Nevin Manimala

PLoS One. 2022 Jan 27;17(1):e0262539. doi: 10.1371/journal.pone.0262539. eCollection 2022.

ABSTRACT

In recent years, online lending has created many risks while providing lending convenience to Chinese individuals and small and medium-sized enterprises. The timely assessment and prediction of the status of industry indicators is an important prerequisite for effectively preventing the spread of risks in China’s new financial formats. The role of investor sentiment should not be underestimated. We first use the BERT model to divide investor sentiment in the review information of China’s online lending third-party information website into three categories and analyze the relationship between investor sentiment and quantitative indicators of online lending product transactions. The results show that the percentage of positive comments has a positive relationship to the borrowing interest rate of P2P platforms that investors are willing to participate in for bidding projects. The percentage of negative comments has an inverse relationship to the borrowing period. Second, after introducing investor sentiment into the long short-term memory (LSTM) model, the average RMSE of the three forecast periods for borrowing interest rates is 0.373, and that of the borrowing period is 0.262, which are better than the values of other control models. Corresponding suggestions for the risk prevention of China’s new financial formats are made.

PMID:35085306 | DOI:10.1371/journal.pone.0262539

PLoS One. 2022 Jan 27;17(1):e0262718. doi: 10.1371/journal.pone.0262718. eCollection 2022.

ABSTRACT

The attentional blink (AB) phenomenon reveals a bottleneck of human information processing: the second of two targets is often missed when they are presented in rapid succession among distractors. In our previous work, we showed that the size of the AB can be changed by applying transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) (London & Slagter, Journal of Cognitive Neuroscience, 33, 756-68, 2021). Although AB size at the group level remained unchanged, the effects of anodal and cathodal tDCS were negatively correlated: if a given individual’s AB size decreased from baseline during anodal tDCS, their AB size would increase during cathodal tDCS, and vice versa. Here, we attempted to replicate this finding. We found no group effects of tDCS, as in the original study, but we no longer found a significant negative correlation. We present a series of statistical measures of replication success, all of which confirm that both studies are not in agreement. First, the correlation here is significantly smaller than a conservative estimate of the original correlation. Second, the difference between the correlations is greater than expected due to sampling error, and our data are more consistent with a zero-effect than with the original estimate. Finally, the overall effect when combining both studies is small and not significant. Our findings thus indicate that the effects of lDPLFC-tDCS on the AB are less substantial than observed in our initial study. Although this should be quite a common scenario, null findings can be difficult to interpret and are still under-represented in the brain stimulation and cognitive neuroscience literatures. An important auxiliary goal of this paper is therefore to provide a tutorial for other researchers, to maximize the evidential value from null findings.

PMID:35085301 | DOI:10.1371/journal.pone.0262718

PLoS One. 2022 Jan 27;17(1):e0262256. doi: 10.1371/journal.pone.0262256. eCollection 2022.

ABSTRACT

INTRODUCTION: Induction of labor is a medical iatrogenic stimulation of uterine contraction before the spontaneous onset of labor to achieve vaginal delivery. It is an increasingly being done obstetric procedure throughout the world and associated with poorer outcomes when compared with spontaneous labor. The published evidence is limited in Ethiopia including the study area. Therefore, this study was aimed at assessing the magnitude of failed induction and associated factors among pregnant women who were admitted to the labor ward of Adama hospital medical college.

METHODS: Institution-based cross-sectional study was conducted among 293 women who were eligible for induction using systematic random sampling. The data were collected from 1st January to 30th April 2020 by face-to-face interview using a structured questionnaire and extraction from a maternal chart. Then data was entered into Epi-data version 4.6 and analyzed using Statistical Product and Service Solution version 23. Descriptive statistics were performed to describe the study population. Logistic regression (bivariate and multivariable) analysis was conducted to identify associated factors. The association was expressed in odds ratio with 95% confidence interval and P-value <0.05 was used as cut-off points to declare significance in the final model.

RESULTS: This study showed that the prevalence of failed induction was 20.5% (95% CI: (15.7-25.3%)). The odds of failed induction in unfavorable bishop score were 4.05 higher than the odds in favorable bishop [AOR = 4.05 95%CI (1.19-13.77)]. The odds of failed induction in an intact membrane were 2.05 higher than the ruptured membrane. [AOR = 2.05, 95%CI (1.06-3.98)]. The odds of failed induction in primigravida were 2.33 higher than the odds in the multiparous women [AOR = 2.33, 95%CI (1.26-4.29)].

