Nevin Manimala

BMC Chem. 2022 Oct 21;16(1):79. doi: 10.1186/s13065-022-00869-z.

ABSTRACT

Modafinil (MDF) is one of the neurostimulants with a potential effect in the COVID-19 ICU ventilated patients and post-COVID neurological syndrome treatment. Four rapid, simple and cost-effective stability indicating spectrophotometric methods were used for estimation of MDF in the presence of its acidic degradation product, namely; ratio difference (RD), first derivative of the ratio spectra (¹DD), mean centering (MCR) and ratio subtraction method (RS). These methods were validated according to ICH guidelines and all methods revealed a good linearity in concentration range of (5-30 µg/mL) in addition to a good accuracy and precision with mean percentage recovery of 99.97 ± 0.305 for (RD), 100.10 ± 0.560 for (¹DD), 100.02 ± 0.483 for (MCR) & 99.18 ± 1.145 for (RS) method. Specificity of the proposed methods was assessed and MDF was determined in the presence of up to 80% of its acidic degradation product for RD, ¹DD, MCR and RS methods. The proposed methods were successfully applied for the determination of MDF in bulk powder and its tablet dosage form with mean percentage recovery of 100.33 ± 0.915 for (RD), 100.62 ± 0.985 for (¹DD), 99.70 ± 0.379 for (MCR) and 100.21 ± 0.313 for (RS) method. The results obtained were statistically compared with those of official HPLC method and showed no significant difference with relevance accuracy and precision.

PMID:36271411 | DOI:10.1186/s13065-022-00869-z

Int J Colorectal Dis. 2022 Oct 22. doi: 10.1007/s00384-022-04265-w. Online ahead of print.

ABSTRACT

BACKGROUND: Between people with and without inflammatory bowel disease (IBD), there was no statistically significant difference in the probability of contracting the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the risk of adverse outcomes in IBD patients after virus infection remains unclear.

METHODS: Eligible studies conducted from January 1, 2020 to March 17, 2022 were obtained by searching PubMed, Embase, and Web of Science. Information was collected in tables from the included studies. Random-effects and fixed-effects models were used as measures for the pooled estimates. All data were estimated by R version 4.1.3.

RESULTS: Twenty-four studies were included. The risk ratio (RR) of adverse outcomes in COVID-19 patients with IBD increased by 32% (RR 1.32; 95% CI 1.06-1.66) relative to COVID-19 patients without IBD. The RR of mortality was higher in COVID-19 patients with IBD from Europe (RR 1.72; 95% CI 1.11-2.67) than in those that were not from Europe (RR 1.00; 95% CI 0.79-1.26; χ² = 4.67; P = 0.03). Patients with ulcerative colitis were at higher risk of adverse outcomes after SARS-CoV-2 infection than patients with Crohn’s disease patients (RR1.38; 95% CI 1.27-1.50). The IBD drugs treatment was associated with the risk of adverse outcomes, the pooled odds ratio (OR) of mesalazine (1.79; 95% CI 1.59-2.02), immunomodulators (1.30; 95% CI 1.10-1.53), and anti-TNF (0.47; 95% CI 0.41-0.53) were assessed.

CONCLUSION: COVID-19 patients with IBD had an increased risk of adverse outcomes than those without IBD, whereas anti-TNF treatment might reduce the risk.

PMID:36271206 | DOI:10.1007/s00384-022-04265-w

Aging Clin Exp Res. 2022 Oct 21. doi: 10.1007/s40520-022-02275-w. Online ahead of print.

ABSTRACT

BACKGROUND: Apathy remains a common and problematic neuropsychiatric feature associated with Parkinson’s disease resulting in reductions in health-related quality of life, and effective treatments remain elusive. Meaning in life (MIL) has been implicated in a variety of positive health outcomes, and this study assesses the relationship between apathy and MIL while hoping to identify a potential new interventional target.

