Nevin Manimala

Math Biosci Eng. 2022 Jul 1;19(9):9590-9611. doi: 10.3934/mbe.2022446.

ABSTRACT

We propose stage-structured single-species population models with psychological effects and partial tolerance in polluted environments in this paper. First, the conditions of extinction and the time for extinction are investigated respectively. Especially, the time for extinction takes longer as the value of the psychological effects increases. Then the weak persistence in the mean around the pollution-free equilibrium and the stochastic permanence have been derived under some moderate conditions. Further, the existence of a periodic solution for the periodic single-species population has been determined. The corresponding numerical simulations verify the efficiency of the main theoretical results.

PMID:35942774 | DOI:10.3934/mbe.2022446

Math Biosci Eng. 2022 Jun 29;19(9):9505-9519. doi: 10.3934/mbe.2022442.

ABSTRACT

This paper proposes an anti-rotation template matching method based on a portion of the whole pixels. To solve the problem that the speed of the original template matching method based on NCC (Normalized cross correlation) is too slow for the rotated image, a template matching method based on Sub-NCC is proposed, which improves the anti-jamming ability of the algorithm. At the same time, in order to improve the matching speed, the rotation invariant edge points are selected from the rotation invariant pixels, and the selected points are used for rough matching to quickly screen out the unmatched areas. The theoretical analysis and experimental results show that the accuracy of this method is more than 95%. For the search map at any angle with the resolution at the level of 300,000 pixel, after selecting the appropriate pyramid series and threshold, the matching time can be controlled to within 0.1 s.

PMID:35942770 | DOI:10.3934/mbe.2022442

Math Biosci Eng. 2022 Jun 22;19(9):9125-9146. doi: 10.3934/mbe.2022424.

ABSTRACT

Influenza is a respiratory infection caused influenza virus. To evaluate the effect of environment noise on the transmission of influenza, our study focuses on a stochastic influenza virus model with disease resistance. We first prove the existence and uniqueness of the global solution to the model. Then we obtain the existence of a stationary distribution to the positive solutions by stochastic Lyapunov function method. Moreover, certain sufficient conditions are provided for the extinction of the influenza virus flu. Finally, several numerical simulations are revealed to illustrate our theoretical results. Conclusively, according to the results of numerical models, increasing disease resistance is favorable to disease control. Furthermore, a simple example demonstrates that white noise is favorable to the disease’s extinction.

PMID:35942752 | DOI:10.3934/mbe.2022424

Math Biosci Eng. 2022 Jun 22;19(9):9060-9078. doi: 10.3934/mbe.2022421.

ABSTRACT

Several outbreaks of COVID-19 caused by imported cases have occurred in China following the successful control of the outbreak in early 2020. In order to avoid recurrences of such local outbreaks, it is important to devise an efficient control and prevention strategy. In this paper, we developed a stochastic discrete model of the COVID-19 epidemic in Guangzhou in 2021 to compare the effectiveness of centralized quarantine and compulsory home quarantine measures. The model was calibrated by using the daily reported cases and newly centralized quarantined cases. The estimated results showed that the home quarantine measure increased the accuracy of contact tracing. The estimated basic reproduction number was lower than that in 2020, even with a much more transmissible variant, demonstrating the effectiveness of the vaccines and normalized control interventions. Sensitivity analysis indicated that a sufficiently implemented contact tracing and centralized quarantine strategy in the initial stage would contain the epidemic faster with less infections even with a weakly implemented compulsory home quarantine measure. However, if the accuracy of the contact tracing was insufficient, then early implementation of the compulsory home quarantine with strict contact tracing, screening and testing interventions on the key individuals would shorten the epidemic duration and reduce the total number of infected cases. Particularly, 94 infections would have been avoided if the home quarantine measure had been implemented 3 days earlier and an extra 190 infections would have arisen if the home quarantine measure was implemented 3 days later. The study suggested that more attention should be paid to the precise control strategy during the initial stage of the epidemic, otherwise the key group-based control measure should be implemented strictly.

PMID:35942749 | DOI:10.3934/mbe.2022421

Math Biosci Eng. 2022 Jun 16;19(9):8705-8740. doi: 10.3934/mbe.2022404.

