Nevin Manimala

BMC Neurol. 2022 Sep 22;22(1):360. doi: 10.1186/s12883-022-02876-y.

ABSTRACT

BACKGROUND AND AIM: Stroke patients face various challenges that affect their self-efficacy. The purpose of this study is to evaluate the effect of a self-management program on the self-efficacy of patients with Stroke.

METHODS AND MATERIALS: This study is a clinical trial, in which 72 patients with stroke participated in this study. They were selected based on the convenience sampling method and assigned to either intervention or control group (36 patients in each group) randomly. The intervention group received 5A based self-management program for 6 weeks (in-person and off-site) and the control group received only routine care includes stroke training booklets and post-discharge care training by the ward nurse. Data were collected through demographic and jones self-efficacy questionnaires, before, immediately after, and 3 months after interventions in both groups and were analyzed with descriptive and analytical statistics using SPSS software (with independent t-test, Chi-square, Fisher and analysis of variance with repeated measures with a significance level of 0.05).

RESULTS: Before interventions, the two study groups had no statistically significant difference regarding demographic variables and the mean score of self-efficacy. Immediately and 3 months after interventions, the mean score and mean changes of self-efficacy score in the intervention group were significantly greater than in the control group(p < 0.001).

CONCLUSION: The results of the present study show the appropriate effect of self-management program on self-efficacy of stroke patients. These results can be used by different members of healthcare teams to improve patients’ self-efficacy.

TRIAL REGISTRATION: This study is registered by Iranian Registry of Clinical Trials with decree code: IRCT20190712044181N2 (registration date: 05-11-2019).

PMID:36138361 | DOI:10.1186/s12883-022-02876-y

BMC Public Health. 2022 Sep 22;22(1):1804. doi: 10.1186/s12889-022-14113-9.

ABSTRACT

BACKGROUND: Women living with HIV (WLWH) experience numerous social and structural barriers to stable housing, with substantial implications for access to health care services. This study is the first to apply the Canadian Definition of Homelessness (CDOH), an inclusive national guideline, to investigate the prevalence and correlates of housing status among WLWH in Metro Vancouver, Canada.

METHODS: Our study utilized data from a longitudinal open cohort of cisgender and trans WLWH aged 14 years and older, in 2010-2019. Cross-sectional descriptive statistics of the prevalence of housing status and other social and structural variables were summarized for the baseline visits. Bivariate and multivariable logistic regression analyses were conducted using generalized linear mixed models (GLMM) for repeated measures to investigate the relationship between social and structural correlates and housing status among WLWH.

RESULTS: The study included 336 participants with 1930 observations over 9 years. Housing status derived from CDOH included four categories: unsheltered, unstable, supportive housing, and stable housing (reference). Evidence suggested high levels of precarious housing, with 24% of participants reporting being unsheltered, 47% reporting unstable housing, 11.9% reporting supportive housing, and 16.4% reporting stable housing in the last six months at baseline. According to the multivariable models, living in the Downtown Eastside (DTES) neighbourhood of Metro Vancouver, hospitalization, physical/sexual violence, and stimulant use were associated with being unsheltered, compared to stable housing; DTES residence, hospitalization, and physical/sexual violence were associated with unstable housing; DTES residence and stimulant use were associated with living in supportive housing.

CONCLUSION: Complex social-structural inequities are associated with housing instability among WLWH. In addition to meeting basic needs for living, to facilitate access to housing among WLWH, housing options that are gender-responsive and gender-inclusive and include trauma- and violence-informed principles, low-barrier requirements, and strong connections with supportive harm reduction services are critical.

PMID:36138356 | DOI:10.1186/s12889-022-14113-9

BMC Neurol. 2022 Sep 22;22(1):367. doi: 10.1186/s12883-022-02899-5.

ABSTRACT

BACKGROUND: A thorough understanding of the factors that influence patient survival in Parkinson’s disease (PD) will aid in prognosis prediction and provide a new direction for disease modification treatment. Currently, there are no standardized mortality ratio (SMR) data for PD patients in the northern Chinese mainland. The main focus of this study was to determine which factors in the prospectively collected baseline characteristics can affect the survival of PD patients. In addition, for the first time, we investigated the SMR of PD patients in northern China.

