtek > Estelite Asteria, G-aenial A’CHORD, whereas Vickers Hardness number was as: Filtek, Charisma Diamond > Neo Spectra ST HV > G-aenial A’CHORD, Estelite Asteria. Color change was as: Charisma Diamond > Neo Spectra ST HV, Filtek, G-aenial A’CHORD > Estelite Asteria and the translucency was as: Neo Spectra ST HV > G-aenial A’CHORD, Filtek > Estelite Asteria, Charisma Diamond. SEM examinations revealed smooth surfaces for G-aenial A’CHORD, Neo Spectra ST HV and Estelite Asteria. Mechanical and optical properties of universal composite resins with different compositions show variations.

PMID:34766666 | DOI:10.1002/jemt.23985

J Med Virol. 2021 Nov 12. doi: 10.1002/jmv.27450. Online ahead of print.

ABSTRACT

Patients with COVID-19 may recurrence positive for SARS-CoV-2 RNA after being cured and discharged from hospital. The aim of this study was to explore independent influencing factors as markers for predicting positive SARS-CoV-2 RNA recurrence. The study included 601 COVID-19 patients who were cured and discharged from the Public and Health Clinic Centre of Chengdu from January 2020 to March 2021, and the recurrence positive of patients within 6 weeks after SARS-CoV-2 RNA turned negative was followed up. We used propensity score matching to eliminate the influence of confounding factors, and multivariate Logistic regression analysis was used to determine the independent influencing factors for positive SARS-CoV-2 RNA recurrence. Multivariate Logistic regression showed that the elevated serum potassium (OR=6.537,95% CI:1.864-22.931,P=0.003), elevated blood chlorine (OR=1.169,95% CI:1.032-1.324,P=0.014) and elevated CD3⁺ CD4⁺ count (OR=1.003,95% CI:1.001-1.004,P<0.001) were identified as independent risk factors for positive SARS-CoV-2 RNA recurrence (P< 0.05).The difference in virus shedding duration (OR=1.049, 95% CI:1.000-1.100, P=0.05) was borderline statistically significant. For sensitivity analysis, we included virus shedding duration as a categorical variable in the model again, and found that the OR value related to recurrence positive increased with delayed virus shedding duration, and the trend test showed a statistical difference (P trend=0.03). Meanwhile, shortening of activated partial prothrombinase time (OR=0.908,95% CI:0.824-1.000, P=0.049) was identified as an independent protection factor for SARS-CoV-2 RNA recurrence positive.We have identified independent factors that affect the recurrence of SARS-CoV-2 RNA positive. It is recommended that doctors pay attention to these indicators when first admitted to the hospital. This article is protected by copyright. All rights reserved.

PMID:34766661 | DOI:10.1002/jmv.27450

Mov Disord. 2021 Nov 12. doi: 10.1002/mds.28850. Online ahead of print.

ABSTRACT

BACKGROUND: Recent examination of the STEADY-PD III isradipine clinical trial data concluded that early-stage Parkinson’s disease (PD) participants who had longer exposure to isradipine had a significant delay in their need for symptomatic medication, as well as a lower medication burden at the end of the trial. These findings suggest that greater exposure to isradipine might slow disease progression.

OBJECTIVES: To test this hypothesis, the data from the STEADY-PD II isradipine clinical trial, in which an extended-release (ER) formulation of the drug was used, was re-examined.

METHODS: The re-analysis of the STEADY-PD II data was restricted to participants assigned placebo or tolerable isradipine treatment (10 mg isradipine/day or less). The effect of isradipine treatment was assessed by Unified Parkinson’s Disease Rating Scale (UPDRS) at the end of the 52-week trial, rather than by last observation carried forward at the beginning of symptomatic therapy.

RESULTS: Participant cohorts were well-matched for baseline disability, initial disease progression, and time to initiation of symptomatic therapy. Participants given 10 mg/day ER isradipine had significantly smaller total and part 3 UPDRS scores at the end of the trial than did the placebo cohort. Post hoc adjustment for symptomatic therapy diminished the statistical significance of these differences. In those participants not taking a monoamine oxidase B inhibitor, the progression in UPDRS scores also was significantly reduced.

CONCLUSIONS: These results are consistent with the recent secondary analysis of the STEADY-PD III clinical trial-suggesting that clinically attainable brain exposure to isradipine may slow early-stage PD progression. © 2021 International Parkinson and Movement Disorder Society.

PMID:34766657 | DOI:10.1002/mds.28850

J Med Virol. 2021 Nov 12. doi: 10.1002/jmv.27451. Online ahead of print.

ABSTRACT

The appearance of emerging variants of SARS-CoV-2 carrying mutations into the spike protein has recently raised concern with respect to tracking their transmission and mitigating the impact in the evolving pandemic across countries. AY.4.2, a recently detected Delta variant sub-lineage, is considered a new variant under investigation (VUI) since it carries specific genetic signatures present in the spike protein, called Y145H and A222V. Here using genomic epidemiology we provide the first preliminary insight regarding the circulation of this emerging VUI in Italy. This article is protected by copyright. All rights reserved.

PMID:34766651 | DOI:10.1002/jmv.27451

J Med Virol. 2021 Nov 12. doi: 10.1002/jmv.27452. Online ahead of print.

