Nevin Manimala

Campbell Syst Rev. 2023 Jan 13;19(1):e1296. doi: 10.1002/cl2.1296. eCollection 2023 Mar.

ABSTRACT

BACKGROUND: Involving men and boys as both users and supporters of Family Planning (FP) is now considered essential for optimising maternal and child health outcomes. Evidence on how to engage men and boys to meet FP needs is therefore important.

OBJECTIVES: The main objective of this review was to assess the strength of evidence in the area and uncover the effective components and critical process- and system-level characteristics of successful interventions.

SEARCH METHODS: We searched nine electronic databases, seven grey literature databases, organisational websites, and the reference lists of systematic reviews relating to FP. To identify process evaluations and qualitative papers associated with the included experimental studies, we used Connected Papers and hand searches of reference lists.

SELECTION CRITERIA: Experimental and quasi-experimental studies of behavioural and service-level interventions involving males aged 10 years or over in low- and middle-income countries to increase uptake of FP methods were included in this review.

DATA COLLECTION AND ANALYSIS: Methodology was a causal chain analysis involving the development and testing of a logic model of intervention components based on stakeholder consultation and prior research. Qualitative and quantitative data relating to the evaluation studies and interventions were extracted based on the principles of ‘effectiveness-plus’ reviews. Quantitative analysis was undertaken using r with robust variance estimation (RVE), meta-analysis and meta-regression. Qualitative analysis involved ‘best fit’ framework synthesis.

RESULTS: We identified 8885 potentially relevant records and included 127 in the review. Fifty-nine (46%) of these were randomised trials, the remainder were quasi-experimental studies with a comparison group. Fifty-four percent of the included studies were assessed as having a high risk of bias. A meta-analysis of 72 studies (k = 265) showed that the included group of interventions had statistically significantly higher odds of improving contraceptive use when compared to comparison groups (odds ratio = 1.38, confidence interval = 1.21 to 1.57, prediction interval = 0.36 to 5.31, p < 0.0001), but there were substantial variations in the effect sizes of the studies (Q = 40,647, df = 264, p < 0.0001; I ² = 98%) and 73% was within cluster/study. Multi-variate meta-regression revealed several significant intervention delivery characteristics that moderate contraceptive use. These included community-based educational FP interventions, interventions delivered to women as well as men and interventions delivered by trained facilitators, professionals, or peers in community, home and community, or school settings. None of the eight identified intervention components or 33 combinations of components were significant moderators of effects on contraceptive use. Qualitative analysis highlighted some of the barriers and facilitators of effective models of FP that should be considered in future practice and research.

AUTHORS’ CONCLUSIONS: FP interventions that involve men and boys alongside women and girls are effective in improving uptake and use of contraceptives. The evidence suggests that policy should continue to promote the involvement of men and boys in FP in ways that also promote gender equality. Recommendations for research include the need for evaluations during conflict and disease outbreaks, and evaluation of gender transformative interventions which engage men and boys as contraceptive users and supporters in helping to achieve desired family size, fertility promotion, safe conception, as well as promoting equitable family planning decision-making for women and girls.

PMID:36911859 | PMC:PMC9837728 | DOI:10.1002/cl2.1296

Campbell Syst Rev. 2023 Jan 10;19(1):e1302. doi: 10.1002/cl2.1302. eCollection 2023 Mar.

ABSTRACT

BACKGROUND: Police-initiated pedestrian stops have been one of the most widely used crime prevention tactics in modern policing. Proponents have long considered police stops to be an indispensable component of crime prevention efforts, with many holding them responsible for the significant reductions in violent crime observed across major US cities in recent decades. Critics, however, have taken issue with the overuse of pedestrian stops, linking them to worsening mental and physical health, attitudes toward the police, and elevated delinquent behavior for individuals directly subject to them. To date, there has been no systematic review or meta-analysis on the effects of these interventions on crime and individual-level outcomes.

OBJECTIVES: To synthesize the existing evaluation research regarding the impact of police-initiated pedestrian stops on crime and disorder, mental and physical health, individual attitudes toward the police, self-reported crime/delinquency, violence in police-citizen encounters, and police misbehavior.

SEARCH METHODS: We used the Global Policing Database, a repository of all experimental and quasi-experimental evaluations of policing interventions conducted since 1950, to search for published and unpublished evaluations of pedestrian stop interventions through December of 2019. This overarching search was supplemented by additional searches of academic databases, gray literature sources, and correspondence with subject-matter experts to capture eligible studies through December 2021.