METHODS: Between 2009 and 2012, 218 PD patients were continuously recruited from the movement disorder clinic of the First Affiliated Hospital of Dalian Medical University and followed up until death or May 31, 2021. The prespecified prognostic variables were demographics, clinical features, lifestyle factors, and drug dose prospectively collected at baseline. To determine the independent predictors of survival during follow-up, the Cox proportional hazards model was used. Kaplan-Meier analysis was applied to estimate the overall survival curve and to compare survival between layers based on statistically significant predictors. The SMR of this northern Chinese mainland PD cohort was calculated.

RESULTS: After a mean follow-up of 9.58 ± 2.27 years, 50 patients (22.90%) died. Factors that could individually predict shortened survival during follow-up included older age at onset (hazard ratio [HR] 1.10, 95% confidence interval [CI] 1.06-1.15), Hoehn and Yahr (H&Y) stage ≥ 3 (HR 9.36, 95% CI 2.82-31.03) and severe cognitive impairment (HR 6.18, 95% CI 2.75-13.88). Univariate Cox regression revealed that a certain amount of physical activity was associated with better survival (HR 0.41, 95% CI 0.22-0.74), while fatigue was associated with an increased risk of death (HR 2.54, 95% CI 1.37-4.70). The overall SMR was 1.32 (95% CI 0.98-1.74).

CONCLUSIONS: Older age at onset, higher baseline H&Y stage, and severe cognitive impairment have a negative impact on survival. The 10-year survival of PD patients is not significantly different from that of the general population in China.

PMID:36138355 | DOI:10.1186/s12883-022-02899-5

BMC Oral Health. 2022 Sep 22;22(1):421. doi: 10.1186/s12903-022-02442-5.

ABSTRACT

BACKGROUND: A change in how a dentist looks may affect the child’s anxiety in the dental office. This study compared the effect of conventional facial PPE versus extra PPE as reusable respirators; on the preoperative child’s anxiety in the dental office.

METHODS: Fifty two children were randomly allocated into 4 groups, (1) goggles + surgical mask, and (2) face shield + surgical mask versus (3) half-face respirator and (4) full-face respirator. Each child was communicated with and clinically examined by a dentist wearing the assigned PPE, and then his anxiety was assessed using CFSS-DS. Shapiro-Wilk’s test was used to analyse normality. Kruskal-Wallis test followed by Dunn’s post hoc test with Bonferroni correction test, were used to analyse non-parametric anxiety score data. Correlations between different factors and anxiety scores were analysed using Spearman’s rank-order correlation coefficient.

RESULTS: There were no statistically significant differences in the number of anxious children in each group, boys had significantly higher scores than girls (p < 0.001) For the “Goggles and surgical mask” group and “overall”. There was no significant correlation between age and anxiety scores. Children who didn’t have a previous dental visit had statistically significant higher scores than children with previous experience for “Goggles and surgical mask”, “Face shield and surgical mask “groups and “overall”.

CONCLUSIONS: Half-face and full-face respirators have not affected the child’s preoperative anxiety in the dental office when compared to the conventionally used PPE. Overall, there is an association between gender and previous dental visits, and dental anxiety, however; there is no correlation between child’s age and dental anxiety. Dentists dealing with children should feel free to use reusable respirators, without the risk of affecting children’s anxiety in the dental office. Trial Registration This study was registered on www.

CLINICALTRIALS: gov , ID: NCT05371561 on 12/05/2022.

PMID:36138354 | DOI:10.1186/s12903-022-02442-5

BMC Nephrol. 2022 Sep 23;23(1):319. doi: 10.1186/s12882-022-02942-0.

ABSTRACT

BACKGROUND: Sarcopenia is associated with various adverse outcomes in hemodialysis patients. However, current tools for assessing and diagnosing sarcopenia have limited applicability. In this study, we aimed to develop a simple and reliable nomogram to predict the risk of sarcopenia in hemodialysis patients that could assist physicians identify high-risk patients early.

METHODS: A total of 615 patients undergoing hemodialysis at the First Affiliated Hospital College of Medicine Zhejiang University between March to June 2021 were included. They were randomly divided into either the development cohort (n = 369) or the validation cohort (n = 246). Multivariable logistic regression analysis was used to screen statistically significant variables for constructing the risk prediction nomogram for Sarcopenia. The line plots were drawn to evaluate the effectiveness of the nomogram in three aspects, namely differentiation, calibration, and clinical net benefit, and were further validated by the Bootstrap method.

