Nevin Manimala

Mol Imaging Biol. 2022 Jun 14. doi: 10.1007/s11307-022-01745-x. Online ahead of print.

ABSTRACT

PURPOSE: In Lewy body diseases (LBD), various symptoms occur depending on the distribution of Lewy body in the brain, and the findings of brain perfusion and dopamine transporter single-photon emission computed tomography (DAT-SPECT) also change accordingly. We aimed to evaluate the correlation between brain perfusion SPECT and quantitative indices calculated from DAT-SPECT in patients with LBD.

PROCEDURES: We retrospectively enrolled 35 patients with LBD who underwent brain perfusion SPECT with N-isopropyl-p-[¹²³I] iodoamphetamine and DAT-SPECT with ¹²³I-ioflupane. Mini-mental state examination (MMSE) data were also collected from 19 patients. Quantitative indices (specific binding ratio [SBR], putamen-to-caudate ratio [PCR], and caudate-to-putamen ratio [CPR]) were calculated using DAT-SPECT. These data were analysed by the statistical parametric mapping procedure.

RESULTS: In patients with LBD, decreased PCR index correlated with hypoperfusion in the brainstem (medulla oblongata and midbrain) (uncorrected p < 0.001, k > 100), while decreased CPR index correlated with hypoperfusion in the right temporoparietal cortex (family-wise error corrected p < 0.05), right precuneus (uncorrected p < 0.001, k > 100), and bilateral temporal cortex (uncorrected p < 0.001, k > 100). However, there was no significant correlation between decreased SBR index and brain perfusion. Additionally, the MMSE score was correlated with hypoperfusion in the left temporoparietal cortex (uncorrected p < 0.001).

CONCLUSIONS: This study suggests that regional changes in striatal ¹²³I-ioflupane accumulation on DAT-SPECT are related to brain perfusion changes in patients with LBD.

PMID:35701723 | DOI:10.1007/s11307-022-01745-x

Hepatol Int. 2022 Jun 14. doi: 10.1007/s12072-022-10362-3. Online ahead of print.

ABSTRACT

BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed definition of fatty liver disease (FLD) independent of excessive alcohol consumption (EAC) and hepatitis viral infection. Evidence on the mortality risk in different types of FLD [nonalcoholic FLD (NAFLD), alcoholic FLD (AFLD), and MAFLD] is sparse, hindering the identification of high-risk populations for preferential clinical surveillance.

METHODS: A total of 11,000 participants in the Third National Health and Nutrition Examination Survey were enrolled. Participants were categorized into three groups [FLD( – ), MAFLD( – ), and MAFLD( +)] according to FLD and MAFLD criteria, and further categorized into six groups by EAC. Multivariate Cox proportional hazard model was used to estimate the risk of all-cause, cardiovascular-related, and cancer-related mortality.

RESULTS: During a median follow-up of 23.2 years, a total of 3240 deaths were identified. Compared with FLD( – )/EAC( – ) participants, MAFLD( +) individuals had higher all-cause mortality risk [hazard ratio (HR) = 1.28, 95% confidence interval (CI) = 1.18-1.39] regardless of EAC status [MAFLD( +)/NAFLD: HR = 1.22, 95%CI = 1.11-1.34; MAFLD( +)/AFLD: HR = 1.83, 95%CI = 1.46-2.28], while not for MAFLD( – ) individuals. Furthermore, diabetes-driven-MAFLD had higher mortality risk (HR = 2.00, 95%CI = 1.77-2.27) followed by metabolic dysregulation-driven-MAFLD (HR = 1.30, 95%CI = 1.06-1.60) and overweight/obesity-driven-MAFLD (HR = 1.11, 95%CI = 1.00-1.22). Additionally, MAFLD( – ) participants with elevated fibrosis score were also associated with statistically significantly higher mortality risk (HR = 3.23, 95%CI = 1.63-6.40).

CONCLUSIONS: Utilizing a representative sample of the US population, we proved the validity of MAFLD subtype and fibrosis score, rather than the traditional definition (NAFLD and AFLD), in the risk stratification of FLD patients. These findings may be applied to guide the determination of surveillance options for FLD patients.

PMID:35701716 | DOI:10.1007/s12072-022-10362-3

Environ Sci Pollut Res Int. 2022 Jun 15. doi: 10.1007/s11356-022-21173-2. Online ahead of print.

