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Nevin Manimala Statistics

A pipeline for stochastic and controlled generation of realistic language input for simulating infant language acquisition

Behav Res Methods. 2025 Sep 4;57(10):275. doi: 10.3758/s13428-025-02772-6.

ABSTRACT

Computational models of early language development involve implementing theories of learning as functional learning algorithms, exposing these models to realistic language input, and comparing learning outcomes to those in infants. While recent research has made major strides in developing more powerful learning models and evaluation protocols grounded in infant data, models are still predominantly trained with non-naturalistic input data, such as crowd-sourced read speech or text transcripts. This is due to the lack of suitable child-directed speech (CDS) corpora in terms of scale and quality. In parallel, the question of how properties and individual variability in language input affect learning outcomes is an active area of empirical research, underlining the need for realistic yet controllable data for modeling such phenomena. This paper presents a solution to the training data problem through stochastic generation of naturalistic CDS data using statistical models, thereby enabling controlled computational simulations with naturalistic input. We provide a proof-of-concept demonstration of the approach by showing how naturalistic CDS transcripts can be generated with a language model conditioned on recipient information (here, infant age), and how text-to-speech systems can be used to convert the transcripts to high-quality speech with a controllable speaking style. We also conduct modeling experiments with generated speech corpora by varying different aspects of the data, showing how this maps into different learning outcomes, thereby demonstrating the feasibility of the approach for controlled language learning simulations. Finally, we discuss the limitations of using synthetic data in general, and of the present proof-of-concept pipeline in particular.

PMID:40908330 | DOI:10.3758/s13428-025-02772-6

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Nevin Manimala Statistics

Expression patterns of plasma microRNAs in patients with cervical cancer from two teaching hospitals in Ghana

J Cancer Res Clin Oncol. 2025 Sep 5;151(9):242. doi: 10.1007/s00432-025-06281-z.

ABSTRACT

AIM: Early cervical cancer diagnosis is a global challenge that needs to be addressed by the discovery of less invasive diagnostic and prognostic approaches. Circulating miRNAs are stable in plasma and their diagnostic potentials have been elucidated in some cancers. Therefore, in this cross-sectional study, we determined the patterns of expression of 7 selected circulating microRNAs that differ between patients with cervical cancer receiving therapy, patients with cervical not on therapy and healthy females. The goal was to investigate the diagnostic and prognostic potential of these selected miRNAs.

METHODS: Total RNA was extracted from plasma samples collected from 53 participants recruited from Komfo Anokye Teaching Hospital and the Cape Coast Teaching Hospital, Ghana. Complementary DNA (cDNA) synthesis was performed, followed by quantitative polymerase chain reaction (qPCR) to amplify and quantify the expression levels of the target microRNAs. Expression levels of seven microRNAs-hsa-miR-146a, hsa-miR-29a, hsa-miR-29b, hsa-miR-34a, hsa-miR-233, hsa-miR-155, and hsa-miR-27a were compared among three groups: healthy controls (n = 27), patients with cervical cancer on therapy (n = 13), and those not on therapy (n = 13).

RESULTS: miR-155 and miR-27a showed statistically significant differential expression between cancer patients and healthy controls. In addition, miR-29b expression levels differed significantly between stage 4b and stage 4a of patient with cervical cancer undergoing treatment.

CONCLUSION: These findings suggest that circulating plasma miRNAs may serve as non-invasive biomarkers for the early detection of cervical cancer, monitoring disease progression, and evaluating treatment response.

PMID:40908329 | DOI:10.1007/s00432-025-06281-z

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Nevin Manimala Statistics

Radiological Comparison of Piezosurgery and Classical Osteotomies in Rhinoplasty

Aesthetic Plast Surg. 2025 Sep 4. doi: 10.1007/s00266-025-05191-2. Online ahead of print.

ABSTRACT

OBJECTIVE: The aim of this study is to compare the radiological measurements of patients who underwent rhinoplasty using a piezo device with those of patients who underwent rhinoplasty using a classical osteotome.

METHODS: A total of 60 patients were included in the study: 30 rhinoplasty patients who underwent piezosurgical osteotomy and 30 who underwent classical osteotomy. Preoperative and postoperative functional and aesthetic outcomes were compared using NOSE and ROE scores. Four anthropometric parameters were measured radiologically before and after surgery: nasofrontal angle (NFA), nasal bone length (NL), pyramidal angle (PA) and the closest distance between the nasolacrimal canal and the rhinoplasty fracture line (N-R). The pyramidal angle (PA) was measured separately at two levels: at the nasal root (PA-R) and at the tip of the nasal bone (PA-T).