CONCLUSIONS: This study revealed that the magnitude of failed induction was higher when compared to other similar findings. Bishop scores, membrane status, and parity were significantly associated factors with failed induction. Preparation of the cervix before commencing induction is recommended to improve induction success.

PMID:35085270 | DOI:10.1371/journal.pone.0262256

PLoS One. 2022 Jan 27;17(1):e0261701. doi: 10.1371/journal.pone.0261701. eCollection 2022.

ABSTRACT

Understanding what factors influence postpartum contraceptive use among young people (ages 15-24 years) is important since this group often has closely spaced and unintended births. Using secondary data gathered for an evaluation of a Bill & Melinda Gates Foundation funded initiative designed to increase modern contraceptive use in select urban areas of Nigeria, we determine the direct and indirect effects of community beliefs and attitudes on adolescent and youth postpartum contraceptive method choice. Our statistical methods control for the endogenous timing of the initiation of sexual activity and the timing and number of births to each respondent by simultaneous estimation of equations for these choices with the choice of postpartum contraceptive method. We find that community beliefs and attitudes have important effects on our primary outcome of postpartum contraceptive use and we quantify the size of both direct and indirect effects on postpartum contraceptive method choice using simulations. The findings from this study can be used to inform programs seeking to increase young women’s postpartum contraceptive use for healthy spacing and timing of births.

PMID:35085264 | DOI:10.1371/journal.pone.0261701

PLoS One. 2022 Jan 27;17(1):e0259722. doi: 10.1371/journal.pone.0259722. eCollection 2022.

ABSTRACT

BACKGROUND: Undernutrition among children is one of the leading major public health problems and about 49.5 million children were wasted worldwide. Asia and African countries contributed 69% and 27.2% of wasting respectively. In Ethiopia, 7% of children were wasted and 1% was severely wasted. Although Ethiopia has achieved remarkable progress in reducing under-five mortality and designed multi-dimensional approaches to address malnutrition, the data on acute malnutrition among children in the study setting is limited. Therefore, this study was aimed to assess the prevalence of acute malnutrition and associated factors among 6-59-month-old children.

METHODS: Community-based cross-sectional study design was conducted at Gurage Zone, Southern Ethiopia. A total of 293 study participants were selected using a systematic sampling technique. Data were collected using structured and pre-tested interviewer-administered questionnaires by face-to-face interview. Data entry and analysis were made using Epi Data version 4.6 and Statistical Package for Social Science (SPSS) version 24 respectively. Descriptive statistical analysis and some of the statistical tests like the odds ratio were carried out. Both Bivariable and multivariable logistic regression analysis with 95% confidence interval was carried out to identify associated factors and variables with P value < 0.05 were taken as statistically significant.

RESULTS: The prevalence of wasting among children aged from 6-59 months in this study was 14.7% (95% CI: 10.9, 18.8). After controlling for all possible confounding factors, the result revealed that age of children between 6-11 months [AOR = 2.78(95% CI: 1.67, 6.19)], caregivers who were unable to read and write [AOR = 2.23 (95% CI: 1.04, 5.34)], presence of diarrheal disease in the past two weeks [AOR = 1.68 (95% CI: 1.23, 5.89)] and mothers who had a history of poor handwashing practice before food preparation and child feeding [AOR = 2.64(95% CI: 1.52, 4.88)] were found to be significantly associated with wasting.

CONCLUSIONS: The study findings indicate that respondents’ wasting was mainly affected by age of the child, educational status of caregivers, presence of diarrheal disease and hand washing practice of the mother. Providing acceptable, quality and honorable care for all children is very crucial to prevent child wasting and proper handwashing during breastfeeding and food handling is recommended and interventions aimed at improving maternal health and access to health care services for children are urgently needed.

PMID:35085254 | DOI:10.1371/journal.pone.0259722

Yonsei Med J. 2022 Feb;63(2):187-194. doi: 10.3349/ymj.2022.63.2.187.