SELECTION CRITERIA: Eligibility was limited to studies that included a treatment group of people or places experiencing pedestrian stops and a control group of people or places not experiencing pedestrian stops (or experiencing a lower dosage of pedestrian stops). Studies were required to use an experimental or quasi-experimental design and evaluate the intervention using an outcome of area-level crime and disorder, mental or physical health, individual or community-level attitudes toward the police, or self-reported crime/delinquency.

DATA COLLECTION AND ANALYSIS: We adopted standard methodological procedures expected by the Campbell Collaboration. Eligible studies were grouped by conceptually similar outcomes and then analyzed separately using random effects models with restricted maximum likelihood estimation. Treatment effects were represented using relative incident rate ratios, odds ratios, and Hedges’ g effect sizes, depending on the unit of analysis and outcome measure. We also conducted sensitivity analyses for several outcome measures using robust variance estimation, with standard errors clustered by each unique study/sample. Risk of bias was assessed using items adapted from the Cochrane randomized and non-randomized risk of bias tools.

RESULTS: Our systematic search strategies identified 40 eligible studies corresponding to 58 effect sizes across six outcome groupings, representing 90,904 people and 20,876 places. Police-initiated pedestrian stop interventions were associated with a statistically significant 13% (95% confidence interval [CI]: -16%, -9%, p < 0.001) reduction in crime for treatment areas relative to control areas. These interventions also led to a diffusion of crime control benefits, with a statistically significant 7% (95% CI: -9%, -4%, p < 0.001) reduction in crime for treatment displacement areas relative to control areas. However, pedestrian stops were also associated with a broad range of negative individual-level effects. Individuals experiencing police stops were associated with a statistically significant 46% (95% CI: 24%, 72%, p < 0.001) increase in the odds of a mental health issue and a 36% (95% CI: 14%, 62%, p < 0.001) increase in the odds of a physical health issue, relative to control. Individuals experiencing police stops also reported significantly more negative attitudes toward the police (g = -0.38, 95% CI: -0.59, -0.17, p < 0.001) and significantly higher levels of self-reported crime/delinquency (g = 0.30, 95% CI: 0.12, 0.48, p < 0.001), equating to changes of 18.6% and 15%, respectively. No eligible studies were identified measuring violence in police-citizen encounters or officer misbehavior. While eligible studies were often considered to be at moderate to high risk of bias toward control groups, no significant differences based on methodological rigor were observed. Moderator analyses also indicated that the negative individual-level effects of pedestrian stops may be more pronounced for youth, and that significant differences in effect sizes may exist between US and European studies. However, these moderator analyses were limited by a small number of studies in each comparison, and we were unable to compare the effects of police stops across racial groupings.

AUTHORS’ CONCLUSIONS: While our findings point to favorable effects of pedestrian stop interventions on place-based crime and displacement outcomes, evidence of negative individual-level effects makes it difficult to recommend the use of these tactics over alternative policing interventions. Recent systematic reviews of hot spots policing and problem-oriented policing approaches indicate a more robust evidence-base and generally larger crime reduction effects than those presented here, often without the associated backfire effects on individual health, attitudes, and behavior. Future research should examine whether police agencies can mitigate the negative effects of pedestrian stops through a focus on officer behavior during these encounters.

PMID:36911857 | PMC:PMC9831287 | DOI:10.1002/cl2.1302

Food Sci Nutr. 2023 Jan 11;11(3):1486-1498. doi: 10.1002/fsn3.3188. eCollection 2023 Mar.

ABSTRACT

The integrity of the distal alveolar epithelium is crucial for lung regeneration following an injury. The present study aimed to evaluate the effect of Cinnamomum verum extract; cross-talk of epidermal growth factor (EGF) and erythropoietin (EPO) genes in a smoke-induced lung injury rat model. For experimentation (n = 27), albino rats were divided equally into three groups, i.e., negative control (NC), positive control (PC), and treatment group (TG). Cigarette smoke was exposed to PC and TG (4 CG/day). C. verum was given orally (350 mg/kg body weight) for 21 days. Decapitation (n = 3) was done on 14th, 18th, and 21st days, respectively. Analyses (hematology, biochemical, high performance liquid chromatography [HPLC], histology, and gene expression) were carried out and results were statistically analyzed by two-way analysis of variance. HPLC analysis of ethanolic extract of C. verum was done to identify the presence of phenolic constituents which showed high concentrations of quercetin and P-coumaric acid. Serum oxidative parameters such as total oxidant status, malondialdehyde, and hematological parameters such as red blood cells, hemoglobin, hematocrit, and white blood cells were significantly (p < .05) elevated in the PC group; however, these parameters were significantly (p < .05) improved in TG. While total antioxidant capacity and serum parameters such as total protein, albumin, and globulin were significantly (p < .05) reduced in the PC group but significantly improved (p < .05) in TG. Histological analysis revealed that smoke exposure resulted in a measurable increase in alveolar septal thickening while ethanolic extract of C. verum greatly ameliorated the histopathological changes in the lung alveoli. The gene expression analysis of EGF and EPO genes showed a significant upregulation (p < .05) of both genes in PC group while in TG, the level of both genes downregulated, in which lung damage was ameliorated due to cytoprotective effects of ethanolic extract of C. verum.