METHODS: A cross-sectional sample of 237 PwPD completed surveys to evaluate MIL and a variety of non-motor symptoms (NMS), and a hierarchical regression analysis was conducted to evaluate relationships of interest.

RESULTS: Correlational analysis indicated the presence of meaning in life was statistically negatively and moderately to strongly correlated with apathy (r = – 0.60, p < .001). Hierarchical regression analysis results showed that presence of meaning in life explained a total of 48% of variance in apathy. More specifically, the presence of meaning in life (β = – 0.43, p < .001) was associated with apathy after controlling for sociodemographic and other potentially confounding variables.

CONCLUSIONS: This study demonstrates the significant negative relationship between MIL and apathy. Considering the lack of effective treatments for apathy, which is one of the most disabling symptoms affecting PwPD, identifying a potential target for intervention is exciting. MIL has the potential to offer clinicians a novel intervention to provide a much-needed treatment option to improve both apathy and HRQoL.

PMID:36271201 | DOI:10.1007/s40520-022-02275-w

Int J Biometeorol. 2022 Oct 21. doi: 10.1007/s00484-022-02385-0. Online ahead of print.

ABSTRACT

Tuberculosis (TB) is recognized as being a major public health concern owing to its increase in Qinghai, China. In this study, we aimed to estimate the long-term effects of meteorological variables on TB incidence and construct an advanced hybrid model with seasonal autoregressive integrated moving average (SARIMA) and a neural network nonlinear autoregression (SARIMAX-NNARX) by integrating meteorological factors and evaluating the model fitting and prediction effect. During 2005-2017, TB experienced an upward trend with obvious periodic and seasonal characteristics, peaking in spring and winter. The results showed that TB incidence was positively correlated with average relative humidity (ARH) with a 2-month lag (β = 1.889, p = 0.003), but negatively correlated with average atmospheric pressure (AAP) with a 1-month lag (β = – 1.633, p = 0.012), average temperature (AT) with a 2-month lag (β = – 0.093, p = 0.027), and average wind speed (AWS) with a 0-month lag (β = – 13.221, p = 0.033), respectively. The SARIMA (3,1,0)(1,1,1)_12, SARIMAX(3,1,0)(1,1,1)₁₂, and SARIMAX(3,1,0)(1,1,1)₁₂-NNARX(15,3) were considered preferred models based on the evaluation criteria. Of them, the SARIMAX-NNARX technique had smaller error values than the SARIMA and SARIMAX models in both fitting and forecasting aspects. The sensitivity analysis also revealed the robustness of the mixture forecasting model. Therefore, the SARIMAX-NNARX model by integrating meteorological variables can be used as an accurate method for forecasting the epidemic trends which would be great importance for TB prevention and control in the coming periods in Qinghai.

PMID:36271168 | DOI:10.1007/s00484-022-02385-0

Environ Monit Assess. 2022 Oct 21;195(1):11. doi: 10.1007/s10661-022-10512-y.

ABSTRACT

The present work focuses on total concentrations of trace elements such as chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), and lead (Pb) and their operationally defined speciation in surface sediments from three Ethiopian Rift Valley Lakes (Hawassa, Koka, and Ziway). Total concentrations were determined using inductively coupled plasma-mass spectrometer (ICP-MS). A six-step sequential extraction was also applied to evaluate the mobilization potential of these elements. Compared with the consensus-based sediment quality guidelines (SQGs) developed for freshwater ecosystems, the total Zn concentration in sediments from Lakes Hawassa and Ziway, as well as Cr, Ni, and Zn in sediments from Lake Koka, was higher than the probable effect concentration (PEC), suggesting that these elements could have a negative effect on benthic organisms. The sequential extraction results showed that Cd, Mn, and Se were to a certain extent associated with the reversible fractions (F1-F3) in sediments, and thereby more mobile than the other investigated trace elements. Predictions of mobility of trace elements using the distribution coefficients (K_d) values were also in agreement with the sequential extraction results. Furthermore, multivariate statistical analyses showed that redox-sensitive fractions (F4 and F6) and the residual fraction (F7) were the dominant factors controlling most trace element mobility. Finally, applying the Risk Assessment Code (RAC) classification system, results showed that Mn in Lake Koka could pose a high risk, while Cd and Mn in Lake Hawassa as well as Cd, Mn, and Se in Lake Ziway sediments could pose medium risk to benthic organisms.

