Nevin Manimala

Acta Orthop Belg. 2022 Jun;88(2):335-341. doi: 10.52628/88.2.8383.

ABSTRACT

Perioperative intravenous (IV) TA has become routine in knee and hip arthroplasty. Less evidence exists on the administration of oral TA in the post- operative period. Our study aims to identify the efficacy and safety of combined perioperative IV and post-operative oral TA on blood loss and Hemoglobin (Hb) drop compared to perioperative IV TA alone. Patients undergoing primary elective knee arthro- plasty at our institution were invited to participate in the study (n=50). A computer-generated randomisation sequence was created online (www.randomization. org), with an allocation ratio of 1:1 and a block size of 50. Group A received perioperative IV TA alone and post-operative oral TA (n= 26) and Group B received perioperative IV TA plus 48 hours additional oral placebo (n= 24). Day 3 total blood loss and Hb drop was calculated. Continuous, normally distributed data (total blood loss) was compared utilising using one-way analysis of variance with post hoc Tukey test. Continuous skewed data (Hb drop) was compared using the Kruskal-Wallis test. P <0.05 was considered statistically significant. Group A demonstrated a trend in decreased total blood loss that was close to statistical significance ( p = 0.072). No difference in Hb drop was identified between the 2 groups. Increased nausea was also observed in Group A. The administration of oral TA to post-operative knee arthroplasty patients does not improve further blood loss compared to patients receiving perioperative IV TA pre-operatively and at wound closure.

PMID:36001840 | DOI:10.52628/88.2.8383

Acta Orthop Belg. 2022 Jun;88(2):329-334. doi: 10.52628/88.2.10276.

ABSTRACT

Fixed flexion deformity also called flexion contracture is relatively rare, but a very demanding functional limitation that both surgeons and patients may have to deal with. The purpose of the present study was to evaluate the functional outcomes after posteromedial capsular release in case of fixed flexed deformity > 15 o . Between June 2011 and November 2018, 15 patients (6 males and 9 females) were treated with open posterior capsular release through medial approach for fixed flexion deformity of the knee > 15 o and prospectively followed with a minimum follow-up of 2 years. Primary outcome was knee extension measured with a manual goniometer and secondary outcome treatment related complications. All patients reported inability to walk and clinical semiology of pain and swelling. The mean age of the study population at surgery was 61.7 years with a mean BMI of 30.9 kg/m2. Complete data were recorded for all patients. Statistically significant improvement was found in clinical and functional assessment tools analyzed from baseline to the latest follow-up (p<0.05). More precisely, the mean postoperative fixed flexion deformity was decreased from 23.57 o to 2.86 o . No adverse effect or major complications were recorded during follow-up. Posterior open release via posteromedial was shown to be an efficient and safe salvage procedure to deal with persistent fixed flexion deformity of more than 15 o following TKA at two years follow-up. However, future studies with a higher number of participants and longer follow-up should be conducted to validate our data.

PMID:36001839 | DOI:10.52628/88.2.10276

Acta Orthop Belg. 2022 Jun;88(2):319-327. doi: 10.52628/88.2.9002.

ABSTRACT

In older patients with highly comminuted intra- articular tibial plateau fractures (TPFs), primary total knee arthroplasty (TKA) may be a treatment option. Our aim was to report and rank decisional factors considered by Dutch orthopaedic trauma and knee surgeons that may lead to the decision for TKA as treatment for TPFs. A survey was distributed among 141 experts on traumatology and arthroplasty of the knee. The survey assessed the likelihood of TKA surgery after TPF in various patient and radiological characteristics. The level of experience with this of each responder was also noted. Descriptive statistics were calculated for all items. 141 participants were approached and 68 responded (48.2%). Responders were not more likely to proceed with TKA based on fracture types, impaired mobility, multiple incisions for ORIF, body mass index and ASA classification. However, in patients with pre-existing osteoarthritis (OA) and age ≥ 80 a majority would be more likely to proceed with TKA, with respectively 69.1% and 50.0%. The most strongly considered factors were the presence of pre-existing OA, the age of the patient and the type of fracture, with respectively 55.9%, 51.4% and 42.6% of responders ranking it in their top three most important factors. The study showed that the presence of pre-existing symptomatic OA and age of the patient were valued highest and increased the probability of a TKA in acute TPFs.