PMID:36911850 | PMC:PMC10002988 | DOI:10.1002/fsn3.3188

Food Sci Nutr. 2022 Nov 24;11(3):1212-1222. doi: 10.1002/fsn3.3155. eCollection 2023 Mar.

ABSTRACT

Sea buckthorn leaf tea, an emerging potential functional beverage product, has not yet had appropriate product standards and corresponding quality evaluation methods, and its poor taste directly affects the acceptance of the population, thus limiting its market consumption potential. In this study, two major packaging forms of sea buckthorn leaf tea available in the Chinese market were selected. The contents of total phenolics, total flavonoids, and 10 phenolic compounds, as well as the in vitro antioxidant capacity and sensory characteristics of sea buckthorn leaf tea were analyzed. Results showed that the quality of sea buckthorn leaf tea in the Chinese market varied widely. The total phenolic content, total flavonoid content, antioxidant activity, and consumer acceptance of bagged sea buckthorn leaf tea were higher than those of bulk sea buckthorn leaf tea. Multifactorial statistical analysis showed that the taste astringency of sea buckthorn leaf tea was closely related to ellagic acid and isorhamnetin-3-O-neohesperidin. Furthermore, isorhamnetin-3-O-neohesperidin had a greater effect on the antioxidant activity of sea buckthorn leaf tea. Therefore, ellagic acid and isorhamnetin-3-O-neohesperidin can be used as potential quality markers for sea buckthorn leaf tea. This work provides a reference for taste improvement and quality control of sea buckthorn leaf tea.

PMID:36911815 | PMC:PMC10003008 | DOI:10.1002/fsn3.3155

Food Sci Nutr. 2023 Jan 24;11(3):1309-1317. doi: 10.1002/fsn3.3165. eCollection 2023 Mar.

ABSTRACT

Natural herbs are now receiving more attention due to the growing demand for their antioxidant properties. This study compared flaxseed and fennel seeds for their nutritional composition, bioactive moieties, and antioxidant activity-the study comprised two different phases. According to methods, phase I analyzed flaxseed and fennel seeds for proximate composition, mineral profile, dietary fiber, and amino acid content. In phase II, seeds were extracted using three different solvents, i.e., ethanol 80%, acetone 80%, and distilled water, to probe the total phenolic and flavonoid content. Antioxidant activity was measured using DPPH and a FRAP in the final phase. Current study revealed that flaxseed had higher protein (17.33 ± 0.02%), fat content (36.76 ± 0.02%), potassium (763.66 ± 4.04 mg/100 g), iron (5.13 ± 0.03 mg/100 g), phosphorus (581.46 ± 4.07 mg/100 g), magnesium (406.60 ± 5.12 mg/100 g), and zinc (3.30 ± 0.49 mg/100 g), respectively. In fennel seed, high dietary fiber (53.2 ± 0.01 g/100 mg), calcium, manganese, and sodium (588.93 ± 7.77, 20.30 ± 0.95, and 57.34 ± 0.33 mg/100 g, respectively) were found. Acetone showed better extraction efficiency than acetone, ethanol, and distilled water. Moreover, acetone flaxseed extract showed higher total phenolic content (84.13 ± 7.73 mgGAE/g), flavonoid content (5.11 ± 1.50 mgQE/g), and FRAP (5031 ± 15.92 μMFe^2+/g) than fennel seed extract. This study showed that, among both herbs, flaxseed extract may have pharmacological potential in preventing illnesses and may be suggested for use in the food industry as a natural antioxidant.

PMID:36911814 | PMC:PMC10003022 | DOI:10.1002/fsn3.3165

J 3D Print Med. 2023 Mar;7(1):3DP3. doi: 10.2217/3dp-2022-0012. Epub 2023 Jan 18.

ABSTRACT

BACKGROUND: Post-infarct ventricular septal defect (PIVSD) is a serious complication of myocardial infarction. We evaluated 3D-printing models in PIVSD clinical assessment and the feasibility of statistical shape modeling for morphological analysis of the defects.