ABSTRACT

There has been a disparity in familiarity regarding the public interest in gastroenterology terminologies during the COVID-19 pandemic. This study aimed to understand the outcomes of the public’s view on gastrointestinal topics and their potential social effects. This study is a comparative analysis of American Google Trends gastrointestinal terminology during the COVID-19 pandemic compared to a similar time frame (March 2018-February 2020) to determine how trends in the patient-seeking behavior of gastrointestinal terminology changed throughout the pandemic. The analysis discovered a substantial decrease in search volumes of gastrointestinal topics, more significantly in the first pandemic months. Later in the pandemic, search volumes trended toward pre-pandemic years in terms of public interest. In the case of gastrointestinal procedures, endoscopy and colonoscopies, they surpassed pre-pandemic interest levels statistically (p-values of 0.01 and 0.002). The public’s decreased interest in gastrointestinal topics at the beginning of the COVID-19 pandemic may have adverse effects on the healthcare maintenance of patients who could have had a positive outcome in their gastrointestinal health with proper monitoring. Although gastrointestinal internet searches increased toward pre-pandemic levels as the seasons progressed, further research is needed to determine the social impact of decreased public interest.

PMID:35701702 | DOI:10.1007/s11356-022-21173-2

Dysphagia. 2022 Jun 14. doi: 10.1007/s00455-022-10466-w. Online ahead of print.

ABSTRACT

Bedside dysphagia assessment protocols are not well developed in acute pediatric stroke unlike adults. The objective of this study was to identify items deemed relevant and feasible by expert consensus to inform the development of a bedside dysphagia screening tool for acute pediatric stroke. A two-phase study was conducted: (1) literature review and expert consultation generated a comprehensive list of dysphagia assessment items; (2) items were formatted in an online survey asking respondents opinion of relevance to acute pediatric stroke and feasibility for bedside administration by a trained health professional. The Dillman Tailored Design approach optimized response rate. Respondents were identified using the snowball method. Speech-language pathologists with > 2 years in pediatric dysphagia were invited to complete the survey. Demographic and practice variables were compared using univariate statistics. Item relevance and feasibility were made using binary or ordinal responses, combined to derive item-content validity indices (I-CVI) to guide item reduction. Items with I-CVI > 0.78 (excellent content validity) were moved forward to tool development. Of the 71 invited respondents, 57(80.3%) responded, of which 34(59.6%) were from North America. Sixty-one items were generated of which 4(6.6%) items were rated ‘to keep’. These were face symmetry (I-CVI:0.89), salivary control (I-CVI:0.95), alertness (I-CVI:0.89) and choking (I-CVI:0.84). Of all respondents, 31(54.4%) endorsed swallowing trials, of which 25(80.6%) endorsed thin liquid by teaspoon (n = 17, 68%) or open cup (n = 20, 80%). We identified candidate items for bedside dysphagia screening with excellent content validity for acute pediatric stroke patients. Next steps include assessment of the psychometric value of each item in identifying dysphagia in children in the acute stage of recovery from stroke.

PMID:35701690 | DOI:10.1007/s00455-022-10466-w

Radiol Med. 2022 Jun 14. doi: 10.1007/s11547-022-01508-2. Online ahead of print.

ABSTRACT

PURPOSE: To evaluate efficacy and safety of radiofrequency ablation (RFA) and microwave ablation (MWA) in unresectable lung malignancies.

METHODS: Data regarding patients with primary and secondary lung tumors treated with RFA or MWA from 2008 to 2020 were reviewed retrospectively. Primary study objectives such as technical success, primary and secondary technique efficacy rates, local tumor progression (LTP) rate, LPT-free survival (LPTFS) and overall survival (OS) were assessed. Secondary study objectives were side effects and complications. RFA and MWA were compared using the Chi-square test for continuous variables. Kaplan-Meier curves were calculated for survival statistical analysis.

RESULTS: A total of 113 patients with primary or secondary lung tumor underwent 74 RFA (48%) and 81 MWA (52%). Technical success rate was 151/155 (97%); primary and secondary technique efficacy rates were 123/155 (79%) and 129/155 (83%), respectively. During the entire study follow-up, 32 cases experienced disease progression (20%), of which 18 underwent repeat ablation (12%), in 6 cases with success (4%). Residual unablated tumor happened in 4/155 cases (3%). LTP occurred in 28/155 cases (17%). The only factor associated with poorer LTP-FS was lesion diameter ≥ 30 mm (P < 0.05). One-, 3- and 5-years LTP-FS was 83%, 82%, 82%, respectively. One-, 3- and 5-years OS of the entire population was 87%, 74%, 73%, respectively. Minor and major complication rates were 53/155 (34%) and 29/155 (19%), respectively.

CONCLUSIONS: In conclusion, this study confirms the appropriateness of RFA and MWA for lung tumors treatment, in terms of safety and efficacy.