ABSTRACT

PURPOSE: A pilot project using epinephrine at the scene under medical control is currently underway in Korea. This study aimed to determine whether prehospital epinephrine administration is associated with improved survival and neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients who received epinephrine during cardiopulmonary resuscitation (CPR) in the emergency department.

MATERIALS AND METHODS: This retrospective observational study used a nationwide multicenter OHCA registry. Patients were classified into two groups according to whether they received epinephrine at the scene or not. The associations between prehospital epinephrine use and outcomes were assessed using propensity score (PS)-matched analysis. Multivariable logistic regression analysis was performed using PS matching. The same analysis was repeated for the subgroup of patients with non-shockable rhythm.

RESULTS: PS matching was performed for 1084 patients in each group. Survival to discharge was significantly decreased in the patients who received prehospital epinephrine [odds ratio (OR) 0.415, 95% confidence interval (CI) 0.250-0.670, p<0.001]. However, no statistical significance was observed for good neurological outcome (OR 0.548, 95% CI 0.258-1.123, p=0.105). For the patient subgroup with non-shockable rhythm, prehospital epinephrine was also associated with lower survival to discharge (OR 0.514, 95% CI 0.306-0.844, p=0.010), but not with neurological outcome (OR 0.709, 95% CI 0.323-1.529, p=0.382).

CONCLUSION: Prehospital epinephrine administration was associated with decreased survival rates in OHCA patients but not statistically associated with neurological outcome in this PS-matched analysis. Further research is required to investigate the reason for the detrimental effect of epinephrine administered at the scene.

PMID:35083905 | DOI:10.3349/ymj.2022.63.2.187

Yonsei Med J. 2022 Feb;63(2):133-140. doi: 10.3349/ymj.2022.63.2.133.

ABSTRACT

PURPOSE: Bone mineral density (BMD) determined by dual-energy X-ray absorptiometry is considered a gold standard for diagnosing osteoporosis. Some people show discordance in BMD values measured at the femur and that at the lumbar spine (LS). The aim of the present study was to investigate whether differences in BMD T-scores between the LS and femur neck (FN) are associated with renal dysfunction in the general population of Korea.

MATERIALS AND METHODS: We analyzed national data for 17306 adults from the Korean National Health and Nutrition Examination Survey conducted between 2008 and 2011. BMD T-score differences between LS and FN (termed BMD offset) were calculated by subtracting FN T-scores from LS T-scores. Diminished renal function was defined as estimated glomerular filtration rates (eGFR) less than 60 mL/min/1.73 m².

RESULTS: Among those aged ≥50 years, BMD offset was negatively associated with eGFR levels. Additionally, eGFR levels decreased linearly across increasing BMD offset quartiles. Men and women with an offset of >1.5 showed a 4.79-times and 2.51-times higher risk of renal dysfunction, respectively, compared to individuals with an offset of ≤0, after adjusting for age, body mass index, educational level, current smoking, and physical activity. In contrast, there was little evidence of an association between renal dysfunction and BMD offset in subjects aged <50 years.

CONCLUSION: Discordance between LS and FN BMDs was significantly associated with renal dysfunction in subjects aged ≥50 years. When assessing bone health in older chronic kidney disease patients, physicians should consider the possibility of BMD discordance between LS and FN.

PMID:35083898 | DOI:10.3349/ymj.2022.63.2.133

J Esthet Restor Dent. 2022 Jan 27. doi: 10.1111/jerd.12877. Online ahead of print.

ABSTRACT

OBJECTIVE: Bi-layer zirconia-based posterior fixed dental prostheses (FDPs) have reportedly a high incidence of veneering ceramic fractures. The CADon technique employs zirconia frameworks veneered with milled lithium disilicate glass-ceramic to overcome these shortcomings but long-term clinical studies are missing. This study evaluated the clinical efficacy of posterior 3-unit CADOn FDPs over a 5-year period.

MATERIALS AND METHODS: A total of 25 patients, 16 male and 9 female with a mean age of 55.6 years, received a total of 25 posterior three-unit CADOn FDPs. Patients were recalled for baseline and for follow-up visits at 6, 12, 24, and 60 months. Parameters evaluated were fracture, marginal adaptation, marginal discoloration, wear, polish, color match, surface staining, and retention of these restorations as well as secondary caries of the abutment teeth.