ABSTRACT

The modern trend in distribution theory is to propose hybrid generators and generalized families using existing algebraic generators along with some trigonometric functions to offer unique, more flexible, more efficient, and highly productive G-distributions to deal with new data sets emerging in different fields of applied research. This article aims to originate an odd sine generator of distributions and construct a new G-family called “The Odd Lomax Trigonometric Generalized Family of Distributions”. The new densities, useful functions, and significant characteristics are thoroughly determined. Several specific models are also presented, along with graphical analysis and detailed description. A new distribution, “The Lomax cosecant Weibull” (LocscW), is studied in detail. The versatility, robustness, and competency of the LocscW model are confirmed by applications on hydrological and survival data sets. The skewness and kurtosis present in this model are explained using modern graphical methods, while the estimation and statistical inference are explored using many estimation approaches.

PMID:35942732 | DOI:10.3934/mbe.2022404

Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221119809. doi: 10.1177/10760296221119809.

ABSTRACT

INTRODUCTION: Hemorrhagic early death (HED) remains a major cause of treatment failure among patients with acute promyelocytic leukemia (APL). We aimed to investigate the prognostic potential of rotational thromboelastometry (ROTEM) for bleeding in patients with APL.

MATERIALS AND METHODS: 31 newly-diagnosed APL patients (median age of 40 years; 14 female/17 male) that underwent treatment at the Clinic of Hematology UCCS from 2016-2020 with all-trans retinoic acid and anthracyclines were recruited. CBCs (complete blood count), conventional coagulation tests (CCTs), and ROTEM parameters obtained before treatment initiation were evaluated.

RESULTS: All patients demonstrated at least one ROTEM parameter out of the reference range. ROTEM parameters associated with significant hemorrhage were EXTEM clotting time (CT) (P = 0.041) and INTEM amplitude 10 (A10) (P = 0.039), however, only EXTEM CT (P = 0.036) was associated with HED. Among CBCs and CCTs, only platelets were associated with significant bleeding (P = 0.015), while D-dimer was associated with both bleeding and HED (P = 0.001 and P = 0.002, respectively).

CONCLUSION: Our results indicate that ROTEM parameters may reveal hypocoagulability in APL patients and have the potential to improve current hemorrhage prognostic methods. Additionally, these results suggest the combination of ROTEM and CCTs might be useful in identifying patients at risk for HED.

PMID:35942712 | DOI:10.1177/10760296221119809

Public Health Nutr. 2022 Aug 9:1-31. doi: 10.1017/S1368980022001665. Online ahead of print.

ABSTRACT

OBJECTIVE: To assess in 2021 the acceptance and perception of the French tax on sweetened beverages, following its revision in 2018, and factors associated with a higher level of acceptance.

DESIGN: A cross-sectional survey within the NutriNet-Santé cohort study. Participants were invited to complete a self-reported questionnaire in March 2021. Weighting was applied to the sample to allow inferences on the French population. Individual characteristics associated with support for the tax were investigated using logistic regression modelling.

SETTINGS: NutriNet-Santé prospective cohort study.

PARTICIPANTS: Adults engaged in the NutriNet-Santé cohort, aged 18 or older (n = 28,344), living in mainland France.

RESULTS: Almost two thirds (63.4%) of the participants were aware of the existence of a tax on sweetened beverages, although less than a quarter had specific knowledge regarding its design and the 2018 revision. In turn; 64.7% of participants expressed a favourable opinion toward the taxation scheme. This proportion was higher if tax revenues were used to finance health-related measures (respectively 68.8% of favourable opinion if used to finance a reduction in prices of healthy products and 76.4% if used to finance the healthcare system). Multivariable analyses showed that support toward the tax varied among sub-groups of the population. Groups who tended to be less financially affected by the measure and those who perceived sugar-sweetened beverages as having detrimental effects were more likely to support the tax.

CONCLUSION: The revised French sugar-sweetened beverage tax appeared to be favourably received and perceived by the public.

PMID:35942709 | DOI:10.1017/S1368980022001665

J Sch Nurs. 2022 Aug 9:10598405221118824. doi: 10.1177/10598405221118824. Online ahead of print.

ABSTRACT

The Human Papillomavirus (HPV) vaccine can prevent 90% of cancers caused by HPV. Health care provider recommendations affect vaccine uptake, yet there are a lack of studies examining the impact of the school nurse (SN) in vaccine recommendations. The purpose of this study was to evaluate the impact of adding a SN HPV recommendation to the standard vaccination letter sent to parents/guardians. The rate of vaccination between the intervention and control schools was not statistically significant (Estimate (Std. Error) = -0.3066 (0.2151), p = 0.154). After controlling for age, sex, race, insurance type, and medical practice type, there was no significant difference in the likelihood to receive the HPV vaccine (OR = 1.53, 95% CI: 0.563-4.19 in 2018; OR = 1.34, 95% CI: 0.124-14.54 in 2019. Further work is needed to clarify how school nurses can better promote HPV vaccine, and which adolescent demographic groups (e.g., race, insurance type, provider type) face barriers to HPV vaccine uptake.