PMID:36271163 | DOI:10.1007/s10661-022-10512-y

Arch Orthop Trauma Surg. 2022 Oct 21. doi: 10.1007/s00402-022-04657-1. Online ahead of print.

ABSTRACT

INTRODUCTION: Despite the increasing number of revision total ankle arthroplasty (TAA), the literature on indications, surgical options, and outcomes is limited. This study reports on failure rates and patient-reported outcomes (PROM) for a cohort of 122 patients who underwent revision of TAA.

MATERIALS AND METHODS: A retrospective review of revision TAA between 2006 and 2020 was performed at one institution. Patient’s demographics and different surgical procedures were analyzed with particular attention to comparing polyethylene exchange with revision of both metallic components and to additional interventions for axis correction. Failure rates and the European Foot and Ankle Society (EFAS) score were collected. The average follow-up period was 70.37 ± 46.76 months.

RESULTS: 122 patients were treated with an exchange procedure. The surgery included 69 polyethylene exchanges, 12 revisions of one metallic component, and 41 revisions of both metallic components. The overall failure rate was 14.75%. The EFAS score, completed by 94 of the 122 patients, was used to evaluate clinical outcomes. Median EFAS score was 12.51 ± 5.53, and median EFAS sports score was 2.97 ± 3.04. Revision rates after polyethylene exchange were significantly higher than after exchanging both metallic components (p value = 0.03), while the EFAS score showed slightly better results in patients treated with polyethylene exchange. Adding procedures to induce axis correction led to significantly lower revision rates (p value = 0.03), and the EFAS score was also improved but without statistical significance.

CONCLUSIONS: The high failure rate of polyethylene exchange indicates that the intervention does not address the actual cause of failed TAA in many cases. Additional axis correction should be considered more frequently. If the underlying issues of prosthesis failure can be identified and sufficiently addressed, the results of revision surgery are likely to improve.

PMID:36271162 | DOI:10.1007/s00402-022-04657-1

Sci Rep. 2022 Oct 21;12(1):17723. doi: 10.1038/s41598-022-22859-w.

ABSTRACT

The aim of this study is to evaluate whether the patient-oriented strategies encompassing individualized oocyte number (POSEIDON) criteria can reflect the prognosis of controlled ovarian stimulation (COS) by comparing the results of assisted reproductive technologies (ART) between four POSEIDON and normal responder (NR) groups. In total, 225 patients were included in this retrospective observational study. The patients underwent various COS protocols and in vitro fertilization or intracytoplasmic sperm injection, followed by fresh or frozen embryo transfer. Based on their clinical and demographic data, patients were divided into four groups according to the POSEIDON classification, and their ART outcomes were evaluated. Statistical analyses were performed using R version 4.0.5, and a p-value of < 0.05 was considered significant. The NR group had the highest number of total oocytes retrieved and total embryos obtained, as well as the best ART outcome in terms of clinical pregnancy rate ([CPR], 47.6%). The POSEIDON groups 1 and 2 had better COS and ART outcomes than groups 3 and 4 (CPR, 22.6%, 22.1%, 16.7%, and 4.8% in groups 1-4, respectively); the patients in group 3 were younger than those in group 2 by definition, but their CPR was lower than that of patients in group 2. When comparing young and old women with low anti-Müllerian hormone (AMH) levels, the younger group (POSEIDON group 2) had better COS and ART outcomes than their older counterparts, especially POSEIDON group 4. A binary logistic regression adjusted for body mass index (BMI) comparing the ART outcomes of patients that did not get pregnant in the POSEIDON groups compared to the NR group showed odds ratios (ORs) (95% confidence interval) of 2.938 (1.496-5.768), 3.376 (1.848-6.167), 6.801 (2.740-16.881), and 20.497 (8.284-50.713) for groups 1, 2, 3, and 4, respectively. Ovarian reserve still seems to outweigh patients’ age when predicting the ART outcomes of low-responder infertile women, as suggested by the results of POSEIDON groups 2 and 3. However, when there are no differences in ovarian reserve, as in POSEIDON groups 2 and 4, younger women with low AMH have a higher probability of pregnancy than their AMH-matched older counterparts.

