Nevin Manimala

J Clin Monit Comput. 2022 Mar 8. doi: 10.1007/s10877-022-00835-z. Online ahead of print.

ABSTRACT

The nociception level index (NOL) is a multi-parameter index that incorporates changes in autonomic parameters to evaluate nociception, with more painful stimuli causing more pronounced index variations. How this nociception monitor relates to the pain experience is uncertain, and patients with chronic pain may respond differently to acute pain due to alterations in pain processing. The goal of this pilot study was to evaluate NOL index variations after a painful physiotherapy exercise in patients with upper limb complex regional pain syndrome. Baseline NOL indexes were recorded using a finger probe (PMD-200™ Monitor, Medasense, Israel) and patient reported baseline pain scores using an 11-point numeric rating scale (NRS). Patients then performed a painful physiotherapy exercise and NOL index and pain scores were again recorded. The same procedure and recordings were repeated after a stellate ganglion block. Data were analyzed using a paired Student T test and a P value < 0.05 was considered statistically significant. Twenty patients (12/20 female, 10/20 right-sided) were included in this study. Patients reported moderate baseline pain (4.0 ± 2.7) despite having a low baseline NOL index (7.66 ± 5.76 out of 100). NRS and NOL index scores increased significantly during exercise, both before and after the block. The NOL index increased significantly when patients reported increased pain, indicating that it could eventually be useful in the objective assessment of acute pain in the chronic pain patients. However, NOL index was not able to reflect pain levels at rest, before the painful stimulation, in this chronic pain population. Further studies are needed to better assess NOL index utility at rest and to confirm these findings in this specific chronic pain population.

PMID:35260985 | DOI:10.1007/s10877-022-00835-z

Jpn J Ophthalmol. 2022 Mar 9. doi: 10.1007/s10384-022-00910-7. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the utility of Optos ultrawide-field fundus autofluorescence (UWF-FAF) imaging for postoperative follow-up of gas-filled eyes after vitrectomy with subretinal tissue-plasminogen activator (t-PA) injection for subretinal hemorrhage (SRH) displacement.

STUDY DESIGN: Retrospective consecutive case series.

METHODS: This study included 24 eyes with SRH. Vitrectomy with subretinal t-PA injection was performed, followed by postoperative prone positioning. FAF images acquired using Optos California were examined and the SRH occupancy in the macula was calculated. The main outcome measures were displacement rate and direction of SRH for 3 days postoperatively, and postoperative best-corrected visual acuity (BCVA).

RESULTS: The postoperative BCVA ranged from improvement (23 eyes; 95.8%) to no change (one eye; 4.2%). Analysis was done using postoperative Optos FAF images for 20 eyes (83.3%). Postoperative SRH occupancy was significantly reduced, by 27.4%, compared with the preoperative occupancy (P = 0.03). A statistically significant reduction was found between the preoperative and postoperative day (POD)1 (P = 0.04), but not between POD1 and POD2 (P = 0.7), or between POD2 and POD3 (P = 1.0).

CONCLUSION: UWF-FAF imaging is useful for postoperative follow-up of gas-filled eyes after vitrectomy with subretinal t-PA injection for SRH displacement.

PMID:35260984 | DOI:10.1007/s10384-022-00910-7

Probiotics Antimicrob Proteins. 2022 Mar 9. doi: 10.1007/s12602-022-09930-8. Online ahead of print.

ABSTRACT

This study aimed to assess the effects of the probiotic (PROB) Bifidobacterium animalis subsp. lactis HN019 in two different delivery vehicles in experimental periodontitis (EP), including the gene expression for IL-10, IFN-γ, and FOXP3. In total, 32 rats were assigned into groups (n=8): C (control), EP, EP-PROB/Water, and EP-PROB/Milk. The probiotic was administered for 4 weeks, from baseline to euthanasia. Periodontitis was induced by ligatures 14 days after baseline. Data were statistically analyzed (p<0.05). Both probiotic groups presented decreased alveolar bone loss and increased interproximal attachment level than group EP. Also, these parameters were significantly improved in the Milk group when compared with the Water group. EP-PROB/Milk showed higher gene expression for IL-10 and lower for FOXP3 in relation to EP-PROB/Water and EP groups. The use of milk was able to potentiate the protective effects of B. lactis HN019 in rats under EP.