RESULTS: The study finally included five clinical factors to construct the nomogram, including age, C-reactive protein, serum phosphorus, body mass index, and mid-upper arm muscle circumference, and constructed a nomogram. The area under the ROC curve of the line chart model was 0.869, with a sensitivity and specificity of 77% sensitivity and 83%, the Youden index was 0.60, and the internal verification C-statistic was 0.783.

CONCLUSIONS: This study developed and validated a nomogram model to predict the risk of sarcopenia in hemodialysis patients, which can be used for early identification and timely intervention in high-risk groups.

PMID:36138351 | DOI:10.1186/s12882-022-02942-0

AMB Express. 2022 Sep 22;12(1):124. doi: 10.1186/s13568-022-01464-0.

ABSTRACT

Design of experiment (DOE) is a statistical approach for designing, performing, and interpreting a large set of data with the minimum number of tests. In our previous study, we developed a novel Hsp27 SILEX system for production of recombinant proteins. In the present study, we optimized indirectly the most effective factors including inoculation load, self-induction temperature, and culture media on autoinduction of staphylokinase (SAK) expression using RSM methodology and fluorometry. The expression level of SAK was assayed at different runs after 6 h incubation at 90 rpm. The results indicated all parameters significantly affect the SAK expression level (p < 0.05). The optimum expression condition was obtained with an inoculation load of 0.05, a temperature of 25 °C, and TB culture medium. The analysis of variance with a R² value of 0.91 showed that a quadratic model well described this prediction (p < 0.05). Applying the optimized condition led to an approximately fourfold increase in the SAK expression level (from 1.3 to 5.2 µg/ml). Moreover, the recombinant protein was purified using immobilized metal affinity chromatography and the activity was also confirmed by semi-quantitative caseinolytic method.

PMID:36138332 | DOI:10.1186/s13568-022-01464-0

J Patient Rep Outcomes. 2022 Sep 23;6(1):100. doi: 10.1186/s41687-022-00508-0.

ABSTRACT

BACKGROUND: The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale has demonstrated good internal consistency and responsiveness to changes in clinical status among patients with ankylosing spondylitis (AS). We aimed to further evaluate the psychometric properties of the FACIT-F scale in adult patients with AS.

METHODS: Measurement properties of the FACIT-F scale were evaluated using data from tofacitinib phase 2/3 (NCT01786668/NCT03502616) studies in adult patients with active AS.

RESULTS: Second-order confirmatory factor modeling supported the measurement structure of the FACIT-F scale (Bentler’s comparative fit index ≥ 0.91), and FACIT-F demonstrated excellent internal consistency (Cronbach’s coefficient α ≥ 0.88) and test-retest reliability (Intraclass Correlation Coefficient ≥ 0.75). Correlation coefficients between FACIT-F and other patient-reported outcomes generally exceeded 0.40, supporting convergent validity. Meaningful within-patient change was estimated as 3.1-6.3 for FACIT-F total score, and 1.4-2.8 and 1.7-3.6 for FACIT-F Experience and Impact domain scores, respectively. Large (effect size ≥ 1.17 standard deviation units), statistically significant differences in FACIT-F domain/total scores between ‘no disease activity’ (Patient Global Assessment of Disease Activity [PtGA] = 0) and ‘very active disease’ (PtGA = 10) patient groups supported known-groups validity. Ability to detect change was evidenced by an approximately linear relationship between changes in FACIT-F and PtGA scores.

CONCLUSIONS: FACIT-F is a reliable and valid measure for evaluating fatigue in adult patients with active AS.

TRIAL REGISTRATION: ClinicalTrials.gov; NCT01786668 (registered 6 February 2013, https://clinicaltrials.gov/ct2/show/NCT01786668 ) and NCT03502616 (registered 11 April 2018, https://clinicaltrials.gov/ct2/show/NCT03502616 ).

PMID:36138330 | DOI:10.1186/s41687-022-00508-0

Vet Med Sci. 2022 Sep 22. doi: 10.1002/vms3.945. Online ahead of print.