METHODS: Models (n = 15) reconstructed from computed tomography data were evaluated by clinicians (n = 8). Statistical shape modeling was performed on 3D meshes to calculate the mean morphological configuration of the defects.

RESULTS: Clinicians’ evaluation highlighted the models’ utility in displaying defects for interventional/surgical planning, education/training and device development. However, models lack dynamic representation. Morphological analysis was feasible and revealed oval-shaped (n = 12) and complex channel-like (n = 3) defects.

CONCLUSION: 3D-PIVSD models can complement imaging data for teaching and procedural planning. Statistical shape modeling is feasible in this scenario.

PMID:36911812 | PMC:PMC9990116 | DOI:10.2217/3dp-2022-0012

Clean Eng Technol. 2023 Apr;13:100615. doi: 10.1016/j.clet.2023.100615. Epub 2023 Mar 4.

ABSTRACT

Due to global supply chain disruptions and high demand for personal protective equipment (PPE), the rapidly expanding COVID-19 crisis left millions of front-line fighters unprotected. The disposal of PPE in the environment caused significant environmental pollution. Hence, indigenous initiatives have been taken to fabricate antiviral and biodegradable face shields with the help of neoteric and cleaner technologies. This paper describes a novel endeavor to design, manufacture, and performance analysis of a face shield made by plastic injection molding and LASER Cutting. Because of the requirement of permanent wear, the face shield’s ergonomic design is considered low weight and easy head fixation, alongside high production ability. Here, face shield frames are made with lightweight, biodegradable plastic called Poly Lactic Acid (PLA), whereas an optical grade PLA sheet is used as the visor for better clarity. Visors PLA Sheet is coated with Nano-Silver disinfectant spray to incorporate antiviral properties to the Faceshield. Partially circumferential adjustable elastic straps are used for comfortable head fixation. To evaluate the product, clinical fit tests along with statistical survey were conducted, and the feedback from the end-users on comfort (41% Excellent, 30% Good, 26% Average and 3% Poor), clear view (33% Excellent, 38% Good, 24% Average, and 5% Poor), design features (43% Excellent, 35% Good, and 22% Average), simplicity of installation and disassembly (29% Excellent, 33% Good, and 38% Average), and ease of wearing/removing (45% Excellent, 40% Good, and 15%Average) are encouraging.

PMID:36911790 | PMC:PMC9984231 | DOI:10.1016/j.clet.2023.100615

Paediatr Neonatal Pain. 2022 Dec 5;5(1):10-15. doi: 10.1002/pne2.12091. eCollection 2023 Mar.

ABSTRACT

Pediatric burns affect approximately 15-20 patients per 100 000 hospital admissions, but unfortunately there is a lack of evidence to guide optimal strategies for acute pain control. The aim of this study was to evaluate whether caudal analgesia with single injection of local anesthetics reduced pain medication consumption in pediatric patients who required surgical intervention for burn injuries. Retrospective data from patients <7 years old who had burn surgery in the operating rooms at a single regional burn center from 2013 to 2021 was obtained and analyzed. A 1:1 propensity-score matching method using nearest neighbor matching without replacement was utilized to create matched cohorts. Primary outcome was opioid consumption, which is presented as opioid equivalents divided by patient weight in kilograms, at 24 h after surgery. Comparing propensity-score matched groups, there were no statistically significant differences in adjusted morphine equivalents received by the caudal group (0.122 [0.0646;0.186]) and the no caudal group (0.0783 [0.0384;0.153]) at 24 h after surgery (p = 0.06). This is the first study to the best of our knowledge of the association of caudal analgesia in pediatric burn patients with postoperative pain control. The data showed an increase in pain medication consumption postoperative at 24 h and intraoperative for patients who received single injection caudal blocks, but when adjusted using propensity-score matching, the difference was no longer statistically significant.

PMID:36911788 | PMC:PMC9997120 | DOI:10.1002/pne2.12091

JSES Int. 2022 Dec 20;7(2):336-341. doi: 10.1016/j.jseint.2022.12.007. eCollection 2023 Mar.

ABSTRACT

BACKGROUND: The purpose of this study was to identify prognostic factors that are associated with improvements in patient-reported outcomes measures (PROMs) related to upper extremity function and pain in those suffering from idiopathic adhesive capsulitis.