PMID:35260963 | DOI:10.1007/s12602-022-09930-8

Breast Cancer Res Treat. 2022 Mar 8. doi: 10.1007/s10549-022-06553-z. Online ahead of print.

ABSTRACT

OBJECTIVE: Our purpose is to evaluate the correlation of TILs with clinicopathological characteristics and disease free survival (DFS) in DCIS and DCIS-Mi breast cancer (BC) patients.

METHODS: We retrospectively reviewed the data of 360 DCIS patients and 125 DCIS-Mi patients treated by a single institution from 2016 to 2019. TILs are regarded as continuous variables and are divided into low (≤ 5%), medium (5-40%) and high (≥ 40%) for statistical analysis.

RESULTS: In DCIS and DCIS-Mi patients, larger tumor size, higher nuclear grade, hormone receptor (HR) negativity and human epidermal growth factor receptor 2(HER2) overexpression are all related to high TILs (P < 0.05). In addition, compared with DCIS, DCIS-Mi patients were significantly associated with high TILs (P < 0.001). Based on the different results of the subtypes, we further studied the correlation between TILs and DFS in 279 cases of HER2+ patients (204 of DCIS; 75 of DCIS-Mi). In HER2+ group, DCIS-Mi was significantly associated with HR negativity (P = 0.015) and high TILs (P = 0.002) compared with DCIS patients. In the survival analysis, we found that TILs had no effect on the DFS of DCIS (P = 0.938), DCIS-Mi (P = 0.807), and HER2+ (P = 0.379) BC patients. In the univariate and multivariate cox regression analysis, the correlation between TILs and the prognosis of DFS has not been confirmed in the three BC groups (P > 0.05).

CONCLUSION: TILs have played an non-negligible role in the progress of DCIS to DCIS-Mi, especially in HER2+ BC. The predictive and prognostic value of TILs still needs further research to confirm.

PMID:35260954 | DOI:10.1007/s10549-022-06553-z

Psychother Psychosom Med Psychol. 2022 Mar 8. doi: 10.1055/a-1749-6379. Online ahead of print.

ABSTRACT

This study examined the implementation of a behavioral medicine oriented rehabilitation concept in a cardiological rehabilitation clinic. Psychotherapeutic interventions were based on an Acceptance and Commitment Therapy framework. Participants were treated in a behavioral cardiac rehabilitation program (BCR; n=149), or in a conventional cardiac rehabilitation program (CCR, n=100). We tested and compared the reach of the targeted group, the fidelity of the concept implementation in the BCR, as well as the completeness of the intervention (dose delivered) and the patient-reported behavioral medical treatment dose (dose received). Changes from beginning of rehabilitation until discharge with regard to mental and physical performance were assessed in both groups. BCR-patients were more impaired than CCR-patients, and they confirmed more behavioral medical content, a higher consistency of the behavioral medical strategy and a stronger gain of competence. Adherence ratings indicated a largely accurate implementation of the intervention. In both groups, depression, somatization, anxiety, heart anxiety, exercise self-efficacy expectation, and maximum power in bicycle ergometry improved statistically significant from admission to discharge. Large or nearly large effect sizes were found for avoidance behavior (d=0.78), somatization (d=0.82), depression (d=0.76), anxiety (d=0.72) and performance in bicycle ergometry (d=0.86) in the BCR. A further evaluation by means of a randomized controlled trial should follow this implementation study.

PMID:35259767 | DOI:10.1055/a-1749-6379

Cereb Cortex. 2022 Mar 8:bhac091. doi: 10.1093/cercor/bhac091. Online ahead of print.