PMID:35942704 | DOI:10.1177/10598405221118824

Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221117997. doi: 10.1177/10760296221117997.

ABSTRACT

OBJECTIVE: To derive and validate a D-dimer cutoff for ruling out pulmonary embolism (PE) in COVID-19 patients presenting to the emergency department (ED).

METHODS: A retrospective cohort study was performed in an integrated healthcare system including 22 adult ED’s between March 1, 2020, and January 31, 2021. Results were validated among patients enrolled in the RECOVER Registry, representing data from 154 ED’s from 26 US states. Consecutive ED patients with laboratory confirmed COVID-19, a D-dimer performed within 48 h of ED arrival, and with objectively confirmed PE were compared to those without PE. After identifying a D-dimer threshold at which the 95% confidence lower bound of the negative predictive value for PE was higher than 98% in the derivation cohort, it was validated using RECOVER registry data.

RESULTS: Among 3978 patients with a D-dimer result, 3583 with confirmed COVID-19 infection were included in the derivation cohort. Overall, PE incidence was 4.1% and a D-dimer cutoff of <2 μ/mL (2000 ng/mL) was associated with a NPV of 98.5% (95% CI = 98.0%-98.9%). In the validation cohort of 13,091 patients with a D-dimer, 7748 had confirmed COVID-19 infection, and the PE incidence was 1.14%. A D-dimer cutoff of <2 μ/mL was associated with a NPV of 99.5% (95% CI = 99.3%-99.7%).

CONCLUSION: A D-dimer cutoff of <2 μ/ml was associated with a high negative predictive value for PE among patients with COVID-19. However, the resultant sensitivity for PE result at that threshold without pre-test probability assessment would be considered clinically unsafe.

PMID:35942703 | DOI:10.1177/10760296221117997

J Food Sci. 2022 Aug 9. doi: 10.1111/1750-3841.16266. Online ahead of print.

ABSTRACT

Traditional enzymatic hydrolysis methods have defects such as low efficiency and poor bioactivity in the production of active peptides. In this study, radio frequency (RF) technology was innovatively used to assist the hydrolysis of Rosa roxburghii Tratt. seed protein (RTSP) by papain and alcalase. RF-assisted hydrolysis was compared with ultrasound-(US) and microwave (MW)-assisted techniques in terms of the degree of hydrolysis, structure, antioxidant properties, and changes in the peptidome of the hydrolysates to clarify the mechanism of functional change of physically-assisted hydrolysate. All three methods improved hydrolysis efficiency. The degree of hydrolysis (DH) of papain group increased from 6.38% to 7.97%, 9.97% and 8.37% after US-, MW- and RF-assisted hydrolysis, respectively, while the DH of alcalase-treated group increased from 21.13% to 25.66%, 26.03%, and 23.01%, respectively. The in vitro antioxidant capacity and intracellular antioxidant capacity of RTSP and its hydrolysates were measured and evaluated by fuzzy statistical evaluation, and MW-assisted alcalase hydrolysis had the highest in vitro and intracellular antioxidant activity scores of 0.713 and 0.820, respectively. Fourier transform infrared and amino acid composition analysis explained the enhanced antioxidant properties of the hydrolysates. Further peptide profiling showed the physical assistance led to an increase in the species and contents of small molecule antioxidant peptides compared to enzyme treatment alone. Pearson’s linear correlation analysis showed that AY, LY, IY, PHW, SVL, LHL, YYV, VYY, and NHAV were significantly correlated with the antioxidant properties of hydrolysates. Our data suggested that physical assistance such as US, MW, and RF were effective to improve the efficiency of enzymatic hydrolysis and produce novel antioxidant peptides. PRACTICAL APPLICATION: In this study, it was found that electromagnetic wave-assisted enzymatic hydrolysis could improve the efficiency of hydrolysis and enhance the antioxidant activity of hydrolysates compared to unassisted means. Compared with MW treatment, RF has the comparable hydrolysis effect, but has the advantages of high penetration ability, good uniformity, and low energy consumption and has greater potential for the production of bioactive peptides.

PMID:35942684 | DOI:10.1111/1750-3841.16266