RESULTS: The two groups were similar in terms of age, gender, and follow-up period (p > 0.05). The operative time was significantly longer in the Piezo group (p < 0.001). Preoperative and postoperative ROE values, as well as preoperative NOSE values, were comparable between the two groups (p > 0.05). However, postoperative NOSE values were statistically significantly lower in the Piezo group compared to the Osteotome group (p = 0.004). Surgery significantly affected both NOSE and ROE values in each group (p < 0.001). No statistically significant differences were found between the groups in terms of preoperative and postoperative NFA, PA-R, and PA-T values (p > 0.05). Preoperative NL values were also similar between the groups; however, postoperative NL values were significantly shorter in the Piezo group (p < 0.001). A statistically significant difference was observed in both right and left side N-R values between the groups (right: p = 0.025; left: p = 0.010), with the N-R distance being shorter in the Piezo group.

CONCLUSION: The long-term aesthetic outcomes of the piezosurgery and conventional osteotomy groups were similar; however, the piezosurgery group demonstrated better functional results. The safe margin for the nasolacrimal canal was narrower when osteotomy was performed using piezosurgery. This finding warrants caution regarding potential complications in the lacrimal system.

LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

PMID:40908317 | DOI:10.1007/s00266-025-05191-2

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Nevin Manimala Statistics

Optimal estimation of power Chris-Jerry distribution parameters using ranked set sampling design with application

Sci Rep. 2025 Sep 2;15(1):32321. doi: 10.1038/s41598-025-11152-1.

ABSTRACT

Effective sample design has a major role in the quality of parameter estimation in statistical parameter estimation issues. The ranking set sampling (RSS) strategy is effective and a less costly option than simple random sampling (SRS). A novel mixture continuous lifetime distribution that has been proposed recently is the power Chris-Jerry distribution (PC-JD). It is useful for modeling a number of real data sets. This paper investigates the RSS approach for estimating the PC-JD’s parameters. There are roughly sixteen different techniques of estimation that are used, such as the maximum likelihood method, the percentiles method, some methods based on minimum distance, the Kolmogorov method, and some methods based on minimum and maximum spacing distances. In comparison to a SRS, the simulation research assesses the performance of the suggested RSS-based estimates in terms of some measures of accuracy. To identify the optimal estimating strategy, the partial and overall ranks of many estimates are shown. According to numerical results, the maximum likelihood approach seems to be quite beneficial in evaluating the estimated quality of RSS and SRS. RSS is a more effective sampling approach than SRS owing to its better efficiency. Additionally, the different estimation techniques with survival data for both sampling techniques are examined.

PMID:40908291 | DOI:10.1038/s41598-025-11152-1

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Nevin Manimala Statistics

Clinical Outcomes of RA FE-TLIF Compared to FE-TLIF in Patients With Lumbar Spondylolisthesis: A Retrospective Study

Orthop Surg. 2025 Sep 4. doi: 10.1111/os.70166. Online ahead of print.

ABSTRACT

BACKGROUND: Lumbar spondylolisthesis (LS) is a spinal disorder that often necessitates surgical intervention. However, evidence on the comparative clinical value of robot-assisted full-endoscopic transforaminal lumbar interbody fusion (RA FE-TLIF) versus conventional FE-TLIF in early-grade (Grades I and II) LS remains limited, leaving uncertainty about its true clinical value in this patient population. This study aims to compare the clinical efficacy and safety of FE-TLIF with RA FE-TLIF in patients with Grade I and II LS.

METHODS: A retrospective analysis was conducted on 47 patients who underwent surgical treatment for LS between April 2022 and April 2023 at our hospital. Patients were divided into two groups: 22 underwent RA FE-TLIF, and 25 underwent FE-TLIF. Key outcomes measured included operative time, intraoperative blood loss, postoperative recovery time, fusion rate, screw placement accuracy, Visual Analogue Scale (VAS), the Japanese Orthopaedic Association (JOA) scores, and the incidence of postoperative complications. Statistical analyses were performed using the independent-sample t test for continuous variables and the chi-square test for categorical variables, with a significance threshold of p < 0.05.