ABSTRACT

Preterm (PT) birth is a potential factor for abnormal brain development. Although various alterations of cortical structure and functional connectivity in preterm infants have been reported, the underlying microstructural foundation is still undetected thoroughly in PT infants relative to full-term (FT) neonates. To detect the very early cortical microstructural alteration noninvasively with advanced neurite orientation dispersion and density imaging (NODDI) on a whole-brain basis, we used multi-shell diffusion MRI of healthy newborns selected from the Developing Human Connectome Project. 73 PT infants and 69 FT neonates scanned at term-equivalent age were included in this study. By extracting the core voxels of gray matter (GM) using GM-based spatial statistics (GBSS), we found that comparing to FT neonates, infants born preterm showed extensive lower neurite density in both primary and higher-order association cortices (FWE corrected, P < 0.025). Higher orientation dispersion was only found in very preterm subgroup in the orbitofrontal cortex, fronto-insular cortex, entorhinal cortex, a portion of posterior cingular gyrus, and medial parieto-occipital cortex. This study provided new insights into exploring structural MR for functional and behavioral variations in preterm population, and these findings may have marked clinical importance, particularly in the guidance of ameliorating the development of premature brain.

PMID:35259759 | DOI:10.1093/cercor/bhac091

ORL J Otorhinolaryngol Relat Spec. 2022 Mar 8:1-8. doi: 10.1159/000521789. Online ahead of print.

ABSTRACT

INTRODUCTION: Bell’s palsy is acute facial paralysis with unclear etiology that results in weakness of facial muscles or paralysis on one side of the face.

METHODS: This prospective, randomized, single-blind, controlled study was conducted on 45 patients with Bell’s palsy who were randomly divided into three equal groups. Two groups received either low-level laser therapy (LLLT) or electrical stimulation (E.S.) both in conjunction to medications, massage, and facial exercise treatment. The third group (control) was treated with medication, massage, and facial exercise.

RESULTS: The primary outcome was the improvement of nerve conduction velocity of facial nerve while the secondary outcome was the change of Sunnybrook facial grading system (SBGS). The outcome measures were evaluated pre- and posttreatment. There was statistically significant difference between the three groups in favor of the LLLT group regarding the nerve action potential amplitude and latency, in addition to signs of nerve regeneration and improved SBGS.

CONCLUSION: This short-term investigation revealed that LLLT proved to be more efficient than E.S. in facial nerve regeneration for patients with Bell’s palsy.

PMID:35259753 | DOI:10.1159/000521789

Gerontology. 2022 Mar 8:1-9. doi: 10.1159/000521146. Online ahead of print.

ABSTRACT

INTRODUCTION: The first cases of COVID-19 in Israel were reported in February 2020. Family visits were prohibited from March 10, 2020, and then allowed on a limited basis on April 20, 2020. This article examines how COVID-19 impacted long-term care residents and their family members from the perspective of long-term care facility (LTCF) administrative staff.

METHODS: An online survey was sent to Israeli LTCF administrators between mid-July and mid-October 2020, resulting in 52 completed questionnaires. Quantitative analysis involved descriptive statistics using SPSS, with differences compared via t tests, ANOVA, and χ2 tests. Qualitative analysis involved thematic analysis of responses to open-ended questions.

RESULTS: COVID-19 was reported to have multiple types of negative impact on residents, including direct effects on morbidity and mortality as well as indirect effects manifested as negative reactions to measures aimed at limiting infection, including isolation from relatives, decreased activities for residents, and COVID-19 testing. The impact of isolation on LTCF residents was reported as negative or very negative by over three-quarters of the respondents. Behavioral problems among residents increased in 32% of the facilities. The qualitative results suggested that adverse effects on residents and family members were partially mitigated by the use of communication technologies.

DISCUSSION/CONCLUSION: The interplay of multiple factors affected LTCF residents against the backdrop of COVID-19 restrictions. The emergence of mitigating factors which provide solutions to some of the challenges has the potential of improving quality of care for LTCF residents as the pandemic continues and thereafter.

PMID:35259746 | DOI:10.1159/000521146

Phys Ther Sport. 2022 Feb 19;55:55-60. doi: 10.1016/j.ptsp.2022.02.004. Online ahead of print.

ABSTRACT

CONTEXT: Strength ratios are important because imbalances in opposing muscle groups can cause articular instability and subsequently increase the risk of musculoskeletal injury (MSKI). Therefore, the purpose of this study was to evaluate the association between lower extremity (LE) musculoskeletal isometric strength ratios and the history of LE MSKI.

PARTICIPANTS: One hundred eighty-two NCAA Division 1 soccer, football, volleyball, and basketball athletes.

