Nevin Manimala

Int J Clin Pract. 2021 May 22:e14384. doi: 10.1111/ijcp.14384. Online ahead of print.

ABSTRACT

BACKGROUND: We tend to find out whether BMI and weight have difference in the connection with the disease severity of AECOPD patients. Besides, we aim to explore the relationships between body fat (BF) and lean body mass (LBM) with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

METHODS: Information like weight and body mass index (BMI) were recorded at hospital admission. BF and LBM were assessed using dual energy X-ray absorptiometry (DEXA). Logistic regression analysis, receiver operating characteristic (ROC) curves and other statistical analyses were performed.

RESULTS: Weight and BF + LBM showed significant linkages with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in multivariate logistic regression analysis (Model 3: OR = 0.932, p = 0.016; OR = 0.915, p = 0.006, respectively). And BMI did not show correlation with GOLD. In Stratification analysis, BF showed the predictive value for GOLD (AUC = 0.709, p = 0.004) while LBM showed the predictive ability for modified Medical Research Council scale (mMRC) (AUC = 0.761, p < 0.001).

CONCLUSION: BF + LBM and weight were better than BMI in the connection with the disease severity of AECOPD patients represtented by GOLD. BF and LBM may have different or even opposite effects on patients with AECOPD.

PMID:34021950 | DOI:10.1111/ijcp.14384

J Nurs Manag. 2021 May 22. doi: 10.1111/jonm.13384. Online ahead of print.

ABSTRACT

BACKGROUND: There is a scarcity of literature assessing the impact of job engagement and satisfaction in the nurse’s caring behaviors. This study aim to identify how these factors affect the caring behaviours of nurses.

METHODS: This study used a cross-sectional design and employed self-report questionnaires. A total of 549 nurses from private and government hospitals participated in the survey conducted in the year 2019. Descriptive and inferential statistics were utilized to analyse the data.

RESULTS: Results revealed that the nurses display high caring behaviours and job engagement and moderate sense of satisfaction. Remarkably there are no profile variables significantly related to the nurse’s caring behaviors. Findings suggest that job engagement and satisfaction are significantly associated with the nurses’ caring behaviours.

CONCLUSION: Factors such as job engagement and satisfaction affect nurses caring behaviours.

IMPLICATIONS TO NURSING MANAGEMENT: Health organizations must provide strategies to increase job engagement and satisfaction of nurses to yield high caring behaviours, which is vital to the achievement of patient safety.

PMID:34021940 | DOI:10.1111/jonm.13384

JPEN J Parenter Enteral Nutr. 2021 May 22. doi: 10.1002/jpen.2195. Online ahead of print.

ABSTRACT

INTRODUCTION: Hospital-acquired central line-associated bloodstream infections (CLABSI) are “never events” in U.S. healthcare. Efforts to eliminate CLABSI are critically important to children with intestinal failure (IF) who depend on long-term, daily use of a central venous catheter (CVC) and often undergo extended hospitalizations. They are also vital to the safety of any patient with a CVC. We sought to describe long-term outcomes of a multidisciplinary CLABSI elimination effort on a 24-bed medical-surgical unit caring for children with IF.

METHODS: Unit CLABSI events from 1/9/2012 to 4/16/2020 were evaluated in the context of multiple interventions aimed at preventing CLABSI; leveraging prospectively maintained clinical registries and National Healthcare Safety Network (NHSN) reporting data, patient and unit demographics, ethanol lock utilization, and unit CVC days. Interventions, including zinc oxide-based adhesive barriers, environmental cleaning, and simulation as part of staff education were developed utilizing consensus of hospital experts and Centers for Disease Control and Prevention guidelines with staff engagement. Descriptive statistics and tests of non-parametric data were employed for analysis.

RESULTS: Ninety-five patients with IF and 862 non-IF patients experienced a total of 1,629 admissions with 20,372 CVC days during the study period. Twelve hospital-acquired CLABSI events occurred, including 7 following NHSN definition change on 1/1/2015 (0.56 per 1,000 CVC days). Following the last unit CLABSI on 12/5/2016, there were 7,117 CVC days without CLABSI through study conclusion.

CONCLUSIONS: Use of described interventions in the context of an enhanced culture of collaborative care and ownership is associated with hospital-acquired CLABSI elimination. Success in a specific population translated to all other unit patients with a CVC. Findings suggest that CLABSI elimination is not the result of a single new product or practice but rather an approach that supports and empowers those most closely responsible for care of the patient and their CVC is key. This article is protected by copyright. All rights reserved.

PMID:34021937 | DOI:10.1002/jpen.2195

Hepatology. 2021 May 22. doi: 10.1002/hep.31916. Online ahead of print.