RESULTS: The RA FE-TLIF group exhibited significantly shorter operative times and lower intraoperative blood loss compared to the FE-TLIF group (p < 0.05). Postoperative recovery, as measured by hospital stay, was also shorter in the RA FE-TLIF group (p = 0.001). VAS and JOA scores indicated greater pain relief and functional improvement in the RA FE-TLIF group, with statistically significant differences observed at both 1 month and final follow-up (p < 0.05). The incidence of postoperative complications was lower in the RA FE-TLIF group, though this difference was not statistically significant (p = 0.144). Complete fusion rates were 95.45% in the RA FE-TLIF group and 88.00% in the FE-TLIF group, with no significant difference (p > 0.05). Screw placement accuracy was higher in the RA FE-TLIF group (97.73%) than in the FE-TLIF group (89.00%), with a significant difference (p < 0.05).

CONCLUSION: RA FE-TLIF demonstrates superior clinical outcomes compared to FE-TLIF in the treatment of LS. These findings support the broader adoption of RA FE-TLIF as a preferred surgical technique for this condition.

PMID:40908279 | DOI:10.1111/os.70166

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Nevin Manimala Statistics

Safety and potential utility of integrated Yoga and Ayurveda (IYA) intervention for psychotropic-associated metabolic syndrome in patients with severe mental disorders: A prospective single-arm pre-post pilot study

J Ayurveda Integr Med. 2025 Sep 3;16(5):101198. doi: 10.1016/j.jaim.2025.101198. Online ahead of print.

ABSTRACT

BACKGROUND: Metabolic syndrome (MetS) is a major side-effect of antipsychotic and antidepressant medications that increases risk for cardiac and neurological disorders and hinders long-term adherence to treatment. Integrated Yoga and Ayurveda (IYA) intervention can potentially aid in counteracting these side effects.

OBJECTIVE: To evaluate the efficacy and safety of Integrated Yoga and Ayurveda (IYA) intervention in psychotropic associated metabolic syndrome (MetS) in patients with severe mental disorders MATERIALS AND METHODS: A single-arm exploratory observational trial was conducted in an outpatient setting at a major tertiary mental healthcare hospital in South India. The study included 29 consenting patients(11 females and 18 males) with severe mental disorders (SMDs) stable on anti-psychotic and antidepressant medications diagnosed with MetS (NCEP-ATP III criteria). A 45-day IYA intervention comprising an Ayurveda herbal formulation (Triphala choorna 6 gm per dose) with warm water twice daily and a 10-min specific yoga program was administered. Assessments were performed at the baseline and after 45 days for the following variables: anthropometry, blood pressure, lipid profile, fasting blood sugar, and safety profile consisting of Renal Function and Liver Function tests. Seventeen patients completed the study. Data on changes in anthropometry and biochemical markers was analyzed using paired samples t-test.

RESULTS: A statistically significant reduction was observed in the following variables: body weight (p < 0.001), BMI (p < 0.001), Total cholesterol (p < 0.05), and triglycerides (p < 0.05). None of the patients reported any side effects of IYA. Clinical assessment at the end of 45 days did not reveal any worsening of psychotic symptoms.

CONCLUSION: IYA may serve as a safe and potentially effective adjuvant in addressing MetS in patients with SMDs who are on psychotropics.

PMID:40907137 | DOI:10.1016/j.jaim.2025.101198

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Nevin Manimala Statistics

Evaluation of Tp-e interval, Tp-e/QT and Tp-e/QTc ratios in patients with hypertensive crisis

J Electrocardiol. 2025 Aug 26;93:154097. doi: 10.1016/j.jelectrocard.2025.154097. Online ahead of print.

ABSTRACT

BACKGROUND: Hypertensive crisis (HC) is recognized as a contributing factor in the development of cardiac arrhythmias. This study aims to assess Tp-e interval, Tp-e/QT (TQR), and Tp-e/QTc (TQcR) ratios in patients experiencing hypertensive urgency and emergency, in order to evaluate the potential risk of ventricular arrhythmias.

METHODS: A prospective study was conducted involving HC patients admitted to a tertiary hospital’s emergency department between June 1, 2022, and June 30, 2024. Patients were categorized into three groups: hypertensive emergency, hypertensive urgency, and control group. Data collected included demographic characteristics, vital signs, laboratory results, and electrocardiography (ECG) parameters such as Tp-e interval, TQR, and TQcR.

RESULTS: Among the 235 eligible patients, 57 % were female and 43 % male. The hypertensive urgency group included 130 patients, the emergency group 45, and the control group 60. Statistically significant differences in Tp-e, TQR, and TQcR values were observed across all groups (p < 0.001). These metrics demonstrated moderate positive correlations with both systolic and diastolic blood pressures.