RESULTS: A total of 21 FDPs evaluated at 60-months revealed a 100% survival rate. All evaluated clinical parameters were satisfactory (alpha or bravo) and there was no statistically significant difference at different time points, except for surface staining, which was also worse at 60 months compared to baseline (p ≤ 0.001).

CONCLUSIONS: CADOn three-unit posterior FDPs demonstrate excellent fracture resistance after 5 years of clinical function. All evaluated clinical parameters were satisfactory, except for surface stain, which also increased over time.

CLINICAL SIGNIFICANCE: Conventionally veneered bi-layer zirconia-based posterior FDPs have limited clinical success. Based on this study, alternative methods such as zirconia frameworks veneered with milled lithium disilicate glass-ceramic provide a viable alternative with excellent long-term clinical outcomes.

PMID:35083844 | DOI:10.1111/jerd.12877

Dent Traumatol. 2022 Jan 26. doi: 10.1111/edt.12732. Online ahead of print.

ABSTRACT

BACKGROUND/AIM: Mouthguard thickness influences the protection ability from orofacial trauma. The aim of this study was to propose a new design for mouthguards and to evaluate the effect of the lamination order on the thicknesses of mouthguards.

MATERIALS AND METHODS: Mouthguard sheets of 2.0-mm and 4.0-mm ethylene vinyl acetate were used. The sheets were pressure formed using a pressure former. Two lamination conditions were examined: The condition 24P used the 2.0-mm sheet as the first layer and 4.0-mm sheet as the second layer. The condition 42P used the 4.0-mm sheet as the first layer and 2.0-mm sheet as the second layer. The first layer was trimmed to cover only the anterior region, and then the second layer was formed over the first layer. Mouthguard thickness was measured using a measuring device at the labial surface of the central incisor, plus the buccal and occlusal surfaces of the first molar. Differences in thickness by measurement region of mouthguards formed under different lamination conditions were analyzed by two-way analysis of variance.

RESULTS: Mouthguard thickness differed among the regions at the central incisors and the first molars (p < .01). The thickness at the labial surface of the central incisor became statistically significantly larger with the 42P condition (3.38 mm) than with the 24P condition (3.30 mm) (p < .05). The thickness at the buccal and occlusal surfaces of the first molar became statistically significantly larger with the 24P condition (2.25 mm and 2.72 mm, respectively) than with the 42P condition (1.23 mm and 1.44 mm, respectively) (p < .01).

CONCLUSIONS: The results suggest that the combination of the 2.0-mm and 4.0-mm sheets could obtain the necessary thickness for the prevention at the labial surface of the central incisor and buccal surface of the first molar.

PMID:35083841 | DOI:10.1111/edt.12732

Pediatr Transplant. 2022 Jan 26:e14229. doi: 10.1111/petr.14229. Online ahead of print.

ABSTRACT

BACKGROUND: Medulloblastoma outcomes have improved with craniospinal irradiation and chemotherapy, but such therapy has resulted in poor neurocognitive outcomes for young patients. Chemotherapy-only regimens with autologous transplant have been implemented with the intention of avoiding radiation. It is not yet known whether single or tandem transplantation is superior with respect to efficacy and/or safety.

METHODS: We performed a retrospective review of children with medulloblastoma treated at Dana-Farber Cancer Institute from 1996 to 2016 who received either single or tandem autologous transplantation after completion of induction chemotherapy. We compared safety and outcome data between the two groups.

RESULTS: Among 23 patients, 12 received tandem transplants. Median follow-up was 6.4 years (IQR = 0.8-10.5). There was no statistically significant difference in 5-year EFS or OS between the single (70.7 ± 14%, 80.2 ± 13%) and tandem transplant groups (57.1 ± 15%, 79.6 ± 13%). Seven tandem transplant patients received subsequent radiation while only four required radiation in the single transplant group (p = .41). In the single transplant regimen, patients experienced longer antibiotic duration (p = .03) and LOS (p = .01) and a trend toward increased number of transfusions (p = .06). Four cases of veno-occlusive disease were reported in the single transplant group (p = .04).

CONCLUSIONS: Outcomes were similar between regimens, but the single transplant regimen had more hepatic complications. These data suggest that tandem transplant regimens may have reduced toxicity compared to the single transplant regimen with similar outcome measures.

PMID:35083822 | DOI:10.1111/petr.14229