PMID:36001838 | DOI:10.52628/88.2.9002

Acta Orthop Belg. 2022 Jun;88(2):285-291. doi: 10.52628/88.2.7727.

ABSTRACT

The aim of this retrospective study is to evaluate and compare the clinical and radiological results of the use of Zero-P implant and the integrated cage-plate implant in surgical treatment of single level cervical disc disease. It includes 54 consecutive patients who underwent single level anterior cervical discectomy and fusion. The patients were divided into 2 groups. Group (A) including 28 patients operated with zero- profile implant and group (B) including 26 patients operated with integrated cage-plate implant. Mean operative time, blood loss, incidence of dysphagia and any other complications related to the procedure were recorded and compared. Patients were assessed radiologically by measuring cervical lordosis using the Cobb angle and the segmental angle. Patients were assessed clinically by the Japanese orthopedic association score and the neck disability index. These values were also compared. The mean age of the patients in group (A) was 49.5±11 years, and in group (B) it was 49.8±11.6 years. Mean blood loss and operative time in group (A) were 77.3±9.4 ml and 72.1±7.9 minutes, while in group B, they were 80.7±9.5 ml and 74.8±8.4 minutes with no statistically significant difference between both groups. There were also no statistically significant difference between both groups as regards incidence of dysphagia, clinical scores nor radiological parameters. In conclusion, both zero-profile implant and integrated cage-plate implant have comparable satisfactory clinical and radiological results in treatment of single level cervical disc diseases with little complications.

PMID:36001834 | DOI:10.52628/88.2.7727

Acta Orthop Belg. 2022 Jun;88(2):217-221. doi: 10.52628/88.2.8784.

ABSTRACT

The aim of the study is to find the correlation between vitamin D level and the severity of slippage and bilateral development in slipped capital femoral epiphysis (SCFE) cases if any. Thirty-nine patients with moderate-severe stable SCFE were evaluated regarding their vitamin D level and to which extent the severity of vitamin D deficiency, if present, can be correlated with the severity and bilaterality of the slip. Vitamin D serum level was assessed pre- operatively for all patients. In case of deficiency, the patient underwent in situ pinning unless performed before his/her presentation. Alongside, he/she received a vitamin D course until correction prior to the definitive surgery (Imhäuser osteotomy with osteochondroplasty) 6-12 weeks after. Thereafter, osteotomy healing and physis closure were monitored radiologically. Results show that all patients but one had vitamin D deficiency, with an average of 14.39 ng/mL, necessitating vitamin D therapy before proceeding to the definitive surgery. No correlation existed between vitamin D level and Southwick angle severity with a p-value of 0.85. A negative correlation existed between vitamin D level and bilaterality, but not statistically significant (p-value 0.192). Patients’ osteotomy healing was uneventful, and physeal closure was achieved in all the cases that had in situ pinning. We conclude that the severity of Vitamin D deficiency could be linked to the bilateral development of SCFE but not the severity of slippage. Treatment of Vitamin D deficiency facilitates physeal closure.

PMID:36001825 | DOI:10.52628/88.2.8784

Am J Audiol. 2022 Aug 24:1-6. doi: 10.1044/2022_AJA-21-00241. Online ahead of print.

ABSTRACT

PURPOSE: Military service personnel are at increased risk for developing tinnitus due to heightened exposure to acoustic trauma. The auditory disorder is the leading service-connected disability among veterans and is highly comorbidly diagnosed with posttraumatic stress disorder (PTSD). The biopsychosocial model illustrates that chronic health conditions are exacerbated or maintained by psychiatric distress. Therefore, alleviation of such psychiatric distress can have beneficial impacts on health conditions, such as tinnitus. The aim of this study was to determine whether individuals with both disorders who receive evidence-based therapy for PTSD will experience decreases in both PTSD and tinnitus-related distress.

METHOD: Veterans with comorbid bothersome tinnitus and PTSD received cognitive processing therapy and were assessed for PTSD, tinnitus-related distress, and depression at baseline and 1 month posttreatment follow-up.

RESULTS: At posttreatment follow-up, participants demonstrated significant decreases in PTSD symptoms compared to their baseline scores. Participants also demonstrated decreased tinnitus-related distress and depression, with high effect sizes.