ABSTRACT

The first aim of the study was to analyze the change in antibody titer at 15-day intervals until 60 days post symptom onset (PSO) The second aim was to analyze relationship between antibody titer and symptom grade, gender, age, BMI, medications, vitamin supplements, and herbal therapies. Blood samples were collected from 43 patients (5 mild, 21 moderate, 17 severe diseases), 18 women (41.9 %), and 25 men (58.1 %), on 15, 30, 45, and 60 days PSO after COVID-19 infection. The serum antibody titers were determined by measuring the COVID-19 IgG antibodies by ELISA. Associations between the duration of symptoms, demographic and clinical parameters, medications and vitamins used, and herbal therapies were evaluated by interviewing the participants. Within the first 15 days of illness, 81.4% of the patients were positive. From day 45 PSO, seropositivity was 89.5%. The anti-SARS-CoV-2 antibody titers were statistically higher in men than women at all-time (p<0.01). Antibody titer was higher in older participants compared to younger participants (p<0.02). Plaquenil or Favipiravir use did not effect antibody response (p>0.05). Men had higher fever (p=0.006), shortness of breath (p=0.004), and chest pain (p=0.03) than women. We found powerful antibody response by sixty days PSO, as well as higher antibody response and severity of symptoms in men gender. Data also showed that SARS-CoV-2 antibodies are higher in individuals with older age, whereas BMI, concomitant chronic disease, and medications had no effect on antibody titers. This article is protected by copyright. All rights reserved.

PMID:34766646 | DOI:10.1002/jmv.27452

Medicine (Baltimore). 2021 Nov 12;100(45):e27835. doi: 10.1097/MD.0000000000027835.

ABSTRACT

BACKGROUND: The efficacy of traditional rehabilitation, proprioceptive training, and neuromuscular training after anterior cruciate ligament (ACL) reconstruction is also controversial. In order to help medical staff better choose the rehabilitation treatment plan after ACL reconstruction, we conducted this network meta-analysis.

METHODS: Chinese and English databases such as Wanfang, Weipu, China Zhiwang, and PubMed, Cochrane Library, Embase were retrieved. We collected clinical controlled trial papers on traditional rehabilitation therapy, proprioceptive training and neuromuscular training after ACL reconstruction for meta-analysis.

RESULTS: In this meta-analysis, 12 studies were included, including 486 patients who received rehabilitation treatment after ACL reconstruction. Based on network meta-analysis, it was found that 4 groups of direct comparison and 6 groups of indirect comparison were formed for 5 rehabilitation treatment schemes after ACL reconstruction. The curative effect of traditional rehabilitation training combined with proprioception training is better than that of traditional rehabilitation training (mean difference value of traditional rehabilitation training combined with proprioception training vs traditional rehabilitation training was 8.00, 95% confidence interval: 2.61,13.39). The efficacy of proprioceptive training is better than that of traditional rehabilitation training (mean difference value of proprioceptive training vs traditional rehabilitation training is 11.01, 95% confidence interval: 0.62,21.39). There was no statistical significance between the other rehabilitation trainings. According to the surface under cumulative ranking curve, the therapeutic effects of the 5 rehabilitation treatment programs after ACL reconstruction were ranked as follows: proprioceptive training (72%) > traditional rehabilitation training combined with neuromuscular training (70.8%) > traditional rehabilitation training combined with proprioception training (57.1%) > neuromuscular training (45.5%) > traditional rehabilitation training (4.6%). No publication bias was found in the funnel plot.

CONCLUSION: Combined with the results of meta-analysis and surface under cumulative ranking efficacy sequence diagram, it can be seen that traditional rehabilitation training combined with proprioceptive training and traditional rehabilitation training combined with neuromuscular training have significant efficacy. Due to the limitations of this study, the conclusions of this network meta-analysis still need to be further confirmed by a large sample size and well-designed randomized controlled trials.

PMID:34766600 | DOI:10.1097/MD.0000000000027835

Medicine (Baltimore). 2021 Nov 12;100(45):e27811. doi: 10.1097/MD.0000000000027811.

ABSTRACT

General practitioners are still facing great challenges in the management of occlusal caries. Therefore, the development of better diagnostic protocols and assessment of caries activity might improve the results of nonoperative treatment. This study aimed to evaluate the effectiveness of visual inspection based on ICDAS-II (International Caries Detection and Assessment System) and DiagnoDent pen in the detection of pit-and-fissure early lesions in young permanent molars. The evaluation of 237 occlusal surfaces and caries risk assessment were performed in 96 children aged 7 to 15 years. The presence of pit-and-fissure noncavitated lesions was recorded using ICDAS-II scoring system and laser fluorescence. Statistical analysis was performed using McNemar test, with a level of significance of P < .05. The caries risk was measured for all participants. In 109 occlusal surfaces both methods identified enamel changes (46%) and in 62 cases both methods excluded the carious lesion (26.2%). The statistical analysis showed a significant moderate agreement between ICDAS-II code and DiagnoDent pen measurements (McNemar chi-squared statistic 9.5, P = .002 and Cohen kappa coefficient = 0.427). The majority of children (69.8%) had moderate caries risk and the most frequent risk factors recorded were sugar intake between meals, lack of regular dental control and poor oral hygiene. We concluded that ICDAS-II is a valuable and reliable diagnostic tool for early pit-and-fissure lesions and could be used alone during dental examination in children. The evaluation of caries risk should become clinical routine, as parameters belonging to high risk were frequently recorded in our study group.

PMID:34766591 | DOI:10.1097/MD.0000000000027811