CONCLUSION: Increased Tp-e, TQR, and TQcR values identified in HC patients suggest a heightened risk for ventricular arrhythmias. These findings support the routine evaluation of these ECG.

PMID:40907074 | DOI:10.1016/j.jelectrocard.2025.154097

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Nevin Manimala Statistics

Adopting the estimand framework in prophylactic vaccine trials

Vaccine. 2025 Sep 3;64:127645. doi: 10.1016/j.vaccine.2025.127645. Online ahead of print.

ABSTRACT

The estimand framework as outlined in ICH E9(R1) has been extensively discussed and implemented in clinical trials of therapeutic products. However, there is limited literature on the application of the framework in preventive vaccine trials, which has many unique characteristics, including emphasis on estimating the per-protocol or “biological” effect. We provide a comprehensive review of the application of the framework to preventive vaccine trials evaluating clinical outcome and immunogenicity, focusing on commonly encountered intercurrent events including but not limited to: noncompliance with vaccination schedule and blood sampling window, infection not meeting protocol definition, death, and use of prohibited products. We discuss various considerations in choosing strategies to handle intercurrent events in terms of their utility in addressing the scientific questions. Finally, we provide considerations and examples for summarizing study estimands and data handling which may be incorporated into the protocol and statistical analysis plan.

PMID:40907068 | DOI:10.1016/j.vaccine.2025.127645

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Nevin Manimala Statistics

Integrated genomic approaches improve Treponema pallidum phylogenetics and lineage classification

Can J Microbiol. 2025 Sep 4. doi: 10.1139/cjm-2025-0021. Online ahead of print.

ABSTRACT

Syphilis cases have been consistently rising since its near elimination in the late 1990s. This resurgence, along with increasing rates of macrolide resistance and congenital syphilis, has triggered renewed efforts to better understand and control the disease. We analyzed 827 T. pallidum genomes and created a new genome-based hierarchical lineage framework, recapitulating the major T. pallidum lineages and characterizing sub-lineages. An updated pangenome was constructed, revealing that T. pallidum subsp. pallidum lineages are determined by a single hypothetical major outer sheath C-terminal domain-containing gene while no significant genetic difference was observed between T. pallidum subsp. pertenue and T. pallidum subsp. endemicum. This study introduces an integrated genomic approach to characterize T. pallidum and highlights the significance of pangenomes in supporting public health.

PMID:40907038 | DOI:10.1139/cjm-2025-0021

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Nevin Manimala Statistics

The Effect of Two-Piece Abutment Concept and Abutment Reconnection/Disconnection on Marginal Bone Level Changes: A Split-Mouth Randomized, Parallel-Designed, 36-Month Follow-Up, Preliminary Clinical Study

Int J Oral Maxillofac Implants. 2025 Sep 4;0(0):1-28. doi: 10.11607/jomi.11454. Online ahead of print.

ABSTRACT

PURPOSE: The objective of this study was to conduct a comparative evaluation of the clinical and radiographic findings of definitive two-piece abutments placed at secondary surgery following submerged healing and definitive abutments used in standard prosthetic treatments.

MATERIALS AND METHODS: The study was designed as a prospective, split-mouth, randomised, parallel-design, blinded clinical trial. The study comprised two groups: a test group and a control group. The test group received a two-piece abutment, while the control group received a standardized healing abutment. The study analyzed a total of 10 patients and 20 implants. Clinical and radiographic measurements were obtained at baseline (T0), 6 months (T1), 12 months (T2) and 36 months follow-up (T3). Radiographic measurements were calculated on standardized periapical radiographs, with the aim of determining marginal bone level changes (ΔMBL) at different time points, emergence angles, and emergence profiles in mesially and distally.

RESULTS: A significant difference was found between the groups in mesial, distal, and mean ΔMBL at T0-T1 and distal and mean ΔMBL at T0-T3 values. (p<0.05) Emergence angle values were found to be below 30 degrees both mesially and distally in both groups. (p>0.05) A statistically significant correlation was found between healing/definitive abutment disconnection/reconnection and distal ΔMBL T0-T3. (p<0.05) Conclusion: Within the limitations of the study, although the sample size was limited, with the study design and minimizing confounding factors, it was concluded that two-piece definitive abutment application may have significant effects in terms of reducing ΔMBL changes in both the short and long term. However, further studies with a larger sample size are needed. The study was prospectively registered on the international Clinicaltrials.com registry (NCT05592821).

PMID:40907027 | DOI:10.11607/jomi.11454