CONCLUSIONS: This pilot study demonstrated that clinical management addressing psychiatric distress, as associated with PTSD, may simultaneously provide benefit for patients with bothersome tinnitus. Although not statistically significant due to the small sample size, large effect sizes indicate that tinnitus-related distress decreased as a function of receiving evidence-based therapy for PTSD. Future clinical trials should increase sample sizes and compare effects to control conditions.

PMID:36001823 | DOI:10.1044/2022_AJA-21-00241

J Speech Lang Hear Res. 2022 Aug 24:1-22. doi: 10.1044/2022_JSLHR-21-00607. Online ahead of print.

ABSTRACT

PURPOSE: Systematic review and meta-analysis are regarded as standard and valuable tools for providing an objective and reproducible synthesis of research findings in the literature. Their increasing popularity has led to heightened expectations for comprehensiveness and rigor in conducting scientific reviews and analyses. The purpose of this tutorial is to provide an overview and guidance on how to address the key elements for conducting a high-quality systematic review with meta-analysis.

METHOD: This tutorial describes practical guidelines to conduct systematic review and meta-analysis for researchers who are interested in learning and applying the method. Drawing on previous meta-analytic reviews of second-language learning as illustrative examples, it discusses the methodological choices and judgment calls in each step of the review and analysis process. As a hands-on tutorial, it uses a published data set concerning the role of talker variability in speech training studies as a running example to elucidate the statistical process and interpret the results of meta-analysis with freely available R software.

RESULTS/CONCLUSIONS: This tutorial provides a walk-through of the methodological choices, controversial issues, and common practices in conducting systematic reviews and meta-analyses. The data set and R codes are offered as publicly accessible supplementary materials (https://osf.io/e9bkf/) for replication and practice, which we hope will motivate more applications in the speech, language, and hearing sciences field as well as behavioral and social sciences research in general.

PMID:36001816 | DOI:10.1044/2022_JSLHR-21-00607

Am J Speech Lang Pathol. 2022 Aug 24:1-9. doi: 10.1044/2022_AJSLP-21-00310. Online ahead of print.

ABSTRACT

PURPOSE: Patients undergoing cardiac surgery are reported to be at higher risk for oropharyngeal dysphagia and aspiration, which may predispose them to respiratory complications such as pneumonia. Speech-language pathology consultation facilitates early identification of swallowing difficulties providing appropriate and timely interventions during the postoperative period. This study explores the association between pneumonia and timing of speech-language pathology order entry and evaluation following cardiac surgery.

METHOD: A retrospective study was performed on adults who underwent cardiac surgery in a tertiary care center, from July 2016 through December 2019. Patients with preexisting tracheostomy upon admission for cardiac surgery were excluded. The medical records of patients who had speech-language pathology consultation orders for swallowing concerns were analyzed in order to compare the timing of speech-language pathology order entry, completion of speech-language pathology evaluation, and incidence of pneumonia during hospitalization following cardiac surgery.

RESULTS: During the study period, 3,168 patients underwent cardiac surgery, of which 2,864 patients met the inclusion criteria. Speech-language pathology was ordered for 473 cases (16.5%), and clinical swallow evaluation (CSE) was completed by speech-language pathology in 419 patients (88.6%), of which 309 patients were suspected to have dysphagia (73.7%). Among the 2,391 patients without speech-language pathology consultation, pneumonia was reported in 34 patients (1.42%). Pneumonia was reported in 53 patients in the speech-language pathology cohort, of which 43 patients (13.9%) were suspected to have dysphagia. Patients with pneumonia had significantly longer median time (20.0 hr, range: 4.9-26.7) from speech-language pathology orders to completion of CSE, compared to those without pneumonia (13.2 hr, range: 3.2-22.4, p = .025). There was no significant difference in the median time from extubation to speech-language pathology consultation order time in patients with pneumonia versus those without pneumonia. Patients with pneumonia were observed to have prolonged, although not statistically significant, median time from extubation to CSE (70.4 hr, range: 21.2-215) compared to those without pneumonia (42.2 hr, range: 19.5-105.8, p = .066).

CONCLUSIONS: Patients without pneumonia in the postoperative period were observed to have shorter median time from extubation to speech-language pathology evaluation. Future studies are needed to further understand the impact of early speech-language pathology consultation and incidence of pneumonia in this population.