ABSTRACT

To investigate the potential intraocular pressure (IOP)-lowering effects of nitric oxide (NO)-donating compounds in healthy canine eyes METHODS: A total of 79 dogs were divided into 3 groups in a masked, controlled and randomised study. Group N (n = 26) was administered 0.03% nitroglycerin in one eye and vehicle-control in the other, Group H (n = 26) was administered 0.1% hydralazine in one eye and vehicle-control in the other, while Group C (n = 27) received vehicle-control in both eyes (control group). Following eye drop administration, IOP was measured in both eyes at selected times (10-250 min), along with monitoring of heart rate and signs of ocular discomfort. Data was analysed with repeated measures mixed model and one-way ANOVA RESULTS: IOP was significantly reduced over the 4-h period with 0.03% nitroglycerin (p < 0.0001) but not 0.1% hydralazine (p = 0.520) when compared to contralateral vehicle-controlled eyes. IOP was reduced by up to 12% with 0.03% nitroglycerin from 10 to 70 min post-treatment; however, differences in IOP at individual time points were not statistically significant for either drug (p ≥ 0.133) as compared to contralateral vehicle-control eyes. No treatment group significantly affected heart rate (compared to Group C), and both treatment groups appeared well tolerated CONCLUSIONS: Both compounds were well-tolerated in healthy dogs. Nitroglycerin mildly reduced IOP in canine eyes, and further investigations are warranted in healthy and diseased states (e.g. glaucoma, ocular hypertension).

PMID:36137290 | DOI:10.1002/vms3.945

PLoS One. 2022 Sep 22;17(9):e0274694. doi: 10.1371/journal.pone.0274694. eCollection 2022.

ABSTRACT

The two studies presented in this paper concern the Italian epistemic marker mi sa [lit. to me it knows], which seems to have no equivalent in other European languages and has received very little attention in the literature. No analysis of the occurrences of mi sa in contemporary spoken corpora can be found (first gap) as well as no investigation on the epistemic relationship between mi sa and (1) the other modal expressions that use the verb sapere [to know] in the first person singular of the simple present, i.e., so [I know], non so [I do not know], non so se [I do not know whether] as well as (2) its supposed synonyms credo [I believe] and penso [I think] (second gap). The two studies are closely intertwined, the first being an exploratory, qualitative pilot study for the second. Study 1 aims to fill the first gap through the analysis of the contemporary Italian spoken corpus KIParla. The quantitative and qualitative analyses revealed five types of occurrences (theoretically reducible to two main ones), the most numerous of which are ‘mi sa che + proposition’. Study 2 aims to fill the second gap through a questionnaire administered online. The quantitative and statistical results showed the epistemic relationships between the six markers: for the majority of the participants, in the epistemic continuum that goes from unknowledge to uncertainty and then to knowledge, (1) non so refers to unknowledge; non so se, mi sa, credo and penso refer to uncertainty; so refers to knowledge; (2) mi sa, credo, penso confirm to be synonyms; (3) non so se is evaluated as much more uncertain than mi sa, credo, penso. These four epistemic markers seem to occupy a different position along the uncertainty continuum ranging between two poles: doubt (high uncertainty) and belief (low uncertainty).

PMID:36137275 | DOI:10.1371/journal.pone.0274694

J Homosex. 2022 Sep 22:1-24. doi: 10.1080/00918369.2022.2122361. Online ahead of print.

ABSTRACT

This study aims to analyze cultural competence through the knowledge and attitudes regarding LGBT people held by the students of social work at two universities in southern Spain (N = 512). An ex post facto correlational study has been conducted. The Sex Education and Knowledge about Homosexuality Questionnaire, the Modern Homonegativity Scale and the Negative Attitudes toward Transgender People Scale have been applied to gather information. Data analysis was carried out using frequencies, descriptive statistics, correlations and inferential statistics. The findings show that men, religious, and politically conservative people reported higher levels of homonegative and transphobic attitudes than women, non-religious and politically more liberal people. There is also a lack of specific knowledge on the reality of and specific legislation regarding LGBT people. There is a need to continue to examine and to progress in the training of future social workers in cultural competence, incorporating the contributions of feminist theory.

PMID:36137263 | DOI:10.1080/00918369.2022.2122361