ABSTRACT

We read with great interests the study by Dr. John et al. In this retrospective study using national data on USA Veterans, multivariate competing risk analysis identified that male gender was independently associated with a higher risk of death/transplantation, and liver-related death/transplantation for patients with primary biliary cholangitis (PBC) and cirrhosis.

PMID:34021935 | DOI:10.1002/hep.31916

Mol Biol Rep. 2021 May 22. doi: 10.1007/s11033-021-06413-x. Online ahead of print.

ABSTRACT

The rhizosphere of a plant is an important interface for the plant-microbe interaction that plays a significant role in the uptake and removal of heavy metal from contaminated sites. Eichhornia crassipes is a free-floating macrophyte and a well-known metal hyperaccumulator. It is a promising plant, which harbors a diverse microbial community in its rhizosphere. Therefore it is hypothesized that it can be a good habitat for microorganisms that supports plant growth and increases its phytoremediation potential. The rhizospheric DNA was extracted from the procured plant samples. The library was prepared and sequenced using the Illumina platform. 16S rRNA data from the Next Generation Sequencing (NGS) platform was analyzed using the QIIME software package. Alpha diversity was estimated from statistical indices i.e. Shannon index, Chao1 index, and observed species. The rarefaction plots, rank abundance curve, krona graph, and heat map were generated to study the rhizospheric community in detail. Metagenome consisted of 225,408 flash reads, 185,008 non-chimeric sequences with 17,578 Operational Taxonomic Units (OTU’s), and 4622 OTU’s without singletons. The data of present study are available at NCBI Bioproject (PRJNA631882). The taxonomic analysis of OTU’s showed that the sequences belonged to major Phyla revealing the dominance of Proteobacteria, Bacteroidetes, Cyanobacteria, and Verrucomicrobia. The most abundant Genera in the sampled rhizosphere recorded were Thiothrix and Flavobacterium.

PMID:34021896 | DOI:10.1007/s11033-021-06413-x

Acta Ortop Mex. 2020 Nov-Dec;34(6):226-432.

ABSTRACT

INTRODUCTION: Intraarticular distal radius fractures are a therapeutic challenge for the orthopedist surgeon there are studies that support the use of fluoroscopy, and others promote arthroscopy, with this work we try to summarize the evidence, to determine whether arthroscopic assistance provides additional benefits to avoid joint incongruities compared to results obtained under fluoroscopic assistance.

MATERIAL AND METHODS: Systematic search for prospective, retrospective, cohort, follow-up, clinical trials on PubMed, MEDLINE, Scopus, Scielo, Embase, Google Scholar and other national sources, including as keywords the terms: “intra-articular distal radius fracture”, “wrist arthroscopy”, “arthroscopy”, “fluoroscopy”. The average values and standard offsets for each characteristic, obtained from the selected works, were analyzed using descriptive statistics and illustrative graphs.

RESULTS: 463 patients (256 women and 207 men) were evaluated, with an average age of 48.29 years and range from 39 to 64 years. The two treatments (A and F) were homogeneous in terms of the age of the patients reporting (p = 0.5820) and the average follow-up time (p = 0.9597). Only the ulnar deviation and DASH score, for which the arthroscopy group performed best, in the remaining variables the differences were not significant.

CONCLUSION: The evidence available to date is conflicting, and does not allow recommendations to be made for or against these interventions, finding other factors that could influence decision-making.

PMID:34020525

Acta Ortop Mex. 2020 Nov-Dec;34(6):388-398.

ABSTRACT

INTRODUCTION: A comparative clinical study has been conducted on patients involved using lateral intersomatic arthrodesis for the treatment of adjacent segment disease using titanium and PEEK intersomatic devices.

MATERIAL AND METHODS: Clinical (EVA and oswestry disability index ODI) and radiological (alignment and fusion), complications (major and minor) and quality of life (EQ5D) of 32 patients intervened from September 2015 to September 2018 have been analyzed and compared, with an average follow-up of 25 months (46-18). The average age in surgery was 66 years (39-89) and 68% of patients were women.

RESULTS: The most common segment involved was L3-L4 (62%) right retroperitoneal approach 86%. Lumbar EVA improved from 6.2 ± 2.12 to 4.1 ± 1.71 (p = 0.028). The LEG EVA descended from 5.3 ± 2.26 to 1.9 ± 1.58 (p = 0.02). The ODI scales improved from 50.2 ± 18.9 to 33.3 ± 10.2 (p = 0.025) and the EQ5D went from 0.52 to 0.73 (p = 0.039) with no statistically significant differences between the groups (ODI p = 0.18, EQ5D p = 0.293). Radiologically increased intervertebral height, lumbar and segmental lordosis, decreased Cobb’s angle and the overall melting rate was 84.3% (88% Ti/82% PEEK), with no differences between the groups.

CONCLUSION: Lateral lumbar interbody fusion is an effective method for treating adjacent segment disease with clinical-radiological results and literature-like complications. No differences have been found between Ti and PEEK implants.