PMID:35701683 | DOI:10.1007/s11547-022-01508-2

Acta Odontol Latinoam. 2022 Apr 30;35(1):67-73. doi: 10.54589/aol.35/1/67.

ABSTRACT

The aim of this study was to determine color change after accelerated artificial ageing (AAA) of different composite cements that are used with veneers. Five cylindrical test specimens, 15 mm in diameter and 2 mm thick, were made from a single layer of each of the following: RelyX Veneer 3M ESPE (RX), Paracore White Coltene (PC), Solocem White Opaque Coltene (SO), Resin Duo Cement Densell (DC), Panavia V5 Paste Kuraray Noritake (PA) and Panavia F2.0 Kuraray Noritake (PF) (30 specimens altogether). The specimens were light cured following manufacturers’ instructions using a Coltolux LED (Coltene) unit. Initial color was determined using an Easyshade – Vita Zahnfabrik Spectrophotometer. Then, the specimens were subjected to AAA for two weeks (336 hours) with cycles of 4 hours of UV light at 60 °C and 4 hours of vapor condensation at 50 °C, successively, after which color was recorded again. Color change was determined for each specimen according to the differenceinshadeon the Vita scale before and after AAA. Results were analyzed using Kruskal Wallis test. Mean and standard deviation for each group were: RX 8.40 (1.52); PC 8.60 (3.13); SO 6.40 (3.51); DC 10.00 (0.00); PA 7.60 (3.29); PF 2.00 (0.00). The Kruskal Wallis test showed significant difference for material (p<0.05), and comparison of means showed difference between Panavia F2.0 and the other materials. A table providing equivalence between the Vita Classic and CIELAB scales was used to transfer the recorded colors to the CIELAB scale, and the color difference ΔE was calculated for each group, where ΔL, Δa and Δb are the differences in the L, a and b values before and after the AAA. The mean and standard deviation were analyzed statistically by the ANOVA test and Tukey’s test. Mean and standard deviation for each group were: RX 14.94 (2.02); PC 14.51 (4.02); SO 12.08 (4.53); DC 16.31 (0.00); PA 10.9 (3.38); PF 7.24 (0.00). The ANOVA test showed significantdifferenceformaterial (p<0.05). Tukey’s test showed two groups (PF-DC, RX, PA). Under the experimental conditions of this study, it can be concluded that accelerated ageing significantly affects the color stability of the resin based cements tested.

PMID:35700544 | DOI:10.54589/aol.35/1/67

Acta Odontol Latinoam. 2022 Apr 30;35(1):31-38. doi: 10.54589/aol.35/1/31.

ABSTRACT

The aim of this study was to test two low-level laser therapy protocols by evaluating pain control, swelling and trismus in the postoperative period of lower third molar surgeries. This was a randomized, double-blind, placebo-controlled, crossover trial. Patients presenting two symmetrically impacted mandibular third molars were included. One side was randomly assigned for LLLT applied immediately after surgery (T1) and then after 24 (T2) and 48 hours (T3) (Protocol A). The other side received LLLT applied immediately after surgery and placebo after 24 and 48 hours (Protocol B). LLLT was given by intraoral application (660nm, 5 J/cm2, 10 s, 20 mW, 4 points) followed by extraoral application (789 nm, 30 J/cm2, 20 s, 60 mW, 8 points). The placebo application was similar to that of the experimental side but with laser simulation. The primary outcomes were pain control, swelling and trismus intensity at T1, T2, T3 and 7 days after surgery (T4). Data were analyzedbyANOVArepeated measures and Wilcoxon test (p<.05). The final sample consisted of 21 patients (42 teeth). There were no statistical differences for pain level between protocols A and B over time (p= .909), although the amount of analgesic medication was lower with protocol A at T2 (p=.022). There were no differences in swelling (p=.958) or trismus (p=.837) between the protocols used over time. Both protocols performed similarly for pain control, swelling and trismus. Therefore, for practical reasons, a single laser application in the immediate postoperative period could be indicated for the management of postoperative discomfort in lower third molar surgery.

PMID:35700539 | DOI:10.54589/aol.35/1/31

Phys Chem Chem Phys. 2022 Jun 14. doi: 10.1039/d2cp01725c. Online ahead of print.