INTERVENTIONS: All isometric strength assessments were measured bilaterally using a handheld dynamometer. Strength assessments included: ankle inversion/eversion, ankle dorsiflexion/plantarflexion, knee flexion/extension, hip abduction/adduction, and hip external/internal rotation. LE MSKI history was collected through self-report; a report of the LE MSKI sustained in the one year prior to testing were collected.

RESULTS: The hip external/internal rotation ratio was statistically significant for side to side differences in the non-injured (NINJ) group (p = 0.001). The dominant leg of the NINJ group had a mean external/internal rotation ratio of 1.109 ± 0.221, and the non-dominant leg had a mean ratio of 1.177 ± 0.208.

CONCLUSIONS: There were no statistically significant differences between the injured (INJ) and NINJ groups. This could indicate that injury history does not play a role in current strength ratios and could suggest that the athletes in the INJ group are performing successful rehabilitation for their injuries.

PMID:35259716 | DOI:10.1016/j.ptsp.2022.02.004

Eur J Radiol. 2022 Mar 2;150:110232. doi: 10.1016/j.ejrad.2022.110232. Online ahead of print.

ABSTRACT

PURPOSE: To investigate the feasibility of simultaneous multi-slice readout-segmented diffusion-weighted echo-planar imaging (SMS rs-EPI DWI) in predicting invasive breast cancer molecular subtypes using whole-tumor histogram and texture analyses.

METHODS: In our retrospective study, 125 patients (mean age, 52.81 ± 12.01 years; range, 24-84 years) with single invasive breast cancer who underwent preoperative MRI with SMS rs-EPI DWI and surgery at our institution were included. Two radiologists independently performed whole-tumor histogram and texture analyses on the apparentdiffusioncoefficient (ADC) map of SMS rs-EPI DWI (TR, 3800.0 ms; TE 90.0 ms; field of view, 340 mm × 206 mm; in-plane matrix, 244 × 148; section thickness, 5 mm; readout segments, 5, b = 0, 800 s/mm²; scan time, 3 mins; slice acceleration factor, 2). The Mann-Whitney U test or Kruskal-Wallis test were used to compare histogram and texture parameters to assess their potential in differentiating molecular subtypes of breast cancer and predicting axillary lymph node status. Receiver operating characteristic (ROC) curves were generated for parameters with significant differences, and the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.

RESULTS: Compared to luminal A breast cancer, the HER2-positive breast cancer subtype showed higher ADC_{_95th percentile} values (p = 0.016). In addition, HER2-positive breast cancer yielded significantly higher ADC_{_mean} (p = 0.025), ADC_{_median} (p = 0.025), and ADC_{_5th percentile} (p = 0.041) values than luminal B breast cancer. The ADC_{_skewness} value was higher for triple-negative breast cancer (TNBC) than Luminal A breast cancer (p = 0.021). The difference in ADC_{_mean}, ADC_{_median}, ADC_{_5th percentile} and ADC_{_95th percentile} values between the HER2-positive breast cancer and luminal types was statistically significant, with a combined AUC for these parameters of 0.762 (sensitivity 72.41%, specificity 75.00%, PPV 27.27 %, and NPV 95.45 %). The ADC_{_skewness} value for TNBC was higher than for luminal types (p = 0.012) and yielded an AUC value of 0.688 (sensitivity 96.15%, specificity 36.78%, PPV 31.25%, and NPV 96.97 %). Additionally, significantly higher ADC_{_skewness} and ADC_{_95th percentile} values (p = 0.003, 0.002, respectively) were reported for non-luminal types than luminal types yielding a combined AUC value of 0.712 (sensitivity 92.11%, and specificity 50.23%, PPV 41.18%, and NPV 92.50%). The AUC value for ADC_{_5th percentile} for axillary lymph node status prediction was 0.659 (sensitivity 65.38%, specificity of 64.86%).

CONCLUSIONS: The whole-tumor histogram and texture analyses parameters based on SMS rs-EPI DWI may provide biological information on aggressive molecular subtypes of breast cancer. In addition, ADC_{_5th percentile} values were significantly different between lymph node-positive and lymph node-negative breast cancer.

PMID:35259708 | DOI:10.1016/j.ejrad.2022.110232