METHODS: All patients treated conservatively for primary idiopathic adhesive capsulitis were identified from our institutional database between 2019 and 2021. Exclusion criteria included any patients treated surgically, follow-up less than one year, or incomplete survey results. PROMs including Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity Computer Adaptive Test Version 2.0 (P-UE), Pain Interference (P-Interference), Pain Intensity (P-Intensity), and visual analog scale (VAS) pain scores. They were obtained at initial consultation and at one year to assess patient-perceived impact of their condition. Multiple linear and multivariable logistic regressions were performed to identify factors associated with improvement in patient-perceived pain and shoulder function using final PROM scores and difference in PROM scores from initial consultation. An independent t-test was used to compare baseline and one-year minimum follow-up PROMs. Odds ratios and their 95% confidence intervals were calculated for each factor; a P value of < .05 was considered statistically significant.

RESULTS: A total of 56 patients (40 females and 16 males) were enrolled in the study with an average age of 54.7 ± 7.7 years. A significant improvement (P < .001) was demonstrated at one-year minimum outcomes for P-UE, P-Interference, P-Intensity, and VAS scores. With respect to comorbid conditions, hypothyroidism [P-UE (β: 9.57, P = .006)] was associated with greater improvements in PROMs, while hyperlipidemia [P-UE (β: -4.13, P = .01) and P-Intensity (β: 2.40, P = .02)] and anxiety [P-UE (β: -4.13, P = .03)] were associated with poorer reported changes in PROMs. Female sex [P-UE (β: 4.03, P = .007) and P-Interference (β: -2.65, P = .04)] and employment in manual labor professions [P-Interference (β: -3.07, P = .01), P-Intensity (β: -2.92, P = .006), and VAS (β: -0.66, P = .03)] were associated with significantly better patient-perceived outcomes. Hispanic heritage was associated with higher reported changes of P-Intensity (β: 8.45, P = .004) and VAS (β: 2.65, P = .002).

CONCLUSION: Patient-perceived improvements in PROMIS score during the natural history of adhesive capsulitis are likely multifactorial, with anxiety, hyperlipidemia, increased body mass index, and Hispanic heritage associated with reduced improvement in PROMIS scores.

PMID:36911781 | PMC:PMC9998727 | DOI:10.1016/j.jseint.2022.12.007

JSES Int. 2022 Dec 23;7(2):364-369. doi: 10.1016/j.jseint.2022.12.012. eCollection 2023 Mar.

ABSTRACT

BACKGROUND: Despite technical advancement, elbow ulnar collateral ligament (UCL) reconstruction is a challenging procedure due to the limitations regarding the challenging tunnel placement and potential injury to the ulnar nerve. Furthermore, current techniques for reconstruction and repair are inferior functionally and biomechanically when compared to native UCL tissue. A modified docking technique using a single-tunnel proximal suspensory fixation may reduce complications and potentially provide a technique for UCL reconstruction that is biomechanically superior. Decreasing the number of bone tunnels decreases the number of places that bone tear through could occur. The purpose was to evaluate and compare the biomechanical performances for 2 elbow UCL reconstruction techniques: (1) standard docking technique (SD) and (2) a proximal single tunnel (PST) technique using a suspensory fixation. We hypothesized that the PST technique would be biomechanically superior to the SD technique.

METHODS: Twelve matched pairs of cadaveric elbows were dissected and fixed at 70 degrees for biomechanical testing. Gracilis grafts were used for a docking reconstruction and the modified reconstruction with a PST suspensory fixation. A cyclic valgus torque protocol was used to precondition specimens for either reconstruction technique and the ulnohumeral gapping was then assessed. Following gapping measurements, postsurgical specimens underwent a valgus rotation applied at a rate of 5°/s until the anterior band of the UCL failed or fracture occurred. Ultimate load to failure, stiffness, and mode of failure were recorded.

RESULTS: There were no statistical differences between the two groups. Mean rotational stiffness of the SD (2.3 ± 0.6 Nm/deg) compared to the PST (1.9 ± 0.7 Nm/deg) (P = .41) and mean ultimate failure torque of the SD (30.5 ± 9.2 Nm) compared to the PST (30.9 ± 8.6 Nm) (P = .86) were similar. There was also no statistically significant difference (P = .83) when comparing the native UCL ulnohumeral gapping (6.0 ± 2.0 mm) to the mean ulnohumeral gapping of the SD reconstruction (6.0 ± 1.8 mm).

CONCLUSIONS: This study compares the biomechanical strength of elbow UCL reconstructions performed using the SP technique to that of a PST technique. Among all tested parameters, including ultimate failure torque, stiffness, and ulnohumeral gapping, there were no statistically significant differences between the 2 techniques.

PMID:36911780 | PMC:PMC9998889 | DOI:10.1016/j.jseint.2022.12.012