ABSTRACT

Every practical method to solve the Schrödinger equation for interacting many-particle systems introduces approximations. Such methods are therefore plagued by systematic errors. For computational chemistry, it is decisive to quantify the specific error for some system under consideration. Traditionally, the primary way for such an error assessment has been benchmarking data, usually taken from the literature. However, their transferability to a specific molecular system, and hence, the reliability of the traditional approach always remains uncertain to some degree. In this communication, we elaborate on the shortcomings of this traditional way of static benchmarking by exploiting statistical analyses using one of the largest quantum chemical benchmark sets available. We demonstrate the uncertainty of error estimates in the light of the choice of reference data selected for a benchmark study. To alleviate the issues with static benchmarks, we advocate to rely instead on a rolling and system-focused approach for rigorously quantifying the uncertainty of a quantum chemical result.

PMID:35700515 | DOI:10.1039/d2cp01725c

Med Sci Sports Exerc. 2022 Jun 11. doi: 10.1249/MSS.0000000000002969. Online ahead of print.

ABSTRACT

PURPOSE: Greater articular cartilage T1ρ magnetic resonance imaging relaxation times indicate less proteoglycan density and are linked to posttraumatic osteoarthritis development following anterior cruciate ligament reconstruction (ACLR). While changes in T1ρ relaxation times are associated with gait biomechanics, it is unclear if excessive or insufficient knee joint loading is linked to greater T1ρ relaxation times 12 months post-ACLR. The purpose of this study was to compare external knee adduction (KAM) and flexion (KFM) moments in individuals after ACLR with high vs. low tibiofemoral T1ρ relaxation profiles and uninjured controls.

METHODS: Gait biomechanics were collected in 26 uninjured controls (50% females, age 22 ± 4 yrs., BMI 23.9 ± 2.8 kg/m2) and 26 individuals after ACLR (50% females, age 22 ± 4 yrs., BMI 24.2 ± 3.5 kg/m2) at 6 and 12 months post-ACLR. ACLR-T1ρHigh (n = 9) and ACLR-T1ρLow (n = 17) groups were created based on 12-month post-ACLR T1ρ relaxation times using a k-means cluster analysis. Functional analyses of variance were used to compare KAM and KFM.

RESULTS: ACLR-T1ρHigh exhibited lesser KAM than ACLR-T1ρLow and Uninjured Controls 6 months post-ACLR. ACLR-T1ρLow exhibited greater KAM than Uninjured Controls 6 and 12 months post-ACLR. KAM increased in ACLR-T1ρHigh and decreased in ACLR-T1ρLow between 6-12 months, both groups becoming more similar to Uninjured Controls. There were scant differences in KFM between ACLR-T1ρHigh and ACLR-T1ρLow 6 or 12 months post-ACLR, but both groups demonstrated lesser KFM compared to Uninjured Controls.

CONCLUSIONS: Associations between worse T1ρ profiles and increases in KAM may be driven by the normalization of KAM in individuals who initially exhibit insufficient KAM 6-months post-ACLR.

PMID:35700436 | DOI:10.1249/MSS.0000000000002969

Med Sci Sports Exerc. 2022 Jun 11. doi: 10.1249/MSS.0000000000002971. Online ahead of print.

ABSTRACT

PURPOSE: The magnitude and location of hip contact force influences the local mechanical environment of the articular tissue, driving remodelling. We used a neuromusculoskeletal model to investigate hip contact force magnitudes and their regional loading patterns on the articular surfaces in those with femoroacetabular impingement (FAI) syndrome and controls during walking.

METHODS: An EMG-assisted neuromusculoskeletal model was used to estimate hip contact forces in eligible participants with FAI syndrome (n = 41) and controls (n = 24), walking at self-selected speed. Hip contact forces were used to determine the average and spread of regional loading for femoral and acetabular articular surfaces. Hip contact force magnitude and region of loading were compared between groups using statistical parametric mapping and independent t-tests, respectively (p < 0.05).

RESULTS: All the following report comparisons with controls. Those with FAI syndrome walked with lower magnitude hip contact forces (mean difference -0.7 N·BW-1, p < 0.001) during first and second halves of stance, and with lower anteroposterior, vertical and mediolateral contact force vector components. Participants with FAI syndrome also had less between-participant variation in average regional loading which was located more anteriorly (3.8°, p = 0.035) and laterally (2.2°, p = 0.01) on the acetabulum but more posteriorly (-4.8°, p = 0.01) on the femoral head. Participants with FAI syndrome had a smaller spread of regional loading across both the acetabulum (-1.9 mm, p = 0.049) and femoral head (1 mm, p < 0.001) during stance.

CONCLUSIONS: Compared with controls, participants with FAI syndrome walked with lower magnitude hip contact forces that were constrained to smaller regions on the acetabulum and femoral head. Differences in regional loading patterns might contribute to the mechanobiological processes driving cartilage maladaptation in those with FAI syndrome.

PMID:35700435 | DOI:10.1249/MSS.0000000000002971