PMID:36001815 | DOI:10.1044/2022_AJSLP-21-00310

Oper Dent. 2022 Jul 1;47(4):382-391. doi: 10.2341/21-016-C.

ABSTRACT

OBJECTIVE: The aim of this in vivo study was to evaluate the clinical one-year follow-up of a silica- and flouroapatite-reinforced glass carbomer filling material as compared to a resin composite restorative material.

METHODS AND MATERIALS: In this study, a total of 100 restorations were performed. Caries were removed conventionally with diamond burs. Half of the restorations were restored with nanocomposite resin (TEP) (Tokuyama Estelite, Tokuyama Dental, Japan) and the other half were restored with glass carbomer (GC) material (GCP Dental, The Netherlands). Each restorative material was applied according to the manufacturer’s instructions. Restorations were evaluated with modified USPHS criteria at the end of the first week, 6 months, and 12 months. Data were analyzed using Fisher’s Exact Chi-Square test, Fisher Freeman Halton Test, and Continuity (Yates) Correction. The Wilcoxon sign test was used for intra-group comparisons of the parameters.

RESULTS: When the filling materials were compared with one another, a statistically significant difference was observed in the 12th month on the marginal discoloration. A statistically significant difference was observed between the two materials in the 6th month on the marginal adaptation (p<0.05).

CONCLUSIONS: In view of these results, there is a need to improve the physical properties of the GC filling material in further in vivo studies.

PMID:36001813 | DOI:10.2341/21-016-C

JMIR Form Res. 2022 Apr 27. doi: 10.2196/35114. Online ahead of print.

ABSTRACT

BACKGROUND: The COVID-19 pandemic represents the most unprecedented global challenge in recent times. As the global community attempts to manage the pandemic long-term, it is pivotal to understand what factors drive prevalence rates, and to predict the future trajectory of the virus.

OBJECTIVE: This study has two objectives. Firstly, it tests the statistical relationship between socioeconomic status and COVID-19 prevalence. Secondly, it utilises machine learning techniques to predict cumulative COVID-19 cases in a multi-country sample of 182 countries. Taken together, these objectives will shed light upon socioeconomic status as a global risk factor of the COVID-19 pandemic.

METHODS: This research utilised exploratory data analysis and supervised machine learning methods. Exploratory analysis included variable distribution, variable correlations and outlier detection. Following this, three supervised regression techniques were applied: linear regression, random forest, and adaptive boosting. Results were evaluated using k-fold cross validation and subsequently compared to analyse algorithmic suitability. The analysis involved two models. Firstly, the algorithms were trained to predict 2021 COVID-19 prevalence using only 2020 reported case data. Following this, socioeconomic indicators were added as features and the algorithms were trained again. The Human Development Index metrics of life expectancy, mean years of schooling, expected years of schooling, and Gross National Income were used to approximate socioeconomic status.

RESULTS: All variables correlated positively with 2021 COVID-19 prevalence, with R2 values ranging from 0.55-0.85. Using socioeconomic indicators, COVID-19 prevalence was predicted with a reasonable degree of accuracy. Using 2020 reported case rates as a lone predictor to predict 2021 prevalence rates, the average predictive accuracy of the algorithms was low (R2=0.543). When the socioeconomic indicators were added alongside 2020 prevalence rates as features, average predictive performance improved considerably (R2=0.721) and all error statistics decreased. This suggested that adding socioeconomic indicators alongside 2020 reported case data optimised prediction of COVID-19 prevalence to a considerable degree. Linear regression was the strongest learner with R2=0.693 on the first model and R2=0.763 on the second model, followed by random forest (0.481 and 0.722) and AdaBoost (0.454 and 0.679). Following this, the second model was retrained using a selection of additional COVID-19 risk factors (population density, median age, and vaccination uptake) instead of the HDI metrics. Average accuracy dropped to 0.649 however, which highlights the value of socioeconomic status as a predictor of COVID-19 cases in the chosen sample.

CONCLUSIONS: Results show that socioeconomic status should be an important variable to consider in future epidemiological modelling, and highlights the reality of the COVID-19 pandemic as a social phenomenon as well as a healthcare phenomenon. This paper also puts forward new considerations about the application of statistical and machine learning techniques to understand and combat the COVID-19 pandemic.

PMID:36001798 | DOI:10.2196/35114