PMID:34020519

Planta Med. 2021 May 21. doi: 10.1055/a-1499-7829. Online ahead of print.

ABSTRACT

Cocoa bean shell is one of the main by-products of chocolate manufacturing and possesses several compounds with biofunctionalities. It can function as an antibacterial agent, and its action is mostly reported against Streptococcus mutans. However, only a few studies have investigated the cocoa bean shell compounds responsible for this activity. This study aimed to evaluate several extracts of cocoa bean shells from different geographical origins and cocoa varieties and estimate their antimicrobial properties against different fungal and bacterial strains by determining their minimal inhibitory concentration. The results demonstrated antimicrobial activity of cocoa bean shell against one of the tested strains, S. mutans. Cocoa bean shell extracts were further analysed via LC-HRMS for untargeted metabolomic analysis. LC-HRMS data were analysed (preprocessing and statistical analyses) using the Workflow4Metabolomics platform. The latter enabled us to identify possible compounds responsible for the detected antimicrobial activity by comparing the more and less active extracts. Active extracts were not the most abundant in polyphenols but contained higher concentrations of two metabolites. After tentative annotation of these metabolites, one of them was identified and confirmed to be 7-methylxanthine. When tested alone, 7-methylxanthine did not display antibacterial activity. However, a possible cocktail effect due to the synergistic activity of this molecule along with other compounds in the cocoa bean shell extracts cannot be neglected. In conclusion, cocoa bean shell could be a functional ingredient with benefits for human health as it exhibited antibacterial activity against S. mutans. However, the antimicrobial mechanisms still need to be confirmed.

PMID:34020491 | DOI:10.1055/a-1499-7829

J AOAC Int. 2021 May 21;104(2):466-471. doi: 10.1093/jaoacint/qsaa112.

ABSTRACT

BACKGROUND: Physicochemical and microbiological methods are found in the literature for the analysis of daptomycin, an antimicrobial.

OBJECTIVE: This paper brings a miniaturized turbidimetric microbiological method for analysis of daptomycin in lyophilized powder.

METHODS: The method was performed using 96-well microplates, 4-h incubation, 2, 4 and 8 μg/mL, 7% Staphylococcus aureus ATCC 6538 IAL 2082, and BHI broth.

RESULTS: Linearity was proven by obtaining analytical curves with a correlation coefficient greater than 0.99 and statistical evaluation by ANOVA. The method was also selective, since the standard and sample analytical curves were parallel, proving that the excipient does not interfere with daptomycin analysis. Intraday, interday and inter-analyst precision presented RSDs of 2, 2.27, and 1.08%, respectively. Accuracy was assessed by the recovery test, where known quantities of standard solution are added to the sample and an average recovery value of 100.73% (RSD = 0.71%) was obtained. The present method was robust when minor changes were made in the parameters of used antimicrobial volume, inoculum volume and incubation time.

CONCLUSIONS: This work is an innovative and ecological proposal and has advantages such as (i) less waste generation, (ii) miniaturized quantities of sample, culture media and inoculum, (iii) no need to use formaldehyde as in the traditional turbidimetric method, (iv) lower volume of glassware used and (v) shorter incubation time compared to other methods as agar diffusion requiring approximately 24 h.

HIGHLIGHTS: This work is focuses on a current, innovative and sustainable theme for pharmaceutical analysis around the world.

PMID:34020456 | DOI:10.1093/jaoacint/qsaa112

J Phys Condens Matter. 2021 May 21. doi: 10.1088/1361-648X/ac03d2. Online ahead of print.

ABSTRACT

Equilibrium statistical mechanics rests on the assumption of ergodic dynamics of a system modulo the conservation laws of local observables: extremization of entropy immediately gives Gibbs’ ensemble (GE) for energy conserving systems and a generalized version of it (GGE) when the number of local conserved quantities (LCQ) is more than one. Through the last decade, statistical mechanics has been extended to describe the late-time behavior of periodically driven (Floquet) quantum matter starting from a generic state. The structure built on the fundamental assumptions of ergodicity and identification of the relevant “conservation laws” in this inherently non-equilibrium setting. More recently, it has been shown that the statistical mechanics has a much richer structure due to the existence of {it emergent} conservation laws: these are approximate but stable conservation laws arising {it due to the drive}, and are not present in the undriven system. Extensive numerical and analytical results support the perpetual stability of these emergent (though approximate) conservation laws, probably even in the thermodynamic limit. This banks on the recent finding of a sharp ergodicity threshold for Floquet thermalization in clean, interacting non-integrable Floquet systems. This opens up a new possibility of stable Floquet engineering in such systems. This review intends to give a theoretical overview of these developments. We conclude by briefly surveying the experimental scenario.

PMID:34020440 | DOI:10.1088/1361-648X/ac03d2