PMID:36271137 | DOI:10.1038/s41598-022-22859-w

Sci Rep. 2022 Oct 21;12(1):17655. doi: 10.1038/s41598-022-21267-4.

ABSTRACT

We describe a novel type of blockade in a hybrid mode generated by linear coupling of photonic and phononic modes. We refer to this effect as hybrid photon-phonon blockade and show how it can be generated and detected in a driven nonlinear optomechanical superconducting system. Thus, we study boson-number correlations in the photon, phonon, and hybrid modes in linearly coupled microwave and mechanical resonators with a superconducting qubit inserted in one of them. We find such system parameters for which we observe eight types of different combinations of either blockade or tunnelling effects (defined via the sub- and super-Poissonian statistics, respectively) for photons, phonons, and hybrid bosons. In particular, we find that the hybrid photon-phonon blockade can be generated by mixing the photonic and phononic modes which do not exhibit blockade.

PMID:36271120 | DOI:10.1038/s41598-022-21267-4

Sci Rep. 2022 Oct 21;12(1):17629. doi: 10.1038/s41598-022-22526-0.

ABSTRACT

Neurons convert external stimuli into action potentials, or spikes, and encode the contained information into the biological nervous system. Despite the complexity of neurons and the synaptic interactions in between, rate models are often adapted to describe neural encoding with modest success. However, it is not clear whether the firing rate, the reciprocal of the time interval between spikes, is sufficient to capture the essential features for the neuronal dynamics. Going beyond the usual relaxation dynamics in Ginzburg-Landau theory for statistical systems, we propose that neural activities can be captured by the U(1) dynamics, integrating the action potential and the “phase” of the neuron together. The gain function of the Hodgkin-Huxley neuron and the corresponding dynamical phase transitions can be described within the U(1) neuron framework. In addition, the phase dependence of the synaptic interactions is illustrated and the mapping to the Kinouchi-Copelli neuron is established. It suggests that the U(1) neuron is the minimal model for single-neuron activities and serves as the building block of the neuronal network for information processing.

PMID:36271115 | DOI:10.1038/s41598-022-22526-0

Environ Monit Assess. 2022 Oct 22;195(1):13. doi: 10.1007/s10661-022-10529-3.

ABSTRACT

Agriculture is a distinct sector of a country’s economy. In recent years, new patterns have evolved in the agricultural industry. In conjunction with sensor scaling down and precision agriculture, the field of remote sensor networks, such as the wireless sensor network (WSN), was developed. Its major purpose is to make horticultural operations simpler to identify, assess, and manage. This paper uses the proposed DCNN to predict soil moisture and plan irrigation for precision agriculture farmers to reduce water consumption used for cultivation and increase production yield by comparing water content during various stages of plant growth and integrating IoT applications into agriculture. It also optimizes the water level for future irrigation decisions to maintain crop growth and water stability. The data must be served and stored in the form of a grid view, according to Apriori and GRU (gated recurrent unit). Using numerous sensor and parameter modelling methodologies, this system assists in the prediction of irrigation planning based on irrigation needs. The predicted parameters include soil moisture, temperature, and humidity. This observed experimental data supports smart irrigation in crop production with a high yield and little water use. DCNN has a 98.5% experimental result accuracy rate and the MSE value is predicted in DCNN 99.25% of the time.

PMID:36271063 | DOI:10.1007/s10661-022-10529-3